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  1. Article ; Online: Has there been an increased interest in smoking cessation during the first months of the COVID-19 pandemic? A Google Trends study.

    Heerfordt, C / Heerfordt, I M

    Public health

    2020  Volume 183, Page(s) 6–7

    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2020.04.012
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  2. Article: Has there been an increased interest in smoking cessation during the first months of the COVID-19 pandemic? A Google Trends study

    Heerfordt, C / Heerfordt, I M

    Public Health

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #88348
    Database COVID19

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  3. Article ; Online: Has there been an increased interest in smoking cessation during the first months of the COVID-19 pandemic? A Google Trends study

    Heerfordt, C. / Heerfordt, I.M.

    Public Health

    2020  Volume 183, Page(s) 6–7

    Keywords Public Health, Environmental and Occupational Health ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2020.04.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Daylight photodynamic therapy of actinic keratosis without curettage is as effective as with curettage: a randomized clinical trial.

    Heerfordt, I M / Wulf, H C

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2019  Volume 33, Issue 11, Page(s) 2058–2061

    Abstract: Background: Guidelines for photodynamic therapy (PDT) of actinic keratosis (AK) recommend pretreatment with curettage. The impact of curettage on cure rate is, however, not well established.: Objective: The present study aimed to evaluate whether ... ...

    Abstract Background: Guidelines for photodynamic therapy (PDT) of actinic keratosis (AK) recommend pretreatment with curettage. The impact of curettage on cure rate is, however, not well established.
    Objective: The present study aimed to evaluate whether daylight PDT without curettage could be as effective as daylight PDT with curettage.
    Methods: Twenty-five patients with multiple AKs were treated in two even-sized areas on the face and scalp. One area was treated with standard daylight PDT starting with curettage followed by incubation with methyl aminolevulinate (MAL) for 30 min before 2 h of daylight exposure. The other area was incubated with MAL for 1 h without prior curettage before 2 h of daylight exposure. The longer incubation time was used to obtain a sufficiently high protoporphyrin IX concentration in the non-curettaged area.
    Results: There was no difference in cure rate 3 months after daylight PDT in areas pretreated with curettage (86%) compared to non-curettaged areas (84%) (P = 0.1). Neither was there any difference between reported pain during daylight exposure (P > 0.7) or clinically evaluated erythema the day after treatment (P = 1.0).
    Conclusion: Daylight PDT without curettage but with 1 h of MAL incubation before daylight exposure was shown to be as effective in treatment of thin AKs on the face and scalp as standard daylight PDT with curettage. This modification of daylight PDT eases the task for the clinic and makes it more convenient for the patients as well, creating the possibility of performing daylight PDT as an entirely home-based treatment for AKs of the face and scalp without training the patients to perform pretreatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Aminolevulinic Acid/analogs & derivatives ; Aminolevulinic Acid/therapeutic use ; Curettage ; Humans ; Keratosis, Actinic/drug therapy ; Keratosis, Actinic/surgery ; Male ; Middle Aged ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Single-Blind Method ; Sunlight ; Treatment Outcome
    Chemical Substances Photosensitizing Agents ; methyl 5-aminolevulinate (585NM85KYM) ; Aminolevulinic Acid (88755TAZ87)
    Language English
    Publishing date 2019-07-02
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.15744
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  5. Article ; Online: Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review.

    Heerfordt, Ida M / Lerche, Catharina M / Philipsen, Peter A / Wulf, Hans Christian

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 158, Page(s) 114132

    Abstract: ... of organic sunscreen application, or oral treatment with beta-carotene, cysteine, N-acetylcysteine, vitamin C ...

    Abstract Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are characterized by skin photosensitivity caused by accumulation of protoporphyrin IX. We aimed to review the clinical evidence of efficacy and safety of skin photosensitivity treatments in individuals with EPP or XLP. We systematically searched MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.gov. A total of 40 studies with data on 18 treatment modalities were included. Comprehensive treatment safety data were obtained from the European Medicines Agency and the United States Food and Drug Administration. The studies used different outcome measures to evaluate the sensitivity without a generally accepted method to assess treatment effect on skin photosensitivity. Of the included studies, 13 were controlled trials. Gathered, the trials showed moderate positive effect of inorganic sunscreen application and subcutaneous implant of afamelanotide and no effect of organic sunscreen application, or oral treatment with beta-carotene, cysteine, N-acetylcysteine, vitamin C, or warfarin. Studies without control groups suggested treatment effect of foundation cream, dihydroxyacetone/lawsone cream, narrow-band ultraviolet B phototherapy, erythrocyte transfusion, extracorporeal erythrocyte photodynamic therapy, or oral treatment with zinc sulphate, terfenadine, cimetidine, or canthaxanthin, but the real effect is uncertain. Assessment of treatment effect on photosensitivity in patients with EPP or XLP carries a high risk of bias since experienced photosensitivity varies with both weather conditions, exposure pattern, and pigmentation. Controlled trials of promising treatment options are important although challenging in this small patient population.
    Language English
    Publishing date 2022-12-14
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.114132
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  6. Article ; Online: Patients with erythropoietic protoporphyria have reduced erythrocyte protoporphyrin IX from early in pregnancy.

    Heerfordt, I M / Wulf, H C

    The British journal of dermatology

    2017  Volume 177, Issue 3, Page(s) e38–e40

    MeSH term(s) Adult ; Erythrocytes/metabolism ; Female ; Humans ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Trimesters ; Protoporphyria, Erythropoietic/blood ; Protoporphyrins/metabolism
    Chemical Substances Protoporphyrins ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15228
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  7. Article ; Online: Image Gallery: Pitfalls when measuring protoporphyrin IX during photodynamic therapy.

    Heerfordt, I M / Wulf, H C

    The British journal of dermatology

    2017  Volume 177, Issue 5, Page(s) e225

    MeSH term(s) Aminolevulinic Acid/metabolism ; Humans ; Microscopy, Fluorescence/methods ; Photochemotherapy ; Photosensitizing Agents/metabolism ; Protoporphyrins/metabolism ; Skin/metabolism
    Chemical Substances Photosensitizing Agents ; Protoporphyrins ; Aminolevulinic Acid (88755TAZ87) ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2017-12-02
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15953
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  8. Article ; Online: Inhaled corticosteroids and risk of lower respiratory tract infection with

    Johnsen, Rikke Helin / Heerfordt, Christian Kjer / Boel, Jonas Bredtoft / Dessau, Ram Benny / Ostergaard, Christian / Sivapalan, Pradeesh / Eklöf, Josefin / Jensen, Jens-Ulrik Stæhr

    BMJ open respiratory research

    2023  Volume 10, Issue 1

    Abstract: Background: Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia. : Objective: To investigate if accumulated ICS use in patients with ... ...

    Abstract Background: Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia.
    Objective: To investigate if accumulated ICS use in patients with COPD, is associated with a dose-dependent risk of infection with
    Methods: This observational cohort study included 18 870 persons with COPD who were registered in The Danish Register of COPD. Linkage to several nationwide registries was performed.Exposure to ICS was determined by identifying all prescriptions for ICS, redeemed within 365 days prior to study entry. Main outcome was a lower respiratory tract sample positive for
    Results: We found an increased, dose-dependent, risk of a lower respiratory tract sample with
    Conclusion: Our study shows a dose-dependent increased risk of infection with
    MeSH term(s) Humans ; Moraxella catarrhalis ; Respiratory Tract Infections/epidemiology ; Patients ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Adrenal Cortex Hormones/adverse effects
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-001726
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  9. Article ; Online: Inhaled corticosteroids and

    Rønn, Christian / Kamstrup, Peter / Heerfordt, Christian Kjer / Sivapalan, Pradeesh / Eklöf, Josefin / Boel, Jonas Bredtoft / Ostergaard, Christian / Dessau, Ram Benny / Moberg, Mia / Janner, Julie / Ulrik, Charlotte Suppli / Jensen, Jens-Ulrik Stæhr

    BMJ open respiratory research

    2024  Volume 11, Issue 1

    Abstract: Objectives: Inhaled corticosteroids (ICS) are widely used in patients with chronic obstructive pulmonary disease (COPD). However, ICS are associated with an increased risk of adverse effects.We aimed to determine whether an association between a lower ... ...

    Abstract Objectives: Inhaled corticosteroids (ICS) are widely used in patients with chronic obstructive pulmonary disease (COPD). However, ICS are associated with an increased risk of adverse effects.We aimed to determine whether an association between a lower respiratory tract culture with
    Design: An observational cohort study of outpatients with COPD in Denmark between 2010 and 2018.ICS exposure was categorised into four groups based on average daily consumption 1 year prior to inclusion: no use, low ICS dose (≤400 µg), moderate ICS dose (400-800 µg) and high ICS dose (>800 µg). Dose-response relationship was investigated by a multivariable Cox proportional hazards regression.
    Results: Of the total 22 689 patients, 459 had lower respiratory tract cultures positive for
    Conclusions: We found that ICS was associated with a high, dose-dependent increased hazard of
    MeSH term(s) Humans ; Stenotrophomonas maltophilia ; Retrospective Studies ; Outpatients ; Administration, Inhalation ; Pulmonary Disease, Chronic Obstructive ; Adrenal Cortex Hormones ; Cohort Studies
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-001929
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  10. Article ; Online: Protoporphyrin IX in the skin measured noninvasively predicts photosensitivity in patients with erythropoietic protoporphyria.

    Heerfordt, I M / Wulf, H C

    The British journal of dermatology

    2016  Volume 175, Issue 6, Page(s) 1284–1289

    Abstract: Background: Erythropoietic protoporphyria (EPP) is a rare genetic disease that causes severe sensitivity to visible light as a result of protoporphyrin IX (PpIX) accumulation in the skin.: Objectives: To establish a noninvasive method to measure PpIX ...

    Abstract Background: Erythropoietic protoporphyria (EPP) is a rare genetic disease that causes severe sensitivity to visible light as a result of protoporphyrin IX (PpIX) accumulation in the skin.
    Objectives: To establish a noninvasive method to measure PpIX in the skin of patients with EPP and to investigate how skin PpIX relates to erythrocyte PpIX and photosensitivity.
    Methods: Skin PpIX was measured in 25 patients with EPP by calculating the difference in PpIX fluorescence before and after complete photobleaching of PpIX using controlled illumination. The patients reported symptoms during the illumination and skin erythema was measured before and after illumination. Confirmation of the presence of PpIX was obtained in seven patients by measuring the in vivo fluorescence emission spectrum. This method was used to examine skin PpIX during the hours after an illumination in seven patients.
    Results: We established a noninvasive method to measure skin PpIX based on measurements of PpIX fluorescence before and after complete PpIX photobleaching. The patients had an average skin PpIX of 2·0 units and skin emission spectra confirmed the presence of skin PpIX (peak emission 632 nm). Skin PpIX was associated with erythrocyte PpIX (P = 0·002, R
    Conclusions: We have developed a noninvasive method to measure skin PpIX in patients with EPP. Skin PpIX is dependent on erythrocyte PpIX and exposure of the skin to light. This method can be used for objective monitoring of treatment effect.
    MeSH term(s) Case-Control Studies ; Erythema/diagnosis ; Female ; Fluorescence ; Humans ; Male ; Photobleaching ; Protoporphyria, Erythropoietic/diagnosis ; Protoporphyrins/metabolism ; Skin/metabolism
    Chemical Substances Protoporphyrins ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15050
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