LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 9744

Search options

  1. Article ; Online: m

    Benavides-Serrato, Angelica / Saunders, Jacquelyn T / Kumar, Sunil / Holmes, Brent / Benavides, Kennedy E / Bashir, Muhammad T / Nishimura, Robert N / Gera, Joseph

    Cancer letters

    2023  Volume 562, Page(s) 216178

    Abstract: ... events regulating cyclin D1 and c-myc IRES activity. Here we describe the requirement for m ...

    Abstract A major mechanism conferring resistance to mTOR inhibitors is activation of a salvage pathway stimulating internal ribosome entry site (IRES)-mediated mRNA translation, driving the synthesis of proteins promoting resistance of glioblastoma (GBM). Previously, we found this pathway is stimulated by the requisite IRES-trans-acting factor (ITAF) hnRNP A1, which itself is subject to phosphorylation and methylation events regulating cyclin D1 and c-myc IRES activity. Here we describe the requirement for m
    MeSH term(s) Humans ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Internal Ribosome Entry Sites ; Methyltransferases/metabolism ; Protein Biosynthesis ; TOR Serine-Threonine Kinases/metabolism ; Genes, myc
    Chemical Substances Cyclin D1 (136601-57-5) ; Heterogeneous Nuclear Ribonucleoprotein A1 ; Internal Ribosome Entry Sites ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-04-14
    Publishing country Ireland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216178
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: FDA/M-CERSI Co-Processed API Workshop Proceedings.

    Schenck, Luke / Patel, Paresma / Sood, Ramesh / Bonaga, Llorente / Capella, Peter / Dirat, Olivier / Erdemir, Deniz / Ferguson, Steven / Gazziola, Cinzia / Gorka, Lindsey Saunders / Graham, Laurie / Ho, Raimundo / Hoag, Stephen / Hunde, Ephrem / Kline, Billie / Lee, Sau Larry / Madurawe, Rapti / Marziano, Ivan / Merritt, Jeremy Miles /
    Page, Sharon / Polli, James / Ramanadham, Mahesh / Sapru, Mohan / Stevens, Ben / Watson, Tim / Zhang, Haitao

    Journal of pharmaceutical sciences

    2023  Volume 112, Issue 8, Page(s) 2069–2078

    Abstract: ... of Maryland Center of Excellence in Regulatory Science and Innovation (M-CERSI) Workshop on Co-processed API ...

    Abstract These proceedings contain presentation summaries and discussion highlights from the University of Maryland Center of Excellence in Regulatory Science and Innovation (M-CERSI) Workshop on Co-processed API, held on July 13 and 14, 2022. This workshop examined recent advances in the use of co-processed active pharmaceutical ingredients as a technology to improve drug substance physicochemical properties and drug product manufacturing process robustness, and explored proposals for enabling commercialization of these transformative technologies. Regulatory considerations were discussed with a focus on the classification, CMC strategies, and CMC documentation supporting the use of this class of materials from clinical studies through commercialization. The workshop format was split between presentations from industry, academia and the FDA, followed by breakout sessions structured to facilitate discussion. Given co-processed API is a relatively new concept, the authors felt it prudent to compile these proceedings to gain further visibility to topics discussed and perspectives raised during the workshop, particularly during breakout discussions. Disclaimer: This paper reflects discussions that occurred among stakeholder groups, including FDA, on various topics. The topics covered in the paper, including recommendations, therefore, are intended to capture key discussion points. The paper should not be interpreted to reflect alignment on the different topics by the participants, and the recommendations provided should not be used in lieu of FDA published guidance or direct conversations with the Agency about a specific development program. This paper should not be construed to represent FDA's views or policies.
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Reply to Spadaccini M. et al.

    Ahmad, Ahmir / Bassett, Paul / Saunders, Brian P

    Endoscopy

    2023  Volume 55, Issue 12, Page(s) 1152

    Language English
    Publishing date 2023-11-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2147-0532
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Reply to M Rishniw et al.

    Singh, Pawanpreet / Banton, Sydney / Raheb, Shari / Templeman, James R / Saunders-Blades, Jennifer / Kostiuk, Darcia / Kelly, Janelle / Marinangeli, Christopher Pf / Verbrugghe, Adronie / Verton-Shaw, Shoshana / Shoveller, Anna K

    The Journal of nutrition

    2023  Volume 153, Issue 11, Page(s) 3343–3344

    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Letter
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Kevin Kealy, M.V.M., M.R.C.V.S., D.V.R. (1921-2021).

    Saunders, Mark

    Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

    2021  Volume 62, Issue 6, Page(s) 721–722

    Language English
    Publishing date 2021-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142058-0
    ISSN 1740-8261 ; 1058-8183
    ISSN (online) 1740-8261
    ISSN 1058-8183
    DOI 10.1111/vru.13013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Reply to Spadaccini M. et al.

    Ahmad, Ahmir / Bassett, Paul / Saunders, Brian P.

    Endoscopy

    2023  Volume 55, Issue 12, Page(s) 1152–1152

    Language English
    Publishing date 2023-11-28
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2147-0532
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Sodium bicarbonate improved CrossFit® Benchmark Fran, but not subsequent 500 m rowing performance.

    Silva de Souza, Ricardo Augusto / Barreto, Gabriel / Alves Freire, Peterson Adriano / de Abreu, Wilson Cesar / Saunders, Bryan / da Silva, Sandro Fernandes

    Research in sports medicine (Print)

    2024  , Page(s) 1–16

    Abstract: ... prior to performing the CrossFit® benchmark Fran followed by 500 m of rowing. SB improved time ...

    Abstract The aim of this study was to evaluate the influence of sodium bicarbonate (SB) supplementation on physical performance, neuromuscular and metabolic responses during CrossFit® exercise. Seventeen Advanced CrossFit®-trained athletes completed the randomized, double-blind, placebo-controlled crossover protocol consisting of four visits, including two familiarization sessions and two experimental trials separated by a 7-day washout period. Participants supplemented 0.3 g/kg body mass (BM) of SB or placebo 120-min prior to performing the CrossFit® benchmark Fran followed by 500 m of rowing. SB improved time to complete Fran compared to PLA (291.2 ± 71.1 vs. 303.3 ± 77.8 s,
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2116093-4
    ISSN 1543-8635 ; 1543-8627
    ISSN (online) 1543-8635
    ISSN 1543-8627
    DOI 10.1080/15438627.2024.2324254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The West of Scotland Cohort of Mitochondrial Individuals with the m.3243A>G Variant: Variations in Phenotypes and Predictors of Disease Severity.

    Saunders, Charlie / Longman, Cheryl / Gorman, Grainne / James, Kelly / Oliwa, Agata / Petty, Richard / Snadden, Lesley / Farrugia, Maria Elena

    Journal of neuromuscular diseases

    2024  Volume 11, Issue 1, Page(s) 179–189

    Abstract: Background: The m.3243A>G variant is the commonest mitochondrial (mt) DNA pathogenic variant and ... syndromic phenotypes were incorrectly used by non-neurological specialities.: Conclusions: This m.3243 ...

    Abstract Background: The m.3243A>G variant is the commonest mitochondrial (mt) DNA pathogenic variant and a frequent cause of mitochondrial disease. Individuals present with a variety of clinical manifestations from diabetes to neurological events resembling strokes. Due to this, patients are commonly cared for by a multidisciplinary team.
    Objectives: This project aimed to identify patients with confirmed mt.3243A>G-related mitochondrial disease attending the Muscle Clinic at Queen Elizabeth University Hospital in Glasgow. We explored potential correlates between clinical phenotypes and mtDNA heteroplasmy levels, HbA1c levels, body mass index, and specific clinical manifestations. We investigated if there were discrepancies between non-neurological speciality labelling in clinical records and individuals' phenotypes.
    Methods: Data were gathered from the West of Scotland electronic records. Phenotypes were ascertained by a clinician with expertise in mitochondrial disorders. Statistical analyses were applied to study relationships between tissue heteroplasmy, HbA1c and clinical phenotypes including body mass index (BMI).
    Results: Forty-six individuals were identified from 31 unrelated pedigrees. Maternally inherited diabetes and deafness was the prominent syndromic phenotype (48%). A significant association was found between overall number of symptoms and bowel dysmotility (p < 0.01). HbA1c was investigated as a predictor of severity with potential association seen. Although used widely as a prognosticator, neither corrected blood nor urine mtDNA heteroplasmy levels were associated with increased number of symptoms. In 74.1% of records, syndromic phenotypes were incorrectly used by non-neurological specialities.
    Conclusions: This m.3243 A > G patient cohort present with marked clinical heterogeneity. Urine and blood heteroplasmy levels are not reliable predictors of disease severity. HbA1c may be a novel predictor of disease severity with further research required to investigate this association. We infer that prognosis may be worse in patients with low BMIs and in those with bowel dysmotility. These results underscore a multidisciplinary approach and highlight a problem with inaccurate use of the existing nomenclature.
    MeSH term(s) Humans ; Glycated Hemoglobin ; Mitochondrial Diseases/diagnosis ; Mitochondrial Diseases/genetics ; DNA, Mitochondrial/genetics ; Phenotype ; Patient Acuity
    Chemical Substances Glycated Hemoglobin ; DNA, Mitochondrial
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2214-3602
    ISSN (online) 2214-3602
    DOI 10.3233/JND-230166
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Slow oscillations persist in pancreatic beta cells lacking phosphofructokinase M.

    Marinelli, Isabella / Parekh, Vishal / Fletcher, Patrick / Thompson, Benjamin / Ren, Jinhua / Tang, Xiaoqing / Saunders, Thomas L / Ha, Joon / Sherman, Arthur / Bertram, Richard / Satin, Leslie S

    Biophysical journal

    2022  Volume 121, Issue 5, Page(s) 692–704

    Abstract: Pulsatile insulin secretion by pancreatic beta cells is necessary for tight glucose control in the body. Glycolytic oscillations have been proposed as the mechanism for generating the electrical oscillations underlying pulsatile insulin secretion. The ... ...

    Abstract Pulsatile insulin secretion by pancreatic beta cells is necessary for tight glucose control in the body. Glycolytic oscillations have been proposed as the mechanism for generating the electrical oscillations underlying pulsatile insulin secretion. The glycolytic enzyme 6-phosphofructokinase-1 (PFK) synthesizes fructose-1,6-bisphosphate (FBP) from fructose-6-phosphate. It has been proposed that the slow electrical and Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Glucose/metabolism ; Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans ; Mice ; Phosphofructokinase-1/genetics ; Phosphofructokinase-1/metabolism
    Chemical Substances Insulin ; Phosphofructokinase-1 (EC 2.7.1.11) ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2022.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Jacqueline A Guendouzi and Nicole M

    Saunders, Pamela

    Dementia (London, England)

    2015  Volume 14, Issue 3, Page(s) 385–386

    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article
    ISSN 1741-2684
    ISSN (online) 1741-2684
    DOI 10.1177/1471301215575820
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top