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  1. Article ; Online: Gut flora alterations among aquatic firefly

    Zhao, Zi-Shun / Yang, Lin-Yu / Li, Fu-Xin / Cun, Wei / Wang, Xing-Yan / Cao, Cheng-Quan / Zhang, Qi-Lin

    iScience

    2023  Volume 26, Issue 10, Page(s) 107809

    Abstract: Knowledge about the impact of different dissolved oxygen (DO) on the composition and function of gut bacteria of aquatic insects is largely unknown. Herein, we constructed freshwater environments with different DOs (hypoxia: 2.50 ± 0.50, normoxia: 7.00 ± ...

    Abstract Knowledge about the impact of different dissolved oxygen (DO) on the composition and function of gut bacteria of aquatic insects is largely unknown. Herein, we constructed freshwater environments with different DOs (hypoxia: 2.50 ± 0.50, normoxia: 7.00 ± 0.50, and hyperoxia: 13.00 ± 0.50 mg/L) where aquatic firefly
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intestinal flora: New perspective of type 2 diabetes.

    Liu, Yan / Chang, Jun / Bai, Li-Ding

    World journal of clinical cases

    2024  Volume 12, Issue 11, Page(s) 1996–1999

    Abstract: ... response. Notably, Li and Guo have elucidated the involvement of intestinal flora in the pathogenesis ... This letter briefly summarizes the role of intestinal flora in T2DM based on findings from animal experiments ... associated with targeting intestinal flora as therapeutic interventions. ...

    Abstract Diabetes comprises a group of metabolic diseases characterized by hyperglycemia stemming from various factors. Current diabetes management primarily focuses on blood glucose control, yet it is inherently progressive, necessitating increased reliance on exogenous blood glucose control methods over time. Therefore, there is an urgent need to explore novel intervention strategies addressing both diabetes and its complications. The human intestinal microbiota, often referred to as the "second genome", exhibits significant diversity and plays a pivotal role in insulin resistance, glucose and lipid metabolism, and inflammatory response. Notably, Li and Guo have elucidated the involvement of intestinal flora in the pathogenesis of type 2 diabetes mellitus (T2DM) and proposed a novel therapeutic approach targeting intestinal microbes. This advancement enhances our comprehension of the multifaceted and multi-target regulation of T2DM by intestinal microflora, thereby offering fresh avenues for understanding its pathogenesis and clinical management. This letter briefly summarizes the role of intestinal flora in T2DM based on findings from animal experiments and clinical studies. Additionally, it discusses the potential clinical applications and challenges associated with targeting intestinal flora as therapeutic interventions.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i11.1996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alien flora are accumulating steadily in China over the last 80 years.

    Banerjee, Achyut Kumar / Feng, Hui / Bhowmick, Amiya Ranjan / Peng, Hao / Liang, Xinru / Yin, Minghui / Duan, Fuyuan / Yan, Yubin / Huang, Yelin

    iScience

    2024  Volume 27, Issue 4, Page(s) 109552

    Abstract: ... flora has been accumulating steadily in China, particularly in the coastal regions, for the last 80 ... introduction of alien flora, whereas a large naturalized range, greater number of uses, and multiple ...

    Abstract New alien species are increasingly introduced and established outside their native range. The knowledge of the spatiotemporal dynamics of their accumulation and the factors determining their residence time in the introduced range is critical for proactive management, especially in emerging economies. Based on a comprehensive time series dataset of 721 alien angiosperms in China, we show that new alien flora has been accumulating steadily in China, particularly in the coastal regions, for the last 80 years without saturation. The ability to occupy a large number of habitats facilitates the early introduction of alien flora, whereas a large naturalized range, greater number of uses, and multiple introduction pathways directly contribute to their naturalization and invasion. The temporal pattern is predicted to remain consistent in the foreseeable future. We propose upgrading the country's biosecurity infrastructure based on a standardized risk assessment framework to safeguard the country from ongoing and future invasions.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intestinal Flora in Chemotherapy Resistance of Biliary Pancreatic Cancer.

    Bai, Liuhui / Yan, Xiangdong / Lv, Jin / Qi, Ping / Song, Xiaojing / Zhang, Lei

    Biology

    2023  Volume 12, Issue 8

    Abstract: ... resistance is a major reason leading to poor prognosis. With the advancement of studies on intestinal flora ... it has been found that intestinal flora is correlated with and plays an important role in chemotherapy ... resistance. The application of probiotics and other ways to regulate intestinal flora can improve ...

    Abstract Biliary pancreatic malignancy has an occultic onset, a high degree of malignancy, and a poor prognosis. Most clinical patients miss the opportunity for surgical resection of the tumor. Systemic chemotherapy is still one of the important methods for the treatment of biliary pancreatic malignancies. Many chemotherapy regimens are available, but their efficacy is not satisfactory, and the occurrence of chemotherapy resistance is a major reason leading to poor prognosis. With the advancement of studies on intestinal flora, it has been found that intestinal flora is correlated with and plays an important role in chemotherapy resistance. The application of probiotics and other ways to regulate intestinal flora can improve this problem. This paper aims to review and analyze the research progress of intestinal flora in the chemotherapy resistance of biliary pancreatic malignancies to provide new ideas for treatment.
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12081151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of intestinal flora in the development of nonalcoholic fatty liver disease in children.

    Zhang, Jing / Shi, Mengxuan / Zhao, Chunna / Liang, Guangcai / Li, Chuan / Ge, Xiaomeng / Pei, Caixia / Kong, Yawei / Li, Dongdan / Yang, Wenli / Cao, Bingyan / Fu, Libing / Yan, Yinkun / Wu, Jie / Zhou, Jin / Fang, Yongli / Meng, Xi / Li, Yong / Wang, Liming

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0100623

    Abstract: ... the fecal microbiome of Chinese children with NAFLD and further analyze the potential of flora in regulating ... flora. The findings showed that some fecal microbiota had a negative correlation with body mass index ... fatty liver disease (NAFLD) vary in children, the composition of intestinal microflora has been found to play ...

    Abstract In China, 45% of adolescents with obesity develop fatty liver disease, a condition that increases the long-term risk of developing cirrhosis and liver cancer. Although the factors triggering nonalcoholic fatty liver disease (NAFLD) vary in children, the composition of intestinal microflora has been found to play an increasingly important role. However, evidence is limited on the prevalence of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) in Chinese children. Therefore, this study aimed to evaluate the fecal microbiome of Chinese children with NAFLD and further analyze the potential of flora in regulating NAFLD-related symptoms and metabolic functions. Specifically, the study applied a 16S rRNA and metagenomic sequencing to the fecal samples of pediatric patients with NAFLD, NASH, and NAFL, as well as healthy controls, to explore the correlation among NAFLD-related indexes, metabolic pathways, and gut flora. The findings showed that some fecal microbiota had a negative correlation with body mass index, and various NAFLD-related bacteria, including
    MeSH term(s) Adult ; Adolescent ; Humans ; Child ; Non-alcoholic Fatty Liver Disease ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Follow-Up Studies ; Biomarkers/metabolism ; Liver/metabolism
    Chemical Substances RNA, Ribosomal, 16S ; Biomarkers
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01006-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The pathogenic role of intestinal flora metabolites in diabetic nephropathy.

    Tian, En / Wang, Feng / Zhao, Lei / Sun, Yan / Yang, Jurong

    Frontiers in physiology

    2023  Volume 14, Page(s) 1231621

    Abstract: With the increasing incidence of diabetes, diabetic kidney disease has become a major cause of chronic kidney disease. The role of the gut microbiota in diabetes and its related complications have been extensively investigated; the modulatory effect of ... ...

    Abstract With the increasing incidence of diabetes, diabetic kidney disease has become a major cause of chronic kidney disease. The role of the gut microbiota in diabetes and its related complications have been extensively investigated; the modulatory effect of the gut microbiota on the host depends on several gut microbial metabolites, particularly short-chain fatty acids, secondary bile acids, and trimethylamine N-oxide. In this review, we focused on the evidence related to the pathogenic role of each of the gut microbial metabolites in diabetic nephropathy. The main novel therapies targeting the gut microbiota include probiotics, dietary prebiotics, synbiotic supplements, and faecal microbiota transplants, although there is no standard treatment principle. Further research is therefore needed to elucidate the link between gut microbes and diabetic nephropathy, and more therapeutic targets should be explored to treat diabetic nephropathy with dysbiosis of the gut microbes.
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1231621
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  7. Article ; Online: Impacts of Plant-derived Secondary Metabolites for Improving Flora in Type 2 Diabetes.

    Li, Lin Zehao / Yan, Yan / Song, Qinghe / Wang, Zhibin / Zhang, Wei / Hou, Yanli / Zhang, Xiandang

    Current diabetes reviews

    2023  Volume 19, Issue 7, Page(s) e160123212750

    Abstract: ... The relationship between flora and type 2 diabetes was investigated by reviewing the recent experimental literature ... have shown that intestinal flora exerts positive therapeutic effects on metabolic diseases, and plant ... on intestinal flora and diabetes; these drugs have rarely been reviewed before as a class of drugs for diabetes ...

    Abstract Background: Diabetes has become a problem that plagues public healthcare systems. Recent studies have shown that intestinal flora exerts positive therapeutic effects on metabolic diseases, and plant-derived secondary metabolites are safe, effective and easy to prepare and also have an impact on intestinal flora and diabetes; these drugs have rarely been reviewed before as a class of drugs for diabetes, especially focusing on the intestinal flora. Therefore, studying the relationship between plant-derived secondary metabolites and diabetes mellitus is crucial.
    Objective: The objective of this study is to summarize and investigate the therapeutic mechanism of drugs extracted from natural plants effects on type 2 diabetes mellitus.
    Methods: The relationship between flora and type 2 diabetes was investigated by reviewing the recent experimental literature, and the pathways available for natural plant-derived secondary metabolites in the treatment of type 2 diabetes were summarized.
    Results: The therapeutic mechanisms of common plant-derived secondary metabolites for type 2 diabetes were summarized with a focus on the prebiotic efficacy of natural plant-derived secondary metabolites and the modulation of intestinal flora, and the mechanisms through which plantderived secondary metabolites treat type 2 diabetes via effects on intestinal flora are further reviewed.
    Conclusion: Common plant-derived secondary metabolites can play a role in regulating bacteria in the intestinal tract by enriching beneficial bacteria and removing harmful bacteria to achieve their therapeutic effect on type 2 diabetes. In addition, due to their excellent ability to regulate intestinal flora, plant-derived secondary metabolites may also have excellent efficacy in cancer and obesity, among other diseases.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/metabolism ; Gastrointestinal Microbiome ; Neoplasms
    Language English
    Publishing date 2023-01-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6417
    ISSN (online) 1875-6417
    DOI 10.2174/1573399819666230116111856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [The characteristics and correlations of vaginal flora in women with cervical lesions].

    Zhang, M X / Wang, J H / Zhang, L / Yan, J X / Wu, C H / Pei, R X / Lyu, Y J / Song, L / Cui, M / Ding, L / Wang, Z L / Wang, J T

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2023  Volume 45, Issue 3, Page(s) 253–258

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Female ; Humans ; Vagina/microbiology ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Dysplasia ; Cervix Uteri ; Lactobacillus/genetics ; Papillomavirus Infections
    Language Chinese
    Publishing date 2023-03-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.cn112152-20211024-00782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2277: Show issues Location:
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  9. Article ; Online: Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment.

    Zhang, Yan / Gao, Xueyan / Gao, Shuochen / Liu, Yang / Wang, Wenkang / Feng, Yudi / Pei, Liping / Sun, Zhenqiang / Liu, Lin / Wang, Chengzeng

    Immunology

    2023  Volume 170, Issue 3, Page(s) 301–318

    Abstract: ... the effects of gut flora on the intestinal immune microenvironment via BAs and contribute to the development ... of intestinal flora origin affect T helper cells and regulatory T cells (Treg cells). Th17 cells play a pro ...

    Abstract According to reports, gut microbiota and metabolites regulate the intestinal immune microenvironment. In recent years, an increasing number of studies reported that bile acids (BAs) of intestinal flora origin affect T helper cells and regulatory T cells (Treg cells). Th17 cells play a pro-inflammatory role and Treg cells usually act in an immunosuppressive role. In this review, we emphatically summarised the influence and corresponding mechanism of different configurations of lithocholic acid (LCA) and deoxycholic acid (DCA) on intestinal Th17 cells, Treg cells and intestinal immune microenvironment. The regulation of BAs receptors G protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and farnesoid X receptor (FXR) on immune cells and intestinal environment are elaborated. Furthermore, the potential clinical applications above were also concluded in three aspects. The above will help researchers better understand the effects of gut flora on the intestinal immune microenvironment via BAs and contribute to the development of new targeted drugs.
    MeSH term(s) Gastrointestinal Microbiome ; Receptors, G-Protein-Coupled/metabolism ; Intestines ; Bile Acids and Salts
    Chemical Substances Receptors, G-Protein-Coupled ; Bile Acids and Salts
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.181: Show issues Location:
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  10. Article ; Online: Impacts of changes in intestinal flora on the metabolism of

    Wang, Chengfei / Yan, Dong / Huang, Jianrong / Li, Yongtao

    Bioengineered

    2021  Volume 12, Issue 2, Page(s) 10603–10611

    Abstract: Changes in intestinal flora affect the health and cause metabolic diseases of the host. The extent ... to which the impact of different changes in intestinal flora would have on the metabolism of an individual has not ... been reported. This study aims to investigate the effect of different changes in intestinal flora ...

    Abstract Changes in intestinal flora affect the health and cause metabolic diseases of the host. The extent to which the impact of different changes in intestinal flora would have on the metabolism of an individual has not been reported. This study aims to investigate the effect of different changes in intestinal flora on the metabolism of Sprague-Dawley (SD) normal rats' individuals. Forty-eight SD rats were randomly divided into 6 groups (8 rats per group), which were treated with normal saline, probiotics, nonpathogenic
    MeSH term(s) Animals ; Feces/microbiology ; Gas Chromatography-Mass Spectrometry ; Gastrointestinal Microbiome ; Ileum/microbiology ; Male ; Metabolism ; Metabolome ; Principal Component Analysis ; Rats, Sprague-Dawley ; Serum/metabolism ; Rats
    Language English
    Publishing date 2021-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.2000242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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