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  1. Article: Therapeutic Vaccination for HPV-Mediated Cancers.

    Yan, Flora / Cowell, Lindsay G / Tomkies, Anna / Day, Andrew T

    Current otorhinolaryngology reports

    2023  Volume 11, Issue 1, Page(s) 44–61

    Abstract: Purpose of review: The goal of this narrative review is to educate clinicians regarding the foundational concepts, efficacy, and future directions of therapeutic vaccines for human papillomavirus (HPV)-mediated cancers.: Recent findings: Therapeutic ... ...

    Abstract Purpose of review: The goal of this narrative review is to educate clinicians regarding the foundational concepts, efficacy, and future directions of therapeutic vaccines for human papillomavirus (HPV)-mediated cancers.
    Recent findings: Therapeutic HPV vaccines deliver tumor antigens to stimulate an immune response to eliminate tumor cells. Vaccine antigen delivery platforms are diverse and include DNA, RNA, peptides, proteins, viral vectors, microbial vectors, and antigen-presenting cells. Randomized, controlled trials have demonstrated that therapeutic HPV vaccines are efficacious in patients with cervical intraepithelial neoplasia. In patients with HPV-mediated malignancies, evidence of efficacy is limited. However, numerous ongoing studies evaluating updated therapeutic HPV vaccines in combination with immune checkpoint inhibition and other therapies exhibit significant promise.
    Summary: Therapeutic vaccines for HPV-mediated malignancies retain a strong biological rationale, despite their limited efficacy to date. Investigators anticipate they will be most effectively used in combination with other regimens, such as immune checkpoint inhibition.
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2167-583X
    ISSN 2167-583X
    DOI 10.1007/s40136-023-00443-8
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  2. Article ; Online: The Nose Knows That Margins Matter.

    Day, Andrew T / Salley, Jordan R / Nijhawan, Rajiv I

    Annals of surgical oncology

    2021  Volume 28, Issue 7, Page(s) 3468–3469

    MeSH term(s) Humans ; Margins of Excision ; Nose
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09881-4
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    Zs.A 4042: Show issues Location:
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  3. Article: Evolution of a Pathogenic Microbiome.

    Wong, Pui Yin / Yip, Carmen / Lemberg, Daniel A / Day, Andrew S / Leach, Steven T

    Journal of clinical medicine

    2023  Volume 12, Issue 22

    Abstract: The process of microbiome development arguably begins before birth. Vertical transmission of bacteria from the mother to the infant is a keystone event in microbiome development. Subsequent to birth, the developing microbiome is vulnerable to influence ... ...

    Abstract The process of microbiome development arguably begins before birth. Vertical transmission of bacteria from the mother to the infant is a keystone event in microbiome development. Subsequent to birth, the developing microbiome is vulnerable to influence from a wide range of factors. Additionally, the microbiome can influence the health and development of the host infant. This intricate interaction of the gastrointestinal microbiome and the host has been described as both symbiotic and dysbiotic. Defining these terms, a symbiotic microbiome is where the microbiome and host provide mutual benefit to each other. A pathogenic microbiome, or more precisely a gastrointestinal microbiome associated with disease, is increasing described as dysbiotic. This review seeks to investigate the factors that contribute to evolving a disease-causing or 'dysbiotic' microbiome. This review covers the development of the gastrointestinal microbiome in infants, the interaction of the microbiome with the host, and its contribution to host immunity and investigates specific features of the gastrointestinal microbiome that are associated with disease.
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12227184
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  4. Article ; Online: Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome.

    Horseman, Timothy / Rittase, W Bradley / Slaven, John E / Bradfield, Dmitry T / Frank, Andrew M / Anderson, Joseph A / Hays, Evelyn C / Ott, Andrew C / Thomas, Anjali E / Huppmann, Alison R / Lee, Sang-Ho / Burmeister, David M / Day, Regina M

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Hematopoietic acute radiation syndrome (H-ARS) involves injury to multiple organ systems following total body irradiation (TBI). Our laboratory demonstrated that captopril, an angiotensin-converting enzyme inhibitor, mitigates H-ARS in Göttingen minipigs, ...

    Abstract Hematopoietic acute radiation syndrome (H-ARS) involves injury to multiple organ systems following total body irradiation (TBI). Our laboratory demonstrated that captopril, an angiotensin-converting enzyme inhibitor, mitigates H-ARS in Göttingen minipigs, with improved survival and hematopoietic recovery, as well as the suppression of acute inflammation. However, the effects of captopril on the gastrointestinal (GI) system after TBI are not well known. We used a Göttingen minipig H-ARS model to investigate captopril's effects on the GI following TBI (
    MeSH term(s) Animals ; Acute Radiation Syndrome/drug therapy ; Swine, Miniature ; Swine ; Inflammation/pathology ; Captopril/pharmacology ; Disease Models, Animal ; Whole-Body Irradiation/adverse effects ; Ferroptosis/drug effects ; Gastrointestinal Microbiome/drug effects ; Intestines/microbiology ; Intestines/pathology ; Intestines/drug effects ; Intestines/radiation effects ; Male ; Angiotensin-Converting Enzyme Inhibitors/pharmacology
    Chemical Substances Captopril (9G64RSX1XD) ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084535
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  5. Article ; Online: Enzyme-Linked Immunosorbent Assay to Measure S100A12 in Fecal Samples of Children and Adults.

    Leach, Steven T / Day, Andrew S

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1929, Page(s) 755–761

    Abstract: In recent years there have been numerous attempts to establish reliable and consistent noninvasive biomarkers of gut inflammation. Here we describe the development of an enzyme-linked immunoassay for the measurement of the pro-inflammatory, calcium- ... ...

    Abstract In recent years there have been numerous attempts to establish reliable and consistent noninvasive biomarkers of gut inflammation. Here we describe the development of an enzyme-linked immunoassay for the measurement of the pro-inflammatory, calcium-binding protein S100A12 in fecal samples.
    MeSH term(s) Adult ; Biomarkers/analysis ; Child ; Enzyme-Linked Immunosorbent Assay ; Feces/chemistry ; Female ; Humans ; Male ; ROC Curve ; S100A12 Protein/analysis
    Chemical Substances Biomarkers ; S100A12 Protein ; S100A12 protein, human
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9030-6_47
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  6. Article ; Online: Paediatric gastroenterology: The doors of perception.

    Couper, Richard T L / Day, Andrew S

    Journal of paediatrics and child health

    2020  Volume 56, Issue 11, Page(s) 1667–1668

    MeSH term(s) Child ; Gastroenterology ; Humans ; Perception ; Societies, Medical
    Language English
    Publishing date 2020-11-08
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15020
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    Zs.A 227: Show issues Location:
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  7. Article ; Online: Prevention and Screening of HPV Malignancies.

    Dahlstrom, Kristina R / Day, Andrew T / Sturgis, Erich M

    Seminars in radiation oncology

    2021  Volume 31, Issue 4, Page(s) 297–308

    Abstract: It is estimated that 5% of the global cancer burden, or approximately 690,000 cancer cases annually, is attributable to human papillomavirus (HPV). Primary prevention through prophylactic vaccination is the best option for reducing the burden of HPV- ... ...

    Abstract It is estimated that 5% of the global cancer burden, or approximately 690,000 cancer cases annually, is attributable to human papillomavirus (HPV). Primary prevention through prophylactic vaccination is the best option for reducing the burden of HPV-related cancers. Most high-income countries (HICs) have introduced the HPV vaccine and are routinely vaccinating adolescent boys and girls. Unfortunately, although they suffer the greatest morbidity and mortality due to HPV-related cancers, many lower- and middle-income countries (LMICs) have been unable to initiate and sustain vaccination programs. Secondary prevention in the form of screening has led to substantial declines in cervical cancer incidence in areas with established screening programs, but LMICs with absent or inadequate screening programs have high incidence rates. Meanwhile, HICs have seen incidence rates of anal and oropharyngeal cancers rise owing to the limited availability of organized screening for anal cancer and no validated screening options for oropharyngeal cancer. The implementation of screening programs for individuals at high risk of these cancers has the potential to reduce the burden of cervical cancer in LMICs, of anal and oropharyngeal cancers in HICs, and of anal cancer for highly selected HIV+ populations in LMICs. This review will discuss primary prevention of HPV-related cancers through vaccination and secondary prevention through screening of cervical, anal, and oropharyngeal cancers. Areas of concern and highlights of successes already achieved are included.
    MeSH term(s) Adolescent ; Alphapapillomavirus ; Anus Neoplasms/diagnosis ; Anus Neoplasms/epidemiology ; Anus Neoplasms/prevention & control ; Early Detection of Cancer ; Female ; Humans ; Male ; Oropharyngeal Neoplasms/prevention & control ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2021.02.011
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    Zs.A 3654: Show issues Location:
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  8. Article ; Online: Double paddle ulnar perforator free flap in reconstruction of through-and-through and fistulous defects of the head and neck.

    Huang, Andrew T / Day, Terry A

    The Laryngoscope

    2017  Volume 127, Issue 6, Page(s) 1302–1305

    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.26440
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    Ul II Zs.82: Show issues Location:
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  9. Article ; Online: Manipulating the neonatal gut microbiome: current understanding and future perspectives.

    Wong, Emma / Lui, Kei / Day, Andrew S / Leach, Steven T

    Archives of disease in childhood. Fetal and neonatal edition

    2021  Volume 107, Issue 4, Page(s) 346–350

    Abstract: The development of a healthy intestinal microbiome following birth contributes to the overall health of the infant during childhood and into adulthood. However, modern birth practices such as caesarean delivery, feeding, antibiotic exposure as well as ... ...

    Abstract The development of a healthy intestinal microbiome following birth contributes to the overall health of the infant during childhood and into adulthood. However, modern birth practices such as caesarean delivery, feeding, antibiotic exposure as well as maternal factors have the potential to greatly impact infant microbiome development. Aberrant microbiome development may be a key factor in the increasing incidence of inflammatory and gut diseases. This review will summarise the current understanding of how modern birth practices may contribute to deficiencies in neonatal gut microbiome development and will also present potential methods of microbiome engineering that aim to ensure the development of a healthy and robust microbiome to protect the host from disease throughout their life.
    MeSH term(s) Adult ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Breast Feeding ; Cesarean Section ; Female ; Gastrointestinal Microbiome ; Humans ; Infant ; Infant, Newborn ; Parturition ; Pregnancy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2021-321922
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  10. Article ; Online: Response to "Delay in AF ablation costs lives".

    Sessions, Andrew J / May, Heidi T / Crandall, Brian G / Day, John D / Cutler, Michael J / Groh, Christopher A / Navaravong, Leenapong / Ranjan, Ravi / Steinberg, Benjamin A / Jared Bunch, T

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 4, Page(s) 1094–1095

    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15878
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