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Article ; Online: Unravelling the physisorption characteristics of H

Tabatabaei, Seyed-Mohammad / Farshchi-Heydari, Mohammad-Javad / Asad, Mohsen / Fathipour, Morteza

Nanoscale advances

2019 Volume 1, Issue 9, Page(s) 3452–3462

Abstract: Sensing ultra-low levels of toxic chemicals such as H ...

Abstract	Sensing ultra-low levels of toxic chemicals such as H
Language	English
Publishing date	2019-07-15
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/c9na00069k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique.

Marine drugs

2021 Volume 19, Issue 8

Abstract: The antibiotic-resistant bacteria-associated infections are a major global healthcare threat. New classes of antimicrobial compounds are urgently needed as the frequency of infections caused by multidrug-resistant microbes continues to rise. Recent ... ...

Abstract	The antibiotic-resistant bacteria-associated infections are a major global healthcare threat. New classes of antimicrobial compounds are urgently needed as the frequency of infections caused by multidrug-resistant microbes continues to rise. Recent metagenomic data have demonstrated that there is still biosynthetic potential encoded in but transcriptionally silent in cultivatable bacterial genomes. However, the culture conditions required to identify and express silent biosynthetic gene clusters that yield natural products with antimicrobial activity are largely unknown. Here, we describe a new antibiotic discovery scheme, dubbed the modified crowded plate technique (mCPT), that utilizes complex microbial interactions to elicit antimicrobial production from otherwise silent biosynthetic gene clusters. Using the mCPT as part of the antibiotic crowdsourcing educational program Tiny Earth
MeSH term(s)	Animals ; Anti-Bacterial Agents/chemistry ; Aquatic Organisms/chemistry ; Crowdsourcing ; Macrolides/chemistry
Chemical Substances	Anti-Bacterial Agents ; Macrolides ; desertomycin (12728-25-5)
Language	English
Publishing date	2021-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md19080424
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Article ; Online: A new perspective on the modeling and topological characterization of H-Naphtalenic nanosheets with applications.

Ullah, Asad / Zeb, Aurang / Zaman, Shahid

Journal of molecular modeling

2022 Volume 28, Issue 8, Page(s) 211

Abstract: ... the computation of topological indices for the line graph of subdivision graph of H-Naphtalenic nanosheet has not ... We have computed these degree-based topological indices for the line graph of subdivision graph of H ...

Abstract	In the past few years, two-dimensional (2D) layered nanomaterials have greatly attracted the scientific community. Among 2D nanomaterials, the porphyrin-based Naphtalenic nanosheets have been the subject of intense research due to their utilization in photo-dynamic therapy and nanodevices. New technologies based on nanomaterials or Naphtalenic nanosheet are advantageous in overcoming the problems in conventional drug delivery like poor solubility, toxicity and poor release pattern of drugs. In chemical network theory, various molecular descriptors are used to predict the chemical properties of molecules; these molecular descriptors are found to be very useful for Quantitative Structure-Activity/ Quantitative Structure-Property (QSAR/QSPR) relationship analysis in materials engineering, chemical and pharmaceutical industries. Researchers have computed the molecular descriptors for various nanostructures; however, despite intense research, the topology of nanostructures is not yet well understood. Specially, to our knowledge, the computation of topological indices for the line graph of subdivision graph of H-Naphtalenic nanosheet has not been discussed so far, which may open new perspectives for a more accurate and reliable topological characterization of this nanosheet.In this article, we employed some important degree-based topological indices to study the chemical structure of Naphtalenic nanosheet as a chemical network for QSAR/QSPR analysis. We have computed these degree-based topological indices for the line graph of subdivision graph of H-Naphtalenic nanosheet and derived formulas for them. Based on the derived formulas, numerical results are obtained and the physical and chemical properties of the under study nanosheet are investigated.
MeSH term(s)	Nanostructures ; Pharmaceutical Preparations/chemistry ; Solubility
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2022-07-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-022-05201-z
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Article ; Online: A new perspective on the modeling and topological characterization of H-Naphtalenic nanosheets with applications

Ullah, Asad / Zeb, Aurang / Zaman, Shahid

J Mol Model. 2022 Aug., v. 28, no. 8, p. 211

2022 , Page(s) 211

Abstract	In the past few years, two-dimensional (2D) layered nanomaterials have greatly attracted the scientific community. Among 2D nanomaterials, the porphyrin-based Naphtalenic nanosheets have been the subject of intense research due to their utilization in photo-dynamic therapy and nanodevices. New technologies based on nanomaterials or Naphtalenic nanosheet are advantageous in overcoming the problems in conventional drug delivery like poor solubility, toxicity and poor release pattern of drugs. In chemical network theory, various molecular descriptors are used to predict the chemical properties of molecules; these molecular descriptors are found to be very useful for Quantitative Structure–Activity/ Quantitative Structure–Property (QSAR/QSPR) relationship analysis in materials engineering, chemical and pharmaceutical industries. Researchers have computed the molecular descriptors for various nanostructures; however, despite intense research, the topology of nanostructures is not yet well understood. Specially, to our knowledge, the computation of topological indices for the line graph of subdivision graph of H-Naphtalenic nanosheet has not been discussed so far, which may open new perspectives for a more accurate and reliable topological characterization of this nanosheet.In this article, we employed some important degree-based topological indices to study the chemical structure of Naphtalenic nanosheet as a chemical network for QSAR/QSPR analysis. We have computed these degree-based topological indices for the line graph of subdivision graph of H-Naphtalenic nanosheet and derived formulas for them. Based on the derived formulas, numerical results are obtained and the physical and chemical properties of the under study nanosheet are investigated.
Keywords	chemical structure ; drugs ; models ; nanosheets ; network theory ; solubility ; therapeutics ; topology ; toxicity
Language	English
Dates of publication	2022-08
Size	p. 211
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-022-05201-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Unusual inclusions in hemoglobin H disease post-splenectomy.

Spencer-Chapman, Michael / Luqmani, Asad / Layton, D Mark / Bain, Barbara J

American journal of hematology

2018 Volume 93, Issue 7, Page(s) 963–964

MeSH term(s)	Erythrocyte Inclusions/pathology ; Erythrocytes, Abnormal/pathology ; Erythrocytes, Abnormal/ultrastructure ; Humans ; Postoperative Period ; Splenectomy/adverse effects ; alpha-Thalassemia/blood ; alpha-Thalassemia/pathology ; alpha-Thalassemia/surgery
Language	English
Publishing date	2018-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.25072
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Article ; Online: N -((1 H -Pyrrol-2-yl)methylene)-6-methoxypyridin-3-amine and Its Co(II) and Cu(II) Complexes as Antimicrobial Agents

Vinusha H. Mariwamy / Shiva Prasad Kollur / Bindya Shivananda / Muneera Begum / Chandan Shivamallu / Chandan Dharmashekara / Sushma Pradeep / Anisha S. Jain / Shashanka K. Prasad / Asad Syed / Abdallah M. Elgorban / Salim Al-Rejaie / Joaquín Ortega-Castro / Juan Frau / Norma Flores-Holguín / Daniel Glossman-Mitnik

Molecules, Vol 27, Iss 1436, p

Chemical Preparation, In Vitro Antimicrobial Evaluation, In Silico Analysis and Computational and Theoretical Chemistry Investigations

2022 Volume 1436

Abstract: ... Schiff base ligand, N -((1 H -pyrrol-2-yl)methylene)-6-methoxypyridin-3-amine (MPM) has been synthesized ...

Abstract	Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry of Schiff bases of heterocompounds has got a lot of attention because of the metal’s ability to coordinate with Schiff base ligands. In the current study, a new bidentate Schiff base ligand, N -((1 H -pyrrol-2-yl)methylene)-6-methoxypyridin-3-amine (MPM) has been synthesized by condensing 6-methoxypyridine-3-amine with pyrrole-2-carbaldehyde. Further, MPM is used to prepare Cu(II) and Co(II) metal complexes. Analytical and spectroscopic techniques are used for the structural elucidation of the synthesized compounds. Both MPM and its metal complexes were screened against Escherichia coli , Bacillus subtilis , Staphylococcus aureus and Klebsiella pneumoniae species for antimicrobial studies. Furthermore, these compounds were subjected to in silico studies against bacterial proteins to comprehend their best non-bonded interactions. The results confirmed that the Schiff base ligand show considerably higher binding affinity with good hydrogen bonding and hydrophobic interactions against various tested microbial species. These results were complemented with a report of the Conceptual DFT global reactivity descriptors of the studied compounds together with their biological scores and their ADMET computed parameters.
Keywords	Schiff base ; antimicrobial activity ; molecular docking ; spectroscopic techniques ; Conceptual DFT ; biological scores ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique

Marine Drugs, Vol 19, Iss 424, p

2021 Volume 424

Abstract: ... a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate ...

Abstract	The antibiotic-resistant bacteria-associated infections are a major global healthcare threat. New classes of antimicrobial compounds are urgently needed as the frequency of infections caused by multidrug-resistant microbes continues to rise. Recent metagenomic data have demonstrated that there is still biosynthetic potential encoded in but transcriptionally silent in cultivatable bacterial genomes. However, the culture conditions required to identify and express silent biosynthetic gene clusters that yield natural products with antimicrobial activity are largely unknown. Here, we describe a new antibiotic discovery scheme, dubbed the modified crowded plate technique (mCPT), that utilizes complex microbial interactions to elicit antimicrobial production from otherwise silent biosynthetic gene clusters. Using the mCPT as part of the antibiotic crowdsourcing educational program Tiny Earth TM , we isolated over 1400 antibiotic-producing microbes, including 62 showing activity against multidrug-resistant pathogens. The natural product extracts generated from six microbial isolates showed potent activity against vancomycin-intermediate resistant Staphylococcus aureus . We utilized a targeted approach that coupled mass spectrometry data with bioactivity, yielding a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate a concept that significantly increased our ability to quickly and efficiently identify microbes capable of the silent antibiotic production.
Keywords	antibiotic discovery ; crowded plate technique ; ESKAPE pathogens ; natural products ; Tiny Earth TM ; Biology (General) ; QH301-705.5
Subject code	333
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique

Marine drugs. 2021 July 27, v. 19, no. 8

2021

Abstract: ... a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate ...

Abstract	The antibiotic-resistant bacteria-associated infections are a major global healthcare threat. New classes of antimicrobial compounds are urgently needed as the frequency of infections caused by multidrug-resistant microbes continues to rise. Recent metagenomic data have demonstrated that there is still biosynthetic potential encoded in but transcriptionally silent in cultivatable bacterial genomes. However, the culture conditions required to identify and express silent biosynthetic gene clusters that yield natural products with antimicrobial activity are largely unknown. Here, we describe a new antibiotic discovery scheme, dubbed the modified crowded plate technique (mCPT), that utilizes complex microbial interactions to elicit antimicrobial production from otherwise silent biosynthetic gene clusters. Using the mCPT as part of the antibiotic crowdsourcing educational program Tiny Earthᵀᴹ, we isolated over 1400 antibiotic-producing microbes, including 62 showing activity against multidrug-resistant pathogens. The natural product extracts generated from six microbial isolates showed potent activity against vancomycin-intermediate resistant Staphylococcus aureus. We utilized a targeted approach that coupled mass spectrometry data with bioactivity, yielding a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate a concept that significantly increased our ability to quickly and efficiently identify microbes capable of the silent antibiotic production.
Keywords	Staphylococcus aureus ; antibiotic resistance ; antibiotics ; antimicrobial properties ; biosynthesis ; education programs ; health services ; mass spectrometry ; metabolites ; metagenomics ; multiple drug resistance ; transcription (genetics)
Language	English
Dates of publication	2021-0727
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md19080424
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Psychometric properties of the Urdu version of the EORTC QLQ-H&N35 (European organization for research and treatment of cancer head and neck module) quality of life tool.

Zahid, Nida / Martins, Russell Seth / Zahid, Wajeeha / Azam, Iqbal / Ikram, Mubasher / Hassan, Aneesa / Bhamani, Shireen Shehzad / Jabbar, Adnan Abdul / Asad, Nargis / Akhtar, Shabbir / Siddiqui, Moghira Iqbaluddin / Awan, Mohammad Sohail / Ahmad, Khabir

BMC psychology

2022 Volume 10, Issue 1, Page(s) 194

Abstract: ... and Treatment of Cancer Quality of Life (QoL) Questionnaire's Head and Neck (H&N) Cancer Module (EORTC ... QLQ-H&N35) and assessed its convergent and discriminant validity by examining correlations of QoL ... with depression, anxiety, and resilience.: Methods: We translated the EORTC QLQ-H&N35 according to EORTC ...

Abstract	Background: We translated and validated the Urdu version of the European Organization for Research and Treatment of Cancer Quality of Life (QoL) Questionnaire's Head and Neck (H&N) Cancer Module (EORTC QLQ-H&N35) and assessed its convergent and discriminant validity by examining correlations of QoL with depression, anxiety, and resilience. Methods: We translated the EORTC QLQ-H&N35 according to EORTC instructions. Patients at a tertiary care hospital in Pakistan completed a survey consisting of Urdu versions of EORTC QLQ-C30 (core QoL tool), QLQ-H&N35, Hospital Anxiety and Depression Scale, and Wagnild and Young Resilience Scale (RS-14). Content validity, convergent validity, discriminant validity, and reliability (using Cronbach's alpha) of the EORTC QLQ-H&N35 were assessed. Results: Our sample comprised 250 patients with H&N cancer, most commonly oral (82%). The Urdu translations were comprehensible for all patients. The Cronbach alpha for QLQ-H&N35 multi-item domains ranged from 0.75 to 0.98 (acceptable to excellent), barring "Senses Problems", which was less than the generally acceptable level (0.50). The patient-reported content validity index (CVI) scores for relevance and clarity of the Urdu version of the QLQ-H&N35 were 0.93 and 0.92, respectively (both excellent). Our results revealed weak bidirectional correlations of the QLQ-H&N35 with resilience, depression, and anxiety, showing good discriminant validity. A weak-to-moderate but significant negative correlation (r: - 0.185 to - 0.613; p < 0.01) was seen between the QLQ-H&N35 and the global QoL measure of the QLQ-30. Conclusion: Our Urdu translation of the EORTC QLQ-H&N35 demonstrated validity comparable to previous studies, with good discriminant construct validity when measured against resilience, depression, and anxiety. An issue of concern is the poor internal consistency of the "Senses Problems" domain. Nevertheless, the Urdu translation produced in this study serves as a valid and reliable measure to measure QoL in H&N cancer in clinical or research settings in Pakistan.
MeSH term(s)	Head and Neck Neoplasms/therapy ; Humans ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires ; Translations
Language	English
Publishing date	2022-08-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-022-00900-x
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Article ; Online: Biolistic transformation of sugarcane (Saccharum officinarum L.) with the Oryza sativa L. H+-PPase gene for improved salt stress tolerance

Mazhar ULLAH / Mohammad S. KHAN / Asad JAN / Sayed U.A. SHAH / Navid IQBAL / Iqbal MUNIR

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Vol 50, Iss

2022 Volume 4

Abstract: ... breeding. Therefore, genetic engineering of sugarcane using Oryza sativa L. H+-PPase gene (OVP1) to confer ...

Abstract	Several biotic and abiotic stresses adversely affect sugarcane crop. Amongst the abiotic stresses, salinity causes substantial losses to sugarcane yield. Lack of conducive environment for sugarcane flowering and unstable genome are the main constraints in sugarcane crop improvement via conventional breeding. Therefore, genetic engineering of sugarcane using Oryza sativa L. H+-PPase gene (OVP1) to confer salt tolerance is the preferred alternative strategy. In the present research, tissue culture and biolistic transformation protocols for sugarcane were optimized. For callus induction, Dichlorophenoxyacetic acid (2,4-D) was most effective. Maximum callus induction (50.22%) was achieved on CM-3 augmented with 2.5 mgL-1 2,4-D. The induced calli was subjected to biolistic transformation. For biolistic transformation, the gold particles (0.6 and 1.0 µm) and plasmid DNA (100 and 50 ng) were used for 1X and 2X bombardment. Significant differences (P≤0.05) were observed amongst the gold particles and plasmid DNA concentrations. Maximum transformation frequencies were observed when calli were bombarded 2X with 0.6 µm gold particles coated with 100 ng of DNA (23.60%). Selection and regeneration of transgenic calli were performed on MS media augmented with BAP (2.5 mgL-), NAA (1 mgL-1) hygromycin (25 mgL-1) and 2% coconut water. Regenerated plants after root induction on MS media containing NAA (2 mgL-1) and 2% coconut water were transferred to loam and clay (1:1) and acclimatized to greenhouse condition. The transgenic plants were confirmed through PCR and RT-PCR.
Keywords	biolistic transformation ; OVP1 ; sugarcane ; salinity stress ; tissue culture ; Forestry ; SD1-669.5 ; Agriculture (General) ; S1-972
Subject code	580
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	AcademicPres
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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