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  1. Article ; Online: Comparison of high- and low-molecular-weight sensitizing agents causing occupational asthma: an evidence-based insight.

    Doyen, Virginie / Gautrin, Denyse / Vandenplas, Olivier / Malo, Jean-Luc

    Expert review of clinical immunology

    2024  , Page(s) 1–19

    Abstract: Introduction: The many substances used at the workplace that can cause sensitizer-induced occupational asthma are conventionally categorized into high-molecular-weight (HMW) agents and low-molecular-weight (LMW) agents, implying implicitly that these ... ...

    Abstract Introduction: The many substances used at the workplace that can cause sensitizer-induced occupational asthma are conventionally categorized into high-molecular-weight (HMW) agents and low-molecular-weight (LMW) agents, implying implicitly that these two categories of agents are associated with distinct phenotypic profiles and pathophysiological mechanisms.
    Areas covered: The authors conducted an evidence-based review of available data in order to identify the similarities and differences between HMW and LMW sensitizing agents.
    Expert opinion: Compared with LMW agents, HMW agents are associated with a few distinct clinical features (i.e. concomitant work-related rhinitis, incidence of immediate asthmatic reactions and increase in fractional exhaled nitric oxide upon exposure) and risk factors (i.e. atopy and smoking). However, some LMW agents may exhibit 'HMW-like' phenotypic characteristics, indicating that LMW agents are a heterogeneous group of agents and that pooling them into a single group may be misleading. Regardless of the presence of detectable specific IgE antibodies, both HMW and LMW agents are associated with a mixed Th1/Th2 immune response and a predominantly eosinophilic pattern of airway inflammation. Large-scale multicenter studies are needed that use objective diagnostic criteria and assessment of airway inflammatory biomarkers to identify the pathobiological pathways involved in OA caused by the various non-protein agents.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2024.2306885
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  2. Article ; Online: Reply to "Both quality of life and exacerbation are important outcomes of work-related asthma".

    Suarthana, Eva / Le Moual, Nicole / Henneberger, Paul K / Kigloo, Hormoz Nassiri / Vandenplas, Olivier

    The journal of allergy and clinical immunology. In practice

    2024  Volume 12, Issue 3, Page(s) 804–805

    MeSH term(s) Humans ; Quality of Life ; Asthma ; Surveys and Questionnaires
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.12.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Irritant-Induced Asthma.

    Lemiere, Catherine / Lavoie, Gabriel / Doyen, Virginie / Vandenplas, Olivier

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 11, Page(s) 2799–2806

    Abstract: Irritant-induced asthma (IIA) is a phenotype of asthma caused by the inhalation of irritant agents. Definite, probable, or possible IIA have been described, depending on the concentration of the inhaled irritants and the onset of respiratory symptoms ... ...

    Abstract Irritant-induced asthma (IIA) is a phenotype of asthma caused by the inhalation of irritant agents. Definite, probable, or possible IIA have been described, depending on the concentration of the inhaled irritants and the onset of respiratory symptoms respective to the time of exposure. Definite IIA represents approximately 4% to 14% of all cases of new-onset work-related asthma. Agents responsible for IIA can be encountered as fumes, gases, aerosols, or dusts. The most frequent are chlorine, nitrogen oxides, sulfur dioxide, ammonia, acetic acid, solvents, and cleaning materials. Although the diagnosis of definite IIA is based on a suggestive clinical history along with evidence of reversible airflow limitation and/or nonspecific bronchial hyperresponsiveness, possible IIA cannot be diagnosed with certainty because the relationship between exposure and the onset of symptoms is difficult to establish. This article reviews the epidemiology, pathophysiology, diagnostic approach, and management of IIA.
    MeSH term(s) Humans ; Irritants/adverse effects ; Occupational Diseases ; Occupational Exposure ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/etiology ; Bronchial Hyperreactivity
    Chemical Substances Irritants
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.06.045
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  4. Article ; Online: Assessment and Management of Occupational Asthma.

    Cullinan, Paul / Vandenplas, Olivier / Bernstein, David

    The journal of allergy and clinical immunology. In practice

    2021  Volume 8, Issue 10, Page(s) 3264–3275

    Abstract: Exposures at work can give rise to different phenotypes of "work-related asthma." The focus of this review is on the diagnosis and management of sensitizer-induced occupational asthma (OA) caused by either a high- or low-molecular-weight agent ... ...

    Abstract Exposures at work can give rise to different phenotypes of "work-related asthma." The focus of this review is on the diagnosis and management of sensitizer-induced occupational asthma (OA) caused by either a high- or low-molecular-weight agent encountered in the workplace. The diagnosis of OA remains a challenge for the clinician because there is no simple test with a sufficiently high level of accuracy. Instead, the diagnostic process combines different procedures in a stepwise manner. These procedures include a detailed clinical history, immunologic testing, measurement of lung function parameters and airway inflammatory markers, as well as various methods that relate changes in these functional and inflammatory indices to workplace exposure. Their diagnostic performances, alone and in combination, are critically reviewed and summarized into evidence-based key messages. A working diagnostic algorithm is proposed that can be adapted to the suspected agent, purpose of diagnosis, and available resources. Current information on the management options of OA is summarized to provide pragmatic guidance to clinicians who have to advise their patients with OA.
    MeSH term(s) Asthma, Occupational/diagnosis ; Asthma, Occupational/therapy ; Biomarkers ; Humans ; Occupational Diseases ; Occupational Exposure/adverse effects ; Workplace
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.06.031
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  5. Article ; Online: Occupational asthma: etiologies and risk factors.

    Vandenplas, Olivier

    Allergy, asthma & immunology research

    2011  Volume 3, Issue 3, Page(s) 157–167

    Abstract: The purpose of this article is to critically review the available evidence pertaining to occupational, environmental, and individual factors that can affect the development of occupational asthma (OA). Increasing evidence suggests that exploration of the ...

    Abstract The purpose of this article is to critically review the available evidence pertaining to occupational, environmental, and individual factors that can affect the development of occupational asthma (OA). Increasing evidence suggests that exploration of the intrinsic characteristics of OA-causing agents and associated structure-activity relationships offers promising avenues for quantifying the sensitizing potential of agents that are introduced in the workplace. The intensity of exposure to sensitizing agents has been identified as the most important environmental risk factor for OA and should remain the cornerstone for primary prevention strategies. The role of other environmental co-factors (e.g., non-respiratory routes of exposure and concomitant exposure to cigarette smoke and other pollutants) remains to be further delineated. There is convincing evidence that atopy is an important individual risk factor for OA induced by high-molecular-weight agents. There is some evidence that genetic factors, such as leukocyte antigen class II alleles, are associated with an increased risk of OA; however, the role of genetic susceptibility factors is likely to be obscured by complex gene-environment interactions. OA, as well as asthma in general, is a complex disease that results from multiple interactions between environmental factors and host susceptibilities. Determining these interactions is a crucial step towards implementing optimal prevention policies.
    Language English
    Publishing date 2011-05-20
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2545725-1
    ISSN 2092-7363 ; 2092-7363
    ISSN (online) 2092-7363
    ISSN 2092-7363
    DOI 10.4168/aair.2011.3.3.157
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  6. Article ; Online: Occupational Rhinitis.

    Vandenplas, Olivier / Hox, Valérie / Bernstein, David

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 10, Page(s) 3311–3321

    Abstract: There is convincing evidence that tight relationships between the upper and lower airways also apply to the workplace context. Most patients with occupational asthma (OA) also suffer from occupational rhinitis (OR), although OR is 2 to 3 times more ... ...

    Abstract There is convincing evidence that tight relationships between the upper and lower airways also apply to the workplace context. Most patients with occupational asthma (OA) also suffer from occupational rhinitis (OR), although OR is 2 to 3 times more common than OA. OR most often precedes the development of OA, especially when high-molecular-weight protein agents are involved, and longitudinal cohort studies have confirmed that OR is associated with an increased risk for the development of OA. The level of exposure to sensitizing agents at the workplace is the most important determinant for the development of IgE-mediated sensitization and OR. Atopy is a risk factor for the development of IgE-mediated sensitization only to high-molecular-weight agents. In workers with work-related rhinitis symptoms, documentation of IgE-mediated sensitization to a workplace agent via skin prick testing or serum specific IgE confirms a diagnosis of probable OR, whereas specific nasal provocation testing in the laboratory remains the reference method to establish a definite diagnosis of OR. Complete avoidance of exposure to the causal agent is the most effective therapeutic option for controlling work-related nasal symptoms and preventing the development of OA. If complete elimination of exposure is expected to induce meaningful adverse socioeconomic consequences, reduction of exposure can be considered as an alternative approach, but it is important to consider the individual risk factors for the development of OA to implement a more personalized management of OR.
    MeSH term(s) Asthma, Occupational/diagnosis ; Asthma, Occupational/epidemiology ; Humans ; Immunoglobulin E ; Longitudinal Studies ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Occupational Exposure/adverse effects ; Rhinitis/diagnosis ; Rhinitis/epidemiology
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.06.047
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  7. Article ; Online: Reduction of exposure in the management of occupational asthma.

    Vandenplas, Olivier

    Current opinion in allergy and clinical immunology

    2011  Volume 11, Issue 2, Page(s) 75–79

    Abstract: Purpose of review: The management of immunologically mediated occupational asthma may be difficult in clinical practice since complete avoidance of exposure to the sensitizing agent is associated with a substantial adverse socio-economic impact. The ... ...

    Abstract Purpose of review: The management of immunologically mediated occupational asthma may be difficult in clinical practice since complete avoidance of exposure to the sensitizing agent is associated with a substantial adverse socio-economic impact. The purpose of this review was to critically analyze the available information on the effectiveness of reducing exposure as an alternative to complete avoidance.
    Recent findings: Short-term exposure studies showed that respiratory protective devices can reduce bronchial responses to sensitizing agents in patients with occupational asthma, but do not provide complete protection. Recent systematic reviews of long-term follow-up studies of workers with occupational asthma indicated that reduction of exposure to the causal agent is associated with a lower likelihood of improvement in asthma symptoms and a higher risk of worsening of symptoms and nonspecific bronchial hyper-responsiveness. There are insufficient data to compare the socio-economic consequences related to both of these management options.
    Summary: Available data indicate that a reduction of exposure to the agents causing occupational asthma cannot be routinely recommended as an alternative to complete avoidance. However, due to the methodological weaknesses of the published studies, further investigations are required to determine the evidence-based cost-effectiveness of the occupational asthma management strategies.
    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/economics ; Asthma/physiopathology ; Asthma/therapy ; Cost-Benefit Analysis ; Follow-Up Studies ; Humans ; Occupational Diseases/economics ; Occupational Diseases/physiopathology ; Occupational Diseases/therapy ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Respiratory Protective Devices/utilization ; Socioeconomic Factors ; Treatment Outcome
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0b013e328344575b
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  8. Article ; Online: Asthma and rhinitis in the workplace.

    Vandenplas, Olivier

    Current allergy and asthma reports

    2010  Volume 10, Issue 5, Page(s) 373–380

    Abstract: Accumulating evidence indicates that the workplace environment substantially contributes to the global burden of asthma and rhinitis. Work-related asthma and rhinitis represent a public health concern due to their health and socioeconomic impacts. This ... ...

    Abstract Accumulating evidence indicates that the workplace environment substantially contributes to the global burden of asthma and rhinitis. Work-related asthma and rhinitis represent a public health concern due to their health and socioeconomic impacts. This article summarizes the scientific evidence on sensitizer-induced occupational asthma and rhinitis that has been published during the past 5 years. The review addresses the strategies for diagnosing and managing these highly prevalent occupational diseases.
    MeSH term(s) Asthma/diagnosis ; Asthma/prevention & control ; Asthma/therapy ; Humans ; Occupational Diseases/diagnosis ; Occupational Diseases/prevention & control ; Occupational Diseases/therapy ; Occupational Exposure ; Rhinitis/diagnosis ; Rhinitis/prevention & control ; Rhinitis/therapy ; Risk Factors ; Workplace
    Language English
    Publishing date 2010-05-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-010-0122-2
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  9. Article ; Online: Eosinophilic occupational asthma caused by padauk wood dust.

    Doyen, Virginie / Kespohl, Sabine / Sohy, Carine / Jadot, Ines / Rifflart, Catherine / Thimpont, Joël / de Lovinfosse, Solange / Raulf, Monika / Vandenplas, Olivier

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 10, Page(s) 3240–3241.e1

    MeSH term(s) Humans ; Asthma, Occupational/diagnosis ; Asthma, Occupational/etiology ; Dust ; Occupational Diseases/diagnosis ; Occupational Exposure/adverse effects ; Wood
    Chemical Substances Dust
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Phenotyping occupational asthma caused by platinum salts compared with other low-molecular weight agents.

    van Kampen, Vera / Migueres, Nicolas / Doyen, Virginie / Deckert, Anja / de Blay, Frédéric / Vandenplas, Olivier / Merget, Rolf

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 9, Page(s) 2929–2932.e2

    MeSH term(s) Humans ; Asthma, Occupational/diagnosis ; Platinum ; Salts ; Molecular Weight ; Bronchial Provocation Tests ; Nitric Oxide ; Occupational Diseases/diagnosis ; Breath Tests ; Occupational Exposure/adverse effects
    Chemical Substances Platinum (49DFR088MY) ; Salts ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.014
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