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  1. Article ; Online: Strategies to tackle the unmet need for asthma and allergy services in India.

    Daniel, Jefferson / Christopher, Devasahayam J

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 53, Issue 7, Page(s) 693–696

    MeSH term(s) Humans ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; India/epidemiology
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Editorial
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14361
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    Zs.A 767: Show issues Location:
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  2. Article: Barrier enclosure device: More scientific evidence is required.

    Thangakunam, Balamugesh / Christopher, Devasahayam J

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue 1, Page(s) 104

    Language English
    Publishing date 2021-01-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_722_20
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  3. Article ; Online: Prevalence of drug allergy labels in a tertiary pulmonary service in South India.

    Christopher, Devasahayam J / Natania, Arin / Daniel, Jefferson / Balamugesh, Thangakunam / Isaac, Barney / Krishna, Mamidipudi Thirumala

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 53, Issue 7, Page(s) 781–784

    MeSH term(s) Humans ; Prevalence ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Anaphylaxis ; India/epidemiology ; Food Hypersensitivity
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 767: Show issues Location:
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  4. Article ; Online: Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects.

    Christopher, Devasahayam Jesudas / Isaac, Barney T J / John, Flavita Benna / Shankar, Deepa / Samuel, Prasanna / Gupta, Richa / Thangakunam, Balamugesh

    PLOS global public health

    2024  Volume 4, Issue 2, Page(s) e0002884

    Abstract: After recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian ... ...

    Abstract After recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian subjects. Subjects who had recovered from COVID-19 were recruited. Clinical symptoms, pulmonary function test results, 6-minute walk test (6MWT) results, St George's Respiratory questionnaire (SGRQ) and chest radiographs were obtained. Information on the COVID-19 illness during hospitalization, baseline laboratory biomarkers and the disease severity categories as outlined by WHO (asymptomatic, mild, moderate, severe and critical), were retrieved from the hospital records. The 'COVID pneumonia'(WHO category moderate, severe & critical) group was compared with the 'Mild COVID' (WHO category mild) group and likewise, the WHO category moderate and the WHO category severe/critical groups were compared. In 207 subjects, whose mean age was 48.7 years were assessed after an average of 63 days from onset of symptom, 35% had TLC< 80% (restrictive defect), 8.3% had FEV1/FVC<70% (obstructive defect) and 44.4% had diminished DLCO<80% (diffusing capacity). The 'COVID-19 pneumonia' group when compared to the 'mild COVID-19' group, had lower FVC% (77.85 VS 88.18; P = 0.001), TLC% (79.48 VS 87.91; P = 0.0002), DLCO% (75.30 VS 89.20; P<0.0001) and DLCO/VA% (105.6 VS 111.8; P = 0.032), decreased minimum oxygen saturation (94.89 VS 97.73; P<0.0001) and more subjects had a drop in saturation of ≥ 4% (21.69% VS 4.84%; P = 0.001) during the 6MWT, and a greater mean total SGRQ score (29.2 VS 11.0; P<0.0001). To our knowledge, this is the first such report on Indian subjects. We have shown that post-COVID-19 lung damage leads to significant impairment of lung function, quality of life and effort tolerance.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002884
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  5. Article: Evaluation of humoral immune deficiency in Indian patients with bilateral bronchiectasis with no apparent aetiology.

    Rohit, K O / Thangakunam, Balamugesh / Mehta, Vinay / Christopher, Devasahayam J / James, Prince

    Lung India : official organ of Indian Chest Society

    2023  Volume 40, Issue 1, Page(s) 33–36

    Abstract: Background: Infections continue to be the leading aetiology of bronchiectasis in developing countries like India. Among non-infectious cases, the majority will have no identifiable cause despite extensive evaluation. Recently, immunodeficiency has been ... ...

    Abstract Background: Infections continue to be the leading aetiology of bronchiectasis in developing countries like India. Among non-infectious cases, the majority will have no identifiable cause despite extensive evaluation. Recently, immunodeficiency has been recognized as an important aetiology, but data on its prevalence remain rather sparse.
    Objectives: The objective of this study is to evaluate the prevalence of humoral immunodeficiency in a cohort of adults with bilateral bronchiectasis with no apparent aetiology.
    Methods: This is the single-site study from Christian Medical College (Vellore, India) of adults with HRCT-proven non-infectious bronchiectasis. Humoral immunity was assessed through quantitative analysis of immunoglobulins and IgG subclass levels.
    Results: Among 158 cases, immunoglobulin deficiency was found in 15%. Low IgM was the most predominate finding (7%), followed by common variable immunodeficiency (3%) and low IgA (2.5%). In addition, IgG subclass deficiency was found in 5%. In 53% of cases, no specific aetiology could be identified.
    Conclusion: Humoral immune deficiency is present in a significant proportion of patients with non-infectious bronchiectasis. Routine measurement of serum immunoglobulins should therefore be considered as part of the evaluation.
    Language English
    Publishing date 2023-02-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_319_22
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  6. Article: Pharmacokinetics of rifampicin, isoniazid & pyrazinamide during daily & intermittent dosing: A preliminary study.

    Ramachandran, Geetha / Hemanth Kumar, A K / Kannan, T / Thangakunam, Balamugesh / Shankar, Deepa / Christopher, Devasahayam J

    The Indian journal of medical research

    2023  Volume 157, Issue 2&3, Page(s) 211–215

    Abstract: Background & objectives: The National Tuberculosis (TB) Control Programme has transitioned from thrice-weekly to daily drug treatment regimens in India. This preliminary study was conceived to compare the pharmacokinetics of rifampicin (RMP), isoniazid ( ...

    Abstract Background & objectives: The National Tuberculosis (TB) Control Programme has transitioned from thrice-weekly to daily drug treatment regimens in India. This preliminary study was conceived to compare the pharmacokinetics of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) in TB patients being treated with daily and thrice weekly anti-TB treatment (ATT).
    Methods: This prospective observational study was undertaken in 49 newly diagnosed adult TB patients receiving either daily ATT (n=22) or thrice-weekly ATT (n=27). Plasma RMP, INH and PZA were estimated by high-performance liquid chromatography.
    Results: The peak concentration (C
    Interpretation & conclusions: RMP concentrations were higher and INH concentrations were lower during daily ATT, suggesting that INH doses may need to be increased in case of a daily regimen. Larger studies are, however, required using higher INH doses when monitoring for adverse drug reactions and treatment outcomes.
    MeSH term(s) Adult ; Humans ; Isoniazid/therapeutic use ; Pyrazinamide ; Rifampin/therapeutic use ; Antitubercular Agents ; Tuberculosis/drug therapy
    Chemical Substances Isoniazid (V83O1VOZ8L) ; Pyrazinamide (2KNI5N06TI) ; Rifampin (VJT6J7R4TR) ; Antitubercular Agents
    Language English
    Publishing date 2023-03-01
    Publishing country India
    Document type Observational Study ; Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1835_19
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
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  7. Article ; Online: Preparedness to face the COVID-19 pandemic - is India missing the mark?

    Christopher, Devasahayam J / Isaac, Barney Tj / Thangakunam, Balamugesh

    Journal of global health

    2020  Volume 10, Issue 2, Page(s) 20338

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; Containment of Biohazards/methods ; Humans ; India/epidemiology ; Pandemics/prevention & control ; Therapeutics/methods
    Keywords covid19
    Language English
    Publishing date 2020-11-19
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2978
    ISSN (online) 2047-2986
    ISSN 2047-2978
    DOI 10.7189/jogh.10.020338
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  8. Article ; Online: Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection- a Multicenter Prospective Cohort Analysis.

    Sinha, Pranay / Ezhumalai, Komala / Du, Xinyi / Ponnuraja, Chinnaiyan / Dauphinais, Madolyn Rose / Gupte, Nikhil / Sarkar, Sonali / Gupta, Amita / Gaikwad, Sanjay / Thangakunam, Balamugesh / Paradkar, Mandar / Christopher, Devasahayam J / Mave, Vidya / Viswanathan, Vijay / Ellner, Jerrold J / Kornfeld, Hardy / Horsburgh, C R / Padmapriyadarsini, Chandrasekaran / Gupte, Akshay

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infection among ... ...

    Abstract Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infection among household contacts of persons with TB.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae149
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  9. Article ; Online: The safety and tolerability of pirfenidone in Indian patients with idiopathic pulmonary fibrosis

    Avinash Anil Nair / Richa Gupta / Prince James / Aparna Irodi / Devasahayam J Christopher / Balamugesh Thangagunam

    Current Medical Issues, Vol 20, Iss 1, Pp 27-

    2022  Volume 31

    Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a form of progressive fibrosing interstitial lung disease with a poor prognosis. Pirfenidone is an oral antifibrotic agent used in the treatment of IPF, and it reduces the rate of decline of lung ... ...

    Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a form of progressive fibrosing interstitial lung disease with a poor prognosis. Pirfenidone is an oral antifibrotic agent used in the treatment of IPF, and it reduces the rate of decline of lung function. However, the tolerable dose and adverse effect profile appear to be different in the Indian population. Methodology: This prospective observational study was conducted in the Department of Pulmonary Medicine at a tertiary care center in India between January 2015 and June 2016. All adult patients diagnosed as IPF based on multidisciplinary discussion were enrolled. Subjects with active respiratory tract infection, other end-organ failures, and drugs interacting with Pirfenidone were excluded. Data collection was done with a predesigned questionnaire at baseline. Subsequently, they were followed up telephonically every week and in-person review at 3 and 6 months. Results: The cohort has 30 patients with a mean age of 60 years ± 4.5 (standard deviation 8.9). 80% did not tolerate the recommended total dose (40 mg/kg/day or 2400 mg/kg) and the median tolerated dose was 1800 mg/day (25–30 mg/kg). 75% reported adverse events, the most common being anorexia, and gastroesophageal reflux disease in gastrointestinal (GI) reaction, followed by a rash in dermatological reactions. All these adverse effects were mild to moderate and managed with supportive care or dose reduction. None of them were severe, causing cessation of therapy. Conclusion: Pirfenidone has a lower tolerable dose and predominantly GI adverse effects in our population, and if addressed early, it can prevent cessation of treatment and better quality of life for patients.
    Keywords idiopathic pulmonary fibrosis ; pirfenidone ; pulmonary fibrosis ; side effects ; tolerance ; usual interstitial pneumonia ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Effect of home-based pulmonary rehabilitation on health-related quality of life, lung function, exercise tolerance, and dyspnea in chronic obstructive pulmonary disorder patients in a tertiary care center in South India.

    Priya, N / Isaac, Barney T J / Thangakunam, Balamugesh / Christopher, Devasahayam J

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue 3, Page(s) 211–215

    Abstract: Context: Home-based pulmonary rehabilitation (PR) can increase compliance in chronic obstructive pulmonary disorder (COPD). There is paucity of data on this in India.: Aims: To study the effectiveness of home-based PR on lung function, health-related ...

    Abstract Context: Home-based pulmonary rehabilitation (PR) can increase compliance in chronic obstructive pulmonary disorder (COPD). There is paucity of data on this in India.
    Aims: To study the effectiveness of home-based PR on lung function, health-related quality of life, exercise tolerance and dyspnea among patients with COPD.
    Setting: The Department of Pulmonary Medicine, Christian Medical College, Vellore.
    Subjects and methods: This was a quasi-experimental study which included COPD patients who found hospital-based PR impractical. Those willing for home-based PR constituted the intervention group and those unwilling, constituted the control group. Both groups received standard of care otherwise. At 6 weeks, forced expiratory volume in 1 sec (FEV1), St. George Respiratory Questionnaire (SGRQ), six-minute walk test distance (6MWD), COPD assessment test (CAT) score and modified Borg dyspnea scale were compared with their baseline values.
    Statistical analysis: Student paired t-test.
    Results: A total of 42 patients completed the study, 21 in each arm. The baseline characteristics were comparable. The improvement in FEV1 was 90 ml in the intervention group and 4 ml in the control group (P = 0.01). There was no significant difference in 6MWD change. SGRQ score, Borg scale and CAT score improved significantly by 10.4, 2.4, and 3.4, respectively, in the intervention group when compared to the control group (P = 0.01).
    Conclusions: Home-based PR effectively provides tangible benefits in FEV1, QOL, exercise tolerance and dyspnea. It should be offered to those who are unable to avail institution-based PR, especially in this era of COVID pandemic.
    Language English
    Publishing date 2021-05-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_895_20
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