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Article ; Online: Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

't Mannetje, Andrea / Eng, Amanda / Walls, Chris / Dryson, Evan / Douwes, Jeroen / Bertazzi, Pier / Ryder-Lewis, Simon / Scott, David / Brooks, Collin / McLean, Dave / Cheng, Soo / Pearce, Neil

Environment international

2018 Volume 110, Page(s) 22–31

Abstract: ... of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand.: Methods ... 95%CI 1.2-13.2). IgG was negatively associated with TCDD (linear regression p=0.05 ...

Abstract	Objectives: To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. Methods: Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration≥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity. Results: Diabetes was more common in those who had worked in TCDD exposed jobs (OR 4.0, 95%CI 1.0-15.4) and in those with serum TCDD ≥10pg/g (OR 3.1, 95%CI 0.9-10.7). Non-fasting glucose levels >6.6mmol/l were more common in those with TCDD exposed jobs (OR 3.6, 95%CI 1.0-12.9), as were serum free thyroxine 4<12.8pmol/l (OR 4.5, 95%CI 1.4-14.4), triglycerides >1.7mmol/l (OR 2.5, 95%CI 1.1-5.7) and high density lipoprotein cholesterol (HDL) <1mmol/l (OR 4.0, 95%CI 1.2-13.2). IgG was negatively associated with TCDD (linear regression p=0.05). The neurological examination revealed a higher frequency of abnormal reflexes in those with serum TCDD ≥10pg/g (OR 4.8, 95%CI 1.1-21.0). Conclusions: In this occupationally exposed population, TCDD was associated with an increased risk of diabetes and a range of subclinical responses in multiple systems (peripheral nervous system, immune system, thyroid hormones and lipid metabolism), several decades after last exposure. These results need to be interpreted with caution due to the small study size and the cross-sectional nature of the study.
Language	English
Publishing date	2018-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2017.09.018
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Article: Health significance and statistical uncertainty. The value of P-value.

Consonni, Dario / Bertazzi, Pier Alberto

La Medicina del lavoro

2017 Volume 108, Issue 5, Page(s) 327–331

Abstract: Background: The P-value is widely used as a summary statistics of scientific results ... Unfortunately, there is a widespread tendency to dichotomize its value in "P<0.05" (defined as "statistically ... significant") and "P>0.05" ("statistically not significant"), with the former implying a "positive" result and ...

Abstract	Background: The P-value is widely used as a summary statistics of scientific results. Unfortunately, there is a widespread tendency to dichotomize its value in "P<0.05" (defined as "statistically significant") and "P>0.05" ("statistically not significant"), with the former implying a "positive" result and the latter a "negative" one. Objective: To show the unsuitability of such an approach when evaluating the effects of environmental and occupational risk factors. Methods: We provide examples of distorted use of P-value and of the negative consequences for science and public health of such a black-and-white vision. Results: The rigid interpretation of P-value as a dichotomy favors the confusion between health relevance and statistical significance, discourages thoughtful thinking, and distorts attention from what really matters, the health significance. Discussion: A much better way to express and communicate scientific results involves reporting effect estimates (e.g., risks, risks ratios or risk differences) and their confidence intervals (CI), which summarize and convey both health significance and statistical uncertainty. Unfortunately, many researchers do not usually consider the whole interval of CI but only examine if it includes the null-value, therefore degrading this procedure to the same P-value dichotomy (statistical significance or not). Conclusions: In reporting statistical results of scientific research present effects estimates with their confidence intervals and do not qualify the P-value as "significant" or "not significant".
MeSH term(s)	Humans ; Occupational Health/statistics & numerical data ; Uncertainty
Language	English
Publishing date	2017--27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v108i5.6603
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Article ; Online: Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Andrea 't Mannetje / Amanda Eng / Chris Walls / Evan Dryson / Jeroen Douwes / Pier Bertazzi / Simon Ryder-Lewis / David Scott / Collin Brooks / Dave McLean / Soo Cheng / Neil Pearce

Environment International, Vol 110, Iss , Pp 22-

2018 Volume 31

Abstract: ... production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. Methods ... 95%CI 1.2–13.2). IgG was negatively associated with TCDD (linear regression p=0.05 ...

Abstract	Objectives: To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. Methods: Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration≥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity. Results: Diabetes was more common in those who had worked in TCDD exposed jobs (OR 4.0, 95%CI 1.0–15.4) and in those with serum TCDD ≥10pg/g (OR 3.1, 95%CI 0.9–10.7). Non-fasting glucose levels >6.6mmol/l were more common in those with TCDD exposed jobs (OR 3.6, 95%CI 1.0–12.9), as were serum free thyroxine 4<12.8pmol/l (OR 4.5, 95%CI 1.4–14.4), triglycerides >1.7mmol/l (OR 2.5, 95%CI 1.1–5.7) and high density lipoprotein cholesterol (HDL) <1mmol/l (OR 4.0, 95%CI 1.2–13.2). IgG was negatively associated with TCDD (linear regression p=0.05). The neurological examination revealed a higher frequency of abnormal reflexes in those with serum TCDD ≥10pg/g (OR 4.8, 95%CI 1.1–21.0). Conclusions: In this occupationally exposed population, TCDD was associated with an increased risk of diabetes and a range of subclinical responses in multiple systems (peripheral nervous system, immune system, thyroid hormones and lipid metabolism), several decades after last exposure. These results need to be interpreted with caution due to the small study size and the cross-sectional nature of the study. Keywords: Dioxin, TCDD, Diabetes, Occupation, Health
Keywords	Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

't Mannetje, Andrea / Amanda Eng / Chris Walls / Evan Dryson / Jeroen Douwes / Pier Bertazzi / Simon Ryder-Lewis / David Scott / Collin Brooks / Dave McLean / Soo Cheng / Neil Pearce

Environment international. 2017,

2017

Abstract: ... plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand.Demographic factors and ... 0, 95%CI 1.2â13.2). IgG was negatively associated with TCDD (linear regression p=0.05 ...

Abstract	To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand.Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentrationâ¥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity.Diabetes was more common in those who had worked in TCDD exposed jobs (OR 4.0, 95%CI 1.0â15.4) and in those with serum TCDD â¥10pg/g (OR 3.1, 95%CI 0.9â10.7). Non-fasting glucose levels >6.6mmol/l were more common in those with TCDD exposed jobs (OR 3.6, 95%CI 1.0â12.9), as were serum free thyroxine 4<12.8pmol/l (OR 4.5, 95%CI 1.4â14.4), triglycerides >1.7mmol/l (OR 2.5, 95%CI 1.1â5.7) and high density lipoprotein cholesterol (HDL) <1mmol/l (OR 4.0, 95%CI 1.2â13.2). IgG was negatively associated with TCDD (linear regression p=0.05). The neurological examination revealed a higher frequency of abnormal reflexes in those with serum TCDD â¥10pg/g (OR 4.8, 95%CI 1.1â21.0).In this occupationally exposed population, TCDD was associated with an increased risk of diabetes and a range of subclinical responses in multiple systems (peripheral nervous system, immune system, thyroid hormones and lipid metabolism), several decades after last exposure. These results need to be interpreted with caution due to the small study size and the cross-sectional nature of the study.
Keywords	at-risk population ; blood serum ; body mass index ; diabetes ; employment ; gender ; glucose ; health information ; high density lipoprotein cholesterol ; human resources ; immune system ; immunoglobulin G ; interviews ; lipid metabolism ; morbidity ; neurological examination ; occupational exposure ; peripheral nervous system ; pesticides ; reflexes ; regression analysis ; risk ; surveys ; tetrachlorodibenzo-p-dioxin ; thyroid hormones ; thyroxine ; triacylglycerols ; New Zealand
Language	English
Size	p. .
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2017.09.018
Database	NAL-Catalogue (AGRICOLA)

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Article: 2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident.

Landi, M T / Consonni, D / Patterson, D G / Needham, L L / Lucier, G / Brambilla, P / Cazzaniga, M A / Mocarelli, P / Pesatori, A C / Bertazzi, P A / Caporaso, N E

Environmental health perspectives

1998 Volume 106, Issue 5, Page(s) 273–277

Abstract: ... 8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels ... significantly decrease by distance from the accident site (p = 0.0001), down to general population values (4.9 ... Women have higher TCDD levels than men in the entire study area (p = 0.0003 in Zone B; p = 0.007 in non ...

Abstract	In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing TCDD levels in soil, and cohort including all residents was enumerated. The population of the surrounding noncontaminated area (non-ABR) was chosen as referent population. Two decades after the accident. plasma TCDD levels were measured in 62 subjects randomly sampled from the highest exposed zones (A and B) and 59 subjects from non-ABR, frequency matched for age, gender, and cigarette smoking status. Subjects living in the exposed areas have persistently elevated plasma TCDD levels (range = 1.2-89.9 ppt; geometric mean = 53.2 and 11.0 ppt for Zone A and Zone B, respectively). Levels significantly decrease by distance from the accident site (p = 0.0001), down to general population values (4.9 ppt) in non-ABR, thus validating the original zone classification based on environmental measurements. Women have higher TCDD levels than men in the entire study area (p = 0.0003 in Zone B; p = 0.007 in non-ABR). This gender difference persists after adjustment for location within the zone, consumption of meat derived from locally raised animals, age, body mass index, and smoking. There is no evidence for a gender difference in exposure, so variation in metabolism or elimination due to body fat or hormone-related factors may explain this finding. Elevated TCDD levels in women may contribute to adverse reproductive, developmental, and cancer outcomes.
MeSH term(s)	Accidents, Occupational ; Aging/blood ; Demography ; Diet ; Environmental Pollutants/blood ; Female ; Humans ; Italy ; Male ; Meat ; Middle Aged ; Multivariate Analysis ; Polychlorinated Dibenzodioxins/analogs & derivatives ; Polychlorinated Dibenzodioxins/blood ; Sex Characteristics
Chemical Substances	Environmental Pollutants ; Polychlorinated Dibenzodioxins ; 1,2,3,4-tetrachlorodibenzodioxin (HF5S8P28CC)
Language	English
Publishing date	1998-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.98106273
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Article: P aologia da cloruro di vinile: stato attuale del problema

Foa, V / Bertazzi, P A

La Medicina del lavoro

1974 Volume 65, Issue 11-12, Page(s) 401–420

Title translation	Pathology of the vinyl chloride: current state of the problem.
MeSH term(s)	Humans ; Italy ; Liver Neoplasms/chemically induced ; Occupational Diseases/chemically induced ; Vinyl Chloride/adverse effects ; Vinyl Compounds/adverse effects
Chemical Substances	Vinyl Compounds ; Vinyl Chloride (WD06X94M2D)
Language	Italian
Publishing date	1974-11
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
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Article ; Online: Food environment near schools in the largest Brazilian metropolis: analyses and contributions based on census data.

Leite, Maria Alvim / Barata, Mayra Figueiredo / Levy, Renata Bertazzi

Cadernos de saude publica

2023 Volume 39, Issue 9, Page(s) e00030223

Abstract: ... concentrations or dispersions of food stores (in absolute numbers and densities) were analyzed. A p-trend was ...

Abstract	We aimed to investigate and compare the distribution of establishments that sell food near municipal, state, and private schools in the municipality of São Paulo, Brazil. This cross-sectional, exploratory, and census study was conducted in 3,121 schools. Circular buffers were traced around schools and concentrations or dispersions of food stores (in absolute numbers and densities) were analyzed. A p-trend was calculated to analyze how food stores density behaved as the buffer radius distance increased. Stratified regression models were built to analyze the characteristics of the food environment. Snack bars and street vendors are the most common types of establishments surrounding schools. Some categories of food stores are concentrated (such as candy stores around municipal and private schools, mini markets around municipal schools, and snack bars around private schools), whereas others (such as super and hypermarkets and fruit and vegetable stores) are dispersed around public schools. The food environment around schools shows differences regarding the instance that administers them and private schools have more food stores around them. Poor-quality food environment around schools exposes students to risk factors regarding excessive unhealthy food consumption.
MeSH term(s)	Humans ; Brazil ; Cross-Sectional Studies ; Censuses ; Schools ; Fruit ; Food Supply ; Residence Characteristics ; Commerce
Language	English
Publishing date	2023-10-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311XEN030223
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Article: Manca il lavoro, manca la salute.

Bertazzi, P A

Giornale italiano di medicina del lavoro ed ergonomia

2010 Volume 32, Issue 4 Suppl, Page(s) 143

Title translation	No work, no health.
MeSH term(s)	Health Status ; Humans ; Work
Language	Italian
Publishing date	2010-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article: Il lavoro come bisogno umano e fattore di salute.

Bertazzi, P A

La Medicina del lavoro

2010 Volume 101 Suppl 2, Page(s) 28–43

Abstract: The Italian Constitution (1948) defines 'work' as the founding value of the Italian Republic. This choice was not motivated by mere economic reasons, but rather stemmed from the recognition that work is the most appropriate tool for the expression of the ...

Title translation	Work as a basic human need and health promoting factor.
Abstract	The Italian Constitution (1948) defines 'work' as the founding value of the Italian Republic. This choice was not motivated by mere economic reasons, but rather stemmed from the recognition that work is the most appropriate tool for the expression of the human personality in society, that it is an asset and a right that will increase the dignity of every person, and which corresponds to a fundamental human desire to fulfil oneself in relationship with other persons and the entire world This view of work, including its technical and manual aspects, was unknown to the ancient mentality and became familiar to us through the monastic orders of the early middle ages, which began to conceive and practise human work as a means of participating in the work of creation and transmitted this value over the centuries. As we experience today, if occupation is lacking, a basic condition for the development of the person and for his/her contribution to the growth of society is lost. Given the meaning of work in human experience, it is not surprising that unemployment represents not only a worrisome economic indicator, but also the cause of ill health. At the end of 2009 unemployment in the European Union reached 10%, similar to the rate in the US; in Italy it was estimated at 8.5% in December 2009 and is expected to reach 10% in 2010. In Lombardy, although employment had been constantly increasing between 1995 and 2008, and the current unemployment rate is as low as 4.9%, 100,000 jobs were lost in 2009. Several scientific papers have demonstrated the association between lack of occupation and lack of physical and mental health. In the present period of crisis, increases of 30% in cases of anxiety syndrome and of 15% in cases of depression have been reported. An increase in suicides among unemployed persons has been documented in several countries even if there are still problems of interpretation of the causal chain of events. Mortality among the unemployed increased, not only that due to violent causes, but also mortality for all causes, cardiovascular diseases and cancer. A survey in the Turin area, Northern Italy, showed a twofold increase in mortality among unemployed men. Women were affected both by husbands' unemployment and by their own unemployment because of the previous increasing rate of female occupation. The worse the occupational condition (from "seeking work" to "temporary employment" down to "unemployed and no longer seeking work") the higher the mortality: in the latter category, where the most evident problem is marginalization and social exclusion, the increase in mortality was fourfold. The role of occupational health physicians is to recognize the possible negative effects of working conditions and at the same time promote a positive approach to work, even in difficult conditions. This makes prevention more effective and promotes health. To be aware of the meaning of work makes work itself more liveable and more productive. This is how health promotion contributes to the wellbeing of the individual and, at the same time, to the development of the economy and society at large.
MeSH term(s)	Health Promotion ; Health Status ; Humans ; Sociology ; Work/psychology
Language	Italian
Publishing date	2010
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
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Article: Susceptibility Markers in Normal Subjects: A Pilot Study for the Investigation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Related Diseases

Landi, M. T. / Bertazzi, P. A. / Clark, G. / Lucier, G. W. / Garte, S. J. / Cosma, G. / Shields, P. G.

1992 Volume 10, Page(s) 143–146

Keywords	2,3,7,8-Tetrachlordibenzo-p-Dioxin ; Bioindikator ; Polychlordibenzodioxin ; Epidemiologie ; Mensch ; Schadstoffwirkung ; Kanzerogener Stoff ; Rezeptor ; Genotyp ; Enzymaktivitaet ; Risikoanalyse ; Gesundheitsgefaehrdung ; Krebskrankheit ; DNA ; Lymphozyten ; Versuchsperson ; Blutuntersuchung ; RNA ; Gen
Language	English
Document type	Article
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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