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  1. Article ; Online: m

    Liu, Jun / Eckert, Mark A / Harada, Bryan T / Liu, Song-Mei / Lu, Zhike / Yu, Kangkang / Tienda, Samantha M / Chryplewicz, Agnieszka / Zhu, Allen C / Yang, Ying / Huang, Jing-Tao / Chen, Shao-Min / Xu, Zhi-Gao / Leng, Xiao-Hua / Yu, Xue-Chen / Cao, Jie / Zhang, Zezhou / Liu, Jianzhao / Lengyel, Ernst /
    He, Chuan

    Nature cell biology

    2018  Volume 20, Issue 9, Page(s) 1074–1083

    Abstract: ... ...

    Abstract N
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Animals ; Carcinogenesis ; Cell Line, Tumor ; Cell Proliferation ; Endometrial Neoplasms/enzymology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice, Nude ; Mutation ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism ; Signal Transduction ; Time Factors ; Tumor Burden
    Chemical Substances RNA, Messenger ; RNA, Neoplasm ; N-methyladenosine (CLE6G00625) ; METTL14 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PHLPP2 protein, human (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2018-08-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-018-0174-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  2. Article: Kidney derived apolipoprotein M and its role in acute kidney injury.

    Bisgaard, Line S / Christensen, Pernille M / Oh, Jeongah / Torta, Federico / Füchtbauer, Ernst-Martin / Nielsen, Lars Bo / Christoffersen, Christina

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1328259

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1328259
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  3. Article ; Online: Melphalan 200 mg/m

    Brioli, Annamaria / Vom Hofe, Felix / Rucci, Paola / Ernst, Thomas / Yomade, Olaposi / Hilgendorf, Inken / Scholl, Sebastian / Sayer, Herbert / Mügge, Lars-Olof / Hochhaus, Andreas / von Lilienfeld-Toal, Marie

    Bone marrow transplantation

    2020  Volume 56, Issue 5, Page(s) 1209–1212

    Abstract: Autologous stem cell transplantation (ASCT) conditioned with melphalan 200 mg/m ...

    Abstract Autologous stem cell transplantation (ASCT) conditioned with melphalan 200 mg/m
    MeSH term(s) Disease-Free Survival ; Hematopoietic Stem Cell Transplantation ; Humans ; Melphalan ; Multiple Myeloma/drug therapy ; Retrospective Studies ; Transplantation Conditioning ; Transplantation, Autologous
    Chemical Substances Melphalan (Q41OR9510P)
    Language English
    Publishing date 2020-12-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-020-01170-0
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  4. Article ; Conference proceedings: Evaluation der Gesundheitsziele (GZ) Mecklenburg-Vorpommern (M-V) – Konzept und Durchführung des Projektes GeZi M-V P2

    Ernst, Vanessa Sophie / Franze, Marco / Hoffmann, Wolfgang

    Das Gesundheitswesen

    2023  Volume 85, Issue 08/09

    Event/congress Gemeinsame Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention e.V. (DGSMP)*, des Deutschen Netzwerks Gesundheitskompetenz e. V. (DNGK) und des Nationalen Aktionsplans Gesundheitskompetenz (NAP), Hannover, 2023-08-30
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0043-1770660
    Database Thieme publisher's database

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  5. Article ; Online: AlkAniline-Seq: Profiling of m

    Marchand, Virginie / Ayadi, Lilia / Ernst, Felix G M / Hertler, Jasmin / Bourguignon-Igel, Valérie / Galvanin, Adeline / Kotter, Annika / Helm, Mark / Lafontaine, Denis L J / Motorin, Yuri

    Angewandte Chemie (International ed. in English)

    2018  Volume 57, Issue 51, Page(s) 16785–16790

    Abstract: ... a deep sequencing-based technology for the simultaneous detection of 7-methylguanosine (m ...

    Abstract RNA modifications play essential roles in gene expression regulation. Only seven out of >150 known RNA modifications are detectable transcriptome-wide by deep sequencing. Here we describe a new principle of RNAseq library preparation, which relies on a chemistry based positive enrichment of reads in the resulting libraries, and therefore leads to unprecedented signal-to-noise ratios. The proposed approach eschews conventional RNA sequencing chemistry and rather exploits the generation of abasic sites and subsequent aniline cleavage. The newly generated 5'-phosphates are used as unique entry for ligation of an adapter in library preparation. This positive selection, embodied in the AlkAniline-Seq, enables a deep sequencing-based technology for the simultaneous detection of 7-methylguanosine (m
    MeSH term(s) Aniline Compounds/chemistry ; Cytidine/analogs & derivatives ; Cytidine/analysis ; Guanosine/analogs & derivatives ; Guanosine/analysis ; Molecular Structure ; RNA/chemistry
    Chemical Substances Aniline Compounds ; Guanosine (12133JR80S) ; 3-methylcytidine (2140-64-9) ; 7-methylguanosine (2140-77-4) ; Cytidine (5CSZ8459RP) ; RNA (63231-63-0) ; aniline (SIR7XX2F1K)
    Language English
    Publishing date 2018-11-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201810946
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  6. Article ; Online: New aspects of high-resolution ultrasound for tumor detection and treatments: M-Elite Program.

    Michael, Jung Ernst / Xiaoyan, Xie / Xiaoer, Zhang

    Clinical hemorheology and microcirculation

    2023  Volume 86, Issue 1-2, Page(s) 3–7

    MeSH term(s) Humans ; Ultrasonography ; Running ; Neoplasms/diagnostic imaging ; Neoplasms/therapy
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-238110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1623: Show issues Location:
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  7. Article ; Online: Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.

    Berthold, Frank / Rosswog, Carolina / Christiansen, Holger / Frühwald, Michael / Hemstedt, Nadine / Klingebiel, Thomas / Fröhlich, Birgit / Schilling, Freimut H / Schmid, Irene / Simon, Thorsten / Hero, Barbara / Fischer, Matthias / Ernst, Angela

    Pediatric blood & cancer

    2021  Volume 68, Issue 8, Page(s) e29038

    Abstract: Introduction: The survival of children with stage 4(M) neuroblastoma without MYCN amplification ... Between 1990 and 2015, 177 patients with stage 4(M) MYCN nonamplified neuroblastoma aged less than 18 ... predictive in the investigated subcohort.: Conclusion: The outcome of patients with stage 4(M ...

    Abstract Introduction: The survival of children with stage 4(M) neuroblastoma without MYCN amplification and below the age of 18 months is considered better than the still dismal outcome of older high-risk neuroblastoma patients. This study analyzes the impact of clinical and molecular characteristics on the long-term outcome.
    Patients and methods: Clinical presentation, survival, and recurrence patterns of patients enrolled onto trials NB90, NB97, and NB2004 were retrospectively analyzed. Gene expression signatures based on RNA microarrays (TH10) were investigated if tumor material was available.
    Results: Between 1990 and 2015, 177 patients with stage 4(M) MYCN nonamplified neuroblastoma aged less than 18 months at diagnosis were eligible. After a median follow-up of 9.7 years (IQR 5.0, 13.4), the proportions of 10-year event-free survival (EFS) and overall survival (OS) were 73% (95% confidence interval [CI] 67-79%) and 86% (95% CI 80-92%), respectively. Of the 27 neuroblastoma recurrences, 44% occurred in more than one site. Four additional patients presented histologically mature ganglioneuroma at recurrence. Six patients developed a secondary malignancy. The secondary 5-year EFS and OS of the 27 patients with neuroblastoma recurrence were 44% and 59%, respectively. TH10 gene expression signature was not prognostically predictive in the investigated subcohort.
    Conclusion: The outcome of patients with stage 4(M) neuroblastoma aged less than 18 months is favorable when treated with high-risk or otherwise intensive therapy. The development of secondary malignancies and the potential of maturation to ganglioneuroma call for a controlled stepwise reduction of treatment intensity.
    MeSH term(s) Disease-Free Survival ; Ganglioneuroma/genetics ; Ganglioneuroma/pathology ; Gene Amplification ; Humans ; Infant ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Staging ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Prognosis ; Retrospective Studies
    Chemical Substances MYCN protein, human ; N-Myc Proto-Oncogene Protein
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29038
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    Zs.A 1131: Show issues Location:
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  8. Article: Erfahrungen zum Wettereinfluss bei M. Bechterew

    Feldtkeller, Ernst

    Morbus-Bechterew-Journal

    2019  Volume 40, Issue 158, Page(s) 33

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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  9. Article ; Online: Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection.

    Zha, B Shoshana / Desvignes, Ludovic / Fergus, Tawania J / Cornelius, Amber / Cheng, Tan-Yun / Moody, D Branch / Ernst, Joel D

    mBio

    2022  Volume 13, Issue 3, Page(s) e0133222

    Abstract: In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare ... ...

    Abstract In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the
    MeSH term(s) Animals ; Immunity, Innate ; Lung/microbiology ; Macrophages, Alveolar ; Mice ; Mycobacterium tuberculosis ; Tuberculosis/microbiology
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01332-22
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  10. Article: Gerard M. Guiraudon : Paris 1931-London, Ontario 2019.

    van Hemel, N / Vemeulen, F / Defauw, J / de Bakker, J / Kingma, H / Ernst, J

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2019  Volume 27, Issue 10, Page(s) 520–522

    Language English
    Publishing date 2019-09-18
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-019-01329-5
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