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Article ; Online: Healthcare Workers' Acceptance of COVID-19 Vaccination in Russia.

Briko, Nikolay I / Korshunov, Vladimir A / Mindlina, Alla Ya / Polibin, Roman V / Antipov, Maksim O / Brazhnikov, Alexey I / Vyazovichenko, Yurii E / Glushkova, Ekaterina V / Lomonosov, Kirill S / Lomonosova, Alena V / Lopukhov, Platon D / Pozdnyakov, Artem A / Saltykova, Tatiana S / Torchinsky, Nikolay V / Tsapkova, Natalia N / Chernyavskaya, Olga P / Shamis, Arseny V

International journal of environmental research and public health

2022 Volume 19, Issue 7

Abstract: During the COVID-19 pandemic, the problem of the population's adherence to vaccination has become significantly aggravated around the world. This study is aimed at evaluating healthcare workers' (HCWs) acceptance of COVID-19 vaccination in Russia. A ... ...

Abstract	During the COVID-19 pandemic, the problem of the population's adherence to vaccination has become significantly aggravated around the world. This study is aimed at evaluating healthcare workers' (HCWs) acceptance of COVID-19 vaccination in Russia. A cross-sectional multicenter study was carried out by interviewing HCWs in Russia using an electronic questionnaire and snowball sampling. The analysis included 85,216 questionnaires from 81 out of 85 regions of Russia. Statistical analysis was performed using SPSS v.22. The results indicated that 35.0% (CI 95%, 34.7-35.3) of HCWs were ready to get COVID-19 vaccination. The acceptance level was 42.4% (41.8-42.9) for all physicians and 31.3% (30.9-31.6) for nursing staff. A total of 29.4% (29.1-29.7) of HCWs were willing to recommend COVID-19 vaccination to patients: 38.5% (38.0-39.1) of physicians, and 24.7% (24.4-25.1) of nursing staff. Acceptance of COVID-19 vaccination is higher among HCWs dealing with infectious diseases and involved in vaccination. The low acceptance of HCWs toward vaccination against COVID-19 can be explained by the low level of awareness of HCWs in these issues. Additional educational programs are needed for HCWs, both for physicians and nurses, using all possible forms and methods of education.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Health Personnel ; Humans ; Pandemics ; Russia ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19074136
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Healthcare Workers’ Acceptance of COVID-19 Vaccination in Russia

Nikolay I. Briko / Vladimir A. Korshunov / Alla Ya Mindlina / Roman V. Polibin / Maksim O. Antipov / Alexey I. Brazhnikov / Yurii E. Vyazovichenko / Ekaterina V. Glushkova / Kirill S. Lomonosov / Alena V. Lomonosova / Platon D. Lopukhov / Artem A. Pozdnyakov / Tatiana S. Saltykova / Nikolay V. Torchinsky / Natalia N. Tsapkova / Olga P. Chernyavskaya / Arseny V. Shamis

International Journal of Environmental Research and Public Health, Vol 19, Iss 4136, p

2022 Volume 4136

Abstract: During the COVID-19 pandemic, the problem of the population’s adherence to vaccination has become significantly aggravated around the world. This study is aimed at evaluating healthcare workers’ (HCWs) acceptance of COVID-19 vaccination in Russia. A ... ...

Abstract	During the COVID-19 pandemic, the problem of the population’s adherence to vaccination has become significantly aggravated around the world. This study is aimed at evaluating healthcare workers’ (HCWs) acceptance of COVID-19 vaccination in Russia. A cross-sectional multicenter study was carried out by interviewing HCWs in Russia using an electronic questionnaire and snowball sampling. The analysis included 85,216 questionnaires from 81 out of 85 regions of Russia. Statistical analysis was performed using SPSS v.22. The results indicated that 35.0% (CI 95%, 34.7–35.3) of HCWs were ready to get COVID-19 vaccination. The acceptance level was 42.4% (41.8–42.9) for all physicians and 31.3% (30.9–31.6) for nursing staff. A total of 29.4% (29.1–29.7) of HCWs were willing to recommend COVID-19 vaccination to patients: 38.5% (38.0–39.1) of physicians, and 24.7% (24.4–25.1) of nursing staff. Acceptance of COVID-19 vaccination is higher among HCWs dealing with infectious diseases and involved in vaccination. The low acceptance of HCWs toward vaccination against COVID-19 can be explained by the low level of awareness of HCWs in these issues. Additional educational programs are needed for HCWs, both for physicians and nurses, using all possible forms and methods of education.
Keywords	Russia ; healthcare workers ; SARS-CoV-2 ; vaccine acceptance ; vaccine hesitancy ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cost effectiveness and budget impact of universal varicella vaccination in Russia.

Marijam, Alen / Safonova, Ekaterina / Scherbakov, Mikhail / Shpeer, Evgeniy / Van Oorschot, Desirée / Rudakova, Alla / Tatochenko, Vladimir / Briko, Nikolay

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 5, Page(s) 2045152

Abstract: This economic evaluation assesses the cost-effectiveness and budget impact of introducing a two-dose varicella vaccine in the Russian national immunization program. A static Markov model followed a simulated 2019 Russian cohort over its lifetime and ... ...

Abstract	This economic evaluation assesses the cost-effectiveness and budget impact of introducing a two-dose varicella vaccine in the Russian national immunization program. A static Markov model followed a simulated 2019 Russian cohort over its lifetime and compared outcomes and costs of three varicella vaccination strategies: strategy I (doses given at 12 and 15 months of age), strategy II (doses given at 1 year and 6 years of age), and a no vaccination scenario. Inputs on age-dependent clinical pathways, associated costs, and related health outcomes were collected from national sources and published literature. Results are presented as incremental cost-effectiveness ratio (ICER) from the healthcare payer and societal perspective over the lifetime of the birth cohort and the budget impact over a 10 years' time horizon. Vaccination strategies I and II resulted in an ICER of approximately 1.7 million rubles per quality-adjusted life years gained from the healthcare payer perspective and were cost-saving from the societal perspective. From the healthcare payer perspective, the costs per varicella case averted were 5,989 and 7,140 rubles per case for strategies I and II, respectively. However, from the societal perspective, vaccination is a dominant strategy and the budget impact analysis shows significant healthcare savings over 10 years, with strategy I realizing savings of ~2 billion rubles more than strategy II. From a public health impact perspective, varicella vaccination of children at 12 and 15 months of age through the Russian NIP is expected to be cost-effective with an affordable budget impact compared to no vaccination.
MeSH term(s)	Chickenpox/epidemiology ; Chickenpox/prevention & control ; Chickenpox Vaccine ; Child ; Cost-Benefit Analysis ; Humans ; Immunization Programs ; Vaccination
Chemical Substances	Chickenpox Vaccine
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2045152
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Article ; Online: Sample study protocol for adapting and translating the 5C scale to assess the psychological antecedents of vaccination.

Betsch, Cornelia / Bach Habersaat, Katrine / Deshevoi, Sergei / Heinemeier, Dorothee / Briko, Nikolay / Kostenko, Natalia / Kocik, Janusz / Böhm, Robert / Zettler, Ingo / Wiysonge, Charles Shey / Dubé, Ève / Gagneur, Arnaud / Botelho-Nevers, Elisabeth / Gagneux-Brunon, Amandine / Sivelä, Jonas

BMJ open

2020 Volume 10, Issue 3, Page(s) e034869

Abstract: Introduction: Published in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a ... ...

Abstract	Introduction: Published in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a validated English and German scale to assess these determinants with a short 5-item scale (1 item per antecedent) and a long 15-item scale (3 items per antecedent). This sample study protocol provides a step-by-step guidance for the process of adapting the 5C scale to another country, language or cultural context. Data obtained from the 5C scale can support developing, implementing and evaluating an intervention and monitoring of general vaccine acceptance and demand. Methods and analysis: Phase 1 comprises the adaptation of the 5C scale including the translation and back translation of the antecedents, an expert evaluation of the antecedents and the identification of new antecedents as well as a pretest. Phase 2 involves the validation of the translated and potentially expanded scale including the assessment of reliability, construct and concurrent validity of all items of the scale. Code for data analysis is provided. Ethics and dissemination: The University of Erfurt's institutional review board provided ethical clearance (EV-201900416.2). The authors suggest and encourage publicly sharing all data obtained from the translated 5C scale (eg, on publication). The materials and the code for data analysis to support the process described in this protocol are available in https://osf.io/2agxe/. Sharing data on vaccine acceptance and demand is in the public and the scientific interest and will facilitate gaining a global overview of its current state and development over time. The authors of the original 5C scale are currently working on an online platform to facilitate publishing the data and to visualise the psychological antecedents across different countries.
MeSH term(s)	Humans ; Psychometrics/methods ; Psychometrics/standards ; Reproducibility of Results ; Surveys and Questionnaires ; Translations ; Vaccination/psychology
Language	English
Publishing date	2020-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2019-034869
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Article ; Online: Safety and immunogenicity of a single dose 23-valent pneumococcal polysaccharide vaccine in Russian subjects.

Ciprero, Karen / Zykov, Kirill A / Briko, Nikolay I / Shekar, Tulin / Sterling, Tina M / Bitieva, Elizaveta / Stek, Jon E / Musey, Luwy

Human vaccines & immunotherapeutics

2016 Volume 12, Issue 8, Page(s) 2142–2147

Abstract: Pneumococcal infection is a major cause of pneumonia, bacteremia, and meningitis. Incidence of pneumococcal disease (PD) varies worldwide. The 23-valent pneumococcal polysaccharide vaccine (PPV23) displays an acceptable safety profile and has been ... ...

Abstract	Pneumococcal infection is a major cause of pneumonia, bacteremia, and meningitis. Incidence of pneumococcal disease (PD) varies worldwide. The 23-valent pneumococcal polysaccharide vaccine (PPV23) displays an acceptable safety profile and has been demonstrated cost-effective in reducing burden of PD. Methods: Approximately 100 subjects from the Russian Federation who were either 2 to 49 y of age with increased risk for PD or ≥50 years of age were enrolled into the study (NCT01734239) to receive a single dose of PPV23 administered intramuscularly. Each subject was followed for local and systemic adverse events (AEs) for 5 and 14 days, respectively. Serious AEs were collected for 28 d postvaccination. Blood samples were collected immediately prior to vaccination and 28 d postvaccination for the measurement of IgG to serotypes 1, 6B, 14, 19F, and 23F. Results: High proportion of subjects had ≥2 -fold increase in IgG following receipt of PPV23. Rates were 92.0%, 83.0%, 89.0%, 81%, 84% for serotypes 1, 6B, 14, 19F, and 23F, respectively. Similar rates of responders and increases in the magnitude of immune responses were observed in both age groups (2-49, ≥50 ). PPV23 was generally safe and well tolerated. Injection site and systemic AEs were reported by 14.7% and 18.6% of study subjects, respectively. Conclusions: PPV23 is generally safe, well tolerated, and highly immunogenic when given as a single dose to Russian individuals 50 y of age and older, as well as Russian individuals 2 to 49 y of age who are at high risk for PD.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Bacterial/blood ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Female ; Humans ; Immunoglobulin G/blood ; Injections, Intramuscular ; Male ; Middle Aged ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/adverse effects ; Pneumococcal Vaccines/immunology ; Russia ; Young Adult
Chemical Substances	23-valent pneumococcal capsular polysaccharide vaccine ; Antibodies, Bacterial ; Immunoglobulin G ; Pneumococcal Vaccines
Language	English
Publishing date	2016--02
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2016.1165373
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Article: Sample study protocol for adapting and translating the 5C scale to assess the psychological antecedents of vaccination

BMJ Open

2020 Volume 10, Issue 3, Page(s) No

Title translation	Beispielstudienprotokoll für die Anpassung und Übersetzung der 5C-Skala zur Beurteilung der psychologischen Bedingungen für eine Impfung
Abstract	Introduction: Published in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a validated English and German scale to assess these determinants with a short 5-item scale (1 item per antecedent) and a long 15-item scale (3 items per antecedent). This sample study protocol provides a step-by-step guidance for the process of adapting the 5C scale to another country, language or cultural context. Data obtained from the 5C scale can support developing, implementing and evaluating an intervention and monitoring of general vaccine acceptance and demand. Methods and analysis: Phase 1 comprises the adaptation of the 5C scale including the translation and back translation of the antecedents, an expert evaluation of the antecedents and the identification of new antecedents as well as a pretest. Phase 2 involves the validation of the translated and potentially expanded scale including the assessment of reliability, construct and concurrent validity of all items of the scale. Code for data analysis is provided. Ethics and dissemination: The University of Erfurt's institutional review board provided ethical clearance (EV-201900416.2). The authors suggest and encourage publicly sharing all data obtained from the translated 5C scale (eg, on publication). The materials and the code for data analysis to support the process described in this protocol are available in https://osf.io/2agxe/. Sharing data on vaccine acceptance and demand is in the public and the scientific interest and will facilitate gaining a global overview of its current state and development over time. The authors of the original 5C scale are currently working on an online platform to facilitate publishing the data and to visualise the psychological antecedents across different countries.
Keywords	Concurrent Validity ; Construct Validity ; Cross Cultural Test Adaptation ; Foreign Language Translation ; Fremdsprachenübersetzung ; Immunisierung ; Immunization ; Konkurrente Validität ; Konstruktvalidität ; Kulturelle Testanpassung ; Test Reliability ; Testreliabilität
Language	English
Document type	Article
ZDB-ID	2599832-8
ISSN	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2019-034869
Database	PSYNDEX

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Article ; Online: Multicenter study of serotype distribution of Streptococcus pneumoniae nasopharyngeal isolates from healthy children in the Russian Federation after introduction of PCV13 into the National Vaccination Calendar.

Sidorenko, Sergey / Rennert, Wolfgang / Lobzin, Yuri / Briko, Nikolay / Kozlov, Roman / Namazova-Baranova, Leila / Tsvetkova, Irina / Ageevets, Vladimir / Nikitina, Ekaterina / Ardysheva, Anastasia / Bikmieva, Alina / Bolgarova, Ekaterina / Volkova, Marina / Verentsova, Irina / Girina, Asiya / Gordeeva, Natalia / Demko, Irina / Dushchenko, Anna / Evseeva, Galina /

Diagnostic microbiology and infectious disease

2019 Volume 96, Issue 1, Page(s) 114914

Abstract: Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and ... ...

Abstract	Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose course of PCV13, while 25.6% had received 1 or 2 doses. Pneumococcal DNA detection by PCR demonstrated S. pneumoniae in 37.2% of samples with regional variation between sites (27.3 to 56.9%). There was little difference between vaccinated, partially vaccinated and un-vaccinated children. Children who had received at least 1 dose of PCV13 had lower carriage rates of vaccine serotypes than their unvaccinated peers (49.9 vs. 61.4%; p < 0.001). Children who had received at least 1 dose of PCV13 showed increased carriage rates of non-vaccine serotypes (50 vs 38.6%; P < 0.001). Especially serogroup 15AF was more prevalent among fully immunized children than among their peers (12.5 vs 2.7%; P < 0.05).
MeSH term(s)	Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Child, Preschool ; Healthy Volunteers ; Humans ; Immunization Programs ; Infant ; Infant, Newborn ; Nasopharynx/microbiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Prevalence ; Russia/epidemiology ; Serogroup ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics
Chemical Substances	13-valent pneumococcal vaccine ; Pneumococcal Vaccines
Language	English
Publishing date	2019-11-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2019.114914
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Article ; Online: Sample study protocol for adapting and translating the 5C scale to assess the psychological antecedents of vaccination

Charles Shey Wiysonge / Katrine Bach Habersaat / Sergei Deshevoi / Dorothee Heinemeier / Nikolay Briko / Natalia Kostenko / Janusz Kocik / Robert Böhm / Ingo Zettler / Ève Dubé / Arnaud Gagneur / Elisabeth Botelho-Nevers / Amandine Gagneux-Brunon / Jonas Sivelä

BMJ Open, Vol 10, Iss

2020 Volume 3

Abstract: IntroductionPublished in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a validated ... ...

Abstract	IntroductionPublished in 2018, the 5C scale is psychometrically validated to assess five psychological antecedents of vaccination (confidence, complacency, constraints, calculation and collective responsibility). The original version offers a validated English and German scale to assess these determinants with a short 5-item scale (1 item per antecedent) and a long 15-item scale (3 items per antecedent). This sample study protocol provides a step-by-step guidance for the process of adapting the 5C scale to another country, language or cultural context. Data obtained from the 5C scale can support developing, implementing and evaluating an intervention and monitoring of general vaccine acceptance and demand.Methods and analysisPhase 1 comprises the adaptation of the 5C scale including the translation and back translation of the antecedents, an expert evaluation of the antecedents and the identification of new antecedents as well as a pretest. Phase 2 involves the validation of the translated and potentially expanded scale including the assessment of reliability, construct and concurrent validity of all items of the scale. Code for data analysis is provided.Ethics and disseminationThe University of Erfurt’s institutional review board provided ethical clearance (EV-201900416.2). The authors suggest and encourage publicly sharing all data obtained from the translated 5C scale (eg, on publication). The materials and the code for data analysis to support the process described in this protocol are available in https://osf.io/2agxe/. Sharing data on vaccine acceptance and demand is in the public and the scientific interest and will facilitate gaining a global overview of its current state and development over time. The authors of the original 5C scale are currently working on an online platform to facilitate publishing the data and to visualise the psychological antecedents across different countries.
Keywords	Medicine ; R
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global trends of hand and wrist trauma: a systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study.

Crowe, Christopher Stephen / Massenburg, Benjamin Ballard / Morrison, Shane Douglas / Chang, James / Friedrich, Jeffrey Barton / Abady, Gdiom Gebreheat / Alahdab, Fares / Alipour, Vahid / Arabloo, Jalal / Asaad, Malke / Banach, Maciej / Bijani, Ali / Borzì, Antonio Maria / Briko, Nikolay Ivanovich / Castle, Chris D / Cho, Daniel Youngwhan / Chung, Michael T / Daryani, Ahmad / Demoz, Gebre Teklemariam /

Dingels, Zachary V / Do, Hoa Thi / Fischer, Florian / Fox, Jack T / Fukumoto, Takeshi / Gebre, Abadi Kahsu / Gebremichael, Berhe / Haagsma, Juanita A / Haj-Mirzaian, Arvin / Handiso, Demelash Woldeyohannes / Hay, Simon I / Hoang, Chi Linh / Irvani, Seyed Sina Naghibi / Jozwiak, Jacek Jerzy / Kalhor, Rohollah / Kasaeian, Amir / Khader, Yousef Saleh / Khalilov, Rovshan / Khan, Ejaz Ahmad / Khundkar, Roba / Kisa, Sezer / Kisa, Adnan / Liu, Zichen / Majdan, Marek / Manafi, Navid / Manafi, Ali / Manda, Ana-Laura / Meretoja, Tuomo J / Miller, Ted R / Mohammadian-Hafshejani, Abdollah / Mohammadpourhodki, Reza / Mohseni Bandpei, Mohammad A / Mokdad, Ali H / Naimzada, Mukhammad David / Ndwandwe, Duduzile Edith / Nguyen, Cuong Tat / Nguyen, Huong Lan Thi / Olagunju, Andrew T / Olagunju, Tinuke O / Pham, Hai Quang / Pribadi, Dimas Ria Angga / Rabiee, Navid / Ramezanzadeh, Kiana / Ranganathan, Kavitha / Roberts, Nicholas L S / Roever, Leonardo / Safari, Saeed / Samy, Abdallah M / Sanchez Riera, Lidia / Shahabi, Saeed / Smarandache, Catalin-Gabriel / Sylte, Dillon O / Tesfay, Berhe Etsay / Tran, Bach Xuan / Ullah, Irfan / Vahedi, Parviz / Vahedian-Azimi, Amir / Vos, Theo / Woldeyes, Dawit Habte / Wondmieneh, Adam Belay / Zhang, Zhi-Jiang / James, Spencer L

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

2020 Volume 26, Issue Supp 1, Page(s) i115–i124

Abstract: Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand ... ...

Abstract	Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period. Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations. Results: The global incidence of hand trauma has only modestly decreased since 1990. In 2017, the age-standardised incidence of hand and wrist fractures was 179 per 100 000 (95% uncertainty interval (UI) 146 to 217), whereas the less common injuries of thumb and non-thumb digit amputation were 24 (95% UI 17 to 34) and 56 (95% UI 43 to 74) per 100 000, respectively. Rates of injury vary greatly by region, and improvements have not been equally distributed. The highest burden of hand trauma is currently reported in high SDI countries. However, low-middle and middle SDI countries have increasing rates of hand trauma by as much at 25%. Conclusions: Certain regions are noted to have high rates of hand trauma over the study period. Low-middle and middle SDI countries, however, have demonstrated increasing rates of fracture and amputation over the last 27 years. This trend is concerning as access to quality and subspecialised surgical hand care is often limiting in these resource-limited regions.
MeSH term(s)	Amputation ; Female ; Global Burden of Disease ; Global Health ; Hand Injuries/surgery ; Humans ; Incidence ; Male ; Prevalence ; Quality-Adjusted Life Years ; Wrist ; Wrist Injuries/surgery
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1433667-4
ISSN	1475-5785 ; 1353-8047
ISSN (online)	1475-5785
ISSN	1353-8047
DOI	10.1136/injuryprev-2019-043495
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Article ; Online: The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019.

Cunha, Amanda Ramos da / Compton, Kelly / Xu, Rixing / Mishra, Rashmi / Drangsholt, Mark Thomas / Antunes, Jose Leopoldo Ferreira / Kerr, Alexander R / Acheson, Alistair R / Lu, Dan / Wallace, Lindsey E / Kocarnik, Jonathan M / Fu, Weijia / Dean, Frances E / Pennini, Alyssa / Henrikson, Hannah Jacqueline / Alam, Tahiya / Ababneh, Emad / Abd-Elsalam, Sherief / Abdoun, Meriem /

Abidi, Hassan / Abubaker Ali, Hiwa / Abu-Gharbieh, Eman / Adane, Tigist Demssew / Addo, Isaac Yeboah / Ahmad, Aqeel / Ahmad, Sajjad / Ahmed Rashid, Tarik / Akonde, Maxwell / Al Hamad, Hanadi / Alahdab, Fares / Alimohamadi, Yousef / Alipour, Vahid / Al-Maweri, Sadeq Ali / Alsharif, Ubai / Ansari-Moghaddam, Alireza / Anwar, Sumadi Lukman / Anyasodor, Anayochukwu Edward / Arabloo, Jalal / Aravkin, Aleksandr Y / Aruleba, Raphael Taiwo / Asaad, Malke / Ashraf, Tahira / Athari, Seyyed Shamsadin / Attia, Sameh / Azadnajafabad, Sina / Azangou-Khyavy, Mohammadreza / Badar, Muhammad / Baghcheghi, Nayereh / Banach, Maciej / Bardhan, Mainak / Barqawi, Hiba Jawdat / Bashir, Nasir Z / Bashiri, Azadeh / Benzian, Habib / Bernabe, Eduardo / Bhagat, Devidas S / Bhojaraja, Vijayalakshmi S / Bjørge, Tone / Bouaoud, Souad / Braithwaite, Dejana / Briko, Nikolay Ivanovich / Calina, Daniela / Carreras, Giulia / Chakraborty, Promit Ananyo / Chattu, Vijay Kumar / Chaurasia, Akhilanand / Chen, Meng Xuan / Cho, William C S / Chu, Dinh-Toi / Chukwu, Isaac Sunday / Chung, Eunice / Cruz-Martins, Natália / Dadras, Omid / Dai, Xiaochen / Dandona, Lalit / Dandona, Rakhi / Daneshpajouhnejad, Parnaz / Darvishi Cheshmeh Soltani, Reza / Darwesh, Aso Mohammad / Debela, Sisay Abebe / Derbew Molla, Meseret / Dessalegn, Fikadu Nugusu / Dianati-Nasab, Mostafa / Digesa, Lankamo Ena / Dixit, Shilpi Gupta / Dixit, Abhinav / Djalalinia, Shirin / El Sayed, Iman / El Tantawi, Maha / Enyew, Daniel Berhanie / Erku, Daniel Asfaw / Ezzeddini, Rana / Fagbamigbe, Adeniyi Francis / Falzone, Luca / Fetensa, Getahun / Fukumoto, Takeshi / Gaewkhiew, Piyada / Gallus, Silvano / Gebrehiwot, Mesfin / Ghashghaee, Ahmad / Gill, Paramjit Singh / Golechha, Mahaveer / Goleij, Pouya / Gomez, Ricardo Santiago / Gorini, Giuseppe / Guimaraes, Andre Luiz Sena / Gupta, Bhawna / Gupta, Sapna / Gupta, Veer Bala / Gupta, Vivek Kumar / Haj-Mirzaian, Arvin / Halboub, Esam S / Halwani, Rabih / Hanif, Asif / Hariyani, Ninuk / Harorani, Mehdi / 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Rashidul Alam / Malik, Ahmad Azam / Mathur, Manu Raj / Maulud, Sazan Qadir / Meena, Jitendra Kumar / Mehrabi Nasab, Entezar / Mestrovic, Tomislav / Mirfakhraie, Reza / Misganaw, Awoke / Misra, Sanjeev / Mithra, Prasanna / Mohammad, Yousef / Mohammadi, Mokhtar / Mohammadi, Esmaeil / Mokdad, Ali H / Moni, Mohammad Ali / Moraga, Paula / Morrison, Shane Douglas / Mozaffari, Hamid Reza / Mubarik, Sumaira / Murray, Christopher J L / Nair, Tapas Sadasivan / Narasimha Swamy, Sreenivas / Narayana, Aparna Ichalangod / Nassereldine, Hasan / Natto, Zuhair S / Nayak, Biswa Prakash / Negru, Serban Mircea / Nggada, Haruna Asura / Nouraei, Hasti / Nuñez-Samudio, Virginia / Oancea, Bogdan / Olagunju, Andrew T / Omar Bali, Ahmed / Padron-Monedero, Alicia / Padubidri, Jagadish Rao / Pandey, Anamika / Pardhan, Shahina / Patel, Jay / Pezzani, Raffaele / Piracha, Zahra Zahid / Rabiee, Navid / Radhakrishnan, Venkatraman / Radhakrishnan, Raghu Anekal / Rahmani, Amir Masoud / Rahmanian, Vahid / Rao, Chythra R / Rao, Sowmya J / Rath, Goura Kishor / Rawaf, David Laith / Rawaf, Salman / Rawassizadeh, Reza / Razeghinia, Mohammad Sadegh / Rezaei, Nazila / Rezaei, Negar / Rezaei, Nima / Rezapour, Aziz / Riad, Abanoub / Roberts, Thomas J / Romero-Rodríguez, Esperanza / Roshandel, Gholamreza / S, Manjula / S N, Chandan / Saddik, Basema / Saeb, Mohammad Reza / Saeed, Umar / Safaei, Mohsen / Sahebazzamani, Maryam / Sahebkar, Amirhossein / Salek Farrokhi, Amir / Samy, Abdallah M / Santric-Milicevic, Milena M / Sathian, Brijesh / Satpathy, Maheswar / Šekerija, Mario / Senthilkumaran, Subramanian / Seylani, Allen / Shafaat, Omid / Shahsavari, Hamid R / Shamsoddin, Erfan / Sharew, Mequannent Melaku / Sharifi-Rad, Javad / Shetty, Jeevan K / Shivakumar, K M / Shobeiri, Parnian / Shorofi, Seyed Afshin / Shrestha, Sunil / Siddappa Malleshappa, Sudeep K / Singh, Paramdeep / Singh, Jasvinder A / Singh, Garima / Sinha, Dhirendra Narain / Solomon, Yonatan / Suleman, Muhammad / Suliankatchi Abdulkader, Rizwan / Taheri Abkenar, Yasaman / Talaat, Iman M / Tan, Ker-Kan / Tbakhi, Abdelghani / Thiyagarajan, Arulmani / Tiyuri, Amir / Tovani-Palone, Marcos Roberto / Unnikrishnan, Bhaskaran / Vo, Bay / Volovat, Simona Ruxandra / Wang, Cong / Westerman, Ronny / Wickramasinghe, Nuwan Darshana / Xiao, Hong / Yu, Chuanhua / Yuce, Deniz / Yunusa, Ismaeel / Zadnik, Vesna / Zare, Iman / Zhang, Zhi-Jiang / Zoladl, Mohammad / Force, Lisa M / Hugo, Fernando N

JAMA oncology

2023 Volume 9, Issue 10, Page(s) 1401–1416

Abstract: Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.: Objective: To analyze ... ...

Abstract	Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Global Burden of Disease ; Global Health ; Incidence ; Lip ; Pharyngeal Neoplasms/epidemiology ; Quality-Adjusted Life Years ; Risk Factors ; Tobacco Use/epidemiology
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article ; Systematic Review
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2023.2960
Database	MEDical Literature Analysis and Retrieval System OnLINE

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