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  1. Article ; Online: Long-term metabolic evolution of brain metastases with suspected radiation necrosis following stereotactic radiosurgery: longitudinal assessment by F-DOPA PET.

    Cicone, Francesco / Carideo, Luciano / Scaringi, Claudia / Romano, Andrea / Mamede, Marcelo / Papa, Annalisa / Tofani, Anna / Cascini, Giuseppe Lucio / Bozzao, Alessandro / Scopinaro, Francesco / Minniti, Giuseppe

    Neuro-oncology

    2020  Volume 23, Issue 6, Page(s) 1024–1034

    Abstract: ... of RN by sequential PET/CT imaging with 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA ... patients with 34 suspected radionecrotic brain metastases following SRS repeated F-DOPA PET/CT every 6 ... confirmed histologically or by clinical follow-up. Semi-quantitative parameters of F-DOPA uptake were ...

    Abstract Background: The evolution of radiation necrosis (RN) varies depending on the combination of radionecrotic tissue and active tumor cells. In this study, we characterized the long-term metabolic evolution of RN by sequential PET/CT imaging with 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) in patients with brain metastases following stereotactic radiosurgery (SRS).
    Methods: Thirty consecutive patients with 34 suspected radionecrotic brain metastases following SRS repeated F-DOPA PET/CT every 6 months or yearly in addition to standard MRI monitoring. Diagnoses of local progression (LP) or RN were confirmed histologically or by clinical follow-up. Semi-quantitative parameters of F-DOPA uptake were extracted at different time points, and their diagnostic performances were compared with those of corresponding contrast-enhanced MRI.
    Results: Ninety-nine F-DOPA PET scans were acquired over a median period of 18 (range: 12-66) months. Median follow-up from the baseline F-DOPA PET/CT was 48 (range 21-95) months. Overall, 24 (70.6%) and 10 (29.4%) lesions were classified as RN and LP, respectively. LP occurred after a median of 18 (range: 12-30) months from baseline PET. F-DOPA tumor-to-brain ratio (TBR) and relative standardized uptake value (rSUV) increased significantly over time in LP lesions, while remaining stable in RN lesions. The parameter showing the best diagnostic performance was rSUV (accuracy = 94.1% for the optimal threshold of 1.92). In contrast, variations of the longest tumor dimension measured on contrast-enhancing MRI did not distinguish between RN and LP.
    Conclusion: F-DOPA PET has a high diagnostic accuracy for assessing the long-term evolution of brain metastases following SRS.
    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Dihydroxyphenylalanine ; Humans ; Necrosis ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiosurgery/adverse effects
    Chemical Substances Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noaa239
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  2. Article ; Online: A vascular lesion mimicking a primitive brain tumour in a patient examined by (18)F-choline PET/CT and MRI.

    Cascini, G L / Restuccia, A / De Vincenti, T / Manti, F / Calabria, F

    Revista espanola de medicina nuclear e imagen molecular

    2015  Volume 34, Issue 5, Page(s) 335–336

    MeSH term(s) Aged ; Blood Vessels/injuries ; Blood-Brain Barrier ; Brain Injuries/complications ; Brain Injuries/diagnostic imaging ; Brain Injuries/surgery ; Brain Neoplasms/diagnosis ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Choline ; Diagnosis, Differential ; Fluorine Radioisotopes ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Headache/etiology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Metals ; Multimodal Imaging/methods ; Neuroimaging/methods ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Temporal Lobe/diagnostic imaging
    Chemical Substances Fluorine Radioisotopes ; Metals ; Radiopharmaceuticals ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2015-09
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 2911865-7
    ISSN 2253-8070 ; 2253-654X
    ISSN (online) 2253-8070
    ISSN 2253-654X
    DOI 10.1016/j.remn.2015.02.003
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  3. Article: Current status and future challenges of brain imaging with (18)F-DOPA PET for movement disorders.

    Calabria, Ferdinando Franco / Calabria, Eros / Gangemi, Vincenzo / Cascini, Giuseppe Lucio

    Hellenic journal of nuclear medicine

    2016  Volume 19, Issue 1, Page(s) 33–41

    Abstract: ... 18)F-DOPA) is a positron emission tomography (PET) tracer with selective in vivo affinity ... to the basal ganglia, due to the specific metabolism of substantia nigra. We assessed the effective use of (18)F-DOPA ... of magnetic resonance imaging (MRI) was also discussed.: Conclusion: (18)F-DOPA PET imaging is still the best diagnostic tool ...

    Abstract Objective: Parkinson's disease (PD) is a neurodegenerative disorder (ND) due to progressive loss of dopaminergic neurons in the basal ganglia. The correct differential diagnosis of this disease with parkinsonian syndromes (PS) or with essential tremor (ET) is a diagnostic dilemma, considering that only PD is responsive to treatment with levodopa. Traditional imaging fails to diagnose PD because morphological alterations in the brain are usually detectable only at advanced stages. Single photon emission tomography (SPET) with cocaine analogues has recently been used in the early detection of PD. The fluoro-18-deoxyphenyl-alanine ((18)F-DOPA) is a positron emission tomography (PET) tracer with selective in vivo affinity to the basal ganglia, due to the specific metabolism of substantia nigra. We assessed the effective use of (18)F-DOPA PET in brain imaging in order to describe the function of presynaptic disorders of PD, PS, ET and other movement disorders compared to SPET imaging and also discussed novel radiopharmaceuticals. The role of magnetic resonance imaging (MRI) was also discussed.
    Conclusion: (18)F-DOPA PET imaging is still the best diagnostic tool for the diagnosis of PD and other movement disorders. Fluorine-18-FDG PET can play a role in the differential diagnosis between PD and other PS. The hybrid (18)F-DOPA PET/MRI seems to be able to play an important additional role in early diagnosis of the above syndromes.
    MeSH term(s) Brain/diagnostic imaging ; Dihydroxyphenylalanine/analogs & derivatives ; Forecasting ; Humans ; Image Enhancement/methods ; Parkinson Disease/diagnostic imaging ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; fluorodopa F 18 (2C598205QX) ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2016-01
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2186026-9
    ISSN 1790-5427 ; 1108-1430
    ISSN 1790-5427 ; 1108-1430
    DOI 10.1967/s002449910335
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  4. Article: National Recovery and Resilience Plan and Health: qualitative analysis on the sustainability of the interventions on healthcare.

    Cascini, F / Gentili, A

    Annali di igiene : medicina preventiva e di comunita

    2023  Volume 35, Issue 5, Page(s) 602–610

    Abstract: Background: Sars-CoV2 epidemic was the cause of death of more than 180,000 Italian citizens. The sever-ity of this disease showed to policymakers how easily Italian health services, and particularly hospitals, could be overwhelmed by requests and needs ... ...

    Abstract Background: Sars-CoV2 epidemic was the cause of death of more than 180,000 Italian citizens. The sever-ity of this disease showed to policymakers how easily Italian health services, and particularly hospitals, could be overwhelmed by requests and needs from patients and the general population. As a consequence of the clogging of health services, the government decided to allocate a consistent investment to the com-munity and proximity assistance with a specific section (Mission 6) of the so called "National Recovery and Resilience Plan".
    Objective: The aim of this study is to analyse the economic and social impact of the Mission 6 of the National Recovery and Resilience Plan, with particular regard to the most relevant interventions (Community Homes, Community Hospitals, Integrated Home Care), in order to understand its future sustainability.
    Material and methods: A qualitative research methodology was chosen. Documents containing all the relevant information regarding the sustainability of the plan (called in short "Sustainability Plan") were taken into consideration. In case of missing data regarding the potential costs or expenditure of the afore-mentioned structures, estimates will be made reviewing literature for similar healthcare services, already implemented and active in Italy. Direct content analysis was chosen as the methodology for data analysis and final reporting of results.
    Results: The National Recovery and Resilience Plan states that it will create savings of up to €1.18 bil-lion thanks to the re-organization of healthcare facilities, the reduction of hospitalizations, the reduction of inappropriate access to the emergency room, and the containment of pharmaceutical expenditure. This amount will be used to cover the salaries for the healthcare professionals employed in the newly planned healthcare structures. The analysis of this study has taken into account the number of healthcare profes-sionals that will be needed to operationalize the new facilities, as described in the plan and compared them with the reference salaries for each category (doctors, nurses, other healthcare workers). The annual cost for healthcare professionals has been stratified for each structure, with the following results: € 540 million for the personnel of the Community Hospitals ("Ospedali di Comunità"); € 1.1 billion for the personnel of Integrated Home Care Assistance ("Assistenza Domiciliare Integrata"); and € 540 million for the personnel of Community Homes ("Case della Comunità").
    Discussion: The expected € 1.18 billion expenditure is implausible to be sufficient to cover the cost for salaries of all the healthcare professionals needed, which is expected to be around € 2 billion. The National Agency for the Regional Healthcare Services ("Agenzia nazionale per i servizi sanitari regionali") calculated that in Emilia-Romagna (the only region in Italy to have already implemented a healthcare structure based on the one described in the National Recovery and Resilience Plan), the activation of Community Hospitals and Community Homes reduced the rate of inappropriate access to emergency rooms by 26% (while in the National Recovery and Resilience Plan expectation is a reduction of at least by 90% for "white codes", the identified code for stable and not urgent patients). Moreover, the hypothesis for the daily cost of stay in the Community Hospital is roughly € 106, while the average current cost in the active Community Hospitals in Italy is € 132 (much higher than the National Recovery and Resilience Plan estimate).
    Conclusion: The underlying principle of the National Recovery and Resilience Plan is highly valuable since it strives to enhance the quality and the quantity of the healthcare services in the country that are too often left out of national investments and programs. Nevertheless, the National Recovery and Resilience Plan has critical issues due to the superficial prevision of cost. The success of the reform appears to be established by decision makers and by their long-term prospective, oriented to overcome the resistance to change.
    MeSH term(s) Humans ; Prospective Studies ; RNA, Viral ; COVID-19/prevention & control ; SARS-CoV-2 ; Delivery of Health Care
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-03-03
    Publishing country Italy
    Document type Evaluation Study
    ZDB-ID 1018045-x
    ISSN 1120-9135 ; 0029-6287
    ISSN 1120-9135 ; 0029-6287
    DOI 10.7416/ai.2023.2561
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  5. Article ; Online: Reply to: Ethnic minorities, social media, and attitudes towards COVID-19 vaccination.

    Cascini, Fidelia / Failla, Giovanna / Melnyk, Andriy

    EClinicalMedicine

    2022  Volume 51, Page(s) 101564

    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2022.101564
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  6. Article ; Online: Use of oxygen-ozone therapy to improve the effectiveness of antibiotic treatment on infected arthroplasty: protocol for a superiority, open-label, multicentre, randomised, parallel trial.

    Cascini, Fidelia / Franzini, Marianno / Andreoli, Arnaldo / Manzotti, Alfonso / Cadeddu, Chiara / Quaranta, Gianluigi / Gentili, Andrea / Ricciardi, Walter

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e076739

    Abstract: Introduction: Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use ( ... ...

    Abstract Introduction: Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use (especially the misuse) of antibiotics have led to the rapid appearance of antibiotic-resistant strains today; more and more infections are caused by microorganisms that fail to respond to conventional treatments.Oxygen-ozone therapy has been extensively used and studied for decades across various potential medical applications and has provided consistent effects with minimal side effects.This study aims to determine the superiority of oxygen-ozone therapy in combination with oral antibiotic therapy in patients with wound infections after an orthopaedic device implantation when compared with antibiotic therapy alone.
    Methods and analysis: This is an open-label, multicentre, randomised, parallel-group study that aims to assess the efficacy and safety of oxygen-ozone therapy in combination with oral antibiotic therapy to treat infections in patients (male or female aged ≥18 years) having undergone surgery for the implant of an orthopaedic device. Patients must have at least one (but no more than three) postoperative wounds in the site of surgery (ulcers, eschars and sores) and at least one symptom (pain, burning, redness and malodour) and at least one sign (erythema, local warmth, swelling and purulent secretion) of infection of at least moderate intensity (score ≥2) in the target lesion at the screening visit (patients with wounds without signs of localised infection or with undermining wounds will be excluded).Patients (n=186) will be recruited from five Italian hospitals and studied for 7 weeks. All will be assigned to one of the two treatment groups according to a web-based, centralised randomisation procedure and placed into either the (1) intervention: oxygen-ozone therapy 2-3 times a week for 6 weeks (for a maximum of 15 sessions) simultaneously with an appropriate oral antibiotic therapy prescribed at baseline or (2) control: oral antibiotic therapy prescribed at baseline.The primary outcome is the efficacy and superiority of the treatment (ozone and oral antibiotic therapies); secondary outcomes include the resolution of signs and symptoms, modifications in lesion size and the treatment's safety and tolerability.
    Ethics and dissemination: This study has been reviewed and approved by the responsible Independent Ethics Committee (IEC) of COMITATO ETICO CAMPANIA NORD, located at 'Azienda Ospedaliera San Giuseppe Moscati di Avellino'.After completion of the study, the project coordinator will prepare a draft manuscript containing the final results of the study on the basis of the statistical analysis. The manuscript will be derived by the co-authors for comments, and after revision, it will be sent to a major scientific journal. Findings will be disseminated via online and print media, events and peer-reviewed journals.
    Trial registration number: NCT04787575.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Male ; Anti-Bacterial Agents ; Arthroplasty ; Multicenter Studies as Topic ; Oxygen ; Ozone/therapeutic use ; Randomized Controlled Trials as Topic ; Surgical Wound Infection/drug therapy ; Surgical Wound Infection/prevention & control ; Treatment Outcome ; Equivalence Trials as Topic
    Chemical Substances Anti-Bacterial Agents ; Oxygen (S88TT14065) ; Ozone (66H7ZZK23N)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-076739
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  7. Article ; Online: Reply to: "Assessment of imaging biomarkers in the follow-up of brain metastases after SRS".

    Cicone, Francesco / Cascini, Giuseppe Lucio / Minniti, Giuseppe

    Neuro-oncology

    2021  Volume 23, Issue 11, Page(s) 1985–1986

    MeSH term(s) Biomarkers ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Follow-Up Studies ; Humans ; Radiosurgery
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-11-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab191
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  8. Article ; Online: Health data sharing attitudes towards primary and secondary use of data: a systematic review.

    Cascini, Fidelia / Pantovic, Ana / Al-Ajlouni, Yazan A / Puleo, Valeria / De Maio, Lucia / Ricciardi, Walter

    EClinicalMedicine

    2024  Volume 71, Page(s) 102551

    Abstract: Background: To receive the best care, people share their health data (HD) with their health practitioners (known as sharing HD for primary purposes). However, during the past two decades, sharing for other (i.e., secondary) purposes has become of great ... ...

    Abstract Background: To receive the best care, people share their health data (HD) with their health practitioners (known as sharing HD for primary purposes). However, during the past two decades, sharing for other (i.e., secondary) purposes has become of great importance in numerous fields, including public health, personalized medicine, research, and development. We aimed to conduct the first comprehensive overview of all studies that investigated people's HD sharing attitudes-along with associated barriers/motivators and significant influencing factors-for all data types and across both primary and secondary uses.
    Methods: We searched PubMed, MEDLINE, PsycINFO, Web of Science, EMBASE, and CINAHL for relevant studies published in English between database inception and February 28, 2023, using a predefined set of keywords. Studies were included, regardless of their design, if they reported outcomes related to attitudes towards sharing HD. We extracted key data from the included studies, including the type of HD involved and findings related to: HD sharing attitudes (either in general or depending on type of data/user); barriers/motivators/benefits/concerns of the study participants; and sociodemographic and other variables that could impact HD sharing behaviour. The qualitative synthesis was conducted by dividing the studies according to the data type (resulting in five subgroups) as well as the purpose the data sharing was focused on (primary, secondary or both). The Newcastle-Ottawa Scale (NOS) was used to assess the quality of non-randomised studies. This work was registered with PROSPERO, CRD42023413822.
    Findings: Of 2109 studies identified through our search, 116 were included in the qualitative synthesis, yielding a total of 228,501 participants and various types of HD represented: person-generated HD (n = 17 studies and 10,771 participants), personal HD in general (n = 69 studies and 117,054 participants), Biobank data (n = 7 studies and 27,073 participants), genomic data (n = 13 studies and 54,716 participants), and miscellaneous data (n = 10 studies and 18,887 participants). The majority of studies had a moderate level of quality (83 [71.6%] of 116 studies), but varying levels of quality were observed across the included studies. Overall, studies suggest that sharing intentions for primary purposes were observed to be high regardless of data type, and it was higher than sharing intentions for secondary purposes. Sharing for secondary purposes yielded variable findings, where both the highest and the lowest intention rates were observed in the case of studies that explored sharing biobank data (98% and 10%, respectively). Several influencing factors on sharing intentions were identified, such as the type of data recipient, data, consent. Further, concerns related to data sharing that were found to be mutual for all data types included privacy, security, and data access/control, while the perceived benefits included those related to improvements in healthcare. Findings regarding attitudes towards sharing varied significantly across sociodemographic factors and depended on data type and type of use. In most cases, these findings were derived from single studies and therefore warrant confirmations from additional studies.
    Interpretation: Sharing health data is a complex issue that is influenced by various factors (the type of health data, the intended use, the data recipient, among others) and these insights could be used to overcome barriers, address people's concerns, and focus on spreading awareness about the data sharing process and benefits.
    Funding: None.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2024.102551
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  9. Article: Unespected dectection of unruptured brain arteriovenous malformation with

    Cuccurullo, Vincenzo / Arcuri, Pier Paolo / Cicone, Francesco / Barberio, Paolo / Manti, Francesco / Cascini, Giuseppe Lucio

    Hellenic journal of nuclear medicine

    2022  Volume 25, Issue 2, Page(s) 213–215

    Abstract: Unruptured brain arteriovenous malformations (AVM) have a heterogeneous clinical presentation, mainly related to the presence of intracerebral hemorrhage. We report the diagnosis of AVM in a patient with Parkinson's disease (PD), who undergone positron ... ...

    Abstract Unruptured brain arteriovenous malformations (AVM) have a heterogeneous clinical presentation, mainly related to the presence of intracerebral hemorrhage. We report the diagnosis of AVM in a patient with Parkinson's disease (PD), who undergone positron emission tomography/magnetic resonance imaging (PET/MRI) molecular brain imaging with fluorine-18-dihydroxyphenylalanine (
    MeSH term(s) Arteriovenous Malformations ; Brain ; Dihydroxyphenylalanine/analogs & derivatives ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
    Chemical Substances fluorodopa F 18 (2C598205QX) ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2022-08-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2186026-9
    ISSN 1790-5427 ; 1108-1430
    ISSN 1790-5427 ; 1108-1430
    DOI 10.1967/s002449912482
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  10. Article ; Online: Investigations into the hypothesis of transgenic cannabis.

    Cascini, Fidelia

    Journal of forensic sciences

    2012  Volume 57, Issue 3, Page(s) 718–721

    Abstract: The unusual concentration of cannabinoids recently found in marijuana samples submitted to the forensic laboratory for chemical analysis prompted an investigation into whether genetic modifications have been made to the DNA of Cannabis sativa L. to ... ...

    Abstract The unusual concentration of cannabinoids recently found in marijuana samples submitted to the forensic laboratory for chemical analysis prompted an investigation into whether genetic modifications have been made to the DNA of Cannabis sativa L. to increase its potency. Traditional methods for the detection of genetically modified organisms (GMO) were used to analyze herbal cannabis preparations. Our analyses support the hypothesis that marijuana samples submitted to forensic laboratories and characterized by an abnormal level of Δ(9)-THC are the product of breeding selection rather than of transgenic modifications. Further, this research has shown a risk of false positive results associated with the poor quality of the seized samples and probably due to the contamination by other transgenic vegetable products. On the other hand, based on these data, a conclusive distinction between the hypothesis of GMO plant contamination and the other of genetic modification of cannabis cannot be made requiring further studies on comparative chemical and genetic analyses to find out an explanation for the recently detected increased potency of cannabis.
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/j.1556-4029.2011.02021.x
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