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Article ; Online: Transcatheter aortic valve replacement for pure aortic regurgitation: using left ventricular outflow tract implant as an auxiliary support.

Zhang, ChangDong / Zhong, YuCheng / Shang, XiaoKe / Dong, NianGuo

European heart journal. Case reports

2024 Volume 8, Issue 4, Page(s) ytae185

Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytae185
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Article ; Online: Comparison of outcomes of high-flow nasal cannula and noninvasive positive-pressure ventilation in patients with hypoxemia and various APACHE II scores after extubation.

Shang, Xiaoke / Wang, Yanggan

Therapeutic advances in respiratory disease

2021 Volume 15, Page(s) 17534666211004235

Abstract: Aims: The study aimed to compare and analyze the outcomes of high-flow nasal cannula (HFNC) and noninvasive positive-pressure ventilation (NPPV) in the treatment of patients with acute hypoxemic respiratory failure (AHRF) who had extubation after ... ...

Abstract	Aims: The study aimed to compare and analyze the outcomes of high-flow nasal cannula (HFNC) and noninvasive positive-pressure ventilation (NPPV) in the treatment of patients with acute hypoxemic respiratory failure (AHRF) who had extubation after weaning from mechanical ventilation. Methods: A total 120 patients with AHRF were enrolled into this study. These patients underwent tracheal intubation and mechanical ventilation. They were organized into two groups according to the score of Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II); group A: APACHE II score <12; group B: 12⩽ APACHE II score <24. Group A had 72 patients and patients given HFNC were randomly assigned to subgroup I while patients given NPPV were assigned to subgroup II (36 patients in each subgroup). Group B had 48 patients and patients given HFNC were randomly assigned to subgroup I while patients given NPPV were assigned to subgroup II (24 patients in each subgroup). General information, respiratory parameters, endpoint event, and comorbidities of adverse effect were compared and analyzed between the two subgroups. Results: The incidence of abdominal distension was significantly higher in patients treated with NPPV than in those treated with HFNC in group A (19.44% Conclusion: There was no significant difference between HFNC and NPPV in preventing respiratory failure in patients with AHRF with an APACHE II score <24 after extubation. However, HFNC was superior to NPPV with less incidence of abdominal distension.
MeSH term(s)	APACHE ; Aged ; Airway Extubation ; Blood Gas Analysis ; Cannula ; Female ; Humans ; Intubation, Intratracheal ; Male ; Middle Aged ; Noninvasive Ventilation/adverse effects ; Noninvasive Ventilation/methods ; Oxygen/blood ; Oxygen Inhalation Therapy/adverse effects ; Oxygen Inhalation Therapy/methods ; Positive-Pressure Respiration/adverse effects ; Positive-Pressure Respiration/methods ; Respiration, Artificial/methods ; Respiratory Insufficiency/therapy
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/17534666211004235
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Article: The Clinical Trial Outcomes of Med-Zenith PT-Valve in the Treatment of Patients With Severe Pulmonary Regurgitation.

Shang, Xiaoke / Dong, Nianguo / Zhang, Changdong / Wang, Yanggan

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 887886

Abstract: Objective: Nearly 2/3 of patients with dilated right ventricular outflow tract (RVOT) were excluded from pulmonary valves transplantation due to the lack of size-matched valves. Here, we explored the safety and efficacy of the Med-Zenith PT-Valve for ... ...

Abstract	Objective: Nearly 2/3 of patients with dilated right ventricular outflow tract (RVOT) were excluded from pulmonary valves transplantation due to the lack of size-matched valves. Here, we explored the safety and efficacy of the Med-Zenith PT-Valve for the treatment of patients with severe pulmonary regurgitation. Methods: 22 Patients with severe PR (grade 3+,4+) were enrolled based on the anatomical features of native RVOT and the valve design. The immediate, 3-months and 1-year post-procedural follow-up data were analyzed. Results: The baseline mean systolic diameters in the distal main pulmonary artery (MPA), MPA sinus junction, MPA sinus, pulmonary annulus, RVOT aneurysm and muscular outlet measured with computed tomography were 33.6 ± 6.1, 34.0 ± 5.8, 37.9 ± 6.0, 32.4 ± 7.3, 41.9 ± 9.3, and 34.4 ± 8.0 mm, respectively. The PT-Valve landing zone was set within these levels. Successful valve implantations were achieved in all patients without noticeable device malposition, coronary artery compression, pulmonary branch obstruction or paravalvular leak during follow-ups. Post-procedural pulmonary artery diastolic pressure increased from 5.8 ± 3.1 to 11.3 ± 2.5 mmHg. In the 3-month and 1-year follow-up, the right ventricular end diastolic volume index reduced from the baseline 181.6 ± 29.0 to 143.7 ± 29.7 ml/m Conclusion: This clinical trial revealed favorable outcomes for the safety, efficacy and feasibility of the Med-Zenith PT-Valve in the treatment of severe PR with significantly enlarged RVOT.
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.887886
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Article ; Online: Effectiveness and Safety of Idarucizumab for Periprocedural Cardiac Tamponade After Catheter Ablation of Atrial Fibrillation in Dabigatran Recipients: A Retrospective Controlled Study.

Huang, Langjing / Yu, Zhihua / Liu, Mei / Shang, Xiaoke

American journal of cardiovascular drugs : drugs, devices, and other interventions

2022 Volume 22, Issue 5, Page(s) 557–565

Abstract: Objective: This study aimed to investigate the effectiveness and safety of idarucizumab for periprocedural cardiac tamponade after catheter ablation of atrial fibrillation (AF) in patients treated with dabigatran.: Methods: We retrospectively studied ...

Abstract	Objective: This study aimed to investigate the effectiveness and safety of idarucizumab for periprocedural cardiac tamponade after catheter ablation of atrial fibrillation (AF) in patients treated with dabigatran. Methods: We retrospectively studied 28 patients who received catheter ablation of AF and developed periprocedural cardiac tamponade. Patients were divided into two groups: control group (14 cases) and the study group (14 cases). Patients in the control group were administered warfarin bridged with low molecular weight heparin, while patients in the study group were given dabigatran for anticoagulation. Heparin was used for anticoagulation during surgery in both groups. Patients with cardiac tamponade in control group was reversed with protamine and the ones in study group were given protamine and idarucizumab. In the two groups, operative time, time to resume anticoagulation, bleeding time, length of hospital stay, hemodynamic parameters, coagulation function parameters, number of patients undergoing thoracotomy for hemostasis, pericardiocentesis drainage volume, and pericardial drainage retention time were recorded. Results: There was no statistical difference in operative time and length of hospital stay between the two groups (p > 0.05); however, time to resume anticoagulation and bleeding time were significantly lower in the study group than in the control group, with a statistical difference (p < 0.05). After anticoagulation therapy, there was no apparent change and no statistical difference in the hemodynamic parameters and SaO Conclusion: Idarucizumab can rapidly and effectively reverse the anticoagulant effect of dabigatran in patients with AF who have periprocedural cardiac tamponade after catheter ablation.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/etiology ; Atrial Fibrillation/surgery ; Benzimidazoles/adverse effects ; Cardiac Tamponade/chemically induced ; Cardiac Tamponade/surgery ; Catheter Ablation/adverse effects ; Dabigatran/adverse effects ; Humans ; Protamines/adverse effects ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Anticoagulants ; Benzimidazoles ; Protamines ; idarucizumab (97RWB5S1U6) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2022-06-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2052547-3
ISSN	1179-187X ; 1175-3277
ISSN (online)	1179-187X
ISSN	1175-3277
DOI	10.1007/s40256-022-00536-7
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Zs.A 5487: Show issues

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Article ; Online: A stent for branch pulmonary artery stenosis after double-lung transplantation in a patient with COVID-19: a case report.

Zheng, Qiang / Shang, Xiaoke / Dong, Nianguo / Shi, Jiawei

European heart journal. Case reports

2021 Volume 5, Issue 10, Page(s) ytab327

Abstract: Background: Coronavirus disease 2019 (COVID-19) continues to be a pandemic worldwide. Lung transplantation is the last option to increase life expectancy of end-stage COVID-19 patients. Branch pulmonary artery stenosis (PAS) is a rare complication after ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) continues to be a pandemic worldwide. Lung transplantation is the last option to increase life expectancy of end-stage COVID-19 patients. Branch pulmonary artery stenosis (PAS) is a rare complication after lung transplantation with an extremely poor prognosis. The current trend in the management of branch PAS is percutaneous balloon angioplasty and/or stent implantation, rather than high-risk reoperation with a lower success rate. Case summary: The subject was a 54-year-old male with severe acute respiratory syndrome coronavirus 2 infection who underwent a double-lung transplantation. He suffered hypoxaemia and right heart dysfunction following the operation. Right cardiac catheterization and pulmonary angiography examination revealed severe stenosis of the right branch pulmonary artery. Due to immunosuppression and reduced coagulation function, the patient underwent pulmonary artery balloon dilatation and stent implantation, and ultimately recovered well. Discussion: The combination of balloon dilatation and stent implantation is a good alternative to reoperation for patients with COVID-19.
Language	English
Publishing date	2021-08-10
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytab327
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Article: Systematic Review of Fixed- Versus Adjustable-Loop Femoral Cortical Suspension Devices for Anterior Cruciate Ligament Reconstruction: Letter to the Editor.

Shang, XiaoKe / Li, Jian / Li, Qi

Orthopaedic journal of sports medicine

2019 Volume 7, Issue 5, Page(s) 2325967119843504

Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/2325967119843504
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Article ; Online: An Auxiliary Tasks Based Framework for Automated Medical Skill Assessment with Limited Data.

Zhao, Shang / Zhang, Xiaoke / Jin, Fang / Hahn, James

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 1613–1617

Abstract: Automated medical skill assessment facilitates medical education by merging varying clinical experiences across instructors for standardizing medical training. However, medical datasets for training such automated assessment rarely have satisfactory ... ...

Abstract	Automated medical skill assessment facilitates medical education by merging varying clinical experiences across instructors for standardizing medical training. However, medical datasets for training such automated assessment rarely have satisfactory sizes due to the cost of data collection, safety concerns and privacy restrictions. Current medical training relies on evaluation rubrics that usually include multiple auxiliary labels to support the overall evaluation from varying aspects of the procedure. In this paper, we explore machine learning algorithms to design a generalizable auxiliary task-based framework for medical skill assessment to address training automated systems with limited data. Our framework exhaustively mines valid auxiliary information in the evaluation rubric to pre-train the feature extractor before training the skill assessment classifier. Notably, a new regression-based multitask weighting method is the key to pre-train a meaningful feature representation comprehensively, ensuring the evaluation rubric is well imitated in the final model. The overall evaluation task can be fine-tuned based on the pre-trained rubric-based feature representation. Our experimental results on two medical skill datasets show that our work can significantly improve performance, achieving 85.9% and 97.4% accuracy in the intubation dataset and surgical skill dataset, respectively.
MeSH term(s)	Algorithms ; Clinical Competence/standards ; Machine Learning
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630498
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Article ; Online: Hip Arthroscopic Surgery With Labral Preservation and Capsular Plication in Patients With Borderline Hip Dysplasia: Minimum 5-Year Patient-Reported Outcomes: Letter to the Editor.

Shang, XiaoKe / Li, Jian / Li, Qi

The American journal of sports medicine

2019 Volume 47, Issue 4, Page(s) NP31–NP32

MeSH term(s)	Arthroscopy ; Femoracetabular Impingement ; Hip Dislocation ; Hip Dislocation, Congenital ; Humans ; Patient Reported Outcome Measures
Language	English
Publishing date	2019-03-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/0363546519825636
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Zs.B 1910: Show issues

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Article ; Online: Right ventricular contractility as a potential independent evaluation parameter in pulmonary hypertension.

Shang, Xiaoke / Zhang, Changdong / Liu, Mei / Lu, Rong / Wang, Yanggan

International journal of clinical practice

2021 Volume 75, Issue 7, Page(s) e14183

Abstract: Background: Pulmonary artery hypertension (PAH) is a common disease with high disability and mortality rates, and can lead to right heart failure. We aimed to evaluate the capability of right ventricular pressure-volume coupling parameters, end-systolic ...

Abstract	Background: Pulmonary artery hypertension (PAH) is a common disease with high disability and mortality rates, and can lead to right heart failure. We aimed to evaluate the capability of right ventricular pressure-volume coupling parameters, end-systolic elastance (Ees), right ventricular afterload (Ea), and arterial elastance (Ees/Ea) for assessing right ventricular performance during the chronic development of PAH. Methods: Thirty-six PAH patients were enrolled in this study. We reported the cutoff values of the right ventricular pressure-volume coupling parameters in the progression of PAH and their relations with other pressure-volume loop measurements in both the right and left ventricles. Results: Ees and normalised Ees (Ees/Ea) calculated from the pressure method performed better than ones from the volume method in correlation with mean pulmonary arterial pressure and mean right arterial pressure. The cutoff sets of Ees and Ees/Ea were capable of grouping pulmonary hypertension patients which were well supported by their significant correlation with several key right ventricular hemodynamic parameters. Additionally, the normalised Ees was able to reflect the changes in left ventricular function during the deterioration of PAH. Conclusion: Ees and Ees/Ea are promising independent reference parameters for assessing ventricular function in progressing PAH patients.
Language	English
Publishing date	2021-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14183
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Article ; Online: Sulforaphane inhibits the migration and invasion of BPDE-induced lung adenocarcinoma cells by regulating NLRP12.

Wang, Wei / Chang, Shufan / He, Xi / Zhou, XiaoLei / Shang, Pingping / Chen, Yusong / Wang, Xiaoke / Chen, Lijuan / Zhang, Qiao / Qiao, Yahong / Feng, Feifei

Toxicology and applied pharmacology

2024 Volume 485, Page(s) 116916

Abstract: This study aims to explore the impact and underlying mechanism of sulforaphane (SFN) intervention on the migration and invasion of lung adenocarcinoma induced by 7, 8-dihydroxy-9, 10-epoxy-benzo (a) pyrene (BPDE). Human lung adenocarcinoma A549 cells ... ...

Abstract	This study aims to explore the impact and underlying mechanism of sulforaphane (SFN) intervention on the migration and invasion of lung adenocarcinoma induced by 7, 8-dihydroxy-9, 10-epoxy-benzo (a) pyrene (BPDE). Human lung adenocarcinoma A549 cells were exposed to varying concentrations of BPDE (0.25, 0.50, and 1.00 μM) and subsequently treated with 5 μM SFN. Cell viability was determined using CCK8 assay, while migration and invasion were assessed using Transwell assays. Lentivirus transfection was employed to establish NLRP12 overexpressing A549 cells. ELISA was utilized to quantify IL-33, CXCL12, and CXCL13 levels in the supernatant, while quantitative real-time PCR (qRT-PCR) and Western Blot were used to analyze the expression of NLRP12 and key factors associated with canonical and non-canonical NF-κB pathways. Results indicated an increase in migratory and invasive capabilities, concurrent with heightened expression of IL-33, CXCL12, CXCL13, and factors associated with both canonical and non-canonical NF-κB pathways. Moreover, mRNA and protein levels of NLRP12 were decreased in BPDE-stimulated A549 cells. Subsequent SFN intervention attenuated BPDE-induced migration and invasion of A549 cells. Lentivirus-mediated NLRP12 overexpression not only reversed the observed phenotype in BPDE-induced cells but also led to a reduction in the expression of critical factors associated with both canonical and non-canonical NF-κB pathways. Collectively, we found that SFN could inhibit BPDE-induced migration and invasion of A549 cells by upregulating NLRP12, thereby influencing both canonical and non-canonical NF-κB pathways.
MeSH term(s)	Humans ; Isothiocyanates/pharmacology ; Sulfoxides/pharmacology ; Cell Movement/drug effects ; A549 Cells ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/drug therapy ; Lung Neoplasms/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Neoplasm Invasiveness ; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/toxicity ; Anticarcinogenic Agents/pharmacology ; NF-kappa B/metabolism ; Cell Survival/drug effects ; Signal Transduction/drug effects ; Gene Expression Regulation, Neoplastic/drug effects
Chemical Substances	Isothiocyanates ; Sulfoxides ; sulforaphane (GA49J4310U) ; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide (55097-80-8) ; Anticarcinogenic Agents ; NF-kappa B
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2024.116916
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