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Article ; Online: Comment on 'Duloxetine for rehabilitation after total knee arthroplasty: a systematic review and meta-analysis'.

Chen, Meiru / Zhang, Dandan / Hu, Wenhui / Tang, Xiumei / Hou, Xiaoling

International journal of surgery (London, England)

2023 Volume 109, Issue 10, Page(s) 3245–3247

MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee ; Duloxetine Hydrochloride ; Osteoarthritis, Knee/surgery
Chemical Substances	Duloxetine Hydrochloride (9044SC542W)
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000567
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Article: Activation of canonical inflammasome complex by acute silica exposure in experimental rat model.

Niu, Yingmei / Yang, Shuangli / Hu, Xiumei

Toxicology research

2022 Volume 11, Issue 1, Page(s) 162–168

Abstract: Silicosis is a chronic irreversible pulmonary disease caused by the inhalation of silica crystals in occupational settings in most cases. Persistent inflammation in the alveolar space is considered to be the major reason for tissue damage and lung ... ...

Abstract	Silicosis is a chronic irreversible pulmonary disease caused by the inhalation of silica crystals in occupational settings in most cases. Persistent inflammation in the alveolar space is considered to be the major reason for tissue damage and lung fibrogenesis. The mechanisms by which silica exposure activates immune cells are not well understood. Here, we employed an
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2684701-2
ISSN	2045-4538 ; 2045-452X
ISSN (online)	2045-4538
ISSN	2045-452X
DOI	10.1093/toxres/tfab127
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Article ; Online: Injectable Magnetic Hydrogel Filler for Synergistic Bone Tumor Hyperthermia Chemotherapy.

Hu, Peilun / Lu, Jingsong / Li, Chengli / He, Zhijun / Wang, Xiumei / Pan, Yongwei / Zhao, Lingyun

ACS applied bio materials

2024 Volume 7, Issue 3, Page(s) 1569–1578

Abstract: The therapeutic efficacy of bone tumor treatment is primarily limited by inadequate tumor resection, resulting in recurrence and metastasis, as well as the deep location of tumors. Herein, an injectable doxorubicin (DOX)-loaded magnetic alginate hydrogel ...

Abstract	The therapeutic efficacy of bone tumor treatment is primarily limited by inadequate tumor resection, resulting in recurrence and metastasis, as well as the deep location of tumors. Herein, an injectable doxorubicin (DOX)-loaded magnetic alginate hydrogel (DOX@MAH) was developed to evaluate the efficacy of an alternating magnetic field (AMF)-responsive, chemothermal synergistic therapy for multimodality treatment of bone tumors. The prepared hydrogel exhibits a superior drug-loading capacity and a continuous DOX release. This multifunctionality can be attributed to the combined use of DOX for chemotherapy and iron oxide nanoparticle-containing alginate hydrogels as magnetic hyperthermia agents to generate hyperthermia for tumor elimination without the limit on penetration depth. Moreover, the hydrogel can be formed when in contact with the calcium ions, which are abundant in bone tissues; therefore, this hydrogel could perfectly fit the bone defects caused by the surgical removal of the bone tumor tissue, and the hydrogel could tightly attach the surgical margin of the bone to realize a high efficacy residual tumor tissue elimination treated by chemothermal synergistic therapy. The hydrogel demonstrates excellent hyperthermia performance, as evidenced by
MeSH term(s)	Animals ; Mice ; Hydrogels/pharmacology ; Calcium ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Bone Neoplasms/drug therapy ; Hyperthermia ; Hyperthermia, Induced/methods ; Alginates ; Ions ; Magnetic Phenomena
Chemical Substances	Hydrogels ; Calcium (SY7Q814VUP) ; Doxorubicin (80168379AG) ; Alginates ; Ions
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c01074
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Article: The Effect of Co-Fermentation with

Hu, Liping / Li, Yue / Huang, Xiang / Du, Chaodong / Huang, Dejian / Tao, Xiumei

Foods (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Sourdough fermentation has been widely used in food products. However, there has been limited study of the effect of co-fermentation with lactic acid bacteria and yeast on the dough and cracker products. In this study, the influence of co-fermentation ... ...

Abstract	Sourdough fermentation has been widely used in food products. However, there has been limited study of the effect of co-fermentation with lactic acid bacteria and yeast on the dough and cracker products. In this study, the influence of co-fermentation with
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12030555
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Article ; Online: Community structure of soil mites under different crops and its response to environmental factors in the buffer zone of Shibing Karst World Natural Heritage

Xiumei Yin / Tong Gong / Wenjun Liu / Hu Chen / Yifan Fei

Environmental Research Communications, Vol 5, Iss 6, p

2023 Volume 065004

Abstract: To reveal the differences in the community structure of soil mites under different crop environments in the buffer zone of the Shibing Karst World Natural Heritage Site, soil mites from corn fields (CF), pear tree lands (PL), tobacco fields (TF), grape ... ...

Abstract	To reveal the differences in the community structure of soil mites under different crop environments in the buffer zone of the Shibing Karst World Natural Heritage Site, soil mites from corn fields (CF), pear tree lands (PL), tobacco fields (TF), grape fields (GF), and plum gardens (PG) were collected in the buffer zone in January 2022. Through the identification of mite specimens and data analysis, differences in the number of families, genera, individuals, individual density, diversity, similarity of communities, ecological groups of oribatid mites, and responses to environmental factors of soil mites under different crop environments were determined. The results showed that: (1) A total of 6941 soil mites were captured in the study area, belonging to 130 genera, 75 families, and 3 orders. The number of soil mite genera (CF and TF > PL > PG > GF) and number of soil mite individuals (PG > PL > GF > TF > CF) showed characteristics of differential distribution and surface soil aggregation in the five habitats. (2) Scheloribates , Protorobotritia , and Tectocepheus were the dominant genera in the study area. Lohmannia , Scheloribates , and Tectocepheus , representative species that indicate a good soil environment, were distributed in the sample plots of CF, PL, and PG to varying degrees, indicating that the ecological environment of these three crops was healthy. (3) The diversity index of PG was the highest, and similarity analysis of the five habitats revealed that they were at a medium level of similarity. (4) The ecological groups of oribatid mites in the different crop environments were dominated by the overall (O) type, which is a combination of Macropylina, Gymnonota, and Poronota. (5) The community structure of soil mites was sensitive to bulk density (BD), natural water content (NWC), total nitrogen (TN), total phosphorus (TP), total potassium (TK), available potassium (AK), and soil organic matter (SOM). Based on the above results, there were differences in the community structures ...
Keywords	soil mites ; community structure ; different crops ; environmental factors ; world heritage buffer zone ; Shibing Karst ; Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
Subject code	630
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Probiotics Bring New Hope for Atherosclerosis Prevention and Treatment.

Zhai, Taiyu / Wang, Pingping / Hu, Xiumei / Zheng, Lei

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 3900835

Abstract: Cardiovascular disease is the leading cause of human mortality and morbidity worldwide. Atherosclerosis (AS) is the underlying pathological responsible in most acute and severe cardiovascular diseases including myocardial infarction and stroke. However, ... ...

Abstract	Cardiovascular disease is the leading cause of human mortality and morbidity worldwide. Atherosclerosis (AS) is the underlying pathological responsible in most acute and severe cardiovascular diseases including myocardial infarction and stroke. However, current drugs applied to the treatment of AS are not clinically effective, and there is a large residual risk of cardiovascular disease and multiple side effects. Increasing evidence supports a close relationship between microorganisms and the incidence of AS. Recent data have shown that probiotics can improve multiple key factors involved in the development and progression of AS, including cholesterol metabolism imbalance, endothelial dysfunction, proinflammatory factor production, macrophage polarization, intestinal flora disturbance, and infection with pathogenic microorganisms, and therefore probiotics have attracted great interest as a novel potential "medicine". This review is aimed at summarizing the effects of probiotics on various influencing factors, and providing valuable insights in the search for early prevention and potential therapeutic strategies for AS.
MeSH term(s)	Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Cardiovascular Diseases ; Cholesterol ; Gastrointestinal Microbiome ; Humans ; Probiotics/therapeutic use
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-09-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/3900835
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Article: Silica exposure activates non-canonical inflammasome complex in intratracheal instilled rat model.

Niu, Yingmei / Yang, Shuangli / Hu, Xiumei

Toxicology research

2022 Volume 11, Issue 5, Page(s) 784–790

Abstract: Background: Inhalation of silica crystals in occupational settings is a main cause of silicosis, a chronic irreversible pulmonary disorder. Our prior studies demonstrated the activation of inflammasome sensors AIM2 and NLRP3, effector protein caspase-1, ...

Abstract	Background: Inhalation of silica crystals in occupational settings is a main cause of silicosis, a chronic irreversible pulmonary disorder. Our prior studies demonstrated the activation of inflammasome sensors AIM2 and NLRP3, effector protein caspase-1, and significant increase in IL-1β in silica exposed rats, suggesting that the canonical inflammasome activation may be associated with silica-induced tissue damage and inflammation. Aims and methods: In our current study using the same animal model system, we further evaluated the components of non-canonical inflammasome, including NEK7, caspase-11, and GSDMD following silica exposure. Results: We demonstrated sustained NEK7 elevation in the rat lung epithelial cells and macrophages following 1- and 3-day exposure. Enhanced NEK7 expression was also detected in lung homogenate by western blot. Similarly, caspase-11 expression was induced by silica exposure in lung sections and homogenate. Elevated GSDMD was observed both in lung sections by immunohistochemical staining and in lung tissue homogenate by western blot. Conclusion: In summary, our current study demonstrated increase in NEK7, caspase-11, and GSDMD in silica exposed rats, indicating activation of non-canonical inflammasome complex, thereby providing a broad inflammasome activation pathway caused by silica exposure.
Language	English
Publishing date	2022-08-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2684701-2
ISSN	2045-4538 ; 2045-452X
ISSN (online)	2045-4538
ISSN	2045-452X
DOI	10.1093/toxres/tfac061
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Article ; Online: Low-Cost Full-Range Detection of C-Reactive Protein in Clinical Samples by Aptamer Hairpin Probes and Coprecipitation of Silver Ions and Gold Nanoparticles.

Yan, Hong / Hu, Xiumei / Shao, Huaze / Li, Jincheng / Deng, Jieqi / Liu, Lihong

Analytical chemistry

2023 Volume 95, Issue 32, Page(s) 11918–11925

Abstract: C-reactive protein (CRP) levels can vary widely related to diverse disease contexts. However, expensive antibodies have impeded the clinical utility of antibody-based full-range CRP assays, especially in developing countries. Herein, we established a low- ...

Abstract	C-reactive protein (CRP) levels can vary widely related to diverse disease contexts. However, expensive antibodies have impeded the clinical utility of antibody-based full-range CRP assays, especially in developing countries. Herein, we established a low-cost, antibody-free, 96-well plate-based full-range CRP detection method by combining gold nanoparticles (AuNPs), silver iodide (AgI), Eosin Y, and the aptamer hairpin probe (AHP) with Ag
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01131
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Article ; Online: Rapid, Ultrasensitive, and Visual Detection of Pathogens Based on Cation Dye-Triggered Gold Nanoparticle Electrokinetic Agglutination Analysis.

Wei, Siqi / Tang, Qing / Hu, Xiumei / Ouyang, Wei / Shao, Huaze / Li, Jincheng / Yan, Hong / Chen, Yue / Liu, Lihong

ACS sensors

2024 Volume 9, Issue 1, Page(s) 325–336

Abstract: Rapid prescribing of the right antibiotic is the key to treat infectious diseases and decelerate the challenge of bacterial antibiotic resistance. Herein, by targeting the 16S rRNA of bacteria, we developed a cation dye-triggered electrokinetic gold ... ...

Abstract	Rapid prescribing of the right antibiotic is the key to treat infectious diseases and decelerate the challenge of bacterial antibiotic resistance. Herein, by targeting the 16S rRNA of bacteria, we developed a cation dye-triggered electrokinetic gold nanoparticle (AuNP) agglutination (CD-TEAA) method, which is rapid, visual, ultrasensitive, culture-independent, and low in cost. The limit of detection (LOD) is as low as 1 CFU mL
MeSH term(s)	Humans ; Gold ; RNA, Ribosomal, 16S/analysis ; Metal Nanoparticles ; Anti-Bacterial Agents ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/microbiology ; Escherichia coli/genetics
Chemical Substances	Gold (7440-57-5) ; RNA, Ribosomal, 16S ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c02014
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Article ; Online: Differences of oribatid mite community and trophic structure between karst caves and surface different moss habitats.

Gong, Tong / Yin, Xiumei / Liu, Wenjun / Chen, Hu / Shi, Zheng

PloS one

2023 Volume 18, Issue 8, Page(s) e0290144

Abstract: In order to reveal the community characteristics and trophic structure of oribatid mites in different moss habitats in karst caves, the oribatid mites in the moss habitats of ground (GD), understory (US), cave wall (CW), surface shrub (SB) and farmland ( ... ...

Abstract	In order to reveal the community characteristics and trophic structure of oribatid mites in different moss habitats in karst caves, the oribatid mites in the moss habitats of ground (GD), understory (US), cave wall (CW), surface shrub (SB) and farmland (FL) outside the cave were collected in October 2021. Through the identification and data analysis of oribatid mites, 2352 oribatid mites were found, belonging to 45 families and 72 genera, most of which were Gymnonota. The family number, genus number, individual number, individual density, dominant genus composition, community diversity, community similarity, MGP (Analysis methods for ecological groups of oribatid mites) ecological group of oribatid mites and trophic structure of oribatid mites in different moss were analyzed. The results showed that: (1) The number of families, genera, individuals, and individual density of SB and FL are higher than those of the other three habitats; (2) Platyliodes, Oppiella, Tectocepheus, Scutovertex, Scheloribates and Trichogalumna are the dominant genera of the oribatid mites in the cave moss habitat, among them, Tectocepheus and Trichogaluna have the most obvious advantages; (3) The diversity index of shrub (SB) was higher than that of other four habitats; Similarity between ground and cave wall, shrub and farmland is high; (4) The MGP ecological group of oribatid mites in different habitats is dominated by O type (Overall type belongs to MGP analysis results, 20%≤M,G,P≤50%), and a total of 42 genera of oribatid mites preliminarily constitute the trophic structure of oribatid mites in the cave moss habitat. Based on the above results, it can be concluded that there are differences in the community structure of oribatid mites in different moss habitats in the study area, and the use of dominant genera of mites can preliminarily indicate the environmental conditions of different moss habitats. This study enriches the study of mites in karst cave mosses, and can provide theoretical significance for the protection of cave biodiversity in karst areas.
MeSH term(s)	Humans ; Animals ; Mites ; Caves ; Biodiversity ; Bryophyta ; Data Analysis
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290144
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