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Article ; Online: Role and intervention of PAD4 in NETs in acute respiratory distress syndrome.

Liu, Xiaojie / Li, Tianjun / Chen, Huailong / Yuan, Li / Ao, Hushan

2024 Volume 25, Issue 1, Page(s) 63

Abstract: Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Acute respiratory distress syndrome (ARDS) is a common sepsis-associated injury that can increase postoperative mortality but the mechanism is ... ...

Abstract	Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Acute respiratory distress syndrome (ARDS) is a common sepsis-associated injury that can increase postoperative mortality but the mechanism is still unclear. Main text: The role of neutrophils in the pathophysiology of sepsis was deeply challenged after the discovery of NETosis, a process resulting in neutrophil extracellular traps (NETs) release. NETs can support thrombin generation and the concept of immunothrombosis has emerged as a new innate response to infection. Immunothrombosis leads to thrombosis in microvessels and supports immune cells together with specific thrombus-related molecules. ARDS is a common sepsis-associated organ injury. Immunothrombosis participates in thrombosis in pulmonary capillaries. Intervention regarding immunothrombosis in ARDS is a key scientific problem. PAD4 is the key enzyme regulating the NET skeleton protein histone H3 to citrulline histone to form NETs in immune thrombosis. This review summarizes NETosis and immunohaemostasis, ARDS and therapeutic opportunities targeting PAD4 via PAD4 inhibitors and lncRNAs potentially, providing future therapies. Conclusions: We identified and summarized the fundamental definition of ARDS and the concept of immune thrombosis and its composition. NETs activation has become particularly relevant in the formation of immune thrombosis. The taskforce highlighted the intervention targets of PAD4, including noncoding RNAs, potentially providing future therapeutic targets to confront the high postoperative mortality of ARDS.
MeSH term(s)	Humans ; Extracellular Traps/metabolism ; Thromboinflammation ; Protein-Arginine Deiminase Type 4/metabolism ; Neutrophils/metabolism ; Histones/metabolism ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/metabolism ; Thrombosis ; Sepsis/metabolism
Chemical Substances	Protein-Arginine Deiminase Type 4 (EC 3.5.3.15) ; Histones
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-024-02676-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Dynamic Accumulation Rules of Chemical Components during the Medicine Formation Period of

Ma, Fang / Jiang, Yuan / Li, Baoshan / Zeng, Yuxin / Shang, Hushan / Wang, Fusheng / Sun, Zhirong

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 21

Abstract: The dried roots of the perennial ... ...

Abstract	The dried roots of the perennial herb
MeSH term(s)	Angelica sinensis/chemistry ; Spectroscopy, Fourier Transform Infrared/methods ; Chemometrics ; Plants, Medicinal ; Plant Extracts ; Least-Squares Analysis
Chemical Substances	ferulic acid (AVM951ZWST) ; Plant Extracts
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28217292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Dynamic Accumulation Rules of Chemical Components during the Medicine Formation Period of Angelica sinensis and Chemometric Classifying Analysis for Different Bolting Times Using ATR-FTIR

Fang Ma / Yuan Jiang / Baoshan Li / Yuxin Zeng / Hushan Shang / Fusheng Wang / Zhirong Sun

Molecules, Vol 28, Iss 21, p

2023 Volume 7292

Abstract: The dried roots of the perennial herb Angelica sinensis (Oliv.) Diels (AS) are commonly used as medicinal and edible resources. In commercial planting, early bolting and flowering (EB) of ca. 60% in the medicine formation period reduces root yield and ... ...

Abstract	The dried roots of the perennial herb Angelica sinensis (Oliv.) Diels (AS) are commonly used as medicinal and edible resources. In commercial planting, early bolting and flowering (EB) of ca. 60% in the medicine formation period reduces root yield and quality, becoming a significant bottleneck in agricultural production. In the cultivation process, summer bolting (SB) occurs from June to July, and autumn bolting (AB) occurs in September. The AB root is often mistaken for the AS root due to its similar morphological characteristics. Few studies have involved whether the root of AB could be used as herbal medicine. This study explored and compared the accumulation dynamics of primary and secondary metabolites in AS and EB roots during the vegetative growth stage (from May to September) by light microscopy, ultraviolet spectrometry, and HPLC methods. Under a microscope, the amount of free starch granules and oil chamber in the AS root increased. On the contrary, they decreased further from EB-Jul to EB-Sep. By comparison, the wall of the xylem vessel was slightly thickened and stacked, and the cell walls of parenchyma and root cortex tissue were thickened in the EB root. Early underground bolting reduces soluble sugar, soluble protein, free amino acids, total C element, total N element, ferulic acid, and ligustilide accumulation, accompanied by the lignification of the root during the vegetative growth stage. Furthermore, a total of 55 root samples from different bolting types of AS root (29 samples), SB root (14 samples), and AB root (12 samples) were collected from Gansu Province during the harvesting period (October). The later the bolting occurred, the less difference there was between unbolted and bolted roots in terms of morphological appearance and efficacy components. Fourier transform infrared spectroscopy with the attenuated total reflection mode (ATR-FTIR) provides a “holistic” spectroscopic fingerprinting of all compositions in the tested sample. The ATR-FTIR spectrum of the AB root was similar to that ...
Keywords	Angelica sinensis ; medicine formation period ; dynamic accumulation rules ; ATR-FTIR ; chemometric classifying analysis ; quality evaluation ; Organic chemistry ; QD241-441
Subject code	580
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Direct sampling of ultrashort laser pulses using third-harmonic generation with perturbation in ambient air.

Huang, Pei / Yuan, Hao / Cao, Huabao / Wang, Hushan / Wang, Xianglin / Wang, Yishan / Zhao, Wei / Fu, Yuxi

Optics letters

2023 Volume 48, Issue 8, Page(s) 2154–2157

Abstract: We propose a simple and robust all-optical pulse sampling method to characterize the temporal profiles of ultrashort laser pulses. The method is based on a third-harmonic generation (THG) process with perturbation in ambient air, which requires no ... ...

Abstract	We propose a simple and robust all-optical pulse sampling method to characterize the temporal profiles of ultrashort laser pulses. The method is based on a third-harmonic generation (THG) process with perturbation in ambient air, which requires no retrieval algorithm and can be potentially applied to electric field measurement. The method has been successfully used to characterize multi-cycle and few-cycle pulses with a spectral range from 800 nm to 2200 nm. Considering the broad phase-matching bandwidth of THG and extremely low dispersion of air, this method is suitable for ultrashort pulse characterization even for single-cycle pulses in the near- to mid-infrared range. Thus, the method provides a reliable and highly accessible approach for pulse measurement in ultrafast optics research.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.485665
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Article ; Online: All-optical sampling of ultrashort laser pulses based on perturbed transient grating.

Huang, Pei / Yuan, Hao / Cao, Huabao / Wang, Hushan / Wang, Xianglin / Wang, Yishan / Zhao, Wei / Fu, Yuxi

Optics letters

2022 Volume 47, Issue 20, Page(s) 5369–5372

Abstract: We propose and demonstrate an all-optical pulse sampling technique based on the transient grating (TG) procedure with perturbation, which provides a simple and robust manner to characterize an ultrashort laser pulse without employing a retrieval ... ...

Abstract	We propose and demonstrate an all-optical pulse sampling technique based on the transient grating (TG) procedure with perturbation, which provides a simple and robust manner to characterize an ultrashort laser pulse without employing a retrieval algorithm. In our approach, a two-orders weaker perturbation pulse perturbs the diffracted pulse from the TG, which is generated by another strong fundamental pulse. The modulation of the diffracted pulse energy directly represents the temporal profile of the perturbation pulse. We have successfully characterized few-cycle and multi-cycle pulses, which is consistent with the results verified by the widely employed frequency-resolved optical gating (FROG) method. Our method provides a potential way to characterize ultrashort laser waveform from the deep-UV to far-infrared region.
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.473294
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Article ; Online: Effects of endogenous potential probiotic Lactobacillus rhamnosus M2-4 on intestinal microflora and metabonomics in juvenile sea cucumber Apostichopus japonicus

Li, Ye / Zhao, Yancui / Liu, Xin / Yuan, Lei / Liu, Xiaoli / Wang, Lei / Sun, Hushan

Aquaculture. 2022 June, v. 555 p.738247-

2022

Abstract: As a lactic acid bacteria, Lactobacillus is an important probiotic used in aquaculture. Intestines play an important role in beneficial function of probiotic. But little is known about the mechanism of lactic acid bacteria effecting on the intestines of ... ...

Abstract	As a lactic acid bacteria, Lactobacillus is an important probiotic used in aquaculture. Intestines play an important role in beneficial function of probiotic. But little is known about the mechanism of lactic acid bacteria effecting on the intestines of sea cucumber Apostichopus japonicus. Herein, the present study was designed to explore the effects of endogenous Lactobacillus rhamnosus M2–4 on the intestinal microflora and metabolism of juvenile A. japonicus with high-throughput sequencing and metabonomics technology. The basal diet was Sargassum thunbergii powder, which was added with M2–4 at 0, 10⁵, 10⁷ and 10⁹ CFU / g to form the experimental diet respectively. The feeding experiment lasted for 30 days. The results showed that dietary M2–4 had a significant effect on intestinal microbial composition of sea cucumber. With the increase of dietary M2–4, the relative abundance of potential probiotics including Haloferula (Verrucomicrobia), Rhodobacteraceae and Lactobacillus were increased and the potential pathogens especially Vibrio were decreased. And dietary M2–4 at 10⁹ CFU / g was beneficial to its self-colonization in the intestines of A. japonicus. Metabonomics analysis showed that the differential lipid metabolites were increased and lipid metabolism pathways were enriched with the increase of dietary M2–4. The highest enriched pathway in the intestines of A. japonicus were mTOR and PPAR signaling pathway and the mostly influenced pathways were glutathione and linoleic acid metabolism pathway. The correlation analysis of intestinal microflora and main differential metabolites indicated that the differential metabolites were mostly correlated to the strains of Flavobacteriaceae. These results shed some light on the mechanism of lactic acid bacteria Lactobacillus influencing the intestine of juvenile sea cucumber A. japonicus.
Keywords	Apostichopus japonicus ; Flavobacteriaceae ; Lactobacillus rhamnosus ; Rhodobacteraceae ; Sargassum thunbergii ; Verrucomicrobia ; Vibrio ; aquaculture ; experimental diets ; glutathione ; intestinal microorganisms ; intestines ; juveniles ; lactic acid ; linoleic acid ; lipid metabolism ; metabolites ; metabolomics ; peroxisome proliferator-activated receptors ; probiotics ; Intestinal microflora ; Metabonomics ; Probiotic ; Lactic acid bacteria
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2022.738247
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer

Xiao-Ting Liu / Zhi-Yong Kou / Hushan Zhang / Jian Dong / Jian-Hua Zhang / You-Jun Peng / Shu Min Ma / Lei Liang / Xuan-Yu Meng / Yuan Zhou / Jun Yang

PeerJ, Vol 11, p e

2023 Volume 15261

Abstract: The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 ... ...

Abstract	The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein are unknown in HER2-amplified colorectal cancer (HACC). In order to explore these characteristics along with their correlation with clinicopathological factors and prognosis in HACC. Samples of 812 CRC patients was collected. After immunohistochemistry (IHC), 59 of 812 were found to be HER2-positive, then 26 of 59 samples were further determined to be HER2 amplification by fluorescence in situ hybridization (FISH). Somatic mutation profiling of HACC was analysed using whole exome sequencing (WES). Multiplex fluorescence immunohistochemistry (mIHC) was used for tumor-infiltrating leukocytes and tertiary lymphoid structures (TLSs), while PD-L1 protein was detected by IHC. Our results indicate that the detection rates of HER2 positivity by IHC and FISH were 7.3% and 3.2% respectively, and HER2 amplification is correlated with distant tumour metastasis. The somatic mutation profiling revealed no differences between HACC and HER2-negative CRC. However, TP 53 strongly correlated with poor prognosis in HACC. Furthermore, tumor-infiltrating T cells and TLSs in the tumor immune microenvironment, as well as PD-L1 expression, were higher in HACC than in HER2-negative controls. However, none of them were associated with the prognosis of HACC. In all, HER2 amplification is correlated with distant metastasis and TP53 gene mutation may be a potential protective mechanism of HACC.
Keywords	Colorectal cancer ; HER2 ; Tumour immune microenvironment ; PD-L1 expression ; Somatic mutation profiling ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer.

Liu, Xiao-Ting / Kou, Zhi-Yong / Zhang, Hushan / Dong, Jian / Zhang, Jian-Hua / Peng, You-Jun / Ma, Shu Min / Liang, Lei / Meng, Xuan-Yu / Zhou, Yuan / Yang, Jun

PeerJ

2023 Volume 11, Page(s) e15261

Abstract	The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein are unknown in HER2-amplified colorectal cancer (HACC). In order to explore these characteristics along with their correlation with clinicopathological factors and prognosis in HACC. Samples of 812 CRC patients was collected. After immunohistochemistry (IHC), 59 of 812 were found to be HER2-positive, then 26 of 59 samples were further determined to be HER2 amplification by fluorescence in situ hybridization (FISH). Somatic mutation profiling of HACC was analysed using whole exome sequencing (WES). Multiplex fluorescence immunohistochemistry (mIHC) was used for tumor-infiltrating leukocytes and tertiary lymphoid structures (TLSs), while PD-L1 protein was detected by IHC. Our results indicate that the detection rates of HER2 positivity by IHC and FISH were 7.3% and 3.2% respectively, and HER2 amplification is correlated with distant tumour metastasis. The somatic mutation profiling revealed no differences between HACC and HER2-negative CRC. However, TP 53 strongly correlated with poor prognosis in HACC. Furthermore, tumor-infiltrating T cells and TLSs in the tumor immune microenvironment, as well as PD-L1 expression, were higher in HACC than in HER2-negative controls. However, none of them were associated with the prognosis of HACC. In all, HER2 amplification is correlated with distant metastasis and TP53 gene mutation may be a potential protective mechanism of HACC.
MeSH term(s)	Humans ; B7-H1 Antigen/genetics ; In Situ Hybridization, Fluorescence ; Tertiary Lymphoid Structures/genetics ; Colorectal Neoplasms/genetics ; Mutation ; Tumor Microenvironment
Chemical Substances	ERBB2 protein, human (EC 2.7.10.1) ; B7-H1 Antigen
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15261
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dispersed pulses created by aperiodic binary spectral phase jump and applications for pulse shaping.

Liu, Xin / Wang, Hushan / Cao, Huabao / Yuan, Hao / Huang, Pei / Wang, Yishan / Zhao, Wei / Fu, Yuxi

Optics express

2021 Volume 29, Issue 8, Page(s) 12319–12329

Abstract: Inspired by pulse-pair generation with periodic phase jump, the generation of dispersed pulses with aperiodic binary spectral phase jump (ABSPJ) is proposed and theoretically investigated. It is presented by the numerical simulations that two dispersed ... ...

Abstract	Inspired by pulse-pair generation with periodic phase jump, the generation of dispersed pulses with aperiodic binary spectral phase jump (ABSPJ) is proposed and theoretically investigated. It is presented by the numerical simulations that two dispersed pulses can be generated by ABSPJ of π. The dispersion of one pulse is opposite to the other and can be tuned freely with engineering of the phase jump. The generated dispersed pulse-pair is potentially of great interest for various applications, such as two-dimensional spectroscopy, double pulses laser-wakefield acceleration (LWFA) and chirp management in dual-chirped optical parametric amplification (DC-OPA) system to generate TW single-cycle mid-infrared (MIR) pulses. Furthermore, a pulse shaper configured as a micro-electro-mechanical systems (MEMS) located at the Fourier plane of a 4-f dispersion-free compressor is suggested and the implementation in a high repetition optical parametric chirped pulse amplification (OPCPA) system with picosecond pump has been numerically studied. The simulations showed that MEMS of 900 pixels is enough to pre-compensate TOD of 200000 fs
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.419450
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Positron annihilation localization by nanoscale magnetization.

Gholami, Yaser H / Yuan, Hushan / Wilks, Moses Q / Josephson, Lee / El Fakhri, Georges / Normandin, Marc D / Kuncic, Zdenka

Scientific reports

2020 Volume 10, Issue 1, Page(s) 20262

Abstract: In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on the spatial resolution of PET images. After annihilation, the photon pair detected by the PET ... ...

Abstract	In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on the spatial resolution of PET images. After annihilation, the photon pair detected by the PET instrumentation is emitted from a location that is different from the positron-emitting source, resulting in image blurring. Here, we report on the localization of positron range, and hence annihilation quanta, by strong nanoscale magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) in PET-MRI. We found that positron annihilations localize within a region of interest by up to 60% more when SPIONs are present (with [Fe] = 3 mM) compared to when they are not. The resulting full width at half maximum of the PET scans showed the spatial resolution improved by up to [Formula: see text] 30%. We also found evidence suggesting that the radiolabeled SPIONs produced up to a six-fold increase in ortho-positronium. These results may also have implications for emerging cancer theranostic strategies, where charged particles are used as therapeutic as well as diagnostic agents and improved dose localization within a tumor is a determinant of better treatment outcomes.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Magnetite Nanoparticles/chemistry ; Positron-Emission Tomography/methods
Chemical Substances	Magnetite Nanoparticles
Language	English
Publishing date	2020-11-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-76980-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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