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  1. Article: [Correlation of serum and seminal plasma HCY levels with semen parameters in men and its effect on recurrent spontaneous abortion].

    Zhan, Xu-Xin / Zhan, Ming-Wei / Lou, Qiang / Lou, Qiang / Xue, Jian-Guo / Shang, Xue-Jun

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 4, Page(s) 311–316

    Abstract: Objective: To investigate the correlation of serum and seminal plasma homocysteine (Hcy) levels with semen parameters in men and its effect on recurrent spontaneous abortion (RSA) in their spouses.: Methods: The study included 103 males subjects ... ...

    Abstract Objective: To investigate the correlation of serum and seminal plasma homocysteine (Hcy) levels with semen parameters in men and its effect on recurrent spontaneous abortion (RSA) in their spouses.
    Methods: The study included 103 males subjects undergoing preconception examination in the reproduction center from March 2022 to June 2023. According to whether their spouses had a history of RSA or not, we divided their subjects into an RSA (n = 43) and a non-RSA group (NRSA, n = 60), obtained their serum and seminal plasma Hcy levels and semen parameters, and analyzed their correlation.
    Results: The serum Hcy level was significantly correlated with the sperm DNA fragmentation index (DFI) (r = 0.316, P = 0.005), but not with the seminal plasma Hcy level (r = －0.041, P = 0.723) and other semen parameters of the subjects (P > 0.05). There was no significant correlation between seminal plasma Hcy and semen parameters (P > 0.05). The median serum Hcy was significantly higher in the RSA than in the NRSA group (18.39 ［13.02, 42.84］ vs 14.65 ［12.00, 18.20］ μmol/L), with statistically significant difference in the overall distribution of serum Hcy between the two groups (Ｚ=－2.20, P = 0.028), so was the median sperm DFI in the former than in the latter group (25.00% ［12.50%, 37.25%］ vs 13.00% ［11.00%, 18.50%］), with statistically significant difference in the overall sperm DFI distribution between the two groups (Ｚ=－2.74, P = 0.006).
    Conclusion: The serum Hcy level was positively correlated with sperm DFI, and both serum Hcy and sperm DFI were significantly elevated in men with spousal RSA, which is expected to be used as a clinical screening indicator for males with spousal RSA.
    MeSH term(s) Female ; Pregnancy ; Male ; Humans ; Semen ; Abortion, Habitual ; Body Fluids ; Spermatozoa
    Language Chinese
    Publishing date 2024-04-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Elevated Circulating Procathepsin L as a Potential Biomarker of Inflamm-aging.

    Zhu, Cassie Shu / Chen, Weiqiang / Qiang, Xiaoling / Lou, Li / Li, Jianhua / Wang, Haichao

    Medical hypotheses

    2024  Volume 186

    Abstract: Inflamm-aging is a condition of low-grade and chronic systemic inflammation characterized by a systemic increase in multiple inflammatory biomarkers such as tumor necrosis factor (TNF), interleukin 6 (IL-6), C-reactive protein (CRP), and CXCL9 (MIG) in ... ...

    Abstract Inflamm-aging is a condition of low-grade and chronic systemic inflammation characterized by a systemic increase in multiple inflammatory biomarkers such as tumor necrosis factor (TNF), interleukin 6 (IL-6), C-reactive protein (CRP), and CXCL9 (MIG) in experimental and clinical settings. However, despite the recent identification of extracellular procathepsin L (pCTS-L) as a novel mediator of inflammatory diseases such as sepsis, its possible role in inflamm-aging was previously not investigated. In the present study, we compared blood levels of pCTS-L and other 62 cytokines and chemokines between young and aged Balb/C mice by Western blotting and Cytokine Antibody Arrays. In light of the surprising finding of a marked increase in blood pCTS-L levels in aged mice, we propose that blood pCTS-L levels may serve as another biomarker of inflamm-aging. Given the capacity of pCTS-L in inducing various cytokines (e.g., TNF and IL-6), it will be important to test the hypothetic role of pCTS-L in inflamm-aging under experimental and clinical conditions.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2024.111322
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  3. Article: Relationship between baseline bicarbonate and 30-day mortality in patients with non-traumatic subarachnoid hemorrhage.

    Du, Wenyuan / Yang, Jingmian / Lou, Yanfang / You, Jiahua / Wang, Qiang

    Frontiers in neurology

    2024  Volume 14, Page(s) 1310327

    Abstract: Objective: This study aimed to explore the relationship between baseline bicarbonate levels and 30-day mortality in individuals with non-traumatic subarachnoid hemorrhage (SAH).: Methods: Patients with non-traumatic SAH were chosen from the Medical ... ...

    Abstract Objective: This study aimed to explore the relationship between baseline bicarbonate levels and 30-day mortality in individuals with non-traumatic subarachnoid hemorrhage (SAH).
    Methods: Patients with non-traumatic SAH were chosen from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The relationship between baseline bicarbonate and 30-day mortality was examined using Cox regression models. Restricted cubic splines were used to test the hypothesis that there was an association between bicarbonate and mortality. With the use of Kaplan-Meier survival curve analysis, we looked deeper into the validity of these correlations. To find subgroups with differences, interaction tests were utilized.
    Results: This retrospective cohort study consisted of 521 participants in total. Bicarbonate had a negative association with death at 30 days (HR = 0.93, 95%CI: 0.88-0.98,
    Conclusion: Finally, 30-day mortality was negatively associated with baseline bicarbonate levels. Patients with non-traumatic SAH are more at risk of mortality if their bicarbonate levels are low.
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1310327
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  4. Article ; Online: G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling.

    Chen, Qiang / Lou, Yifeng

    Journal of bioenergetics and biomembranes

    2022  Volume 55, Issue 1, Page(s) 33–42

    Abstract: Objective: Data in the GEO database (GSE63067) showed that G protein-coupled receptor 39 (GPR39) was down-regulated in tissues from patients with non-alcoholic fatty liver disease (NAFLD). It was intended to explore the mechanism of GPR39 in NAFLD.: ... ...

    Abstract Objective: Data in the GEO database (GSE63067) showed that G protein-coupled receptor 39 (GPR39) was down-regulated in tissues from patients with non-alcoholic fatty liver disease (NAFLD). It was intended to explore the mechanism of GPR39 in NAFLD.
    Methods: HepG2 cells were treated with a mixture of oleic acid and palmitic acid (OA/PA) to mimic NAFLD cell models. The level of GPR39 and the functions of GPR39 on cellular oxidative stress, lipid accumulation, the SIRT1/Nrf2 signaling and mitochondrial dysfunction were assessed. To verify the mediation of the SIRT1 signaling pathway in GPR39 regulation, cells were subjected to SIRT1 inhibitor EX-527 treatment. Afterwards, the abovementioned aspects of cells were all determined.
    Results: GPR39 presented a downward trend in response to OA/PA. GPR39 overexpression could suppress oxidative stress, lipid accumulation and activate the SIRT1/Nrf2 signaling. GPR39 overexpression likewise alleviated mitochondrial dysfunction, whereas EX-527 treatment disturbed the effects of GPR39 overexpression on these aspects.
    Conclusion: The present study found that GPR39 reduced oxidative stress and maintained mitochondrial homeostasis in a cellular model of NAFLD, a process mediated by SIRT1/Nrf2 signaling.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; NF-E2-Related Factor 2/metabolism ; Sirtuin 1/metabolism ; Hepatocytes ; Signal Transduction ; Receptors, G-Protein-Coupled/metabolism ; Hep G2 Cells ; Mitochondria/metabolism ; Lipids ; Oxidative Stress
    Chemical Substances NF-E2-Related Factor 2 ; Sirtuin 1 (EC 3.5.1.-) ; Receptors, G-Protein-Coupled ; Lipids ; SIRT1 protein, human (EC 3.5.1.-) ; GPR39 protein, human
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-022-09953-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1005: Show issues Location:
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  5. Article ; Online: Changes and correlation analysis of intestinal microflora composition, inflammatory index, and skeletal muscle mass in elderly patients with sarcopenia.

    Lou, Junhao / Wang, Qiang / Wan, Xiongfei / Cheng, Jingping

    Geriatrics & gerontology international

    2023  Volume 24, Issue 1, Page(s) 140–146

    Abstract: Aim: This study aimed to explore the alterations in characteristics of intestinal flora, inflammatory factors and skeletal muscle mass in elderly patients affected by sarcopenia, as well as the correlation among the three, in order to provide a ... ...

    Abstract Aim: This study aimed to explore the alterations in characteristics of intestinal flora, inflammatory factors and skeletal muscle mass in elderly patients affected by sarcopenia, as well as the correlation among the three, in order to provide a reference for the early identification, intervention, and treatment of sarcopenia in elderly patients.
    Method: A total of 206 elderly patients (≥60 years old) admitted to the Geriatric Outpatient Department of China Resources Wugang General Hospital were included in this study as the research participants. The differences in the general data, laboratory examination and intestinal flora in patients between the two groups were statistically analyzed, and the correlation between intestinal flora composition and skeletal muscle mass index, grip and inflammatory factors was also determined.
    Results: The normal group and sarcopenia group exhibited a significant difference in the composition of the intestinal flora (P < 0.05). The abundance of Escherichia-Shigella between the two groups was negatively correlated with the patient's relative skeletal muscle mass index and positively correlated with the interleukin-6 (IL-6) level; moreover, Lacchnospira abundance was positively correlated with relative skeletal muscle mass index; Lactobacillus and Roseburia abundance were negatively correlated with IL-6; and Lactobacillus, Lachnospira, and Eubacterium_rectale_group were positively correlated with grip, and the differences were statistically significant (P < 0.05).
    Conclusion: Overall, it was found that elderly patients with sarcopenia have intestinal flora disorders, and the abundance of such flora was negatively correlated with the relative skeletal muscle mass index, which was positively correlated with the IL-6 level. Geriatr Gerontol Int 2024; 24: 140-146.
    MeSH term(s) Humans ; Aged ; Sarcopenia/diagnosis ; Gastrointestinal Microbiome ; Muscle, Skeletal/physiology ; Interleukin-6 ; Hand Strength
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2023-11-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14661
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5801: Show issues Location:
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  6. Article: ED

    Lou, Siwen / Du, Qiang / Yu, Liwei / Wang, Qingfu / Yu, Jing / Mei, Zhong

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1169415

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1169415
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  7. Article ; Online: Enhanced Redox Electrocatalysis in High-Entropy Perovskite Fluorides by Tailoring d-p Hybridization.

    Li, Xudong / Qiang, Zhuomin / Han, Guokang / Guan, Shuyun / Zhao, Yang / Lou, Shuaifeng / Zhu, Yongming

    Nano-micro letters

    2023  Volume 16, Issue 1, Page(s) 55

    Abstract: High-entropy catalysts featuring exceptional properties are, in no doubt, playing an increasingly significant role in aprotic lithium-oxygen batteries. Despite extensive effort devoted to tracing the origin of their unparalleled performance, the ... ...

    Abstract High-entropy catalysts featuring exceptional properties are, in no doubt, playing an increasingly significant role in aprotic lithium-oxygen batteries. Despite extensive effort devoted to tracing the origin of their unparalleled performance, the relationships between multiple active sites and reaction intermediates are still obscure. Here, enlightened by theoretical screening, we tailor a high-entropy perovskite fluoride (KCoMnNiMgZnF
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2642093-4
    ISSN 2150-5551 ; 2150-5551
    ISSN (online) 2150-5551
    ISSN 2150-5551
    DOI 10.1007/s40820-023-01275-3
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  8. Article: Color Tunable Composite Phosphor Ceramics Based on SrAlSiN

    Ye, Shenrui / Li, Yukun / Qiang, Ming / Lou, Wenhui / Dai, Bo / Lin, Hui / Han, Zhaoxia / Hong, Ruijin / Zhang, Dawei

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 17

    Abstract: ... ...

    Abstract Lu
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16176007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Charybdis

    Han, Zhi-Qiang / Gao, Tian-Xiang / Lou, Fang-Rui / Liu, Qi

    Zoological research

    2022  Volume 43, Issue 6, Page(s) 927–930

    MeSH term(s) Animals ; Brachyura/genetics ; Desiccation
    Language English
    Publishing date 2022-09-22
    Publishing country China
    Document type Letter
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2022.155
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  10. Article ; Online: Therapeutic potential of procathepsin L-inhibiting and progesterone-entrapping dimethyl-β-cyclodextrin nanoparticles in treating experimental sepsis.

    Qiang, Xiaoling / Chen, Weiqiang / Zhu, Cassie Shu / Li, Jianhua / Qi, Timothy / Lou, Li / Wang, Ping / Tracey, Kevin J / Wang, Haichao

    Frontiers in immunology

    2024  Volume 15, Page(s) 1368448

    Abstract: The pathogenic mechanisms of bacterial infections and resultant sepsis are partly attributed to dysregulated inflammatory responses sustained by some late-acting mediators including the procathepsin-L (pCTS-L). It was entirely unknown whether any ... ...

    Abstract The pathogenic mechanisms of bacterial infections and resultant sepsis are partly attributed to dysregulated inflammatory responses sustained by some late-acting mediators including the procathepsin-L (pCTS-L). It was entirely unknown whether any compounds of the U.S. Drug Collection could suppress pCTS-L-induced inflammation, and pharmacologically be exploited into possible therapies. Here, we demonstrated that a macrophage cell-based screening of a U.S. Drug Collection of 1360 compounds resulted in the identification of progesterone (PRO) as an inhibitor of pCTS-L-mediated production of several chemokines [e.g., Epithelial Neutrophil-Activating Peptide (ENA-78), Monocyte Chemoattractant Protein-1 (MCP-1) or MCP-3] and cytokines [e.g., Interleukin-10 (IL-10) or Tumor Necrosis Factor (TNF)] in primary human peripheral blood mononuclear cells (PBMCs).
    MeSH term(s) Humans ; Male ; Female ; Mice ; Animals ; Progesterone ; Leukocytes, Mononuclear ; beta-Cyclodextrins ; Sepsis ; Enzyme Precursors ; Cathepsin L
    Chemical Substances heptakis(2,6-O-dimethyl)beta-cyclodextrin (51166-71-3) ; procathepsin L (EC 3.4.22.-) ; Progesterone (4G7DS2Q64Y) ; beta-Cyclodextrins ; Enzyme Precursors ; Cathepsin L (EC 3.4.22.15)
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1368448
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