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Article ; Online: Design and Synthesis of Menthol and Thymol Derived Ciprofloxacin: Influence of Structural Modifications on the Antibacterial Activity and Anticancer Properties.

Szostek, Tomasz / Szulczyk, Daniel / Szymańska-Majchrzak, Jolanta / Koliński, Michał / Kmiecik, Sebastian / Otto-Ślusarczyk, Dagmara / Zawodnik, Aleksandra / Rajkowska, Eliza / Chaniewicz, Kinga / Struga, Marta / Roszkowski, Piotr

International journal of molecular sciences

2022 Volume 23, Issue 12

Abstract: Sixteen new Ciprofloxacin derivatives were designed and successfully synthesized. In an in silico experiment, lipophilicity was established for obtained compounds. All compounds were screened for antimicrobial activity using standard and clinical strains. ...

Abstract	Sixteen new Ciprofloxacin derivatives were designed and successfully synthesized. In an in silico experiment, lipophilicity was established for obtained compounds. All compounds were screened for antimicrobial activity using standard and clinical strains. As for Gram-positive hospital microorganisms, all tested derivatives were active. Measured MICs were in the range 1-16 µg/mL, confirming high antimicrobial potency. Derivative
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antineoplastic Agents/chemistry ; Ciprofloxacin/chemistry ; Ciprofloxacin/pharmacology ; DNA Gyrase/metabolism ; Menthol/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship ; Thymol/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Antineoplastic Agents ; Menthol (1490-04-6) ; Thymol (3J50XA376E) ; Ciprofloxacin (5E8K9I0O4U) ; DNA Gyrase (EC 5.99.1.3)
Language	English
Publishing date	2022-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23126600
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Article: Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs).

Koliński, Tomasz / Marek-Trzonkowska, Natalia / Trzonkowski, Piotr / Siebert, Janusz

Central-European journal of immunology

2016 Volume 41, Issue 3, Page(s) 317–323

Abstract: Heat shock proteins (HSPs) belong to the family of conservative polypeptides with a high homology of the primary structure. The uniqueness of this family lies in their ability to interact with a large number of different proteins and provide protection ... ...

Abstract	Heat shock proteins (HSPs) belong to the family of conservative polypeptides with a high homology of the primary structure. The uniqueness of this family lies in their ability to interact with a large number of different proteins and provide protection from cellular and environmental stress factors as molecular chaperones to keep protein homeostasis. While intracellular HSPs play a mainly protective role, extracellular or membrane-bound HSPs mediate immunological functions and immunomodulatory activity. In immune system are subsets of cells including regulatory T cells (Tregs) with suppressive functions. HSPs are implicated in the function of innate and adaptive immune systems, stimulate T lymphocyte proliferation and immunomodulatory functions, increase the effectiveness of cross-presentation of antigens, and induce the secretion of cytokines. HSPs are also important in the induction, proliferation, suppressive function, and cytokine production of Tregs, which are a subset of CD4
Language	English
Publishing date	2016-10-25
Publishing country	Poland
Document type	Review ; Journal Article
ZDB-ID	1336421-2
ISSN	1644-4124 ; 1426-3912
ISSN (online)	1644-4124
ISSN	1426-3912
DOI	10.5114/ceji.2016.63133
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Article ; Online: Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction

Lukasz Lewicki / Janusz Siebert / Natalia Marek-Trzonkowska / Emilia Masiewicz / Tomasz Kolinski / Magdalena Reiwer-Gostomska / Radoslaw Targonski / Piotr Trzonkowski

Mediators of Inflammation, Vol

Preliminary Report

2015 Volume 2015

Keywords	Pathology ; RB1-214 ; Medicine ; R
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.

Lewicki, Łukasz / Siebert, Janusz / Koliński, Tomasz / Piekarska, Karolina / Reiwer-Gostomska, Magdalena / Targoński, Radosław / Trzonkowski, Piotr / Marek-Trzonkowska, Natalia

Cardiology journal

2018 Volume 26, Issue 6, Page(s) 680–686

Abstract: Background: Coronary artery disease (CAD) affects milions of people and can result in myocardial infarction (MI). Previously, mast cells (MC) have been extensively investigated in the context of hypersensitivity, however as regulators of the local ... ...

Abstract	Background: Coronary artery disease (CAD) affects milions of people and can result in myocardial infarction (MI). Previously, mast cells (MC) have been extensively investigated in the context of hypersensitivity, however as regulators of the local inflammatory response they can potentially contribute to CAD and/or its progression. The aim of the study was to assess if serum concentration of MC proteases: carboxypeptidase A3, cathepsin G and chymase 1 is associated with the extension of CAD and MI. Methods: The 44 patients with angiographically confirmed CAD (23 subjects with non-ST-segment elevation MI [NSTEMI] and 21 with stable CAD) were analyzed. Clinical data were obtained as well serum concentrations of carboxypeptidase A3, cathepsin G and chymase 1 were also measured. Results: Patients with single vessel CAD had higher serum concentration of carboxypeptidase than those with more advanced CAD (3838.6 ± 1083.1 pg/mL vs. 2715.6 ± 442.5 pg/mL; p = 0.02). There were no significant differences in levels of any protease between patients with stable CAD and those with NSTEMI. Patients with hypertension had ≈2-fold lower serum levels of cathepsin G than normotensive individuals (4.6 ± 0.9 pg/mL vs. 9.4 ± 5.8 pg/mL; p = 0.001). Cathepsin G levels were also decreased in sera of the current smokers as compared with non-smokers (3.1 ± 1.2 ng/mL vs. 5.8 ± 1.2 ng/mL, p = 0.02). Conclusions: Decreased serum level of carboxypeptidase is a hallmark of more advanced CAD. Lower serum levels of carboxypeptidase A3 and catepsin G are associated with risk factors of blood vessel damage suggesting a protective role of these enzymes in CAD.
MeSH term(s)	Aged ; Biomarkers/blood ; Carboxypeptidases A/blood ; Case-Control Studies ; Cathepsin G/blood ; Chymases/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/enzymology ; Down-Regulation ; Female ; Humans ; Male ; Mast Cells/enzymology ; Middle Aged ; Non-ST Elevated Myocardial Infarction/blood ; Non-ST Elevated Myocardial Infarction/diagnostic imaging ; Non-ST Elevated Myocardial Infarction/enzymology ; Prospective Studies
Chemical Substances	Biomarkers ; CPA3 protein, human (EC 3.4.17.1) ; Carboxypeptidases A (EC 3.4.17.1) ; CTSG protein, human (EC 3.4.21.20) ; Cathepsin G (EC 3.4.21.20) ; CMA1 protein, human (EC 3.4.21.39) ; Chymases (EC 3.4.21.39)
Language	English
Publishing date	2018-03-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2488680-4
ISSN	1897-5593 ; 1897-5593
ISSN (online)	1897-5593
ISSN	1897-5593
DOI	10.5603/CJ.a2018.0018
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Article ; Online: Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors.

Natalia Marek-Trzonkowska / Anna Kwieczyńska / Magdalena Reiwer-Gostomska / Tomasz Koliński / Andrzej Molisz / Janusz Siebert

PLoS ONE, Vol 10, Iss 5, p e

2015 Volume 0126190

Abstract: Hypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are characterized by ... ...

Abstract	Hypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are characterized by decreased density of arterioles and capillaries in the tissues, called rarefaction. Rarefaction significantly increases peripheral resistance which results in elevated blood pressure, leads to vessel damage and induction of inflammation. Therefore, we hypothesized that hypertension is associated with decreased serum concentration of physiological pro-angiogenic factors and concomitant increased production of angiogenesis inhibitors.82 patients diagnosed with hypertension and 34 healthy volunteers were recruited to the study. Flow cytometry and enzyme-linked immunosorbent assay (ELISA) techniques were used to measure serum levels of the following cytokines: endostatin, vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), angiogenin, and basic fibroblast growth factor (bFGF).Hypertensive patients were characterized by increased serum concentration of endostatin which is an anti-angiogenic factor. In addition, hypertension was associated with decreased levels of physiological pro-angiogenic mediators such as: angiogenin and bFGF. The hypertensive group was also characterized by elevated levels of CRP, VEGF and IL-8 that are the hallmarks of inflammation.Presented results show that hypertension is characterized by imbalance of pro-angiogenic and anti-angiogenic factors in the background of inflammation.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article: Alteration of surface properties of dipalmitoyl phosphatidylcholine by benzo[a]pyrene: a model of pulmonary effects of diesel exhaust inhalation.

Sosnowski, Tomasz R / Koliński, Michał / Gradoń, Leon

Journal of biomedical nanotechnology

2012 Volume 8, Issue 5, Page(s) 818–825

Abstract: Effects of benzo[a]pyrene (BaP) on the surface properties of dipalmitoyl phosphatidylcholine (DPPC) being the basic component of pulmonary surfactant and lipid membranes were studied experimentally and analyzed by molecular dynamics simulations. ... ...

Abstract	Effects of benzo[a]pyrene (BaP) on the surface properties of dipalmitoyl phosphatidylcholine (DPPC) being the basic component of pulmonary surfactant and lipid membranes were studied experimentally and analyzed by molecular dynamics simulations. Isotherms and surface compressibility of mixed BaP/DPPC monolayers on water were determined using Langmuir-Wilhelmy film balance. It was demonstrated that BaP induced concentration-dependent deviations from the initial surface activity of the phospholipid film and a noticeable decrease of its fluidity. Results obtained by molecular dynamics simulations allow to explain the observed effects indicating a migration of BaP molecules towards hydrophobic part of the interfacial layer of DPPC and the concentration-dependent restriction of flexibility of the hydrocarbon chains of phospholipid molecules. The results of the study may be related to the physicochemical disturbance of the pulmonary surfactant system after breathing with air contaminated by diesel exhaust components. It is speculated that such phenomena may have an input to undesired health effects.
MeSH term(s)	1,2-Dipalmitoylphosphatidylcholine/chemistry ; Air Pollutants/chemistry ; Benzopyrenes/chemistry ; Computer Simulation ; Models, Chemical ; Models, Molecular ; Pulmonary Surfactants/chemistry ; Surface Properties ; Vehicle Emissions/analysis
Chemical Substances	Air Pollutants ; Benzopyrenes ; Pulmonary Surfactants ; Vehicle Emissions ; 1,2-Dipalmitoylphosphatidylcholine (2644-64-6)
Language	English
Publishing date	2012-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2012.1436
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Article ; Online: Interactions of benzo[a]pyrene and diesel exhaust particulate matter with the lung surfactant system.

Sosnowski, Tomasz R / Koliński, Michal / Gradón, Leon

The Annals of occupational hygiene

2011 Volume 55, Issue 3, Page(s) 329–338

Abstract: One of the reasons for cellular changes in the lung tissue exposed to the diesel exhaust composed of soot particles with adsorbed volatile organic molecules is the reduction of the clearance rate in the pulmonary region of the respiratory system. The ... ...

Abstract	One of the reasons for cellular changes in the lung tissue exposed to the diesel exhaust composed of soot particles with adsorbed volatile organic molecules is the reduction of the clearance rate in the pulmonary region of the respiratory system. The interaction of the fractal-like particles and organic substances with a surfactant monolayer limits its dynamic activity. The surface properties of Survanta, a purified extract of bovine lung surfactant (LS), which interacted with carbon particles (200 nm aggregates) and benzo[a]pyrene (BaP), molecules were measured with the oscillating bubble technique. The results showed a significant lowering of the dynamics of the surfactant monolayer compared to the control case (no exposure). Additional measurements of surface pressure during the monotonic compression of the air-water interface containing the major LS phospholipid, dipalmitoylphosphatidylcholine (DPPC), showed that the presence of BaP molecules in the system influenced its stability. The experimental results were supplemented with a theoretical molecular dynamics model of the interaction between BaP and DPPC molecules. The simulation results indicated the insertion of BaP molecules into the lipid layer, which explained the measured effects.
MeSH term(s)	Animals ; Benzo(a)pyrene/toxicity ; Cattle ; Models, Biological ; Molecular Dynamics Simulation ; Particulate Matter/toxicity ; Phospholipids/physiology ; Pulmonary Surfactants/chemistry ; Surface Properties/drug effects ; Vehicle Emissions/toxicity
Chemical Substances	Particulate Matter ; Phospholipids ; Pulmonary Surfactants ; Vehicle Emissions ; Benzo(a)pyrene (3417WMA06D)
Language	English
Publishing date	2011-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390312-6
ISSN	1475-3162 ; 0003-4878
ISSN (online)	1475-3162
ISSN	0003-4878
DOI	10.1093/annhyg/mer007
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Article ; Online: Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors.

Marek-Trzonkowska, Natalia / Kwieczyńska, Anna / Reiwer-Gostomska, Magdalena / Koliński, Tomasz / Molisz, Andrzej / Siebert, Janusz

PloS one

2015 Volume 10, Issue 5, Page(s) e0126190

Abstract: Objective: Hypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are ... ...

Abstract	Objective: Hypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are characterized by decreased density of arterioles and capillaries in the tissues, called rarefaction. Rarefaction significantly increases peripheral resistance which results in elevated blood pressure, leads to vessel damage and induction of inflammation. Therefore, we hypothesized that hypertension is associated with decreased serum concentration of physiological pro-angiogenic factors and concomitant increased production of angiogenesis inhibitors. Materials and methods: 82 patients diagnosed with hypertension and 34 healthy volunteers were recruited to the study. Flow cytometry and enzyme-linked immunosorbent assay (ELISA) techniques were used to measure serum levels of the following cytokines: endostatin, vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), angiogenin, and basic fibroblast growth factor (bFGF). Results: Hypertensive patients were characterized by increased serum concentration of endostatin which is an anti-angiogenic factor. In addition, hypertension was associated with decreased levels of physiological pro-angiogenic mediators such as: angiogenin and bFGF. The hypertensive group was also characterized by elevated levels of CRP, VEGF and IL-8 that are the hallmarks of inflammation. Conclusions: Presented results show that hypertension is characterized by imbalance of pro-angiogenic and anti-angiogenic factors in the background of inflammation.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Angiogenesis Inducing Agents/blood ; Angiogenesis Inhibitors/blood ; Endostatins/blood ; Female ; Fibroblast Growth Factor 2/blood ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypertension/blood ; Hypertension/drug therapy ; Interleukin-8/blood ; Male ; Middle Aged ; Ribonuclease, Pancreatic/blood ; Vascular Endothelial Growth Factor A/blood ; Young Adult
Chemical Substances	Angiogenesis Inducing Agents ; Angiogenesis Inhibitors ; Endostatins ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Interleukin-8 ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3) ; angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0126190
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Article ; Online: Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report.

Lewicki, Lukasz / Siebert, Janusz / Marek-Trzonkowska, Natalia / Masiewicz, Emilia / Kolinski, Tomasz / Reiwer-Gostomska, Magdalena / Targonski, Radoslaw / Trzonkowski, Piotr

Mediators of inflammation

2015 Volume 2015, Page(s) 395173

Abstract: Unlabelled: An inflammatory response plays a crucial role in myocardial damage after an acute myocardial infarction.: Objectives: To measure serum concentrations of several mediators in patients with an acute myocardial infarction (STEMI) and to ... ...

Abstract	Unlabelled: An inflammatory response plays a crucial role in myocardial damage after an acute myocardial infarction. Objectives: To measure serum concentrations of several mediators in patients with an acute myocardial infarction (STEMI) and to assess their potential relationship with a risk of coronary instability. Patients and methods: The 33 patients with STEMI and 19 healthy volunteers were analyzed. The clinical data were obtained; as well serum concentrations of tryptase, endothelin (ET-1), angiogenin, soluble c-kit, and PDGF were measured. Results: Patients with STEMI had higher serum tryptase and ET-1 than healthy volunteers (2,5 ± 0,4 ng/mL versus 1,1 ± 0,4 ng/mL and 0,7 ± 0,1 ng/mL versus 0,3 ± 0,1 ng/mL, resp.). Subjects with significant lesion in left anterior descending artery (LAD) had lower serum ET-1 compared to those with normal LAD (0,6 ± 0,2 pg/mL versus 0,9 ± 0,4 pg/mL). Patients with three-vessel coronary artery disease (CAD) had higher level of soluble c-kit compared to those with one- or two-vessel CAD: 19,9 ± 24,1 ng/mL versus 5,6 ± 1,9 ng/mL. Conclusions: Elevated serum tryptase and ET-1 may be markers of increased coronary instability; some cytokines may be related to the extension of CAD.
MeSH term(s)	Aged ; Endothelins/blood ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Platelet-Derived Growth Factor/metabolism ; Prospective Studies ; Proto-Oncogene Proteins c-kit/blood ; Ribonuclease, Pancreatic/blood ; Tryptases/blood
Chemical Substances	Endothelins ; Platelet-Derived Growth Factor ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5) ; Tryptases (EC 3.4.21.59)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2015/395173
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Article ; Online: Taxonomic position and phylogeny of the genus Vargasiella (Orchidaceae, Vandoideae) based on molecular and morphological evidence.

Dariusz L Szlachetko / Marcin Górniak / Marta Kolanowska / Joanna Mytnik-Ejsmont / Agnieszka K Kowalkowska / Piotr Rutkowski / Tomasz Koliński

PLoS ONE, Vol 9, Iss 6, p e

2014 Volume 98472

Abstract: Since the description of the Neotropical genus Vargasiella in 1952, its taxonomic position has remained unclear, mainly due to a lack of sufficient data. In this study, the taxonomic position of Vargasiella was revised based on the outcomes of macro- and ...

Abstract	Since the description of the Neotropical genus Vargasiella in 1952, its taxonomic position has remained unclear, mainly due to a lack of sufficient data. In this study, the taxonomic position of Vargasiella was revised based on the outcomes of macro- and micromorphological studies, analyses of selected molecular markers and ecological methods of niche distribution modeling. The phylogenetic relationships were inferred using three DNA markers: matK, trnL-F and ITS sequences. The morphological studies included the analysis of macromorphological features of herbarium specimens as well as micromorphological examination of preserved flowers. The ecological niche modeling was applied to identify the distribution of the suitable niches of the studied taxa. The relationships between Vargasiella and most similar taxa remain unresolved based on the molecular analysis. The outcomes from the morphological studies indicated significant differences between Vargasiella, Warrea and Warreopsis. Moreover, a niche shift in response to changing climate after the last glacial maximum is observed in Vargasiella, while no substantial changes in the occupied habitats were identified in the other related taxa. The clocktree of the Zygopetaleae estimated from the matK gene indicated that the most recent common ancestors of Vargasiella, Warrea and Warreopsis originated in the Miocene, while the divergence time for Vargasiella and Warrea was assessed at approximately 5.4 Ma ago. Vargasiella seems to be an outshoot of the main branch of evolution of the Zygopetaleae. It is noteworthy that the Vargasiella-Warrea dichotomy could have taken place later than the divergence of Warreopsis from the mutual lineage. The molecular analysis and morphological data suggest that Vargasiella and Warrea could have evolved from a common ancestor. Accumulation of morphological differences and acceleration of the evolution of Vargasiella were more intensive than in other Warreinae and this could probably be synchronized with adaptation to different climatic ...
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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