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Book ; Online: Pediatric and Adolescent Nephrology Facing the Future: Diagnostic Advances and Prognostic Biomarkers in Everyday Practice

Taranta-Janusz, Katarzyna / Musiał, Kinga / Musiał, Kinga

2022

Keywords	Medicine ; Clinical & internal medicine ; chronic kidney disease ; cytokines ; solitary functioning kidney ; tumor necrosis factor-like weak inducer of apoptosis ; netrin-1 ; renal tubular damage ; premature newborns ; overactive bladder ; urinary microbiome ; children ; adolescents ; cystatin C ; galectin-3 ; periostin ; primary hypertension ; arterial damage ; blood pressure ; neurogenic bladder ; myelomeningocele ; markers ; furosemide stress test ; hyperfiltration ; [IGFBP-7] × [TIMP-2] ; NGAL ; renal angina index ; renal functional reserve ; tubular damage ; tubuloglomerular feedback ; neurotrophins ; transcutaneous electrical nerve stimulation ; hemopexin ; nephrotic syndrome ; HNF1B ; hyperuricemia ; PTH ; renal function ; uric acid ; FEUA ; sclerostin ; obesity ; childhood ; dental caries ; gingivitis ; kidney injury ; glomerulopathy ; glomerular injury ; alpha-1 acid glycoprotein ; urinary mRNA expression of podocyte-associated proteins ; cathepsin B ; premature neonates ; immaturity ; NT-proBNP ; cardiovascular disease ; common carotid artery intima-media thickness ; bone morphogenetic protein (BMP)-2 ; bone morphogenetic protein (BMP)-6 ; extracellular matrix metalloproteinases inducer (EMMPRIN) ; macrophage migration inhibitory factor (MIF) ; tubular functional reserve ; cytokeratin-18 ; endoglin ; transforming growth factor-β1 ; renal fibrosis ; congenital obstructive nephropathy ; diabetic kidney disease ; vascular endothelial markers ; eGFR ; adenine nucleotide metabolites ; chronic renal failure ; antibiotic resistance ; Escherichia coli ; inflammatory markers ; urinary tract infection ; B2M ; cancer ; CCS ; CKD ; nephropathies ; renal toxicity ; voiding cystography ; infection ; urinary tract ; IgA nephropathy ; IgA vasculitis with nephritis ; vanin-1 ; biomarker ; urinary tract infections ; artificial intelligence ; machine learning ; medical decision support system ; n/a
Language	English
Size	1 electronic resource (304 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030380023
ISBN	9783036559742 ; 3036559744
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Biomarkers in Pediatric Nephrology-From Bedside to Bench and Back Again.

Musiał, Kinga

Journal of clinical medicine

2022 Volume 11, Issue 19

Abstract: The progress in biomarker research is characterized by the perpetual quest for parameters that fulfill the strict criteria of sensitivity, specificity, ease and speed in performance and cost-effectiveness [ ... ]. ...

Abstract	The progress in biomarker research is characterized by the perpetual quest for parameters that fulfill the strict criteria of sensitivity, specificity, ease and speed in performance and cost-effectiveness [...].
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11195919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Update on Innate Immunity in Acute Kidney Injury-Lessons Taken from COVID-19.

Musiał, Kinga

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: The serious clinical course of SARS-CoV-2 infection is usually accompanied by acute kidney injury (AKI), worsening prognosis and increasing mortality. AKI in COVID-19 is above all a consequence of systemic dysregulations leading to inflammation, ... ...

Abstract	The serious clinical course of SARS-CoV-2 infection is usually accompanied by acute kidney injury (AKI), worsening prognosis and increasing mortality. AKI in COVID-19 is above all a consequence of systemic dysregulations leading to inflammation, thrombosis, vascular endothelial damage and necrosis. All these processes rely on the interactions between innate immunity elements, including circulating blood cells, resident renal cells, their cytokine products, complement systems, coagulation cascades and contact systems. Numerous simultaneous pathways of innate immunity should secure an effective host defense. Since they all form a network of cross-linked auto-amplification loops, uncontrolled activation is possible. When the actions of selected pathways amplify, cascade activation evades control and the propagation of inflammation and necrosis worsens, accompanied by complement overactivity and immunothrombosis. The systemic activation of innate immunity reaches the kidney, where the damage affecting single tubular cells spreads through tissue collateral damage and triggers AKI. This review is an attempt to synthetize the connections between innate immunity components engaged in COVID-19-related AKI and to summarize the knowledge on the pathophysiological background of processes responsible for renal damage.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Acute Kidney Injury/complications ; Immunity, Innate ; Inflammation ; Complement System Proteins ; Necrosis ; Cytokines
Chemical Substances	Complement System Proteins (9007-36-7) ; Cytokines
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012514
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current Concepts of Pediatric Acute Kidney Injury-Are We Ready to Translate Them into Everyday Practice?

Musiał, Kinga

Journal of clinical medicine

2021 Volume 10, Issue 14

Abstract: Pediatric acute kidney injury (AKI) is a major cause of morbidity and mortality in children undergoing interventional procedures. The review summarizes current classifications of AKI and acute kidney disease (AKD), as well as systematizes the knowledge ... ...

Abstract	Pediatric acute kidney injury (AKI) is a major cause of morbidity and mortality in children undergoing interventional procedures. The review summarizes current classifications of AKI and acute kidney disease (AKD), as well as systematizes the knowledge on pathophysiology of kidney injury, with a special focus on renal functional reserve and tubuloglomerular feedback. The aim of this review is also to show the state-of-the-art in methods assessing risk and prognosis by discussing the potential role of risk stratification strategies, taking into account both glomerular function and clinical settings conditioned by fluid overload, urine output, or drug nephrotoxicity. The last task is to suggest careful assessment of eGFR as a surrogate marker of renal functional reserve and implementation of point-of-care testing, available in the case of biomarkers like NGAL and [IGFBP-7] × [TIMP-2] product, into everyday practice in patients at risk of AKI due to planned invasive procedures or treatment.
Language	English
Publishing date	2021-07-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10143113
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current Concepts of Pediatric Acute Kidney Injury—Are We Ready to Translate Them into Everyday Practice?

Kinga Musiał

Journal of Clinical Medicine, Vol 10, Iss 3113, p

2021 Volume 3113

Abstract	Pediatric acute kidney injury (AKI) is a major cause of morbidity and mortality in children undergoing interventional procedures. The review summarizes current classifications of AKI and acute kidney disease (AKD), as well as systematizes the knowledge on pathophysiology of kidney injury, with a special focus on renal functional reserve and tubuloglomerular feedback. The aim of this review is also to show the state-of-the-art in methods assessing risk and prognosis by discussing the potential role of risk stratification strategies, taking into account both glomerular function and clinical settings conditioned by fluid overload, urine output, or drug nephrotoxicity. The last task is to suggest careful assessment of eGFR as a surrogate marker of renal functional reserve and implementation of point-of-care testing, available in the case of biomarkers like NGAL and [IGFBP-7] × [TIMP-2] product, into everyday practice in patients at risk of AKI due to planned invasive procedures or treatment.
Keywords	furosemide stress test ; hyperfiltration ; [IGFBP-7] × [TIMP-2] ; NGAL ; renal angina index ; renal functional reserve ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessment of Risk Factors for Acute Kidney Injury with Machine Learning Tools in Children Undergoing Hematopoietic Stem Cell Transplantation.

Musiał, Kinga / Stojanowski, Jakub / Augustynowicz, Monika / Miśkiewicz-Migoń, Izabella / Kałwak, Krzysztof / Ussowicz, Marek

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD).

Musiał, Kinga / Zwolińska, Danuta

Journal of clinical medicine

2021 Volume 10, Issue 21

Abstract: Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been ... ...

Abstract	Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (CKD). The aim of this study was to determine their usefulness in the assessment of CKD-related tubular dysfunction. The study group consisted of 61 children with CKD stages 1-5 and 23 controls. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were assessed by ELISA and their fractional excretion (FE) was calculated. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were significantly elevated in children with CKD vs. controls. The FE of BMP-2, FE BMP-6, and EMMPRIN increased significantly in CKD stages 1-2, but exceeded 1% in CKD stages 3-5. FE MIF became higher than in controls no sooner than in CKD 3-5, but remained below 1%. The FE values for BMP-2, BMP-6, and EMMPRIN of <1% may result from the tubular adaptive mechanisms, whereas those surpassing 1% suggest irreversible tubular damage. The analysis of serum/urinary concentrations and fractional excretion of examined parameters may allow the assessment of CKD-related tubular dysfunction.
Language	English
Publishing date	2021-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10214893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF)

Kinga Musiał / Danuta Zwolińska

Journal of Clinical Medicine, Vol 10, Iss 4893, p

Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)

2021 Volume 4893

Abstract	Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (CKD). The aim of this study was to determine their usefulness in the assessment of CKD-related tubular dysfunction. The study group consisted of 61 children with CKD stages 1–5 and 23 controls. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were assessed by ELISA and their fractional excretion (FE) was calculated. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were significantly elevated in children with CKD vs. controls. The FE of BMP-2, FE BMP-6, and EMMPRIN increased significantly in CKD stages 1–2, but exceeded 1% in CKD stages 3–5. FE MIF became higher than in controls no sooner than in CKD 3–5, but remained below 1%. The FE values for BMP-2, BMP-6, and EMMPRIN of <1% may result from the tubular adaptive mechanisms, whereas those surpassing 1% suggest irreversible tubular damage. The analysis of serum/urinary concentrations and fractional excretion of examined parameters may allow the assessment of CKD-related tubular dysfunction.
Keywords	bone morphogenetic protein (BMP)-2 ; bone morphogenetic protein (BMP)-6 ; extracellular matrix metalloproteinases inducer (EMMPRIN) ; macrophage migration inhibitory factor (MIF) ; tubular functional reserve ; tubular damage ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Monocyte chemoattractant protein-1, macrophage colony stimulating factor, survivin, and tissue inhibitor of matrix metalloproteinases-2 in analysis of damage and repair related to pediatric chronic kidney injury.

Musiał, Kinga / Zwolińska, Danuta

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2020 Volume 29, Issue 9, Page(s) 1083–1090

Abstract: Background: Kidney injury in the course of chronic kidney disease (CKD) is a consequence of aggravated cell migration, inflammation, apoptosis, and fibrosis. However, the sequence of these phenomena, as well as of the reparatory mechanisms, are not ... ...

Abstract	Background: Kidney injury in the course of chronic kidney disease (CKD) is a consequence of aggravated cell migration, inflammation, apoptosis, and fibrosis. However, the sequence of these phenomena, as well as of the reparatory mechanisms, are not fully known. Monocyte chemoattractant protein 1 (MCP-1) and macrophage colony-stimulating factor (MCSF) trigger monocyte migration to the sites of inflammation and their transition into macrophages. Tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) plays a protective role against excessive matrix remodeling, whereas survivin is known for its anti-apoptotic activity. Objectives: To analyze the serum, urine and fractional excretion (FE) values of MCP1, MCSF, TIMP-2, and survivin in children at subsequent stages of CKD being treated conservatively, and to analyze the potential applicability of these markers in the evaluation of CKD-related renal damage and protective mechanisms against it. Material and methods: The study group consisted of 70 children with conservatively treated CKD, stages 1-5, and 12 controls. The serum and urine concentrations of MCP1, MCSF, TIMP-2, and survivin were assessed using enzyme-linked immunosorbent assay (ELISA). The FE of these parameters in the urine was also assessed. Results: The serum values of all parameters were significantly elevated at CKD stage 1 compared to the controls. The urinary concentrations of MCP-1 and MCSF (stages 1-2) rose earlier than TIMP-2 and survivin (stage 4) concentrations. The FE values started increasing at CKD stage 3 (MCP-1) or stage 4 (other parameters). Conclusions: The complex analysis of serum/urinary/FE values of the selected parameters revealed a sequence of multifaceted CKD-related phenomena, when the migration of cells and inflammation were followed by delayed and insufficient anti-fibrotic and anti-apoptotic activity.
MeSH term(s)	Biomarkers ; Chemokine CCL2 ; Child ; Humans ; Kidney ; Macrophage Colony-Stimulating Factor ; Renal Insufficiency, Chronic ; Survivin ; Tissue Inhibitor of Metalloproteinase-2
Chemical Substances	Biomarkers ; CCL2 protein, human ; Chemokine CCL2 ; Survivin ; TIMP2 protein, human ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Macrophage Colony-Stimulating Factor (81627-83-0)
Language	English
Publishing date	2020-08-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/123350
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: KIM-1, IL-18, and NGAL, in the Machine Learning Prediction of Kidney Injury among Children Undergoing Hematopoietic Stem Cell Transplantation-A Pilot Study.

Musiał, Kinga / Stojanowski, Jakub / Miśkiewicz-Bujna, Justyna / Kałwak, Krzysztof / Ussowicz, Marek

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are prone to developing acute kidney injury (AKI). Markers of kidney damage: kidney injury molecule (KIM)-1, interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin ...

Abstract	Children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are prone to developing acute kidney injury (AKI). Markers of kidney damage: kidney injury molecule (KIM)-1, interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin (NGAL) may ease early diagnosis of AKI. The aim of this study was to assess serum concentrations of KIM-1, IL-18, and NGAL in children undergoing HSCT in relation to classical markers of kidney function (creatinine, cystatin C, estimated glomerular filtration rate (eGFR)) and to analyze their usefulness as predictors of kidney damage with the use of artificial intelligence tools. Serum concentrations of KIM-1, IL-18, NGAL, and cystatin C were assessed by ELISA in 27 children undergoing HSCT before transplantation and up to 4 weeks after the procedure. The data was used to build a Random Forest Classifier (RFC) model of renal injury prediction. The RFC model established on the basis of 3 input variables, KIM-1, IL-18, and NGAL concentrations in the serum of children before HSCT, was able to effectively assess the rate of patients with hyperfiltration, a surrogate marker of kidney injury 4 weeks after the procedure. With the use of the RFC model, serum KIM-1, IL-18, and NGAL may serve as markers of incipient renal dysfunction in children after HSCT.
MeSH term(s)	Child ; Humans ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Artificial Intelligence ; Biomarkers ; Cystatin C ; Hematopoietic Stem Cell Transplantation/adverse effects ; Interleukin-18 ; Kidney ; Lipocalin-2 ; Machine Learning ; Pilot Projects
Chemical Substances	Biomarkers ; Cystatin C ; Interleukin-18 ; Lipocalin-2 ; IL18 protein, human ; LCN2 protein, human ; HAVCR1 protein, human
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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