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  1. Article ; Online: Drosophila melanogaster Hedgehog cooperates with Frazzled to guide axons through a non-canonical signalling pathway.

    Ricolo, Delia / Butí, Elisenda / Araújo, Sofia J

    Mechanisms of development

    2015  Volume 137, Page(s) 11–22

    Abstract: We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline ... ...

    Abstract We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasII-positive axonal tracts. In addition, we show that Hh influences axonal guidance via a non-canonical signalling pathway dependent on Ptc. Our results reveal that the Hh pathway cooperates with the Netrin/Frazzled pathway to guide axons through the midline in invertebrates.
    MeSH term(s) Animals ; Axons/metabolism ; Axons/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology ; Hedgehogs/metabolism ; Nerve Growth Factors/metabolism ; Netrin Receptors ; Neurogenesis/physiology ; Receptors, Cell Surface/metabolism ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; Nerve Growth Factors ; Netrin Receptors ; Receptors, Cell Surface ; fra protein, Drosophila
    Language English
    Publishing date 2015-08
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1055986-3
    ISSN 1872-6356 ; 0925-4773
    ISSN (online) 1872-6356
    ISSN 0925-4773
    DOI 10.1016/j.mod.2015.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.

    Butí, Elisenda / Mesquita, Duarte / Araújo, Sofia J

    PloS one

    2014  Volume 9, Issue 3, Page(s) e92682

    Abstract: Cell migration is a widespread and complex process that is crucial for morphogenesis and for the underlying invasion and metastasis of human cancers. During migration, cells are steered toward target sites by guidance molecules that induce cell direction ...

    Abstract Cell migration is a widespread and complex process that is crucial for morphogenesis and for the underlying invasion and metastasis of human cancers. During migration, cells are steered toward target sites by guidance molecules that induce cell direction and movement through complex intracellular mechanisms. The spatio-temporal regulation of the expression of these guidance molecules is of extreme importance for both normal morphogenesis and human disease. One way to achieve this precise regulation is by combinatorial inputs of different transcription factors. Here we used Drosophila melanogaster mutants with migration defects in the ganglionic branches of the tracheal system to further clarify guidance regulation during cell migration. By studying the cellular consequences of overactivated Hh signalling, using ptc mutants, we found that Hh positively regulates Bnl/FGF levels during embryonic stages. Our results show that Hh modulates cell migration non-autonomously in the tissues surrounding the action of its activity. We further demonstrate that the Hh signalling pathway regulates bnl expression via Stripe (Sr), a zinc-finger transcription factor with homology to the Early Growth Response (EGR) family of vertebrate transcription factors. We propose that Hh modulates embryonic cell migration by participating in the spatio-temporal regulation of bnl expression in a permissive mode. By doing so, we provide a molecular link between the activation of Hh signalling and increased chemotactic responses during cell migration.
    MeSH term(s) Animals ; Cell Movement ; DNA-Binding Proteins/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Epistasis, Genetic ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/metabolism ; Models, Biological ; Morphogenesis/genetics ; Mutation ; Phenotype ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Trachea/cytology ; Trachea/embryology ; Transcription Factors/genetics ; Transcription, Genetic
    Chemical Substances DNA-Binding Proteins ; Drosophila Proteins ; Hedgehog Proteins ; Receptors, Cell Surface ; Transcription Factors ; bnl protein, Drosophila ; ptc protein, Drosophila ; sr protein, Drosophila ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2014-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0092682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.

    Elisenda Butí / Duarte Mesquita / Sofia J Araújo

    PLoS ONE, Vol 9, Iss 3, p e

    2014  Volume 92682

    Abstract: Cell migration is a widespread and complex process that is crucial for morphogenesis and for the underlying invasion and metastasis of human cancers. During migration, cells are steered toward target sites by guidance molecules that induce cell direction ...

    Abstract Cell migration is a widespread and complex process that is crucial for morphogenesis and for the underlying invasion and metastasis of human cancers. During migration, cells are steered toward target sites by guidance molecules that induce cell direction and movement through complex intracellular mechanisms. The spatio-temporal regulation of the expression of these guidance molecules is of extreme importance for both normal morphogenesis and human disease. One way to achieve this precise regulation is by combinatorial inputs of different transcription factors. Here we used Drosophila melanogaster mutants with migration defects in the ganglionic branches of the tracheal system to further clarify guidance regulation during cell migration. By studying the cellular consequences of overactivated Hh signalling, using ptc mutants, we found that Hh positively regulates Bnl/FGF levels during embryonic stages. Our results show that Hh modulates cell migration non-autonomously in the tissues surrounding the action of its activity. We further demonstrate that the Hh signalling pathway regulates bnl expression via Stripe (Sr), a zinc-finger transcription factor with homology to the Early Growth Response (EGR) family of vertebrate transcription factors. We propose that Hh modulates embryonic cell migration by participating in the spatio-temporal regulation of bnl expression in a permissive mode. By doing so, we provide a molecular link between the activation of Hh signalling and increased chemotactic responses during cell migration.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Characterisation of integrated stress biomarkers in two deep-sea crustaceans, Aristeus antennatus and Nephrops norvegicus, from the NW fishing grounds of the Mediterranean sea.

    Antó, Mertixell / Arnau, Susana / Buti, Elisenda / Cortijo, Verónica / Gutiérrez, Elena / Solé, Montserrat

    Ecotoxicology and environmental safety

    2009  Volume 72, Issue 5, Page(s) 1455–1462

    Abstract: Several biomarkers indicative of stress were characterised in the crustaceans Aristeus antennatus and Nephrops norvegicus sampled off the Barcelona coast (NW Mediterranean). The biomarkers selected were cholinesterase (ChE) activities in muscle; and ... ...

    Abstract Several biomarkers indicative of stress were characterised in the crustaceans Aristeus antennatus and Nephrops norvegicus sampled off the Barcelona coast (NW Mediterranean). The biomarkers selected were cholinesterase (ChE) activities in muscle; and catalase, glutathione reductase (GR), total glutathione peroxidase (t-GPX), DT-diaphorase (DT-D), glutathione S-transferases (GSTs) and carboxylesterases (CbEs) in hepatopancreas tissue. Lipid peroxidation (LP) levels and total protein yield (PY) were also determined in muscle and hepatopancreas tissues. The activities and levels are discussed in relation to species and season, and differences in these two factors were observed for most biomarkers. AChEs and pseudocholinesterases were present in the muscles of both crustaceans. Catalase and GST activities were higher in N. norvegicus, whereas GR and t-GPX activities varied according to the season. Hepatic CbE activities were similar in the two crustaceans, whereas LP levels and PY were different between species. Seasonality and species particularities are factors to consider when these crustaceans are used as sentinels.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Carboxylesterase/metabolism ; Catalase/metabolism ; Cholinesterases/metabolism ; Crustacea/drug effects ; Crustacea/enzymology ; Environmental Monitoring/methods ; Female ; Fish Proteins/metabolism ; Glutathione Peroxidase/metabolism ; Glutathione Reductase/metabolism ; Glutathione Transferase/metabolism ; Hepatopancreas/enzymology ; Lipid Peroxidation ; Male ; Mediterranean Sea ; Muscles/enzymology ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Reproducibility of Results ; Seasons ; Spain ; Species Specificity ; Stress, Physiological/drug effects ; Water Pollutants/toxicity
    Chemical Substances Biomarkers ; Fish Proteins ; Water Pollutants ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Glutathione Reductase (EC 1.8.1.7) ; Glutathione Transferase (EC 2.5.1.18) ; Carboxylesterase (EC 3.1.1.1) ; Cholinesterases (EC 3.1.1.8)
    Language English
    Publishing date 2009-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2009.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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