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Article ; Online: The Role of Zuo Jin Wan in Modulating the Tumor Microenvironment of Colorectal Cancer.

Wang, Jiajia / Hua, Dongming / Li, Mengyao / Liu, Ningning / Zhang, Yingru / Zhao, Yiyang / Jiang, Shasha / Hu, Xueqing / Wang, Yan / Zhu, Huirong

Combinatorial chemistry & high throughput screening

2024

Abstract: Introduction: Traditional Chinese medicine (TCM) can modulate the immune function of tumor patients in various ways. Zuojin Wan (ZJW, a 6:1 ratio of Huanglian and Wuzhuyu) can modulate the microenvironment of ulcerative colitis, but its role in ... ...

Abstract	Introduction: Traditional Chinese medicine (TCM) can modulate the immune function of tumor patients in various ways. Zuojin Wan (ZJW, a 6:1 ratio of Huanglian and Wuzhuyu) can modulate the microenvironment of ulcerative colitis, but its role in regulating the CRC microenvironment remains unclear. Exploring the role of ZJW in CRC immunomodulation may improve the antitumor effect of existing immunotherapeutic strategies. Material and methods: The active compounds of each herb in ZJW were obtained from the HIT2.0 database with literature evidence. Single-cell RNA sequencing data of CRC were obtained from published studies (PMID: 32451460, 32103181, and 32561858). Pathway enrichment was analyzed using the reactome database, and intergenic correlation analysis was performed using the corrplot R software package. ZJW-regulated gene expression was verified by RT-qPCR. Results: Huanglian and Wuzhu contain 19 and 4 compounds, respectively. Huang Lian targets 146 proteins, and Wu Zhu Yu targets 28 proteins based on evidence from the literature. ZJW regulates a range of biological processes associated with immune function, including cytokine signaling and Toll-Like Receptor 4 (TLR4) cascade. ZJW regulates malignant CRC cells, immune cells (including T-cells, B-cells, mast cells, NK/NKT cells, and myeloid cells), and other non-immune cells (including endothelial cells, enteric glial cells, and pericytes). We confirmed that ZJW significantly downregulated the expression of TIMP1 and MTDH. Conclusions: ZJW regulates a range of cells in the CRC microenvironment, including malignant CRC, immune cells, and stromal cells. In CRC cell lines, downregulation of TIMP1 and MTDH by ZJW may play an important role in the immunomodulation in CRC.
Language	English
Publishing date	2024-01-25
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073281374231228041841
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Zs.A 5577: Show issues

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Article ; Online: Jin-Zhen oral liquid for pediatric coronavirus disease (COVID-19)

Qian Dong / Hongmei Qiao / Huiyi Jiang / Lixiao Liu / Yanling Ge / Fang-Jiao Zong / Yanan Li / Bingzi Dong / Sujuan Hu / Dongmei Meng / Rong Jin / Xiangshi Wang / Hailing Chang / Xiaolong Xu / Chenjing Wang / Yu Cao / Han-Ting Zhang / Qingquan Liu

Frontiers in Pharmacology, Vol

A randomly controlled, open-label, and non-inferiority trial at multiple clinical centers

2023 Volume 14

Abstract: ... as a therapeutic option. Jin-Zhen Oral Liquid is widely used for pediatric acute bronchitis, while the efficacy and ... to moderate COVID-19. Children eligible for enrollment were randomly assigned in a 1:1 ratio to Jin-Zhen Oral ... randomly into the Jin-Zhen Oral Liquid (117 patients) and Jinhua Qinggan Granules (123 patients) groups ...

Abstract	Background: As the coronavirus disease 2019 (COVID-19) pandemic progressed, especially with the emergence of the Omicron variant, the proportion of infected children and adolescents increased significantly. Some treatment such as Chinese herbal medicine has been administered for COVID-19 as a therapeutic option. Jin-Zhen Oral Liquid is widely used for pediatric acute bronchitis, while the efficacy and safety in the treatment of pediatric COVID-19 are unclear.Methods: We conducted a randomized controlled, open-label, multicenter, non-inferiority clinical study involving hospitalized children with mild to moderate COVID-19. Children eligible for enrollment were randomly assigned in a 1:1 ratio to Jin-Zhen Oral Liquid (the treatment group) and Jinhua Qinggan Granules (the positive control group) and received the respective agent for 14 days, followed by a 14-day follow-up after discontinuation of the treatment. The primary efficacy endpoint was the time to first negative viral testing. The secondary endpoints were the time and rate of major symptoms disappearance, duration of hospitalization, and the proportion of symptoms changed from asymptomatic or mild to moderate or severe/critical illness. In addition, the safety end points of any adverse events were observed.Results: A total of 240 child patients were assigned randomly into the Jin-Zhen Oral Liquid (117 patients) and Jinhua Qinggan Granules (123 patients) groups. There was no significant difference of the baselines in terms of the clinical characteristics and initial symptoms between the two groups. After 14-day administration, the time to first negative viral testing in the Jin-Zhen group (median 6.0 days, 95% CI 5.0-6.0) was significantly shorter compared with the positive control Jinhua Qinggan Granules group (median 7.0 days, 95% CI 7.0-8.0). The time and rate of major clinical symptoms disappearance were comparable to the positive control. The symptom disappearance time of pharyngalgia and hospitalization duration were significantly shortened in the ...
Keywords	traditional Chinese medicine ; Jin-Zhen oral liquid ; pediatric COVID-19 ; randomized controlled clinical trial ; multiple clinical centers ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jin-Zhen oral liquid for pediatric coronavirus disease (COVID-19): A randomly controlled, open-label, and non-inferiority trial at multiple clinical centers.

Dong, Qian / Qiao, Hongmei / Jiang, Huiyi / Liu, Lixiao / Ge, Yanling / Zong, Fang-Jiao / Li, Yanan / Dong, Bingzi / Hu, Sujuan / Meng, Dongmei / Jin, Rong / Wang, Xiangshi / Chang, Hailing / Xu, Xiaolong / Wang, Chenjing / Cao, Yu / Zhang, Han-Ting / Liu, Qingquan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1094089

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1094089
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Therapeutic Effects of Ba-Duan-Jin versus Pregabalin for Fibromyalgia Treatment: Protocol for a Randomized Controlled Trial.

Yang, Yang / Li, Yan-Ting / Sun, Yu-Ruo / Wang, Jing / Li, Yang / Zhang, Jin-Hua / Jiao, Juan / Jiang, Quan

Rheumatology and therapy

2021 Volume 8, Issue 3, Page(s) 1451–1462

Abstract: ... psychological impairment, and may cause adverse effects (e.g. somnolence, dizziness). "Ba-Duan-Jin" (BDJ) is ...

Abstract	Introduction: Fibromyalgia is characterized by multi-focal pain and is associated with fatigue, unrefreshing sleep and psychological impairment. Pregabalin is one of the most frequently used agents in fibromyalgia treatment. However, it has failed to demonstrate benefit over placebo for reducing fatigue and psychological impairment, and may cause adverse effects (e.g. somnolence, dizziness). "Ba-Duan-Jin" (BDJ) is a common form of "Qigong" exercise for health promotion in China. Growing evidence suggests that BDJ may achieve satisfactory control of fibromyalgia-related symptoms in Chinese patients. Therefore, we wish to ascertain if BDJ could overcome the disadvantages of pregabalin. Methods: A single-blind randomized controlled trial has been designed which will recruit 104 patients with fibromyalgia (age 18-70 years) with a visual analog scale (VAS) pain score of ≥ 40 mm These patients will be randomly assigned to one of two groups: (1) BDJ group (to undertake guided BDJ exercise and take a placebo capsule) or (2) pregabalin group (to take a pregabalin capsule and receive wellness education and guided muscle-relaxation exercises). The primary endpoint will be changes in the VAS score for pain. The secondary endpoints will be changes in the score for the Revised Fibromyalgia Impact Questionnaire, Multidimensional Fatigue Inventory-20, Pittsburgh Sleep Quality Index, Beck II Depression Inventory, Perceived Stress Scale and Short Form-36 Health Survey Questionnaire. These parameters will be assessed at 0, 4, 8, 12 and 24 weeks of follow-up. Planned outcomes: Our results are expected to provide more clinical evidence for the beneficial effects of BDJ in treating fibromyalgia. Trial registration: NCT03797560.
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2783278-8
ISSN	2198-6584 ; 2198-6576
ISSN (online)	2198-6584
ISSN	2198-6576
DOI	10.1007/s40744-021-00341-9
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Article ; Online: Response to Jin and Dobry's "ChatGPT for health care providers and patients: Practical implications within dermatology".

Jiang, Melinda / Bacchi, Stephen / Kovoor, Joshua / Stretton, Brandon / Chan, Weng Onn

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 3, Page(s) e105

MeSH term(s)	Humans ; Dermatology ; Health Personnel ; Patients
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Letter
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.10.038
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Zs.A 1540: Show issues

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Article ; Online: Description of two new species of the genus Spinirta Jin & Zhang, 2020 (Araneae, Corinnidae) from southern China

Liu, Ke-Ke / Jiang, Zi-Min / Ma, Ning / Li, Wenhui / Xiao, Yong-Hong

ZooKeys. 2022 Dec. 16, v. 1136 p.57-69

2022

Abstract: AbstractTwo new species of Spinirta Jin & Zhang, 2020 (Araneae: Corinnidae) from Jiangxi Province ...

Abstract	AbstractTwo new species of Spinirta Jin & Zhang, 2020 (Araneae: Corinnidae) from Jiangxi Province, China are described here: S. sanxiandian sp. nov. (♂♀) and S. sishuishan sp. nov. (♂). Detailed descriptions and photographs of the new species are provided.
Keywords	Corinnidae ; new species ; China ; Corinnid ; distribution ; Jiangxi Province ; taxonomy
Language	English
Dates of publication	2022-1216
Size	p. 57-69.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1136.94374
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Maimendong and Qianjinweijing Tang (Jin formula) suppresses lung cancer by regulation of miR-149-3p.

Jiang, Zequn / Ma, Yanxia / Tian, Tian / Sun, Yan / Chen, Hao / Lu, Ye / Wu, Yan / Jiang, Haiying / Li, Wenting / Li, Li / Zhou, Hongguang / Wu, Mianhua

Journal of ethnopharmacology

2020 Volume 258, Page(s) 112836

Abstract: Ethnopharmacological relevance: Maimendong and Qianjinweijing Tang (Jin formula), a classic ... Aim of the study: To evaluate the anti-lung cancer effect of Jin formula in vivo and in vitro, and ... to explore the role of microRNA (miRNA) in the anti-lung cancer mechanism of Jin formula.: Materials and ...

Abstract	Ethnopharmacological relevance: Maimendong and Qianjinweijing Tang (Jin formula), a classic Chinese formula, can enhance therapeutic efficacy and reduce adverse effects in patients with lung cancer. Aim of the study: To evaluate the anti-lung cancer effect of Jin formula in vivo and in vitro, and to explore the role of microRNA (miRNA) in the anti-lung cancer mechanism of Jin formula. Materials and methods: Cell survival was determined via a colorimetric method, and apoptotic condition was revealed by flow cytometric analysis. Cell migration and invasion were detected by scratch and transwell assays. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay was applied to measure the changes of miRNA expression. Pathological histology of lung tissues were assessed by hematoxylin-eosin (HE) staining. Immunohistochemistry and immunoblotting were used to detect the expression of marker proteins of Wnt/β-catenin pathway. The relationship between miR-149-3p and MYC associated zinc finger protein (MAZ) was verified using a dual-luciferase reporter assay system. Results: Our findings demonstrated the anti-cancer effect of Jin formula in vitro, and revealed that Jin formula could suppress the proliferation, migration and invasion of human lung cancer A549 and H1299 cells. We also confirmed the capability of Jin formula to reduce tumor growth through the up-regulation of miR-149-3p and down-regulation of Wnt/β-catenin signaling in animal models. qRT-PCR analysis in vitro further confirmed a dose-dependent increase of miR-149-3p by treatment with Jin formula. Functional studies identified MAZ as a downstream target of miR-149-3p. Overexpression of miR-149-3p inhibited cell proliferation, migration, invasion and induced apoptosis in A549 and H1299 cells, similar to our findings on the effects of Jin formula treatment. In contrast, inhibiting the expression of miR-149-3p reversed the anti-cancer effects of Jin formula. Additionally, we revealed that miR-149-3p was involved in the anti-cancer effects of Jin formula, at least in part, by inhibiting MAZ expression and the Wnt/β-catenin signaling cascade. Conclusion: Our study illustrated that Jin formula suppressed the development of lung cancer and the mechanism may be associated with the miR-149-3p/MAZ/Wnt/β-catenin axis.
MeSH term(s)	A549 Cells ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Down-Regulation ; Drugs, Chinese Herbal/pharmacology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Up-Regulation ; Wnt Signaling Pathway/drug effects ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; MIRN149 microRNA, human ; MicroRNAs ; maimendongtang
Language	English
Publishing date	2020-04-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112836
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Article ; Online: Assessment of vegetation growth and drought conditions using satellite-based vegetation health indices in Jing-Jin-Ji region of China.

Jiang, Rengui / Liang, Jichao / Zhao, Yong / Wang, Hao / Xie, Jiancang / Lu, Xixi / Li, Fawen

Scientific reports

2021 Volume 11, Issue 1, Page(s) 13775

Abstract: ... conditions for the period of 1982-2016 in Jing-Jin-Ji region of China. The Niño 3.4 was used ... growth activity, to monitor and quantify drought using satellite-based VHIs in Jing-Jin-Ji region. ...

Abstract	Terrestrial vegetation growth activity plays pivotal roles on regional development, which has attracted wide attention especially in water resources shortage areas. The paper investigated the spatiotemporal change characteristics of vegetation growth activity using satellite-based Vegetation Health Indices (VHIs) including smoothed Normalized Difference Vegetation Index (SMN), smoothed Brightness Temperature (SMT), Vegetation Condition Index (VCI), Temperature Condition Index (TCI) and VHI, based on 7-day composite temporal resolution and 16 km spatial resolution gridded data, and also estimated the drought conditions for the period of 1982-2016 in Jing-Jin-Ji region of China. The Niño 3.4 was used as a substitution of El Niño Southern Oscillation (ENSO) to reveal vegetation sensitivity to ENSO using correlation and wavelet analysis. Results indicated that monthly SMN has increased throughout the year especially during growing season, starts at approximate April and ends at about October. The correlation analysis between SMN and SMT, SMN and precipitation indicated that the vegetation growth was affected by joint effects of temperature and precipitation. The VCI during growing season was positive trends dominated and vice versa for TCI. The relationships between VHIs and drought make it possible to identify and quantify drought intensity, duration and affected area using different ranges of VHIs. Generally, the intensity and affected area of drought had mainly decreased, but the trends varied for different drought intensities, regions and time periods. Large-scale global climate anomalies such as Niño 3.4 exerted obvious impacts on the VHIs. The Niño 3.4 was mainly negatively correlated to VCI and positively correlated to TCI, and the spatial distributions of areas with positive (negative) correlation coefficients were mainly opposite. The linear relationships between Niño 3.4 and VHIs were in accordance with results of nonlinear relationships revealed using wavelet analysis. The results are of great importance to assess the vegetation growth activity, to monitor and quantify drought using satellite-based VHIs in Jing-Jin-Ji region.
Language	English
Publishing date	2021-07-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-93328-z
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Article: Ba-Duan-Jin alleviates pain and fibromyalgia-related symptoms in patients with fibromyalgia: results of a randomised controlled trial.

Jiao, Juan / Russell, Irwin J / Wang, Wen / Wang, Jing / Zhao, Ya-Yun / Jiang, Quan

Clinical and experimental rheumatology

2019 Volume 37, Issue 6, Page(s) 953–962

Abstract: ... in the development of non-pharmacological therapies. Ba-Duan-Jin is an ancient Chinese exercise for health promotion ... yet easy to learn. The purpose of this study is to evaluate the effectiveness of Ba-Duan-Jin in managing ... controlled study, patients with fibromyalgia practiced Ba-Duan-Jin for one hour, twice a week for 12 weeks ...

Abstract	Objectives: Fibromyalgia is a chronic debilitating pain syndrome. There has been growing interest in the development of non-pharmacological therapies. Ba-Duan-Jin is an ancient Chinese exercise for health promotion, yet easy to learn. The purpose of this study is to evaluate the effectiveness of Ba-Duan-Jin in managing fibromyalgia symptoms experienced by Chinese patients. Methods: In this randomised, usual therapy-controlled study, patients with fibromyalgia practiced Ba-Duan-Jin for one hour, twice a week for 12 weeks. The primary outcome measure was change in the Visual Analogue Scale for pain (pain VAS). Secondary outcomes included the Fibromyalgia Impact Questionnaire (FIQ), the Multidimensional Assessment of Fatigue (MAF), the Pittsburgh Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), the Perceived Stress Scale (PSS), and the Tender Point Count (TPC). These measures were assessed at baseline and after 4, 8, and 12 weeks. The Patient Global Impression of Change (PGIC) was collected at week 12. The Mann-Whitney U-test was performed using the intention-to-treat population. Results: A total of 62 fibromyalgia patients were randomised to the Ba-Duan-Jin or the control groups. For the Ba-Duan-Jin group, significant improvement in pain VAS, FIQ, MAF, PSQI, and TPC were documented at weeks 4 (p≤0.046) and continued at week 8 (p≤0.003). At week 12, all of the outcome measures including BDI and PSS exhibited significant improvement (p≤0.004), and PGIC ratings were significantly better (p<0.001). No significant changes in the control group were observed. Conclusions: This study suggests that Ba-Duan-Jin exercise has the potential to be a valuable non-pharmacological intervention among Chinese fibromyalgia patients.
MeSH term(s)	Fibromyalgia/therapy ; Humans ; Musculoskeletal Pain/therapy ; Pain Measurement ; Qigong/methods ; Surveys and Questionnaires ; Treatment Outcome
Language	English
Publishing date	2019-02-15
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Zs.A 2002: Show issues

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Article ; Online: Erratum: KE JIANG, JIN-LONG REN, JUN-FENG GUO, ZENG WANG, LI DING1 amp; JIA-TANG LI (2020) A new species of the genus Dendrelaphis (Squamata: Colubridae) from Yunnan Province, China, with discussion of the occurrence of D. cyanochloris (Wall, 1921) in China. Zootaxa, 4743: 001-020.

Jiang, K E / Ren, Jin-Long / Guo, Jun-Feng / Wang, Zeng / Ding, L I / Li, Jia-Tang

Zootaxa

2020 Volume 4759, Issue 4, Page(s) zootaxa.4759.4.13

Language	English
Publishing date	2020-04-06
Publishing country	New Zealand
Document type	Journal Article ; Published Erratum
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4759.4.13
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