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  1. Article ; Online: Morphogens, modeling and patterning the neural tube: an interview with James Briscoe.

    Briscoe, James

    BMC biology

    2015  Volume 13, Page(s) 5

    Abstract: James Briscoe has a BSc in Microbiology and Virology (from the University of Warwick, UK) and a PhD ...

    Abstract James Briscoe has a BSc in Microbiology and Virology (from the University of Warwick, UK) and a PhD in Molecular and Cellular Biology (from the Imperial Cancer Research Fund, London, now Cancer Research UK). He started working on the development of the neural tube in the lab of Tom Jessel as a postdoctoral fellow, establishing that there was graded sonic hedgehog signaling in the ventral neural tube. He is currently a group leader and Head of Division in Developmental Biology at the MRC National Institute for Medical Research (which will become part of the Francis Crick Institute in April 2015). He is working to understand the molecular and cellular mechanisms of graded signaling in the vertebrate neural tube.We interviewed him about the development of ideas on morphogenetic gradients and his own work on modeling the development of the neural tube for our series on modeling in biology.
    MeSH term(s) Animals ; Body Patterning ; Chick Embryo ; Cooperative Behavior ; History, 20th Century ; History, 21st Century ; London ; Mice ; Models, Biological ; Neural Tube/embryology
    Language English
    Publishing date 2015-01-20
    Publishing country England
    Document type Autobiography ; Historical Article ; Interview
    ISSN 1741-7007
    ISSN (online) 1741-7007
    DOI 10.1186/s12915-014-0105-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Gradients and Tissue Patterning

    Small, Stephen / Briscoe, James

    (Current topics in developmental biology ; Volume 137)

    2020  

    Author's details edited by Stephen Small, James Briscoe
    Series title Current topics in developmental biology ; Volume 137
    Keywords Morphogenesis
    Subject code 571.8
    Language English
    Size 1 online resource (xvii, 480 pages) :, color illustrations.
    Publisher Academic Press
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-812790-2 ; 978-0-12-812790-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Choose Development in 2024: serious science, community connections, progressive publishing.

    Briscoe, James / Brown, Katherine

    Development (Cambridge, England)

    2024  Volume 151, Issue 1

    MeSH term(s) Publishing ; Science
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.202641
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  4. Article ; Online: Control of Tissue Development by Morphogens.

    Kicheva, Anna / Briscoe, James

    Annual review of cell and developmental biology

    2023  Volume 39, Page(s) 91–121

    Abstract: Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their ... ...

    Abstract Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling.
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1293750-2
    ISSN 1530-8995 ; 1081-0706
    ISSN (online) 1530-8995
    ISSN 1081-0706
    DOI 10.1146/annurev-cellbio-020823-011522
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  5. Article ; Online: Optimal control of gene regulatory networks for morphogen-driven tissue patterning.

    Pezzotta, Alberto / Briscoe, James

    Cell systems

    2023  Volume 14, Issue 11, Page(s) 940–952.e11

    Abstract: The generation of distinct cell types in developing tissues depends on establishing spatial patterns of gene expression. Often, this is directed by spatially graded chemical signals-known as morphogens. In the "French Flag model," morphogen concentration ...

    Abstract The generation of distinct cell types in developing tissues depends on establishing spatial patterns of gene expression. Often, this is directed by spatially graded chemical signals-known as morphogens. In the "French Flag model," morphogen concentration instructs cells to acquire specific fates. How this mechanism produces timely and organized cell-fate decisions, despite the presence of changing morphogen levels, molecular noise, and individual variability, is unclear. Moreover, feedback is present at various levels in developing tissues, breaking the link between morphogen concentration, signaling activity, and position. Here, we develop an alternative framework using optimal control theory to tackle the problem of morphogen-driven patterning: intracellular signaling is derived as the control strategy that guides cells to the correct fate while minimizing a combination of signaling levels and time. This approach recovers experimentally observed properties of patterning strategies and offers insight into design principles that produce timely, precise, and reproducible morphogen patterning.
    MeSH term(s) Gene Regulatory Networks/genetics ; Signal Transduction/genetics ; Cell Differentiation
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2854138-8
    ISSN 2405-4720 ; 2405-4712
    ISSN (online) 2405-4720
    ISSN 2405-4712
    DOI 10.1016/j.cels.2023.10.004
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  6. Article ; Online: Understanding Pattern Formation in Embryos: Experiment, Theory, and Simulation.

    Briscoe, James

    Journal of computational biology : a journal of computational molecular cell biology

    2019  Volume 26, Issue 7, Page(s) 696–702

    MeSH term(s) Animals ; Body Patterning ; Bone Morphogenetic Proteins/metabolism ; Computer Simulation ; Embryo, Mammalian/embryology ; Embryo, Nonmammalian/embryology ; Gene Expression Regulation, Developmental ; Signal Transduction
    Chemical Substances Bone Morphogenetic Proteins
    Language English
    Publishing date 2019-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2030900-4
    ISSN 1557-8666 ; 1066-5277
    ISSN (online) 1557-8666
    ISSN 1066-5277
    DOI 10.1089/cmb.2019.0090
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  7. Article ; Online: In preprints: morphogens in motion.

    Stapornwongkul, Kristina S / Briscoe, James

    Development (Cambridge, England)

    2022  Volume 149, Issue 14

    MeSH term(s) Publishing
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201066
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  8. Article ; Online: Another year of Developments.

    Briscoe, James / Grewal, Seema

    Development (Cambridge, England)

    2022  Volume 149, Issue 1

    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Editorial
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.200445
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  9. Article ; Online: Preprints in Development.

    Briscoe, James / Grewal, Seema

    Development (Cambridge, England)

    2022  Volume 149, Issue 7

    MeSH term(s) Biomedical Research ; Publishing
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Editorial
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.200711
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  10. Article ; Online: The Pathway to Independence programme: helping postdocs navigate the transition to independence.

    Briscoe, James / Brown, Katherine

    Development (Cambridge, England)

    2022  Volume 149, Issue 23

    MeSH term(s) Humans ; Research Personnel
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Editorial
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201456
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