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  1. Article: Interleukin-6 is important for regulation of core body temperature during long-term cold exposure in mice.

    Egecioglu, Emil / Anesten, Fredrik / Schéle, Erik / Palsdottir, Vilborg

    Biomedical reports

    2018  Volume 9, Issue 3, Page(s) 206–212

    Abstract: Interleukin-6 (IL6) is a cytokine important for inducing the fever response during infection and has been reported to uphold core body temperature during acute cold exposure. Recently it has also been indicated that IL6 in serum increases in cold-exposed ...

    Abstract Interleukin-6 (IL6) is a cytokine important for inducing the fever response during infection and has been reported to uphold core body temperature during acute cold exposure. Recently it has also been indicated that IL6 in serum increases in cold-exposed mice. The aim of the present study was to investigate if IL6 is important for core body temperature regulation following a long-term cold exposure in mice. Experiments were performed with global IL6 deficient (-/-) mice, mice with conditional IL6 receptor α (IL6Rα) knockdown in the central nervous system (CNS; IL6Rα
    Language English
    Publishing date 2018-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2018.1118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of a selective long-acting amylin receptor agonist on alcohol consumption, food intake and body weight in male and female rats.

    Kalafateli, Aimilia Lydia / Vestlund, Jesper / Raun, Kirsten / Egecioglu, Emil / Jerlhag, Elisabet

    Addiction biology

    2020  Volume 26, Issue 2, Page(s) e12910

    Abstract: Alcohol use disorder is a complex neuropsychiatric disorder affecting both males and females worldwide; however, the efficacy of current pharmacotherapies varies. Recent advances show that gut-brain peptides, like amylin, regulate alcohol behavioural ... ...

    Abstract Alcohol use disorder is a complex neuropsychiatric disorder affecting both males and females worldwide; however, the efficacy of current pharmacotherapies varies. Recent advances show that gut-brain peptides, like amylin, regulate alcohol behavioural responses by acting on brain areas involved in alcohol reward processes. Thus, the activation of amylin receptors (AMYRs) by salmon calcitonin (sCT) decreases alcohol behaviours in male rodents. Given that sCT also activates the sole calcitonin receptor (CTR), studies of more selective AMYR agonists in both male and female rodents are needed to explore amylinergic modulation of alcohol behaviours. Therefore, we investigated the effects of repeated administration of a selective long-acting AMYR agonist, NNC0174-1213 (AM1213), on alcohol, water and food intake, as well as body weight in male and female rats chronically exposed to alcohol. We confirm our previous studies with sCT in male rats, as repeated AM1213 administration for 2 weeks initially decreased alcohol intake in both male and female rats. However, this reduction ceases in both sexes on later sessions, accompanied by an increase in males. AM1213 reduced food intake and body weight in both male and female rats, with sustained body weight loss in males after discontinuation of the treatment. Moreover, AM1213 administration for 3 or 7 days, differentially altered dopamine, serotonin and their metabolites in the reward-related areas in males and females, providing tentative, but different, downstream mechanism through which selective activation of AMYR may alter alcohol intake. Our data provide clarified insight into the importance of AMYRs for alcohol intake regulation in both sexes.
    MeSH term(s) Alcohol Drinking/drug therapy ; Alcoholism/drug therapy ; Amylin Receptor Agonists/pharmacology ; Animals ; Body Weight/drug effects ; Calcitonin/pharmacology ; Eating/drug effects ; Female ; Male ; Rats ; Rats, Wistar ; Reward ; Water
    Chemical Substances Amylin Receptor Agonists ; Water (059QF0KO0R) ; salmon calcitonin (7SFC6U2VI5) ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.12910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Uterine glycolytic enzyme expression is affected by knockout of different estrogen receptor subtypes.

    Hu, Min / Zhang, Yuehui / Egecioglu, Emil / Li, Xin / Shao, Linus R / Billig, Håkan

    Biomedical reports

    2019  Volume 11, Issue 4, Page(s) 135–144

    Abstract: The estrogen signaling pathway via nuclear estrogen receptors (ER) α and β is considered to be the master regulator of the cellular glucose metabolism in the uterus. ... ...

    Abstract The estrogen signaling pathway via nuclear estrogen receptors (ER) α and β is considered to be the master regulator of the cellular glucose metabolism in the uterus. While
    Language English
    Publishing date 2019-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2019.1234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The additive effect of allopregnanolone on ghrelin's orexigenic effect in rats.

    Löfgren, Magnus / Holmberg, Ellinor / Bäckström, Torbjörn / Egecioglu, Emil / Dickson, Suzanne L

    Neuropeptides

    2019  Volume 76, Page(s) 101937

    Abstract: The progesterone metabolite, allopregnanolone (AlloP), is a ... ...

    Abstract The progesterone metabolite, allopregnanolone (AlloP), is a GABA
    MeSH term(s) Animals ; Arcuate Nucleus of Hypothalamus/drug effects ; Arcuate Nucleus of Hypothalamus/physiology ; Eating/drug effects ; Ghrelin/administration & dosage ; Ghrelin/physiology ; Inhibitory Postsynaptic Potentials/drug effects ; Male ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/physiology ; Pregnanolone/administration & dosage ; Pregnanolone/physiology ; Rats, Wistar
    Chemical Substances Ghrelin ; Pregnanolone (BXO86P3XXW)
    Language English
    Publishing date 2019-06-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/j.npep.2019.101937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Normal Neurodevelopment and Fertility in Juvenile Male Rats Exposed to Polyethylene Glycol Following Dosing With PEGylated rFIX (Nonacog Beta Pegol, N9-GP): Evidence from a 10-Week Repeat-Dose Toxicity Study.

    Jensen, Vivi F H / Schefe, Line H / Jacobsen, Helene / Mølck, Anne-Marie / Almholt, Kasper / Sjögren, Ingrid / Dalsgaard, Charlotte M / Kirk, Rikke K / Benie, Andrew J / Petersen, Bent O / Kyhn, Mette S / Overgaard, Anne J / Bjørnsdottir, Inga / Stannard, Diane R / Offenberg, Hanne K / Egecioglu, Emil

    International journal of toxicology

    2022  Volume 41, Issue 6, Page(s) 455–475

    Abstract: ... N9-GP/ ... ...

    Abstract N9-GP/Rebinyn
    MeSH term(s) Adult ; Animals ; Child ; Factor IX/therapeutic use ; Fertility ; Hemophilia B/drug therapy ; Humans ; Infant ; Male ; Polyethylene Glycols/toxicity ; Rats ; Recombinant Proteins
    Chemical Substances Recombinant Proteins ; nonacog beta pegol (27Y83O992Q) ; Polyethylene Glycols (3WJQ0SDW1A) ; Factor IX (9001-28-9)
    Language English
    Publishing date 2022-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818221121054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1870: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Thylakoids reduce body fat and fat cell size by binding to dietary fat making it less available for absorption in high-fat fed mice.

    Stenkula, Karin G / Stenblom, Eva-Lena / Montelius, Caroline / Egecioglu, Emil / Erlanson-Albertsson, Charlotte

    Nutrition & metabolism

    2017  Volume 14, Page(s) 4

    Abstract: Background: Dietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion in the intestine, without causing ...

    Abstract Background: Dietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion in the intestine, without causing steatorrhea, and increased fatty acid oxidation in intestinal cells. The objective of our study was to elucidate if increased fecal fat excretion is an important mechanism to normalize adipose tissue metabolism during high-fat feeding in mice supplemented with thylakoids.
    Methods: Mice were randomized to receive HFD or thylHFD for 14 days (
    Results: Thylakoid supplementation for 14 days caused an increased faecal fat content without compensatory eating compared to control. As a result, thylakoid treated animals had reduced fat mass depots and reduced liver fat accumulation compared to control. The size distribution of adipocytes isolated from visceral adipose tissue was narrowed and the cell size decreased. Adipocytes isolated from thylakoid-treated mice displayed a significantly increased lipogenesis, and protein expression of peroxisome proliferator-activated receptor gamma (PPARγ), down-stream target FAS, as well as transcription factor coactivators PGC1-α and LPIN-1 were upregulated in adipose tissue from thylakoid-fed mice.
    Conclusions: Together, these data suggest that thylakoid supplementation reduces body fat and fat cell size by binding to dietary fat and increasing its fecal excretion, thus reducing dietary fat available for absorption.
    Language English
    Publishing date 2017-01-11
    Publishing country England
    Document type Journal Article
    ISSN 1743-7075
    ISSN 1743-7075
    DOI 10.1186/s12986-016-0160-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Corrigendum to "Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women" [Appetite 81 (2014), 295-304].

    Montelius, Caroline / Erlandsson, Daniel / Vitija, Egzona / Stenblom, Eva-Lena / Egecioglu, Emil / Erlanson-Albertsson, Charlotte

    Appetite

    2016  Volume 101, Page(s) 239

    Language English
    Publishing date 2016-06-01
    Publishing country England
    Document type Published Erratum
    ISSN 1095-8304
    ISSN (online) 1095-8304
    DOI 10.1016/j.appet.2016.03.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Corrigendum to "Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women" [81 (1 October 2014) 295-304].

    Montelius, Caroline / Erlandsson, Daniel / Vitija, Egzona / Stenblom, Eva-Lena / Egecioglu, Emil / Erlanson-Albertsson, Charlotte

    Appetite

    2016  Volume 96, Page(s) 645–646

    Language English
    Publishing date 2016-01-01
    Publishing country England
    Document type Published Erratum
    ISSN 1095-8304
    ISSN (online) 1095-8304
    DOI 10.1016/j.appet.2015.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The glucagon-like peptide 1 analogue, exendin-4, attenuates the rewarding properties of psychostimulant drugs in mice.

    Egecioglu, Emil / Engel, Jörgen A / Jerlhag, Elisabet

    PloS one

    2013  Volume 8, Issue 7, Page(s) e69010

    Abstract: Glucagon-like peptide 1 (GLP-1) is an incretine hormone that controls consummatory behavior and glucose homeostasis. It is released in response to nutrient ingestion from the intestine and production in the brain has also been identified. Given that GLP- ... ...

    Abstract Glucagon-like peptide 1 (GLP-1) is an incretine hormone that controls consummatory behavior and glucose homeostasis. It is released in response to nutrient ingestion from the intestine and production in the brain has also been identified. Given that GLP-1 receptors are expressed in reward areas, such as the nucleus accumbens and ventral tegmental area, and that common mechanisms regulate food and drug-induced reward we hypothesize that GLP-1 receptors are involved in reward regulation. Herein the effect of the GLP-1 receptor agonist Exendin-4 (Ex4), on amphetamine- and cocaine-induced activation of the mesolimbic dopamine system was investigated in mice. In a series of experiments we show that treatment with Ex4, at a dose with no effect per se, reduce amphetamine- as well as cocaine-induced locomotor stimulation, accumbal dopamine release as well as conditioned place preference in mice. Collectively these data propose a role for GLP-1 receptors in regulating drug reward. Moreover, the GLP-1 signaling system may be involved in the development of drug dependence since the rewarding effects of addictive drugs involves interferences with the mesolimbic dopamine system. Given that GLP-1 analogues, such as exenatide and liraglutide, are clinically available for treatment of type II diabetes, we propose that these should be elucidated as treatments of drug dependence.
    MeSH term(s) Amphetamine/pharmacology ; Animals ; Central Nervous System Stimulants/pharmacology ; Cocaine/pharmacology ; Exenatide ; Glucagon-Like Peptide 1/analogs & derivatives ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor ; Liraglutide ; Male ; Mice ; Motor Activity/drug effects ; Peptides ; Receptors, Glucagon/metabolism ; Venoms
    Chemical Substances Central Nervous System Stimulants ; Glp1r protein, mouse ; Glucagon-Like Peptide-1 Receptor ; Peptides ; Receptors, Glucagon ; Venoms ; Liraglutide (839I73S42A) ; Glucagon-Like Peptide 1 (89750-14-1) ; Exenatide (9P1872D4OL) ; Amphetamine (CK833KGX7E) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2013-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0069010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The glucagon-like peptide 1 analogue Exendin-4 attenuates the nicotine-induced locomotor stimulation, accumbal dopamine release, conditioned place preference as well as the expression of locomotor sensitization in mice.

    Egecioglu, Emil / Engel, Jörgen A / Jerlhag, Elisabet

    PloS one

    2013  Volume 8, Issue 10, Page(s) e77284

    Abstract: The gastrointestinal peptide glucagon-like peptide 1 (GLP-1) is known to regulate consummatory behavior and is released in response to nutrient ingestion. Analogues of this peptide recently emerged as novel pharmacotherapies for treatment of type II ... ...

    Abstract The gastrointestinal peptide glucagon-like peptide 1 (GLP-1) is known to regulate consummatory behavior and is released in response to nutrient ingestion. Analogues of this peptide recently emerged as novel pharmacotherapies for treatment of type II diabetes since they reduce gastric emptying, glucagon secretion as well as enhance glucose-dependent insulin secretion. The findings that GLP-1 targets reward related areas including mesolimbic dopamine areas indicate that the physiological role of GLP-1 extends beyond food intake and glucose homeostasis control to include reward regulation. The present series of experiments was therefore designed to investigate the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on established nicotine-induced effects on the mesolimbic dopamine system in mice. Specifically, we show that treatment with Ex4, at a dose with no effect per se, attenuate nicotine-induced locomotor stimulation, accumbal dopamine release as well as the expression of conditioned place preference in mice. In accordance, Ex4 also blocks nicotine-induced expression of locomotor sensitization in mice. Given that development of nicotine addiction largely depends on the effects of nicotine on the mesolimbic dopamine system these findings indicate that the GLP-1 receptor may be a potential target for the development of novel treatment strategies for nicotine cessations in humans.
    MeSH term(s) Animals ; Conditioning, Psychological/drug effects ; Dopamine/metabolism ; Eating/drug effects ; Exenatide ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor ; Incretins/pharmacology ; Limbic System/drug effects ; Limbic System/metabolism ; Male ; Mice ; Motor Activity/drug effects ; Nicotine/pharmacology ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Peptides/pharmacology ; Receptors, Glucagon/agonists ; Receptors, Glucagon/metabolism ; Reward ; Tobacco Use Disorder/drug therapy ; Tobacco Use Disorder/metabolism ; Tobacco Use Disorder/psychology ; Venoms/pharmacology
    Chemical Substances GLP1R protein, human ; Glp1r protein, mouse ; Glucagon-Like Peptide-1 Receptor ; Incretins ; Peptides ; Receptors, Glucagon ; Venoms ; Nicotine (6M3C89ZY6R) ; Glucagon-Like Peptide 1 (89750-14-1) ; Exenatide (9P1872D4OL) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2013-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0077284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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