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Article: Pursuing an Elusive Prostate Carcinoma: A Case Report Involving Multiparametric MR and CT-Guided Biopsy.

Olson, Dana O / Baisden, Joseph M / Groten, David L / Talug, Can

2019 Volume 12, Issue 3, Page(s) 737–741

Abstract: Prostate cancer is usually diagnosed when elevated PSA levels lead to a TRUS biopsy. We present a case in which there were several negative biopsies and a rising PSA. This led to a multiparametric MR (mpMRI) which demonstrated a large mass which ... ...

Abstract	Prostate cancer is usually diagnosed when elevated PSA levels lead to a TRUS biopsy. We present a case in which there were several negative biopsies and a rising PSA. This led to a multiparametric MR (mpMRI) which demonstrated a large mass which originated in the anterior transition zone and had extended through the anterior fibromuscular stroma and prostate capsule with a significant extra-prostatic component. The mass was successfully approached anteriorly with a CT-guided biopsy. The patient was subsequently successfully treated with radiotherapy utilizing MR in the planning process. This case report summarizes the utility of mpMRI in this clinical setting. For patients with high suspicion of prostate malignancy despite prior negative biopsies, it can identify tumor in locations not amenable to TRUS biopsy. It also is critical for accurate radiation treatment planning, allowing for increased confidence in tumor targeting as well as sparing sensitive normal tissue.
Language	English
Publishing date	2019-09-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000503096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pursuing an Elusive Prostate Carcinoma: A Case Report Involving Multiparametric MR and CT-Guided Biopsy

Olson, Dana O. / Baisden, Joseph M. / Groten, David L. / Talug, Can

Case Reports in Oncology

2019 Volume 12, Issue 3, Page(s) 737–741

Institution	Professional Imaging, Princeton, West Virginia, USA 21st Century Oncology of West Virginia, Princeton, West Virginia, USA Mercer Medical Group Urology, Princeton, West Virginia, USA
Abstract	Prostate cancer is usually diagnosed when elevated PSA levels lead to a TRUS biopsy. We present a case in which there were several negative biopsies and a rising PSA. This led to a multiparametric MR (mpMRI) which demonstrated a large mass which originated in the anterior transition zone and had extended through the anterior fibromuscular stroma and prostate capsule with a significant extra-prostatic component. The mass was successfully approached anteriorly with a CT-guided biopsy. The patient was subsequently successfully treated with radiotherapy utilizing MR in the planning process. This case report summarizes the utility of mpMRI in this clinical setting. For patients with high suspicion of prostate malignancy despite prior negative biopsies, it can identify tumor in locations not amenable to TRUS biopsy. It also is critical for accurate radiation treatment planning, allowing for increased confidence in tumor targeting as well as sparing sensitive normal tissue.
Keywords	Prostate adenocarcinoma ; mpMRI ; IMRT ; IGRT ; CT-guided biopsy
Language	English
Publishing date	2019-09-27
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Case Report ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
ZDB-ID	2458961-5
ISSN	1662-6575 ; 1662-6575
ISSN (online)	1662-6575
ISSN	1662-6575
DOI	10.1159/000503096
Database	Karger publisher's database

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Article ; Online: Helical tomotherapy simultaneous integrated boost provides a dosimetric advantage in the treatment of primary intracranial tumors.

Baisden, Joseph M / Sheehan, Jason / Reish, Andrew G / McIntosh, Alyson F / Sheng, Ke / Read, Paul W / Benedict, Stanley H / Larner, James M

Neurological research

2011 Volume 33, Issue 8, Page(s) 820–824

Abstract: Objective: The research quantitatively evaluates the dosimetric advantage of a helical tomotherapy (HT) intensity-modulated radiation therapy simultaneous integrated boost (SIB) compared to a conventional HT sequential (SEQ) boost for primary ... ...

Abstract	Objective: The research quantitatively evaluates the dosimetric advantage of a helical tomotherapy (HT) intensity-modulated radiation therapy simultaneous integrated boost (SIB) compared to a conventional HT sequential (SEQ) boost for primary intracranial tumors. Methods: Hypothetical lesions (planning target volumes or PTVs) were contoured within computed tomography scans from normal controls. A dose of 50 Gy was prescribed to the larger PTV1, while the boost PTV2 received a total of 60 Gy. HT SEQ and HT SIB plans were generated and compared. We evaluated the mean brain dose, the volume of normal brain receiving 45 Gy (V45), the volume of normal brain receiving 5 Gy (V5), and the integral dose. In addition, patients who were treated with the HT SEQ technique were replanned with the HT SIB technique and compared. Results: The average reduction in mean brain dose with the HT SIB plan compared to the composite HT SEQ plan was 11·0% [standard error (SE): 0·5]. The reductions in brains V45 and V5 were 43·7% (SE: 2·3) and 3·9% (SE: 0·6), respectively. The reduction in the integral dose was 11·0% (SE: 0·5). When comparing the SIB plan to the first 50 Gy only of the SEQ plan, there was only a 2·5% increase in the mean brain dose and a 2·9% increase in brain V45. This increase was dependent on the relative volumes of PTV2 and PTV1. These results were confirmed for the patient plans compared. Conclusions: Treating primary brain tumors with the HT SIB technique provides significant sparing of normal brain parenchyma compared to a conventional HT SEQ boost.
MeSH term(s)	Brain Neoplasms/radiotherapy ; Glioblastoma/radiotherapy ; Humans ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2011-10
Publishing country	England
Document type	Journal Article
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1179/1743132811Y.0000000035
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Zs.A 1491: Show issues

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Article ; Online: Helical TomoTherapy in the treatment of central nervous system metastasis.

Baisden, Joseph M / Benedict, Stanley H / Sheng, Ke / Read, Paul W / Larner, James M

Neurosurgical focus

2007 Volume 22, Issue 3, Page(s) E8

Abstract: In this report the authors review the use of radiotherapy in the treatment of central nervous system (CNS) metastasis. They comment on different treatment methods for both intracranial and extracranial CNS metastasis and discuss some of the evidence ... ...

Abstract	In this report the authors review the use of radiotherapy in the treatment of central nervous system (CNS) metastasis. They comment on different treatment methods for both intracranial and extracranial CNS metastasis and discuss some of the evidence supporting the use of radiotherapy in these settings. Recent advancements in radiation oncology technology are briefly reviewed with a focus on the advantages and disadvantages of helical TomoTherapy-based treatment strategies. A review of pertinent current literature was performed. TomoTherapy research currently underway at the University of Virginia Health System is discussed and a representative case is presented. Radiotherapy for CNS metastasis is an effective treatment that provides palliation of symptoms and confers a survival advantage on selected patients. Advances in radiotherapy techniques continue to improve the therapeutic ratio for patients with CNS metastases. Helical TomoTherapy offers distinct advantages for patients with CNS metastatic disease by sparing normal tissue when intracranial or extracranial disease is targeted.
MeSH term(s)	Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Humans ; Neoplasm Metastasis/radiotherapy ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Recurrence, Local/radiotherapy ; Radiation Dosage ; Radiotherapy, Conformal/instrumentation ; Radiotherapy, Conformal/methods ; Radiotherapy, Conformal/standards ; Tomography, Spiral Computed/methods ; Tomography, Spiral Computed/trends ; Treatment Outcome
Language	English
Publishing date	2007-03-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/foc.2007.22.3.9
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Article: Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance imaging.

Cai, Jing / Read, Paul W / Baisden, Joseph M / Larner, James M / Benedict, Stanley H / Sheng, Ke

International journal of radiation oncology, biology, physics

2007 Volume 69, Issue 3, Page(s) 895–902

Abstract: Purpose: To evaluate the error in four-dimensional computed tomography (4D-CT) maximal intensity projection (MIP)-based lung tumor internal target volume determination using a simulation method based on dynamic magnetic resonance imaging (dMRI).: ... ...

Abstract	Purpose: To evaluate the error in four-dimensional computed tomography (4D-CT) maximal intensity projection (MIP)-based lung tumor internal target volume determination using a simulation method based on dynamic magnetic resonance imaging (dMRI). Methods and materials: Eight healthy volunteers and six lung tumor patients underwent a 5-min MRI scan in the sagittal plane to acquire dynamic images of lung motion. A MATLAB program was written to generate re-sorted dMRI using 4D-CT acquisition methods (RedCAM) by segmenting and rebinning the MRI scans. The maximal intensity projection images were generated from RedCAM and dMRI, and the errors in the MIP-based internal target area (ITA) from RedCAM (epsilon), compared with those from dMRI, were determined and correlated with the subjects' respiratory variability (nu). Results: Maximal intensity projection-based ITAs from RedCAM were comparatively smaller than those from dMRI in both phantom studies (epsilon = -21.64% +/- 8.23%) and lung tumor patient studies (epsilon = -20.31% +/- 11.36%). The errors in MIP-based ITA from RedCAM correlated linearly (epsilon = -5.13nu - 6.71, r(2) = 0.76) with the subjects' respiratory variability. Conclusions: Because of the low temporal resolution and retrospective re-sorting, 4D-CT might not accurately depict the excursion of a moving tumor. Using a 4D-CT MIP image to define the internal target volume might therefore cause underdosing and an increased risk of subsequent treatment failure. Patient-specific respiratory variability might also be a useful predictor of the 4D-CT-induced error in MIP-based internal target volume determination.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Movement ; Observer Variation ; Phantoms, Imaging ; Respiration ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2007-11-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2007.07.2322
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Zs.A 1218: Show issues

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Article: Multimodality Treatment With Helical Tomotherapy Intensity Modulated Radiotherapy, Capecitabine, and Photodynamic Therapy is Feasible and Well Tolerated in Patients With Hilar Cholangiocarcinoma.

Baisden, Joseph M / Kahaleh, Michel / Weiss, Geoffrey R / Sanfey, Hilary / Moskaluk, Christopher A / Yeaton, Paul / de Lange, Eduard E / Rich, Tyvin A

Gastrointestinal cancer research : GCR

2009 Volume 2, Issue 5, Page(s) 219–224

Abstract: Background and purpose: Unresectable cholangiocarcinoma is an intractable disease marked by recurrent bouts of biliary obstruction and infection. Traditional treatment methods provide only symptomatic relief and no proven survival advantage. We assessed ...

Abstract	Background and purpose: Unresectable cholangiocarcinoma is an intractable disease marked by recurrent bouts of biliary obstruction and infection. Traditional treatment methods provide only symptomatic relief and no proven survival advantage. We assessed the tolerability of helical tomotherapy intensity modulated radiotherapy (IMRT) with concurrent capecitabine and photodynamic therapy (PDT) in patients with unresectable hilar cholangiocarcinoma. Methods: Ten patients with unresectable hilar cholangiocarcinoma were treated with helical tomotherapy IMRT. An accelerated dose of 50 Gy in 20 fractions (2.5 Gy/fraction) was used. Planning target volume (PTV) consisted of a 1.5 cm radial expansion and a 2 cm craniocaudal expansion of the magnetic resonance imaging and/or contrast enhanced computed tomography-defined gross target volume. PTV ranged from 123 cc to 693 cc (mean 349 cc). Concurrent chronomodulated capecitabine was administered on days of irradiation. Six patients received PDT. Results: All patients developed side effects, including grade 2 nausea, and 9 of 10 experienced mild fatigue. Patients lost 3% of their body weight on average. Three patients required brief hospital admission and stent revision for cholangitis during chemoradiotherapy. Capecitabine was discontinued in one patient and decreased in dose for another due to increasing liver enzymes. Median overall survival was 13 months, and median disease-free survival was 10 to 11 months. One patient underwent successful cadaveric liver transplant after chemoradiotherapy and remains disease free 2 years later. Conclusions: Concurrent chemoradiotherapy with helical tomotherapy IMRT and capecitabine in conjunction with PDT is well tolerated in patients with hilar cholangiocarcinoma.
Language	English
Publishing date	2009-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483324-1
ISSN	1934-7987 ; 1934-7820
ISSN (online)	1934-7987
ISSN	1934-7820
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Article ; Online: Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy.

Yang, Wensha / Read, Paul W / Mi, Jun / Baisden, Joseph M / Reardon, Kelli A / Larner, James M / Helmke, Brian P / Sheng, Ke

International journal of radiation oncology, biology, physics

2008 Volume 72, Issue 3, Page(s) 633–635

Abstract: Purpose: It has been proposed that quantum dots (QDs) can be used to excite conjugated photosensitizers and produce cytotoxic singlet oxygen. To study the potential of using such a conjugate synergistically with radiotherapy to enhance cell killing, we ... ...

Abstract	Purpose: It has been proposed that quantum dots (QDs) can be used to excite conjugated photosensitizers and produce cytotoxic singlet oxygen. To study the potential of using such a conjugate synergistically with radiotherapy to enhance cell killing, we investigated the energy transfer from megavoltage (MV) X-rays to a photosensitizer using QDs as the mediator and quantitated the enhancement in cell killing. Methods and materials: The photon emission efficiency of QDs on excitation by 6-MV X-rays was measured using dose rates of 100-600 cGy/min. A QD-Photofrin conjugate was synthesized by formation of an amide bond. The role of Förster resonance energy transfer in the energy transferred to the Photofrin was determined by measuring the degree of quenching at different QD/Photofrin molar ratios. The enhancement of H460 human lung carcinoma cell killing by radiation in the presence of the conjugates was studied using a clonogenic survival assay. Results: The number of visible photons generated from QDs excited by 6-MV X-rays was linearly proportional to the radiation dose rate. The Förster resonance energy transfer efficiency approached 100% as the number of Photofrin molecules conjugated to the QDs increased. The combination of the conjugate with radiation resulted in significantly lower H460 cell survival in clonogenic assays compared with radiation alone. Conclusion: The novel QD-Photofrin conjugate shows promise as a mediator for enhanced cell killing through a linear and highly efficient energy transfer from X-rays to Photofrin.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung ; Cell Line, Tumor ; Cell Survival/radiation effects ; Dihematoporphyrin Ether ; Ferric Compounds ; Fluorescence Resonance Energy Transfer/methods ; Humans ; Lung Neoplasms ; Photons ; Photosensitizing Agents ; Polyethylene Glycols ; Quantum Dots ; Quantum Theory ; Radiotherapy/methods ; Radiotherapy, Conformal/methods ; X-Rays
Chemical Substances	Ferric Compounds ; Photosensitizing Agents ; ferric oxide (1K09F3G675) ; Polyethylene Glycols (30IQX730WE) ; Dihematoporphyrin Ether (97067-70-4)
Language	English
Publishing date	2008-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2008.06.1916
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Article: Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.

Gatesman, Amanda / Walker, Valerie G / Baisden, Joseph M / Weed, Scott A / Flynn, Daniel C

Molecular and cellular biology

2004 Volume 24, Issue 17, Page(s) 7578–7597

Abstract: We report that the actin filament-associated protein AFAP-110 is required to mediate protein kinase Calpha (PKCalpha) activation of the nonreceptor tyrosine kinase c-Src and the subsequent formation of podosomes. Immunofluorescence analysis demonstrated ... ...

Abstract	We report that the actin filament-associated protein AFAP-110 is required to mediate protein kinase Calpha (PKCalpha) activation of the nonreceptor tyrosine kinase c-Src and the subsequent formation of podosomes. Immunofluorescence analysis demonstrated that activation of PKCalpha by phorbol 12-myristate 13-acetate (PMA), or ectopic expression of constitutively activated PKCalpha, directs AFAP-110 to colocalize with and bind to the c-Src SH3 domain, resulting in activation of the tyrosine kinase. Activation of c-Src then directs the formation of podosomes, which contain cortactin, AFAP-110, actin, and c-Src. In a cell line (CaOV3) that has very little or no detectable AFAP-110, PMA treatment was unable to activate c-Src or effect podosome formation. Ectopic expression of AFAP-110 in CaOV3 cells rescued PKCalpha-mediated activation of c-Src and elevated tyrosine phosphorylation levels and subsequent formation of podosomes. Neither expression of activated PKCalpha nor treatment with PMA was able to induce these changes in CAOV3 cells expressing mutant forms of AFAP-110 that are unable to bind to, or colocalize with, c-Src. We hypothesize that one major function of AFAP-110 is to relay signals from PKCalpha that direct the activation of c-Src and the formation of podosomes.
MeSH term(s)	Actins/metabolism ; Animals ; Antibodies, Phospho-Specific/metabolism ; Cell Line ; Cell Surface Extensions/metabolism ; Enzyme Activation ; Humans ; Immunohistochemistry ; Indoles/metabolism ; Maleimides/metabolism ; Microfilament Proteins/metabolism ; Phosphoproteins/metabolism ; Protein Binding ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Protein Kinase C-alpha ; Proto-Oncogene Proteins pp60(c-src)/genetics ; Proto-Oncogene Proteins pp60(c-src)/metabolism ; Recombinant Fusion Proteins/metabolism ; Tetradecanoylphorbol Acetate/metabolism ; Tyrosine/metabolism
Chemical Substances	AFAP 110 ; Actins ; Antibodies, Phospho-Specific ; Indoles ; Maleimides ; Microfilament Proteins ; Phosphoproteins ; Recombinant Fusion Proteins ; Tyrosine (42HK56048U) ; Proto-Oncogene Proteins pp60(c-src) (EC 2.7.10.2) ; PRKCA protein, human (EC 2.7.11.13) ; Protein Kinase C (EC 2.7.11.13) ; Protein Kinase C-alpha (EC 2.7.11.13) ; bisindolylmaleimide (MBK3OO5K8T) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.24.17.7578-7597.2004
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Zs.A 1666: Show issues

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Article: Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasis.

Baisden, Joseph M / Reish, Andrew G / Sheng, Ke / Larner, James M / Kavanagh, Brian D / Read, Paul W

International journal of radiation oncology, biology, physics

2006 Volume 66, Issue 2, Page(s) 620–625

Abstract: Purpose: Stereotactic body radiation therapy (SBRT) has been shown to be an effective, well-tolerated treatment for local control of tumors metastatic to the liver. Multi-institutional Phase II trials are examining 60 Gy in 3 fractions delivered by ... ...

Abstract	Purpose: Stereotactic body radiation therapy (SBRT) has been shown to be an effective, well-tolerated treatment for local control of tumors metastatic to the liver. Multi-institutional Phase II trials are examining 60 Gy in 3 fractions delivered by linac-based, 3D-conformal IMRT. HiArt Helical TomoTherapy is a treatment unit that delivers co-planar helical IMRT that is capable of image-guided SBRT. We hypothesized that the maximum tolerable dose (MTD) delivered to a lesion by Helical TomoTherapy-based SBRT could be predicted based on the planning target volume (PTV) and liver volume. Methods and materials: To test this, we performed inverse treatment planning and analyzed the dosimetry for multiple hypothetical liver gross tumor volumes (GTV) with conventional PTV expansions. Inverse planning was carried out to find the maximum tolerated SBRT dose up to 60 Gy to be delivered in 3 fractions based on the dose constraint that 700 cc of normal liver would receive less than 15 Gy. Results: Regression analysis indicated a linear relationship between the MTD, the PTV and the liver volume, supporting our hypothesis. A predictive equation was generated, which was found to have an accuracy of +/-3 Gy. In addition, dose constraints based on proximity to other normal tissues were tested. Inverse planning for PTVs located at varying distances from the heart, small bowel, and spinal cord revealed a predictable decrease in the MTD as the PTV increased in size or approached normal organs. Conclusions: These data provide a framework for predicting the likely MTD for patients considered for Helical TomoTherapy liver SBRT.
MeSH term(s)	Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/secondary ; Models, Biological ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Stereotaxic Techniques ; Tomography, Spiral Computed
Language	English
Publishing date	2006-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2006.05.034
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Article: Treating osteoporotic and neoplastic vertebral compression fractures with vertebroplasty and kyphoplasty.

Hacein-Bey, Lotfi / Baisden, Jamie L / Lemke, Denise M / Wong, Stuart J / Ulmer, John L / Cusick, Joseph F

Journal of palliative medicine

2005 Volume 8, Issue 5, Page(s) 931–938

Abstract: Background: Compression fractures are common in patients with osteoporosis and cancer. In particular, vertebral compression fractures are crippling, and pose an additional risk of cord compression. Although a number of nonmedical options such as bracing ...

Abstract	Background: Compression fractures are common in patients with osteoporosis and cancer. In particular, vertebral compression fractures are crippling, and pose an additional risk of cord compression. Although a number of nonmedical options such as bracing and exercise programs may help these patients, the combination of constant, severe pain and spinal instability was until recently almost invariably synonymous with painful gradual deterioration and a poor quality of life. Vertebroplasty, and more recently kyphoplasty, are minimally invasive procedures that aim at limiting or reversing painful collapse of the vertebrae, while providing stability to the treated segment of the spine. As these new options are highly effective and involve minimal risk, it is important that physicians be familiar with them. Objective: This paper reviews the demographics of vertebral compression fractures, both osteoporotic and neoplastic, the technical aspects of vertebroplasty and kyphoplasty, and current results and outcomes. Results: Pain relief rates in excess of 90% have been reported with both vertebroplasty and kyphoplasty in patients with vertebral compression fractures. Procedural complication rates should be very low, in the 1%-2% range at most with proper technique. Conclusions: Until the advent of vertebroplasty, almost no effective therapeutic option could be offered to patients suffering from neoplastic or osteoporotic vertebral compression fractures, which are relatively common and often crippling. The technical feasibility of these procedures is high, the risk low, and the effectiveness high. Therefore, it is important that physicians consider vertebroplasty and kyphoplasty as viable and strong options.
MeSH term(s)	Fractures, Compression/etiology ; Fractures, Compression/surgery ; Humans ; Minimally Invasive Surgical Procedures ; Neoplasms/complications ; Orthopedic Procedures/methods ; Osteoporosis/complications ; Postoperative Complications ; Spinal Fractures/etiology ; Spinal Fractures/surgery
Language	English
Publishing date	2005-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1427361-5
ISSN	1096-6218
ISSN	1096-6218
DOI	10.1089/jpm.2005.8.931
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