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  1. Article ; Online: Naevoid miliaria profunda, successfully treated with botulinum toxin.

    Berry, William / D'Arcy, Colleen / Welsh, Belinda / Orchard, David / Bekhor, Philip S / Robertson, Susan J

    The Australasian journal of dermatology

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ramsar, Iran, as a Natural Radiobiological Surrogate for Mars.

    Welsh, James S / Bevelacqua, Joseph J / Mortazavi, S M J

    Health physics

    2022  Volume 122, Issue 4, Page(s) 508–512

    Abstract: Abstract: Terrestrial experiments involving acute exposures of low-LET radiation on inbred lab animals are quick, simple, and inexpensive but are relatively uninformative about the real radiobiological hazards of planned manned space missions. A more ... ...

    Abstract Abstract: Terrestrial experiments involving acute exposures of low-LET radiation on inbred lab animals are quick, simple, and inexpensive but are relatively uninformative about the real radiobiological hazards of planned manned space missions. A more predictive model could involve human beings chronically exposed to "space-like" high-LET radiation. Such radiation exposure has been ongoing for thousands of years in Ramsar, Iran, and some other high-LET high background radiation regions on Earth. Examining the health of Ramsar residents can be illuminating and potentially relevant to space missions.
    MeSH term(s) Animals ; Iran ; Mars ; Radiation Exposure ; Radiobiology ; Space Flight
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2406-5
    ISSN 1538-5159 ; 0017-9078
    ISSN (online) 1538-5159
    ISSN 0017-9078
    DOI 10.1097/HP.0000000000001521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Care of Patients with Neurocognitive Disorders: A Qualitative Study of the Psychiatric Residency Training Experience.

    Duong, Karen T / Khasnavis, Siddharth / Welsh, William J / Camp, Mary E

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2024  Volume 48, Issue 2, Page(s) 143–147

    Abstract: Objective: Few data describe how general psychiatry residencies prepare trainees to care for individuals with neurocognitive disorders (NCDs), despite increasing recognition of the need for psychiatrists to provide care for the growing numbers of ... ...

    Abstract Objective: Few data describe how general psychiatry residencies prepare trainees to care for individuals with neurocognitive disorders (NCDs), despite increasing recognition of the need for psychiatrists to provide care for the growing numbers of patients with NCD. This study aims to identify training needs and approaches, as the resident experience is one important perspective that can be added to others, such as milestones developed by expert educators.
    Methods: The authors conducted three focus groups of third- and fourth-year general adult psychiatry residency trainees from three different training programs in May and June of 2021. Focus groups consisted of three to eight unique participants per group. Qualitative data analysis techniques derived in grounded theory were utilized to identify themes.
    Results: Four main themes emerged from the focus groups: unique challenges of NCD care, intrinsic rewards of working with families, perceived gaps in educational experiences, and limited comfort in future practice.
    Conclusions: Participants expressed that aspects of NCD care were fundamentally different than care for other mental health conditions encountered in psychiatry residency. They found the progressive nature of the disease to be particularly challenging, and they also expressed challenges with clinical interviews and establishing rapport with individuals with NCDs. However, working with families was especially rewarding. Regardless of training program, participants expressed a need for additional longitudinal and diversified training opportunities to prepare them for future practice in this area.
    MeSH term(s) Adult ; Humans ; Internship and Residency ; Qualitative Research ; Education, Medical ; Focus Groups ; Neurocognitive Disorders
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-023-01932-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Regard to Papachristofilou et al.

    Bevelacqua, Joseph J / Welsh, James S / Mortazavi, S M J

    International journal of radiation oncology, biology, physics

    2021  Volume 110, Issue 5, Page(s) 1550–1551

    MeSH term(s) Humans ; Radiotherapy Dosage
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Revisiting radiation hormesis: should lung adenocarcinoma patients be advised to reduce radon levels in their environment?

    Welsh, James S / Bevelacqua, Joseph J / Mortazavi, S M J

    International journal of radiation biology

    2021  Volume 97, Issue 7, Page(s) 875–876

    MeSH term(s) Adenocarcinoma of Lung/radiotherapy ; Environment ; Hormesis/radiation effects ; Humans ; Radon/adverse effects
    Chemical Substances Radon (Q74S4N8N1G)
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Letter
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2021.1928788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Regarding: "the risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case".

    Bevelacqua, Joseph J / Welsh, James S / Mortazavi, S M J

    International journal of radiation biology

    2021  Volume 97, Issue 3, Page(s) 313–314

    MeSH term(s) COVID-19 ; Humans ; Lung ; Myocardial Ischemia/etiology ; Neoplasms ; SARS-CoV-2
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2021.1864502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase.

    Fanelli, Matthew J / Welsh, Christofer M / Lui, Dominique S / Smulan, Lorissa J / Walker, Amy K

    Science advances

    2023  Volume 9, Issue 49, Page(s) eadi5545

    Abstract: Infection response and other immunity-linked genes (ILGs) were first named ... ...

    Abstract Infection response and other immunity-linked genes (ILGs) were first named in
    MeSH term(s) Animals ; GTP Phosphohydrolases/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Golgi Apparatus/metabolism ; ADP-Ribosylation Factor 1/genetics ; ADP-Ribosylation Factor 1/metabolism ; Biological Transport
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; ADP-Ribosylation Factor 1 (EC 3.6.5.2)
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi5545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Observation versus intervention for incidental common bile duct stones at intraoperative cholangiogram: a systematic review.

    Crichton, J / Cox, S / Tong, C / Leow, P / Field, X / Welsh, F

    ANZ journal of surgery

    2023  Volume 93, Issue 7-8, Page(s) 1839–1846

    Abstract: Background: The natural history of incidental common bile duct stones (CBDS) is poorly understood. Current evidence is conflicting, with several studies suggesting the majority may pass spontaneously. Despite this, guidelines recommend routine removal ... ...

    Abstract Background: The natural history of incidental common bile duct stones (CBDS) is poorly understood. Current evidence is conflicting, with several studies suggesting the majority may pass spontaneously. Despite this, guidelines recommend routine removal even if asymptomatic. This study aimed to systematically review the outcomes of expectant management for CBDS detected on operative cholangiography during cholecystectomy.
    Methods: MEDLINE, Embase and CINAHL databases were systematically searched. Participants were adult patients with CBDS identified by intraoperative cholangiography. Intervention was regarded as any perioperative effort to remove common bile duct stones, including endoscopic retrograde cholangiopancreatography (ERCP), laparoscopic and open bile duct exploration. This was compared to observation. Outcomes of interest included rates of spontaneous stone passage, success of duct clearance and complications. Risk of bias was assessed using the ROBINS-I tool.
    Results: Eight studies were included. All studies were non-randomized, heterogeneous and at serious risk of bias. In patients observed after a positive IOC, 20.9% went on to have symptomatic retained stones. In patients directed to ERCP for positive IOC, persistent CBDS were found in 50.6%. Spontaneous passage was not associated with stone size. Meta-analysis is dominated by the results from one large database, which recommends intervention for incidental stones, despite low rates of persistent stones seen at postoperative ERCP.
    Conclusions: Further evidence is required before a definitive recommendation on observation can be made. There is some evidence that asymptomatic stones may be safely observed. In clinical scenarios where the risks of biliary intervention are considered high, a conservative strategy could be more widely considered.
    MeSH term(s) Adult ; Humans ; Cholangiography/methods ; Cholangiopancreatography, Endoscopic Retrograde ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystectomy, Laparoscopic/methods ; Choledocholithiasis/diagnostic imaging ; Choledocholithiasis/surgery ; Choledocholithiasis/complications ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/surgery ; Gallstones/diagnostic imaging ; Gallstones/surgery ; Gallstones/complications
    Language English
    Publishing date 2023-06-28
    Publishing country Australia
    Document type Journal Article ; Systematic Review
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A qualitative study assessing allied health provider perceptions of telepractice functionality in therapy delivery for people with disability.

    Benz, Cloe / Dantas, Jaya / Welsh, Mai / Norman, Richard / Robinson, Suzanne / Hendrie, Delia

    Health expectations : an international journal of public participation in health care and health policy

    2024  Volume 27, Issue 1, Page(s) e13988

    Abstract: Introduction: Telepractice service delivery of allied health interventions to people with disability can potentially reduce access barriers and improve service equity. However, questions remain regarding telepractice functionality for people with ... ...

    Abstract Introduction: Telepractice service delivery of allied health interventions to people with disability can potentially reduce access barriers and improve service equity. However, questions remain regarding telepractice functionality for people with disability. This study addressed questions related to how allied health clinicians and managers perceive telepractice as functioning in the provision of therapy services to people with disability.
    Methods: Thirteen interviews of allied health clinicians and managers from across Australia were conducted between 21 November and 22 February via MS teams. Qualitative methodology and critical realist theoretical paradigm underpin the study. Data analysis was completed using a reflective thematic analysis method and five themes were generated and described utilising an analytic metaphor.
    Results: The study themes were described in relation to a shopping for shoes analytic metaphor and the five themes included (1) a shoe for every foot, (2) planned purchases, (3) shoe on the other foot, (4) you need both shoes and (5) help choosing their shoes. In summary, the function of telepractice fits differently for each individual, similar to pairs of shoes.
    Conclusions: Telepractice has its own strengths and weaknesses and isn't a direct substitute for in-person sessions, much like left and right shoes are similar but not the same. The results support participant perceptions that telepractice functions best as an adjunct to in-person sessions through a flexible hybrid delivery model in the provision of therapy services to people with a disability. A strategy for improving perceived usefulness may involve positioning telepractice as unique with strengths and weaknesses, not replacing in-person care.
    Patient or public contribution: The paper forms part of a larger codesign process which included customer and carer participants throughout the design and planning of the project, inclusion of a peer researcher, and the selection of the analytic metaphor including in the findings of this article production.
    MeSH term(s) Humans ; Disabled Persons ; Australia ; Qualitative Research
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2119434-8
    ISSN 1369-7625 ; 1369-6513
    ISSN (online) 1369-7625
    ISSN 1369-6513
    DOI 10.1111/hex.13988
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  10. Article ; Online: H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity.

    Welsh, Robin A / Song, Nianbin / Park, Chan-Su / Peske, J David / Sadegh-Nasseri, Scheherazade

    Frontiers in immunology

    2024  Volume 14, Page(s) 1304798

    Abstract: Regulatory T cells (Treg) are crucial immune modulators, yet the exact mechanism of thymic Treg development remains controversial. Here, we present the first direct evidence for H2-O, an MHC class II peptide editing molecular chaperon, on selection of ... ...

    Abstract Regulatory T cells (Treg) are crucial immune modulators, yet the exact mechanism of thymic Treg development remains controversial. Here, we present the first direct evidence for H2-O, an MHC class II peptide editing molecular chaperon, on selection of thymic Tregs. We identified that lack of H2-O in the thymic medulla promotes thymic Treg development and leads to an increased peripheral Treg frequency. Single-cell RNA-sequencing (scRNA-seq) analysis of splenic CD4 T cells revealed not only an enrichment of effector-like Tregs, but also activated CD4 T cells in the absence of H2-O. Our data support two concepts; a) lack of H2-O expression in the thymic medulla creates an environment permissive to Treg development and, b) that loss of H2-O drives increased basal auto-stimulation of CD4 T cells. These findings can help in better understanding of predispositions to autoimmunity and design of therapeutics for treatment of autoimmune diseases.
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; Lymphocyte Activation/genetics ; T-Lymphocytes, Regulatory ; Histocompatibility Antigens Class II ; Autoimmune Diseases ; Cell Differentiation
    Chemical Substances Histocompatibility Antigens Class II
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1304798
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