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  1. Article ; Online: Minimally Invasive Surgery Using a Shannon Burr for the Treatment of Hallux Valgus Deformity: A Systematic Review.

    Gonzalez, Tyler / Encinas, Rodrigo / Johns, William / Benjamin Jackson, J

    Foot & ankle orthopaedics

    2023  Volume 8, Issue 1, Page(s) 24730114221151069

    Abstract: ... literature on MIS hallux valgus correction in studies reporting the use of the Shannon burr with distal ... published from 2008 to 2022 and included the use of the Shannon burr during distal metatarsal osteotomies ... for the treatment of hallux valgus using the Shannon burr appears to be a safe and effective therapy ...

    Abstract Background: Recently there has been an increase in minimally invasive surgery (MIS) for the correction of hallux valgus deformity. This systematic review aims to evaluate and present the current literature on MIS hallux valgus correction in studies reporting the use of the Shannon burr with distal metatarsal osteotomies to help establish evidence-based guidelines for surgeons using this technique.
    Methods: Two independent authors performed a systematic literature search using the following databases: PubMed, Embase, and the Cochrane library. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol and the Cochrane Handbook guidelines were followed. All studies included were published from 2008 to 2022 and included the use of the Shannon burr during distal metatarsal osteotomies MIS for hallux valgus and at least 12-month follow-up. The MINORS score criteria was used to evaluate the strength and quality of 17 studies by 3 authors. Statistical analysis and meta-analysis were not performed because of the heterogeneity of the included studies and the data being descriptive.
    Results: A total of 17 studies were reviewed. A total of 911 subjects were included, and 1088 MIS procedures were performed. The average follow-up was 23.8 (12-59.1) months. American Orthopaedic Foot & Ankle Society scale and visual analog scale scores improved from 52.1 (41-62.5) to 90.3 (83.3-97.1) and 4.9 (3-8.2) to 0.8 (0-1.9). Satisfaction rates were very high among the studies that reported it. The hallux valgus angle, intermetatarsal angle, and distal metatarsal articular angle improved from 31.4 (23.5-44.1) to 11.1 (7-17.2), 13.4 (8.1-18.6) to 7.3 (4.2-10.3), and 12.3 (9-16.3) to 4.1 (1-6.7), respectively. The complication rate was 16.6%, and recurrence was 2.2%. Nonunion comprised 0.4%, infections 1.1%, nerve injury 2.2%, avascular necrosis 0%, hallux varus 0.09%, transfer metatarsalgia 0.1%, and hardware removal 6.2%.
    Conclusion: MIS for the treatment of hallux valgus using the Shannon burr appears to be a safe and effective therapy, with appropriate correction of the hallux valgus deformity, improvement in functional outcomes, high patient satisfaction, low recurrence, and acceptable complication rates.
    Level of evidence: Level II, systematic review.
    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2473-0114
    ISSN (online) 2473-0114
    DOI 10.1177/24730114221151069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vectors of shannon information from fourier signals characterizing base periodicity in genes and genomes.

    Jackson, J H / George, R / Herring, P A

    Biochemical and biophysical research communications

    2000  Volume 268, Issue 2, Page(s) 289–292

    Abstract: ... a conversion of the FTES signals to a common platform of Shannon information content to facilitate comparisons ... a vector equation to express the Shannon information content of a sequence in a way that preserves ...

    Abstract Equal Symbol Fourier Transforms (FTES), characterizing nucleotide periodicity, comprise components of 5-D vectors that define base-repeat properties of a genomic sequence. This report describes a conversion of the FTES signals to a common platform of Shannon information content to facilitate comparisons of periodic data with other measures of information for genes and genomes. The autocorrelation used to compute the discrete FTES formed the basis to define repeating bases in terms of conditional probabilities. We derived a vector equation to express the Shannon information content of a sequence in a way that preserves the distinct specificity of base repeat patterns characterized by FTES vectors. We suggest application of such information vectors to study the structure of information in genes, chromosomes, and genomes by chi(2) comparisons.
    MeSH term(s) Animals ; Fourier Analysis ; Genes ; Humans ; Mathematical Computing ; Models, Chemical ; Repetitive Sequences, Nucleic Acid
    Language English
    Publishing date 2000-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1006/bbrc.2000.2112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Shake it off: A curious case of rigors.

    Han, Shannon / John, Sherin / Jackson, Christopher D

    Journal of the National Medical Association

    2023  Volume 115, Issue 3, Page(s) 333–336

    Abstract: Heparin-induced Anaphylactoid reactions are rare systemic reactions to heparin exposure. Although the exact pathogenesis of the reaction is unclear, in vivo platelet activation from inflammation may play a role. The reaction involves anti-platelet factor ...

    Abstract Heparin-induced Anaphylactoid reactions are rare systemic reactions to heparin exposure. Although the exact pathogenesis of the reaction is unclear, in vivo platelet activation from inflammation may play a role. The reaction involves anti-platelet factor 4, a common factor also noted to be involved in heparin-induced thrombocytopenia (HIT). Like HIT, prompt identification of the reaction, immediate discontinuation of heparin, and supportive care are the mainstays of treatment to avoid severe and potentially fatal outcomes. Previous cases have described heparin-induced anaphylactoid reactions in the setting of heparin-induced thrombocytopenia. However, we will present a case of an isolated heparin-induced anaphylactoid reaction without HIT.
    MeSH term(s) Humans ; Anticoagulants/adverse effects ; Anaphylaxis/chemically induced ; Anaphylaxis/complications ; Heparin/adverse effects ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Perinatal social work during the Covid-19 pandemic: Reflecting on concepts of time and liminality.

    Wilson, Elaine / Jackson, Kaylene / Shannon, Aoife

    Qualitative social work : QSW : research and practice

    2021  Volume 20, Issue 1-2, Page(s) 443–448

    Abstract: This article reflects upon the experiences of two perinatal, hospital social workers during the unprecedented time of the Covid-19 in Ireland, as discussed with their academic colleague. This encounter revealed the complexity of service delivery that ... ...

    Abstract This article reflects upon the experiences of two perinatal, hospital social workers during the unprecedented time of the Covid-19 in Ireland, as discussed with their academic colleague. This encounter revealed the complexity of service delivery that emerged, when managing the needs of vulnerable clients whilst being mindful of personal safety. One of the social workers was pregnant so was conscious of possible risks to her unborn child, as well as her young family at home. The second social worker, her line manager, discusses the dilemmas associated with the management of risk when allocating staff to contexts where they would be in direct contact with Covid-19. At the core of the analysis of these situations is the notion of liminal space and the realisation that time appears to have a new meaning; what we once knew as normal no longer exists, but we have yet to reach the 'new normal'.
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073436-0
    ISSN 1741-3117 ; 1473-3250
    ISSN (online) 1741-3117
    ISSN 1473-3250
    DOI 10.1177/1473325020973306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Bluetooth-Based Smartphone App for Detecting Peer Proximity: Protocol for Evaluating Functionality and Validity.

    Barnett, Nancy P / Sokolovsky, Alexander W / Meisel, Matthew K / Forkus, Shannon R / Jackson, Kristina M

    JMIR research protocols

    2024  Volume 13, Page(s) e50241

    Abstract: Background: While ecological momentary assessment (EMA) is commonly used to study social contexts and social influence in the real world, EMA almost exclusively relies on participant self-report of present circumstances, including the proximity to ... ...

    Abstract Background: While ecological momentary assessment (EMA) is commonly used to study social contexts and social influence in the real world, EMA almost exclusively relies on participant self-report of present circumstances, including the proximity to influential peers. There is the potential for developing a proximity sensing approach that uses small Bluetooth beacons and smartphone-based detection and data collection to collect information about interactions between individuals passively in real time.
    Objective: This paper aims to describe the methods for evaluating the functionality and validity of a Bluetooth-based beacon and a smartphone app to identify when ≥2 individuals are physically proximal.
    Methods: We will recruit 20 participants aged 18 to 29 years with Android smartphones to complete a 3-week study during which beacon detection and self-report data will be collected using a smartphone app (MEI Research). Using an interviewer-administered social network interview, participants will identify up to 3 peers of the same age who are influential on health behavior (alcohol use in this study). These peers will be asked to carry a Bluetooth beacon (Kontakt asset tag) for the duration of the study; each beacon has a unique ID that, when detected, will be recorded by the app on the participant's phone. Participants will be prompted to respond to EMA surveys (signal-contingent reports) when a peer beacon encounter meets our criteria and randomly 3 times daily (random reports) and every morning (morning reports) to collect information about the presence of peers. In all reports, the individualized list of peers will be presented to participants, followed by questions about peer and participant behavior, including alcohol use. Data from multiple app data sets, including beacon encounter specifications, notification, and app logs, participant EMA self-reports and postparticipation interviews, and peer surveys, will be used to evaluate project goals. We will examine the functionality of the technology, including the stability of the app (eg, app crashes and issues opening the app), beacon-to-app detection (ie, does the app detect proximal beacons?), and beacon encounter notification when encounter criteria are met. The validity of the technology will be defined as the concordance between passive detection of peers via beacon-to-app communication and the participant's EMA report of peer presence. Disagreement between the beacon and self-report data (ie, false negatives and false positives) will be investigated in multiple ways (ie, to determine if the reason was technology-related or participant compliance-related) using encounter data and information collected from participants and peers.
    Results: Participant recruitment began in February 2023, and enrollment was completed in December 2023. Results will be reported in 2025.
    Conclusions: This Bluetooth-based technology has important applications and clinical implications for various health behaviors, including the potential for just-in-time adaptive interventions that target high-risk behavior in real time.
    International registered report identifier (irrid): DERR1-10.2196/50241.
    Language English
    Publishing date 2024-04-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/50241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cryptococcus neoformans

    Telzrow, Calla L / Esher Righi, Shannon / Cathey, Jackson M / Granek, Joshua A / Alspaugh, J Andrew

    Frontiers in physiology

    2023  Volume 14, Page(s) 1150272

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1150272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of Malathion, DIMP, and Strawberry Furanone as CWA Simulants for Consideration in Field-Level Interior Building Remediation Exercises.

    Oudejans, Lukas / Wyrzykowska-Ceradini, Barbara / Morris, Eric / Jackson, Stephen / Touati, Abderrahmane / Sawyer, Jonathan / Mikelonis, Anne / Serre, Shannon

    Journal of chemical health & safety

    2024  Volume 30, Page(s) 270–278

    Abstract: Field-level exercises with the purpose to assess remediation following the deliberate release of a highly toxic chemical in an indoor environment can be conducted using low(er) toxicity simulants if they are closely linked to the behavior of the toxic ... ...

    Abstract Field-level exercises with the purpose to assess remediation following the deliberate release of a highly toxic chemical in an indoor environment can be conducted using low(er) toxicity simulants if they are closely linked to the behavior of the toxic chemical itself. Chemical warfare agent (CWA) simulants have been identified on their suitability based on chemical structural similarities and associated physical and chemical properties. However, there are no reported studies that combine measurement of simulant parameters like persistence on surfaces, ability to sample for, and capability to degrade during the decontamination phase such that the level of success of a field-level exercise can be quantified. Experimental research was conducted to assess these gaps using a select number of CWA simulants. The organophosphate pesticide malathion was found to be a suitable simulant for use in field-level exercises that simulate the release of the highly persistent nerve agent VX based on its high persistence, effective surface sampling and analysis using standard analytical equipment, and the in situ degradation in the presence of different oxidizing decontaminants.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2220441-6
    ISSN 1878-0504 ; 1871-5532
    ISSN (online) 1878-0504
    ISSN 1871-5532
    DOI 10.1021/acs.chas.3c00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Telemedicine Utilization Trends During the COVID-19 Public Health Emergency.

    Dowler, Shannon / Crosbie, Kelly / Thompson, Sam / Drucker, Erin / Jackson, Carlos

    North Carolina medical journal

    2021  Volume 82, Issue 4, Page(s) 255–258

    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 422795-5
    ISSN 0029-2559
    ISSN 0029-2559
    DOI 10.18043/ncm.82.4.255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Treatment changes in hemophilia A with chromogenic factor VIII assay implementation.

    Al Moosawi, Muntadhar / Nicolson, Hamish / Wong, Steven K W / Dallas, Karen L / Jackson, Shannon

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 2, Page(s) 100098

    Abstract: Background: The one-stage assay (OSA) and the chromogenic assay (CSA) are 2 factor VIII (FVIII) assays used for the diagnosis and classification of hemophilia A. Discrepancies between the 2 assays exist in approximately one-third of patients with mild ... ...

    Abstract Background: The one-stage assay (OSA) and the chromogenic assay (CSA) are 2 factor VIII (FVIII) assays used for the diagnosis and classification of hemophilia A. Discrepancies between the 2 assays exist in approximately one-third of patients with mild hemophilia A.
    Objectives: The objectives of this study were to report the proportion of patients with mild or moderate hemophilia A and OSA-CSA discrepancies and to report the observed changes in treatment approach prompted by the presence of assay discrepancy. The study aimed to identify OSA:CSA ratio associated with the highest sensitivity for identification of patients in whom modification of treatment approach may be recommended.
    Methods: This is a retrospective cohort study including adult (>18-year-old) patients with mild or moderate hemophilia A who were followed up at the Adult British Columbia Hemophilia Program between January 2013 and March 2019.
    Results: A total of 75 patients with mild and 23 with moderate hemophilia A based on baseline OSA were included. Overall
    Conclusion: In our population, OSA-CSA discrepancy was observed in 52% of patients with mild or moderate hemophilia A, and the treatment approach in 27% of these patients had to be modified.
    Language English
    Publishing date 2023-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genetic loci regulating the concentrations of anthocyanins and proanthocyanidins in the pericarps of purple and red rice.

    Chen, Ming-Hsuan / Pinson, Shannon R M / Jackson, Aaron K / Edwards, Jeremy D

    The plant genome

    2023  Volume 16, Issue 2, Page(s) e20338

    Abstract: The pigmented flavonoids, anthocyanins and proanthocyanidins, have health promoting properties. Previous work determined that the genes Pb and Rc turn on and off the biosynthesis of anthocyanins (purple) and proanthocyanidins (red), respectively. Not yet ...

    Abstract The pigmented flavonoids, anthocyanins and proanthocyanidins, have health promoting properties. Previous work determined that the genes Pb and Rc turn on and off the biosynthesis of anthocyanins (purple) and proanthocyanidins (red), respectively. Not yet known is how the concentrations of these pigmented flavonoids are regulated in grain pericarps. Quantitative trait locus (QTL) analysis in a population of rice (Oryza sativa L.) F5 recombinant inbred lines from white pericarp "IR36ae" x red+purple pericarp "242" revealed three QTLs associated with grain concentrations of anthocyanins (TAC) or proanthocyanidins (PA). Both TAC and PA independently mapped to a 1.5 Mb QTL region on chromosome 3 between RM3400 (at 15.8 Mb) and RM15123 (17.3 Mb), named qPR3. Across 2 years, qPR3 explained 36.3% of variance in TAC and 35.8% in PA variance not attributable to Pb or Rc. The qPR3 region encompasses Kala3, a MYB transcription factor previously known to regulate purple grain characteristics. Study of PbPbRcrc progeny showed that TAC of RcRc near isogenic lines (NILs) was 2.1-4.5x that of rcrc. Similarly, study of PbPbRcRc NILs, which had 70% higher PA than pbpbRcRc NILs, revealed a mutual enhancement, not a trade-off between these compounds that share precursors. This suggests that Pb and Rc upregulate genes in a shared pathway as they activate TAC and PA synthesis, respectively. This study provides molecular markers for facilitating marker-assisted selection of qPR3, qPR5, and qPR7 to enhance grain concentrations of pigmented flavonoids and documented that stacking Rc and Pb genes further increases both flavonoid compounds.
    MeSH term(s) Anthocyanins ; Proanthocyanidins ; Oryza/genetics ; Lead ; Flavonoids ; Quantitative Trait Loci ; Edible Grain/genetics
    Chemical Substances Anthocyanins ; Proanthocyanidins ; Lead (2P299V784P) ; Flavonoids
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2375444-8
    ISSN 1940-3372 ; 0011-183X
    ISSN (online) 1940-3372
    ISSN 0011-183X
    DOI 10.1002/tpg2.20338
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