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  1. Book ; Online ; E-Book: Antibiotika-Overkill

    Blaser, Martin J. / Magin, Ulrich

    so entstehen moderne Seuchen

    2017  

    Title translation Missing microbes
    Title variant Antibiotika Overkill
    Author's details Martin J. Blaser ; aus dem Englischen von Ulrich Magin
    Language German
    Size 1 Online-Ressource (214 Seiten)
    Publisher Herder
    Publishing place Freiburg
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019362380
    ISBN 978-3-451-81104-3 ; 9783451600234 ; 3-451-81104-9 ; 3451600234
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Microbiome and Infectious Diseases.

    Haraoui, Louis-Patrick / Blaser, Martin J

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue Suppl 6, Page(s) S441–S446

    Abstract: Our perception of microbes has considerably changed since the recognition of their pathogenic potential in the 19th century. The discovery of antibiotics and their subsequent widespread adoption have substantially altered the landscape of medicine, ... ...

    Abstract Our perception of microbes has considerably changed since the recognition of their pathogenic potential in the 19th century. The discovery of antibiotics and their subsequent widespread adoption have substantially altered the landscape of medicine, providing us with treatment options for many infectious diseases and enabling the deployment of previously risky interventions (eg, surgical procedures and chemotherapy), while also leading to the rise of AMR. The latter is commonly viewed as the predominant downside of antibiotic use. However, with the increasing recognition that all metazoan organisms rely on a community of microbes (the microbiota) for normal development and for most physiologic processes, the negative impacts of antibiotic use now extend well beyond AMR. Using the iceberg as a metaphor, we argue that the effects of antibiotics on AMR represent the tip of the iceberg, with much greater repercussions stemming from their role in the rise of so-called noncommunicable diseases (including obesity, diabetes, allergic and autoimmune diseases, neurodevelopmental disorders, and certain cancers). We highlight some of the emerging science around the intersection of the microbiome, antibiotic use, and health (including biological costs and future therapeutic avenues), and we advocate a more nuanced approach in evaluating the impacts of proposed antibiotic use, especially in the setting of preexposure and postexposure prophylaxis.
    MeSH term(s) Humans ; Animals ; Microbiota ; Anti-Bacterial Agents/therapeutic use ; Communicable Diseases/drug therapy ; Hypersensitivity ; Obesity
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad577
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  3. Article ; Online: Fecal Microbiota Transplantation for Dysbiosis - Predictable Risks.

    Blaser, Martin J

    The New England journal of medicine

    2019  Volume 381, Issue 21, Page(s) 2064–2066

    MeSH term(s) Bacteremia ; Dysbiosis ; Escherichia coli ; Fecal Microbiota Transplantation ; Humans ; Microbiota
    Language English
    Publishing date 2019-10-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1913807
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  4. Article ; Online: Denoising sparse microbial signals from single-cell sequencing of mammalian host tissues.

    Ghaddar, Bassel / Blaser, Martin J / De, Subhajyoti

    Nature computational science

    2023  Volume 3, Issue 9, Page(s) 741–747

    Abstract: Existing genomic sequencing data can be used to study host-microbiome ecosystems, however distinguishing signals originating from truly present microbes versus contaminating species and artifacts is a substantial and often prohibitive challenge. Here we ... ...

    Abstract Existing genomic sequencing data can be used to study host-microbiome ecosystems, however distinguishing signals originating from truly present microbes versus contaminating species and artifacts is a substantial and often prohibitive challenge. Here we show that emerging sequencing technologies definitely capture reads from present microbes. We developed SAHMI, a computational resource to identify truly present microbial nucleic acids and filter contaminants and spurious false-positive taxonomic assignments from standard transcriptomic sequencing of mammalian tissues. In benchmark studies, SAHMI correctly identifies known microbial infections present in diverse tissues, and we validate SAHMI's enrichment for correctly classified, truly present species using multiple orthogonal computational experiments. The application of SAHMI to single-cell and spatial genomic data thus enables co-detection of somatic cells and microorganisms and joint analysis of host-microbiome ecosystems.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-023-00507-1
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  5. Article ; Online: Our missing microbes: Short-term antibiotic courses have long-term consequences.

    Blaser, Martin J

    Cleveland Clinic journal of medicine

    2018  Volume 85, Issue 12, Page(s) 928–930

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Humans ; Long Term Adverse Effects/chemically induced ; Long Term Adverse Effects/microbiology ; Microbiota/drug effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.85gr.18005
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  6. Article ; Online: The Past and Future Biology of the Human Microbiome in an Age of Extinctions.

    Blaser, Martin J

    Cell

    2018  Volume 172, Issue 6, Page(s) 1173–1177

    Abstract: The evolutionary fate of humans is intimately linked with that of our microbiome. Medical and technological advances have caused large-scale changes in the composition and maturation of human-associated microbial communities, increasing our ... ...

    Abstract The evolutionary fate of humans is intimately linked with that of our microbiome. Medical and technological advances have caused large-scale changes in the composition and maturation of human-associated microbial communities, increasing our susceptibility to infectious and developmental diseases. Restoration of the human microbiome must become a priority for biomedicine.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Biology/methods ; Biology/trends ; Drug Resistance, Bacterial/genetics ; Gastrointestinal Tract/embryology ; Gastrointestinal Tract/growth & development ; Gastrointestinal Tract/microbiology ; Genetic Variation ; Host Microbial Interactions ; Humans ; Metagenome/genetics ; Microbiota/physiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.02.040
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  7. Article ; Online: A new lexicon in the age of microbiome research.

    Bosch, Thomas C G / Blaser, Martin J / Ruby, Edward / McFall-Ngai, Margaret

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2024  Volume 379, Issue 1901, Page(s) 20230060

    Abstract: At a rapid pace, biologists are learning the many ways in which resident microbes influence, and sometimes even control, their hosts to shape both health and disease. Understanding the biochemistry behind these interactions promises to reveal completely ... ...

    Abstract At a rapid pace, biologists are learning the many ways in which resident microbes influence, and sometimes even control, their hosts to shape both health and disease. Understanding the biochemistry behind these interactions promises to reveal completely novel and targeted ways of counteracting disease processes. However, in our protocols and publications, we continue to describe these new results using a language that originated in a completely different context. This language developed when microbial interactions with hosts were perceived to be primarily pathogenic, as threats that had to be vanquished. Biomedicine had one dominating thought: winning this war against microorganisms. Today, we know that beyond their defensive roles, host tissues, especially epithelia, are vital to ensuring association with the normal microbiota, the communities of microbes that persistently live with the host. Thus, we need to adopt a language that better encompasses the newly appreciated importance of host-microbiota associations. We also need a language that frames the onset and progression of pathogenic conditions within the context of the normal microbiota. Such a reimagined lexicon should make it clear, from the very nature of its words, that microorganisms are primarily vital to our health, and only more rarely the cause of disease. This article is part of the theme issue 'Sculpting the microbiome: how host factors determine and respond to microbial colonization'.
    MeSH term(s) Humans ; Symbiosis ; Microbiota ; Communicable Diseases ; Microbial Interactions ; Learning
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2023.0060
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  8. Article ; Online: The theory of disappearing microbiota and the epidemics of chronic diseases.

    Blaser, Martin J

    Nature reviews. Immunology

    2017  Volume 17, Issue 8, Page(s) 461–463

    Abstract: In recent decades, the incidence of many apparently unrelated chronic diseases has markedly increased. Here, I theorize that losses of particular bacterial species of our ancestral microbiota have altered the context in which immunological, metabolic and ...

    Abstract In recent decades, the incidence of many apparently unrelated chronic diseases has markedly increased. Here, I theorize that losses of particular bacterial species of our ancestral microbiota have altered the context in which immunological, metabolic and cognitive development occur in early life, which results in increased disease. This ominous trend suggests that we must refocus efforts to understand and reverse the underlying circumstances that are responsible for our disappearing microbiota.
    MeSH term(s) Animals ; Bacteria/classification ; Biological Evolution ; Chronic Disease/epidemiology ; Disease Susceptibility ; Humans ; Immune System ; Microbiota
    Language English
    Publishing date 2017-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.77
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  9. Article ; Online: Early-childhood prescribed antibiotics associated with type 1 Diabetes.

    Horton, Daniel B / Blaser, Martin J

    The Journal of pediatrics

    2020  Volume 224, Page(s) 179–183

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/drug therapy ; Humans ; Otitis Media/drug therapy ; Respiratory Tract Infections/drug therapy ; Siblings
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.07.021
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  10. Article ; Online: Tympanostomy Tubes or Medical Management for Recurrent Acute Otitis Media.

    Jayawardena, Asitha D L / Schleiss, Mark R / Blaser, Martin J

    The New England journal of medicine

    2021  Volume 385, Issue 9, Page(s) 860

    MeSH term(s) Chronic Disease ; Humans ; Middle Ear Ventilation ; Otitis Media/drug therapy ; Otitis Media with Effusion
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2109725
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