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  1. Article ; Online: ASXL1 c.1934dup;p.Gly646Trpfs*12-a true somatic alteration requiring a new approach.

    Yannakou, Costas K / Jones, Kate / McBean, Michelle / Thompson, Ella R / Ryland, Georgina L / Doig, Ken / Markham, John / Westerman, David / Blombery, Piers

    Blood cancer journal

    2017  Volume 7, Issue 12, Page(s) 656

    MeSH term(s) DNA Mutational Analysis/methods ; Hematologic Neoplasms/genetics ; Humans ; Mutation ; Repressor Proteins/genetics
    Chemical Substances ASXL1 protein, human ; Repressor Proteins
    Language English
    Publishing date 2017-12-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-017-0025-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Homologous Recombination Repair Deficiency: An Overview for Pathologists.

    Doig, Kenneth D / Fellowes, Andrew P / Fox, Stephen B

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2023  Volume 36, Issue 3, Page(s) 100049

    Abstract: The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prostate cancers. ... ...

    Abstract The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prostate cancers. Cancer cells with homologous recombination deficiency (HRD) are sensitive to targeted inhibition of poly-ADP ribose polymerase (PARP), a key component of alternative backup DNA repair pathways. Identifying patients with cancer with HRD biomarkers allows the identification of patients likely to benefit from PARP inhibitor therapies. In this study, we describe the causes of HRD, the underlying molecular changes resulting from HRD that form the basis of different molecular HRD assays, and discuss the issues around their clinical use. This overview is directed toward practicing pathologists wishing to be informed of this new predictive biomarker, as PARP inhibitors are increasingly used in standard care settings.
    MeSH term(s) Female ; Humans ; Recombinational DNA Repair ; Ovarian Neoplasms/genetics ; Homologous Recombination ; Pathologists ; DNA Repair
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1016/j.modpat.2022.100049
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    Zs.A 2450: Show issues Location:
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  3. Article ; Online: Planning for Change: Co-Designing Implementation Strategies to Improve the Use of Sensory Approaches in an Acute Psychiatric Unit.

    Wright, Lisa / Bennett, Sally / Meredith, Pamela / Doig, Emmah

    Issues in mental health nursing

    2023  Volume 44, Issue 10, Page(s) 960–973

    Abstract: Implementing sensory approaches in psychiatric units has proven challenging. This multi-staged study involved qualitative interviews ( ...

    Abstract Implementing sensory approaches in psychiatric units has proven challenging. This multi-staged study involved qualitative interviews (
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 603180-8
    ISSN 1096-4673 ; 0161-2840
    ISSN (online) 1096-4673
    ISSN 0161-2840
    DOI 10.1080/01612840.2023.2236712
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  4. Article ; Online: The Translation of Nanomedicines in the Contexts of Spinal Cord Injury and Repair.

    Wang, Wenqian / Yong, Joel / Marciano, Paul / O'Hare Doig, Ryan / Mao, Guangzhao / Clark, Jillian

    Cells

    2024  Volume 13, Issue 7

    Abstract: Purpose of this review: Manipulating or re-engineering the damaged human spinal cord to achieve neuro-recovery is one of the foremost challenges of modern science. Addressing the restricted permission of neural cells and topographically organised neural ...

    Abstract Purpose of this review: Manipulating or re-engineering the damaged human spinal cord to achieve neuro-recovery is one of the foremost challenges of modern science. Addressing the restricted permission of neural cells and topographically organised neural tissue for self-renewal and spontaneous regeneration, respectively, is not straightforward, as exemplified by rare instances of translational success. This review assembles an understanding of advances in nanomedicine for spinal cord injury (SCI) and related clinical indications of relevance to attempts to design, engineer, and target nanotechnologies to multiple molecular networks.
    Recent findings: Recent research provides a new understanding of the health benefits and regulatory landscape of nanomedicines based on a background of advances in mRNA-based nanocarrier vaccines and quantum dot-based optical imaging. In relation to spinal cord pathology, the extant literature details promising advances in nanoneuropharmacology and regenerative medicine that inform the present understanding of the nanoparticle (NP) biocompatibility-neurotoxicity relationship. In this review, the conceptual bases of nanotechnology and nanomaterial chemistry covering organic and inorganic particles of sizes generally less than 100 nm in diameter will be addressed. Regarding the centrally active nanotechnologies selected for this review, attention is paid to NP physico-chemistry, functionalisation, delivery, biocompatibility, biodistribution, toxicology, and key molecular targets and biological effects intrinsic to and beyond the spinal cord parenchyma.
    Summary: The advance of nanotechnologies for the treatment of refractory spinal cord pathologies requires an in-depth understanding of neurobiological and topographical principles and a consideration of additional complexities involving the research's translational and regulatory landscapes.
    MeSH term(s) Humans ; Nanomedicine ; Tissue Distribution ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/pathology ; Regenerative Medicine
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070569
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  5. Article ; Online: Attitudes of optometrists towards artificial intelligence for the diagnosis of retinal disease: A cross-sectional mail-out survey.

    Ho, Sharon / Doig, Gordon S / Ly, Angelica

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2022  Volume 42, Issue 6, Page(s) 1170–1179

    Abstract: ... at the point-of-care (+0.12, p = 0.01).: Conclusions: Optometrists have positive attitudes ...

    Abstract Purpose: Artificial intelligence (AI)-based systems have demonstrated great potential in improving the diagnostic accuracy of retinal disease but are yet to achieve widespread acceptance in routine clinical practice. Clinician attitudes are known to influence implementation. Therefore, this study aimed to identify optometrists' attitudes towards the use of AI to assist in diagnosing retinal disease.
    Methods: A paper-based survey was designed to assess general attitudes towards AI in diagnosing retinal disease and motivators/barriers for future use. Two clinical scenarios for using AI were evaluated: (1) at the point of care to obtain a diagnostic recommendation, versus (2) after the consultation to provide a second opinion. Relationships between participant characteristics and attitudes towards AI were explored. The survey was mailed to 252 randomly selected practising optometrists across Australia, with repeat mail-outs to non-respondents.
    Results: The response rate was 53% (133/252). Respondents' mean (SD) age was 42.7 (13.3) years, and 44.4% (59/133) identified as female, whilst 1.5% (2/133) identified as gender diverse. The mean number of years practising in primary eye care was 18.8 (13.2) years with 64.7% (86/133) working in an independently owned practice. On average, responding optometrists reported positive attitudes (mean score 4.0 out of 5, SD 0.8) towards using AI as a tool to aid the diagnosis of retinal disease, and would be more likely to use AI if it is proven to increase patient access to healthcare (mean score 4.4 out of 5, SD 0.6). Furthermore, optometrists expressed a statistically significant preference for using AI after the consultation to provide a second opinion rather than during the consultation, at the point-of-care (+0.12, p = 0.01).
    Conclusions: Optometrists have positive attitudes towards the future use of AI as an aid to diagnose retinal disease. Understanding clinician attitudes and preferences for using AI may help maximise its clinical potential and ensure its successful translation into practice.
    MeSH term(s) Adult ; Artificial Intelligence ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Optometrists ; Optometry ; Postal Service ; Retinal Diseases/diagnosis
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.13034
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  6. Article ; Online: Tumour mutational burden: an overview for pathologists.

    Doig, Kenneth D / Fellowes, Andrew / Scott, Prudence / Fox, Stephen B

    Pathology

    2022  Volume 54, Issue 3, Page(s) 249–253

    Abstract: Cancer immunotherapy holds great promise and has shown durable responses in many patients; however, these responses are not uniform in all patients or all tumour streams. There is an ongoing clinical need for objective diagnostic biomarkers to identify ... ...

    Abstract Cancer immunotherapy holds great promise and has shown durable responses in many patients; however, these responses are not uniform in all patients or all tumour streams. There is an ongoing clinical need for objective diagnostic biomarkers to identify patients that will respond to immunotherapies. Tumour mutational burden (TMB) is a diagnostic biomarker that can stratify cancer patients for response to immune checkpoint inhibitor therapies. It is commonly defined as the average number of somatic mutations per megabase in a tumour exome. Here we describe the TMB biomarker, how it is determined, its underlying molecular basis, the relationship to neoantigens and the issues around its clinical use. This overview is directed toward practising pathologists wishing to be informed of this predictive biomarker.
    MeSH term(s) Biomarkers, Tumor/genetics ; Humans ; Immunotherapy ; Mutation ; Neoplasms/diagnosis ; Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2021.11.008
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  7. Article ; Online: Developing a national oral health strategy.

    Doig, Peter

    Journal (Canadian Dental Association)

    2013  Volume 79, Page(s) d85

    MeSH term(s) Canada ; Delivery of Health Care ; Dental Research ; Health Planning ; Health Policy ; Health Services Accessibility ; Humans ; National Health Programs ; Oral Health
    Language English
    Publishing date 2013
    Publishing country Canada
    Document type Editorial
    ZDB-ID 604786-5
    ISSN 1488-2159 ; 0709-8936 ; 0008-3372
    ISSN (online) 1488-2159
    ISSN 0709-8936 ; 0008-3372
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  8. Article ; Online: CDA advocacy: making a difference in oral health care.

    Doig, Peter

    Journal (Canadian Dental Association)

    2013  Volume 79, Page(s) d119

    MeSH term(s) Canada ; Dental Health Services/organization & administration ; Health Policy ; Humans ; Politics ; Societies, Dental
    Language English
    Publishing date 2013
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 604786-5
    ISSN 1488-2159 ; 0709-8936 ; 0008-3372
    ISSN (online) 1488-2159
    ISSN 0709-8936 ; 0008-3372
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  9. Article ; Online: Response from Dr. Peter Doig.

    Doig, Peter

    Journal (Canadian Dental Association)

    2013  Volume 79, Page(s) d125

    MeSH term(s) Health Planning ; Health Policy ; Humans ; National Health Programs ; Oral Health
    Language English
    Publishing date 2013
    Publishing country Canada
    Document type Comment ; Letter
    ZDB-ID 604786-5
    ISSN 1488-2159 ; 0709-8936 ; 0008-3372
    ISSN (online) 1488-2159
    ISSN 0709-8936 ; 0008-3372
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  10. Article ; Online: Using Updated PubMed: New Features and Functions to Enhance Literature Searches.

    Kang, Pauline / Kalloniatis, Michael / Doig, Gordon S

    JAMA

    2021  Volume 326, Issue 6, Page(s) 479–480

    MeSH term(s) Information Storage and Retrieval/methods ; Medical Subject Headings ; PubMed
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.12021
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