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  1. Article: Best Practices for

    Graham, David Y

    Gastroenterology & hepatology

    2024  Volume 20, Issue 3, Page(s) 159–168

    Abstract: For decades, antimicrobial therapy ... ...

    Abstract For decades, antimicrobial therapy for
    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implications of the paradigm shift in management of

    Graham, David Y

    Therapeutic advances in gastroenterology

    2023  Volume 16, Page(s) 17562848231160858

    Abstract: The recent availability of susceptibility testing ... ...

    Abstract The recent availability of susceptibility testing for
    Language English
    Publishing date 2023-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848231160858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: It Is Time for a Paradigm Shift in Design, Execution, and Publishing of Comparative Helicobacter pylori Treatment Trials.

    Graham, David Y

    The American journal of gastroenterology

    2023  Volume 118, Issue 7, Page(s) 1154–1156

    MeSH term(s) Humans ; Helicobacter pylori ; Anti-Bacterial Agents/therapeutic use ; Helicobacter Infections/drug therapy ; Publishing
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Why the Vonoprazan Helicobacter pylori Therapies in the US-European Trial Produced Unacceptable Cure Rates.

    Graham, David Y

    Digestive diseases and sciences

    2023  Volume 68, Issue 5, Page(s) 1691–1697

    Abstract: Introduction: Helicobacter pylori infects a large percentage of the world's population and is etiologically related to gastric cancer. The U.S. Food and Drug Administration recently approved two 14-day vonoprazan-containing regimens (vonoprazan- ... ...

    Abstract Introduction: Helicobacter pylori infects a large percentage of the world's population and is etiologically related to gastric cancer. The U.S. Food and Drug Administration recently approved two 14-day vonoprazan-containing regimens (vonoprazan-amoxicillin with or without clarithromycin) for H. pylori infections in the United States/Europe.
    Methods: We critically reviewed the trial methods to discover why the results were unacceptable low [i.e., no regimen achieved clinically acceptable (≥ 90%) or even conditionally acceptable cure rates (≥ 85%)]. Cure rates with antibiotic susceptible strains were 84.7 for vonoprazan triple therapy, 78.5 for vonoprazan-amoxicillin, and 78.7 for lansoprazole triple therapy, respectively. As was previously shown in Japan, the benefit from adding clarithromycin to vonoprazan-amoxicillin was minimal and the majority of the clarithromycin administered was unnecessary.
    Results: The possible reasons for failure to achieve high cure rates discussed include (a) reduced intragastric antibiotic concentrations, (b) an increase in heteroresistance, and (c) failure to achieve an intragastric pH conducive for amoxicillin to eradicate the infection. In addition, there was no pilot study or other attempt to optimize any regimen.
    Conclusion: The most likely reason for failure was failure to achieve high intragastric concentrations of antibiotics or to achieve an intragastric pH conducive for amoxicillin to be active. Importantly, vonoprazan triple therapy resulted in > 10 tons of unneeded clarithromycin/million courses of vonoprazan triple therapy. Antibiotic misuse combined with low cure rates suggest that vonoprazan-clarithromycin triple therapies should not be prescribed for H. pylori infection. Dual vonoprazan-amoxicillin therapy has proven effective elsewhere and after optimization may eventually prove useful in the U.S./Europe.
    MeSH term(s) Humans ; Clarithromycin/therapeutic use ; Helicobacter pylori ; Proton Pump Inhibitors ; Drug Therapy, Combination ; Anti-Bacterial Agents ; Amoxicillin ; Helicobacter Infections/drug therapy ; Treatment Outcome
    Chemical Substances Clarithromycin (H1250JIK0A) ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Proton Pump Inhibitors ; Anti-Bacterial Agents ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07886-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dysphagia in a 75-Year-Old Male.

    Perrin, Michael A / Graham, David Y / Larson, Scott A

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comments regarding use of rifabutin for

    Graham, David Y

    Therapeutic advances in gastroenterology

    2021  Volume 14, Page(s) 17562848211044064

    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848211044064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Molecular-based Helicobacter pylori Susceptibility Testing Is Almost Ready for Prime Time.

    Graham, David Y

    Gastroenterology

    2021  Volume 160, Issue 6, Page(s) 1936–1937

    MeSH term(s) Clarithromycin ; Helicobacter Infections/diagnosis ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans
    Chemical Substances Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.02.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Toward Quantification of H pylori-associated Gastric Cancer Risk: Further Evidence Supporting Development of Population-based Strategies for H pylori Eradication.

    Ford, Alexander C / Graham, David Y

    Gastroenterology

    2023  Volume 166, Issue 2, Page(s) 248–249

    MeSH term(s) Humans ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/etiology ; Stomach Neoplasms/prevention & control ; Risk ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.10.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Transitioning of

    Graham, David Y

    Antibiotics (Basel, Switzerland)

    2020  Volume 9, Issue 10

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    Language English
    Publishing date 2020-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics9100671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Response to: a true point-of-care molecular testing method for tailored therapy for

    Graham, David Y / Rokkas, Theodore

    Expert review of gastroenterology & hepatology

    2023  Volume 17, Issue 3, Page(s) 311

    MeSH term(s) Humans ; Helicobacter pylori/genetics ; Point-of-Care Systems ; Anti-Bacterial Agents/adverse effects ; Helicobacter Infections/diagnosis ; Helicobacter Infections/drug therapy ; Molecular Diagnostic Techniques ; Clarithromycin/therapeutic use ; Drug Therapy, Combination ; Drug Resistance, Bacterial ; Amoxicillin ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A) ; Amoxicillin (804826J2HU) ; Proton Pump Inhibitors
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2023.2179987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6978: Show issues Location:
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