LIVIVO - Search results -

Search results

Result 1 - 10 of total 31

Search options

Article ; Online: Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells.

Liu, Ching-Hsuan / Tai, Chen-Jei / Kuo, Yu-Ting / Chang, Shen-Shong / Lin, Liang-Tzung

2023 Volume 15, Issue 6

Abstract: Hepatocellular carcinoma (HCC) remains a difficult-to-treat cancer due to late diagnosis and limited curative treatment options. Developing more effective therapeutic strategies is essential for the management of HCC. Oncolytic virotherapy is a novel ... ...

Abstract	Hepatocellular carcinoma (HCC) remains a difficult-to-treat cancer due to late diagnosis and limited curative treatment options. Developing more effective therapeutic strategies is essential for the management of HCC. Oncolytic virotherapy is a novel treatment modality for cancers, and its combination with small molecules merits further exploration. In this study, we combined oncolytic measles virus (MV) with the natural triterpenoid compound ursolic acid (UA) and evaluated their combination effect against HCC cells, including those harboring hepatitis B virus (HBV) or hepatitis C virus (HCV) replication. We found that the combination of MV and UA synergistically induced more cell death in Huh-7 HCC cells through enhanced apoptosis. In addition, increased oxidative stress and loss of mitochondrial potential were observed in the treated cells, indicating dysregulation of the mitochondria-dependent pathway. Similar synergistic cytotoxic effects were also found in HCC cells harboring HBV or HCV genomes. These findings underscore the potential of oncolytic MV and UA combination for further development as a treatment strategy for HCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Oncolytic Viruses/genetics ; Liver Neoplasms/pathology ; Measles virus/genetics ; Oncolytic Virotherapy ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Hepatitis C/therapy ; Ursolic Acid
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061294
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Late hepatitis C virus diagnosis among patients with newly diagnosed hepatocellular carcinoma: a case-control study.

Chang, Shen-Shong / Hu, Hsiao-Yun / Chen, Yu-Chin / Yen, Yung-Feng / Huang, Nicole

BMC gastroenterology

2022 Volume 22, Issue 1, Page(s) 425

Abstract: Background: New direct-acting antiviral therapies have revolutionized hepatitis C virus (HCV) infection therapy. Nonetheless, once liver cirrhosis is established, the risk of hepatocellular carcinoma (HCC) still exists despite virus eradication. Late ... ...

Abstract	Background: New direct-acting antiviral therapies have revolutionized hepatitis C virus (HCV) infection therapy. Nonetheless, once liver cirrhosis is established, the risk of hepatocellular carcinoma (HCC) still exists despite virus eradication. Late HCV diagnosis hinders timely access to HCV treatment. Thus, we determined trends and risk factors associated with late HCV among patients with a diagnosis of HCC in Taiwan. Methods: We conducted a population-based unmatched case-control study. 2008-2018 Claims data were derived from the Taiwan National Health Insurance Research Database. Individuals with an initial occurrence of liver cancer between 2012 and 2018 were included. The late HCV group were referred as individuals who were diagnosed with HCC within 3 years after HCV diagnosis. The control group were referred as individuals who were diagnosed more than 3 years after the index date. We used multivariable logistic models to explore individual- and provider-level risk factors associated with a late HCV diagnosis. Results: A decreasing trend was observed in the prevalence of late HCV-related HCC diagnosis between 2012 and 2018 in Taiwan. On an individual level, male, elderly patients, patients with diabetes mellitus (DM), and patients with alcohol-related disease had significantly higher risks of late HCV-related HCC diagnosis. On a provider level, patients who were mainly cared for by male physicians, internists and family medicine physicians had a significantly lower risk of late diagnosis. Conclusions: Elderly and patients who have DM and alcohol related disease should receive early HCV screening. In addition to comorbidities, physician factors also matter. HCV screening strategies shall take these higher risk patients and physician factors into consideration to avoid missing opportunities for early intervention.
MeSH term(s)	Aged ; Antiviral Agents ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Delayed Diagnosis/adverse effects ; Diabetes Mellitus ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Male
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-09-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-022-02504-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Factors associated with nonadherence to surveillance for hepatocellular carcinoma among patients with hepatic C virus cirrhosis, 2000-2015.

Chang, Shen-Shong / Hu, Hsiao-Yun / Cheng, Feng-Shiang / Chen, Yu-Chin / Yen, Yung-Feng / Huang, Nicole

Medicine

2022 Volume 101, Issue 47, Page(s) e31907

Abstract: Hepatocellular carcinoma (HCC) surveillance can detect the early stage of tumors and lead to improved survival. Adherence to guideline-concordant HCC surveillance is crucial in at-risk populations, including patients with hepatic C virus (HCV) cirrhosis. ...

Abstract	Hepatocellular carcinoma (HCC) surveillance can detect the early stage of tumors and lead to improved survival. Adherence to guideline-concordant HCC surveillance is crucial in at-risk populations, including patients with hepatic C virus (HCV) cirrhosis. This study was conducted to identify patient and provider factors associated with nonadherence to HCC surveillance in patients with HCV cirrhosis. Data were primarily obtained from the Taiwan National Health Insurance Research Database for the 2000 to 2015 period. Adult patients newly diagnosed as having HCV cirrhosis between 2003 and 2012 were enrolled. Each patient was followed up for 3 years and until the end of 2015. Annual HCC surveillance was defined as the uptake of an abdominal ultrasound and alpha-fetoprotein (AFP) test annually during the 3-years follow-up. Nonannual surveillance was defined as the lack of an annual abdominal ultrasound and AFP test during the same 3-years period. Multinomial logistic regression models were applied to determine factors influencing adherence or nonadherence to annual HCC surveillance. We included a total of 4641 patients with HCV cirrhosis for analysis. Of these patients, only 14% adhered to annual HCC surveillance. HCC surveillance improved in later years, compared with the earlier phases of the study period. Patients with HCV cirrhosis comorbid with coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD) or those with a relatively high number of comorbidities had a significantly higher likelihood of nonadherence. Patients who primarily received care from internists were significantly less likely to exhibit nonadherence to annual HCC surveillance compared with patients receiving care from physicians of other specialties. Patients who primarily received care from physicians practicing in larger hospitals were significantly less likely to exhibit nonadherence. HCC surveillance rates remain unacceptably low among high-risk patients, and our findings may be helpful in the development of effective interventions to increase HCC surveillance. The effective incorporation of HCC surveillance into routine visits for other chronic comorbidities, particularly for CAD or COPD, may be crucial for increasing HCC surveillance.
MeSH term(s)	Adult ; Humans ; Carcinoma, Hepatocellular/epidemiology ; alpha-Fetoproteins ; Liver Neoplasms/epidemiology ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Coronary Artery Disease ; Hepatitis C/complications ; Hepatitis C/epidemiology
Chemical Substances	alpha-Fetoproteins
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031907
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reply: To PMID 24907021.

Chang, Shen-Shong / Hu, Hsiao-Yun

Journal of the Chinese Medical Association : JCMA

2014 Volume 77, Issue 12, Page(s) 657–658

MeSH term(s)	Female ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Kidney Failure, Chronic/complications ; Male ; Peptic Ulcer/complications ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2014-10-24
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1016/j.jcma.2014.09.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2699: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens.

Chang, Shen-Shong / Hu, Hsiao-Yun

World journal of gastrointestinal pharmacology and therapeutics

2015 Volume 6, Issue 4, Page(s) 127–136

Abstract: The presence of concomitant diseases is an independent predictive factor for non-Helicobacter pylori (H. pylori) peptic ulcers. Patients contracting concomitant diseases have an increased risk of developing ulcer disease through pathogenic mechanisms ... ...

Abstract	The presence of concomitant diseases is an independent predictive factor for non-Helicobacter pylori (H. pylori) peptic ulcers. Patients contracting concomitant diseases have an increased risk of developing ulcer disease through pathogenic mechanisms distinct from those of H. pylori infections. Factors other than H. pylori seem critical in peptic ulcer recurrence in end stage renal disease (ESRD) and cirrhotic patients. However, early H. pylori eradication is associated with a reduced risk of recurrent complicated peptic ulcers in patients with ESRD and liver cirrhosis. Resistances to triple therapy are currently detected using culture-based and molecular methods. Culture susceptibility testing before first- or second-line therapy is unadvisable. Using highly effective empiric first-line and rescue regimens can yield acceptable results. Sequential therapy has been included in a recent consensus report as a valid first-line option for eradicating H. pylori in geographic regions with high clarithromycin resistance. Two novel eradication regimens, namely concomitant and hybrid therapy, have proven more effective in patients with dual- (clarithromycin- and metronidazole-) resistant H. pylori strains. We aim to review the prevalence of and eradication therapy for H. pylori infection in patients with ESRD and cirrhosis. Moreover, we summarized the updated H. pylori eradication regimens.
Language	English
Publishing date	2015-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583480-0
ISSN	2150-5349
ISSN	2150-5349
DOI	10.4292/wjgpt.v6.i4.127
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Association between early Helicobacter pylori eradication and a lower risk of recurrent complicated peptic ulcers in end-stage renal disease patients.

Chang, Shen-Shong / Hu, Hsiao-Yun

Medicine

2015 Volume 94, Issue 1, Page(s) e370

Abstract: End-stage renal disease (ESRD) patients exhibit an increased incidence of peptic ulcer disease. Helicobacter pylori plays a central role in the development of peptic ulcers. The effect of early H pylori eradication on the recurrence of complicated peptic ...

Abstract	End-stage renal disease (ESRD) patients exhibit an increased incidence of peptic ulcer disease. Helicobacter pylori plays a central role in the development of peptic ulcers. The effect of early H pylori eradication on the recurrence of complicated peptic ulcer disease in ESRD patients remains unclear. The aim of the present study was to explore whether early H pylori eradication therapy in ESRD patients can reduce the risk of recurrent complicated peptic ulcers.We conducted a population-based cohort study and recruited patients with ESRD who had developed peptic ulcers. We categorized patients into early (time lag ≦120 days after peptic ulcer diagnosis) and late H pylori eradication therapy groups. The Cox proportional hazards model was used. The endpoint was based on hospitalization for complicated recurrent peptic ulcers.The early and late H pylori eradication therapy groups consisted of 2406 and 1356 ESRD patients, respectively, in a time lag of 120 days. After adjusting for possible confounders, the early eradication group exhibited a lower rate of complicated recurrent peptic ulcer disease (hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.64-0.91, P = 0.003) in a time lag of ≦120 days, but a similar rate of complicated recurrent peptic ulcer disease in time lags of ≦1 year (HR = 0.97, 95% CI 0.79-1.19, P = 0.758) and 2 years (HR = 1.11, 95% CI 0.86-1.44, P = 0.433) compared with the late eradication group.We recommend administering H pylori eradication within 120 days after peptic ulcer diagnosis to H pylori infected ESRD patients who have developed peptic ulcers.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cohort Studies ; Female ; Helicobacter Infections/drug therapy ; Humans ; Kidney Failure, Chronic/complications ; Male ; Middle Aged ; Multivariate Analysis ; Peptic Ulcer/complications ; Peptic Ulcer/drug therapy ; Proton Pump Inhibitors/therapeutic use ; Recurrence ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Proton Pump Inhibitors
Language	English
Publishing date	2015-01-08
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000000370
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Long-term use of steroids protects from the development of symptomatic diverticulitis requiring hospitalization in the Asian population.

Chang, Shen-Shong / Hu, Hsiao-Yun

PloS one

2015 Volume 10, Issue 4, Page(s) e0124598

Abstract: Objective: The pathophysiology of diverticulitis is poorly understood. Factors such as physical inactivity, constipation, obesity, smoking, and the use of nonsteroidal antiinflammatory drugs (NSAIDs) have been associated with an increased risk of ... ...

Abstract	Objective: The pathophysiology of diverticulitis is poorly understood. Factors such as physical inactivity, constipation, obesity, smoking, and the use of nonsteroidal antiinflammatory drugs (NSAIDs) have been associated with an increased risk of diverticular disease. To evaluate whether patients exhibiting long-term steroid use are at increased risk of colonic diverticulitis. Method: We conducted a population-based, nested case-control study. Data were retrospectively collected from the National Health Insurance Research Database. The study cohort comprised patients diagnosed with diverticulitis, identified using inpatient discharge records using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes (562.11 and 562.13), and those who were administered one or more prescriptions for corticosteroids for systemic use. Control patients were matched to cases by age, sex, NSAID use, laxative drug use, and index date. We enrolled 690 patients with colonic diverticulitis and 2760 in the control group. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: Compared with steroid nonusers, the adjusted ORs were 0.60 (95% CI = 0.35-1.06) and 0.80 (95% CI = 0.64-1.008) in current steroid users and previous steroid users, respectively. In addition, the adjusted ORs were 0.55 (95% CI = 0.31-0.98), 0.57 (95% CI = 0.31-0.98), and 0.44 (95% CI = 0.22-0.86) for steroid use duration more than half time by an exposure period of 90 days, 180 days, and 365 days before the claim date of colonic diverticulitis, respectively. Conclusions: The results indicated that long-term steroid use within one year is associated with lower risk of colonic diverticulitis.
MeSH term(s)	Acute Disease ; Adult ; Aged ; Asian Continental Ancestry Group ; Case-Control Studies ; Diverticulitis/drug therapy ; Diverticulitis/prevention & control ; Diverticulitis/surgery ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Steroids/therapeutic use ; Time Factors ; Young Adult
Chemical Substances	Steroids
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0124598
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: No inverse relationship between Helicobacter pylori infection and adult asthma with peptic ulcer disease.

Chang, Shen-Shong / Hu, Hsiao-Yun

Hepato-gastroenterology

2014 Volume 61, Issue 130, Page(s) 529–534

Abstract: Background/aims: Inverse correlation between childhood-onset asthma and human gastric Helicobacter pylori (H. pylori) infection exists. To investigate whether adult asthma patients with peptic ulcer disease demonstrated lower rates of H. pylori ... ...

Abstract	Background/aims: Inverse correlation between childhood-onset asthma and human gastric Helicobacter pylori (H. pylori) infection exists. To investigate whether adult asthma patients with peptic ulcer disease demonstrated lower rates of H. pylori infection. Methodology: Asthma patients were identified from records of inpatient treatments or from 3 or more ambulatory care claims using the International Classifications of Diseases, Revision 9, Clinical Modification (ICD-9-CM) diagnosis code: 493. To be defined as a non-asthma patient, a person cannot have the code ICD-9-CM: 490-494, and 496 in inpatient records or in the ambulatory care claims. The sample included 2,894 H. pylori-positive patients with peptic ulcers and 522 H. pylori-negative patients with peptic ulcers. A logistic regression model was used to calculate the odds ratio and a 95% confidence interval. Results: Asthma patients with peptic ulcers included 74 H. pylori-positive and 21 H. pylori-negative. Non-asthma patients with peptic ulcers comprised 2,820 H. pylori-positive and 501 H. pylori-negative. Based on logistic regression analysis, adult asthma patients with peptic ulcers (OR = 0.71, P = 0.187) demonstrated similar H. pylori infection rates, compared to adult non-asthma patients with peptic ulcers. Conclusions: Our data show no inverse relationship between Helicobacter pylori infection and adult asthma with peptic ulcers.
MeSH term(s)	Adult ; Asthma/epidemiology ; Asthma/virology ; Female ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori/isolation & purification ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Peptic Ulcer/complications ; Peptic Ulcer/epidemiology ; Taiwan/epidemiology ; Young Adult
Language	English
Publishing date	2014-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	801013-4
ISSN	0172-6390
ISSN	0172-6390
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui V Zs.50: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lower Helicobacter pylori infection rate in chronic kidney disease and end-stage renal disease patients with peptic ulcer disease.

Chang, Shen-Shong / Hu, Hsiao-Yun

Journal of the Chinese Medical Association : JCMA

2014 Volume 77, Issue 7, Page(s) 354–359

Abstract: Background: Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical.: Methods: We first ... ...

Abstract	Background: Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. Methods: We first stratified the original 1 million study population according to CKD or ESRD. We retrospectively investigated the incidence of H. pylori infection in PUD patients with or without CKD or ESRD between 2000 and 2008 in a nationwide, population-based cohort using data from the Taiwan National Health Insurance Research Database. The comparison cohort consisted of PUD patients without CKD. A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals, to determine whether the occurrence of H. pylori infection in CKD or ESRD patients with PUD differed from that of PUD patients without CKD. Results: Among the CKD patients, 261 patients had H. pylori-positive and 185 H. pylori-negative peptic ulcers. Among the ESRD patients, 81 had H. pylori-positive and 63 H. pylori-negative peptic ulcers. Among the non-CKD control patients, 1658 patients had H. pylori-positive and 702 H. pylori-negative peptic ulcers. Our results revealed a lower H. pylori infection rate in CKD (OR = 0.64, p < 0.001) and ESRD (OR = 0.54, p = 0.001) patients with PUD than in PUD patients without CKD. Conclusion: The H. pylori infection rate is lower in PUD patients with CKD and ESRD than in those without CKD.
MeSH term(s)	Adult ; Female ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Kidney Failure, Chronic/complications ; Male ; Middle Aged ; Peptic Ulcer/complications ; Regression Analysis ; Renal Insufficiency, Chronic/complications ; Retrospective Studies ; Taiwan/epidemiology
Language	English
Publishing date	2014-06-03
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1016/j.jcma.2014.04.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2699: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: H. pylori eradication lower ulcers in cirrhosis. [Corrected].

Chang, Shen-Shong / Hu, Hsiao-Yun

Journal of digestive diseases

2014 Volume 15, Issue 8, Page(s) 451–458

Abstract: Obiective: The study aimed to investigate whether early Helicobacter pylori (H. pylori) eradication therapy in cirrhotic patients caused a dramatic reduction of recurrent peptic ulcers compared with those treated with a late eradication.: Methods: We ...

Abstract	Obiective: The study aimed to investigate whether early Helicobacter pylori (H. pylori) eradication therapy in cirrhotic patients caused a dramatic reduction of recurrent peptic ulcers compared with those treated with a late eradication. Methods: We identified cirrhotic patients using the International Classifications of Diseases, Revision 9 (ICD-9-CM). Decompensated cirrhotic patients can apply for a catastrophic illness card and were identified via the ICD-9-CM codes 571.2, 571.5 and 571.6. Compensated cirrhotic patients were identified via the ICD-9-CM codes 571.2, 571.5 and 571.6, after excluded decompensated cirrhotic patients. We categorized patients into early (time lag ≤365 days after peptic ulcer diagnosis) and late (time lag >365 days) H. pylori eradication therapy groups. The end-point was the occurrence of recurrent peptic ulcers. Cox proportional hazards model was used to calculate the hazard ratios (HRs). Results: Altogether, 154 cirrhotic patients were included in the early H. pylori eradication group and 103 in the late H. pylori eradication group. Cirrhotic patients had a higher risk of recurrent peptic ulcers in the late H. pylori eradication group (HR 1.58, 95% CI 1.09-2.28, P = 0.015). However, the risk of recurrent peptic ulcers in alcoholic cirrhotic patients in both groups (HR 1.47, 95% CI 0.77-2.83, P = 0.247) was similar. Conclusions: Early H. pylori eradication is associated with a lower risk of recurrent peptic ulcers in cirrhotic patients. H. pylori eradication is the mainstay for treating cirrhotic patients who have contracted peptic ulcers.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Drug Therapy, Combination ; Female ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Peptic Ulcer/microbiology ; Peptic Ulcer/prevention & control ; Proton Pump Inhibitors/therapeutic use ; Recurrence ; Retrospective Studies ; Secondary Prevention/methods ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Anti-Ulcer Agents ; Proton Pump Inhibitors
Language	English
Publishing date	2014-05-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2317117-0
ISSN	1751-2980 ; 1751-2972
ISSN (online)	1751-2980
ISSN	1751-2972
DOI	10.1111/1751-2980.12159
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito