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Article ; Online: Percentile-Based Adaptive Immune Plasma Algorithm and Its Application to Engineering Optimization.

Aslan, Selcuk / Demirci, Sercan / Oktay, Tugrul / Yesilbas, Erdal

Biomimetics (Basel, Switzerland)

2023 Volume 8, Issue 6

Abstract: The immune plasma algorithm (IP algorithm or IPA) is one of the most recent meta-heuristic techniques and models the fundamental steps of immune or convalescent plasma treatment, attracting researchers' attention once more with the COVID-19 pandemic. The ...

Abstract	The immune plasma algorithm (IP algorithm or IPA) is one of the most recent meta-heuristic techniques and models the fundamental steps of immune or convalescent plasma treatment, attracting researchers' attention once more with the COVID-19 pandemic. The IP algorithm determines the number of donors and the number of receivers when two specific control parameters are initialized and protects their values until the end of termination. However, determining which values are appropriate for the control parameters by adjusting the number of donors and receivers and guessing how they interact with each other are difficult tasks. In this study, we attempted to determine the number of plasma donors and receivers with an improved mechanism that depended on dividing the whole population into two sub-populations using a statistical measure known as the percentile and then a novel variant of the IPA called the percentile IPA (pIPA) was introduced. To investigate the performance of the pIPA, 22 numerical benchmark problems were solved by assigning different values to the control parameters of the algorithm. Moreover, two complex engineering problems, one of which required the filtering of noise from the recorded signal and the other the path planning of an unmanned aerial vehicle, were solved by the pIPA. Experimental studies showed that the percentile-based donor-receiver selection mechanism significantly contributed to the solving capabilities of the pIPA and helped it outperform well-known and state-of-art meta-heuristic algorithms.
Language	English
Publishing date	2023-10-14
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics8060486
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Altitudinal Migration of Species of Fir (Abies spp.) in Adaptation to Climate Change

Tekin, Oktay / Cetin, Mehmet / Varol, Tugrul / Ozel, Halil Baris / Sevik, Hakan / Zeren Cetin, Ilknur

Water, air, and soil pollution. 2022 Sept., v. 233, no. 9

2022

Abstract: Global climate change is considered an irreversible problem, which might directly or indirectly affect all the organisms and ecosystems on the earth and the world has to struggle with. Plants having no effective movement mechanism are the group that ... ...

Abstract	Global climate change is considered an irreversible problem, which might directly or indirectly affect all the organisms and ecosystems on the earth and the world has to struggle with. Plants having no effective movement mechanism are the group that global climate change will affect the most. In order to minimize the species and population losses, it is important to estimate the changes in the available distribution areas of species and to ensure the migration mechanism, which the species will need, by the hand of humans. The present study aims to reveal how potential distribution areas of fir, which is among the significant tree species of Turkey and significant portion of global distribution of which is in Turkey, will change from an altitudinal aspect because of the climate change. The results achieved showed that, because of the effects of global climate change, the suitable distribution areas of Abies nordmanniana subsp. nordmanniana will significantly decrease especially at high altitudes and that suitable distribution areas of Abies nordmanniana subsp. equi-trojani will reduce at altitudes higher than 1400 m but increase generally at the altitudes between 200 and 600 m. Moreover, suitable distribution areas of Abies cilicica will shift towards higher altitudes.
Keywords	Abies cilicica ; Abies nordmanniana subsp. equi-trojani ; Abies nordmanniana subsp. nordmanniana ; air ; altitude ; climate change ; geographical distribution ; soil pollution ; trees ; water
Language	English
Dates of publication	2022-09
Size	p. 385.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	120499-3
ISSN	1573-2932 ; 0049-6979 ; 0043-1168
ISSN (online)	1573-2932
ISSN	0049-6979 ; 0043-1168
DOI	10.1007/s11270-022-05851-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Helicopter Control Energy Reduction Using Moving Horizontal Tail.

Oktay, Tugrul / Sal, Firat

TheScientificWorldJournal

2015 Volume 2015, Page(s) 523914

Abstract: Helicopter moving horizontal tail (i.e., MHT) strategy is applied in order to save helicopter flight control system (i.e., FCS) energy. For this intention complex, physics-based, control-oriented nonlinear helicopter models are used. Equations of MHT are ...

Abstract	Helicopter moving horizontal tail (i.e., MHT) strategy is applied in order to save helicopter flight control system (i.e., FCS) energy. For this intention complex, physics-based, control-oriented nonlinear helicopter models are used. Equations of MHT are integrated into these models and they are together linearized around straight level flight condition. A specific variance constrained control strategy, namely, output variance constrained Control (i.e., OVC) is utilized for helicopter FCS. Control energy savings due to this MHT idea with respect to a conventional helicopter are calculated. Parameters of helicopter FCS and dimensions of MHT are simultaneously optimized using a stochastic optimization method, namely, simultaneous perturbation stochastic approximation (i.e., SPSA). In order to observe improvement in behaviors of classical controls closed loop analyses are done.
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1537-744X
ISSN (online)	1537-744X
DOI	10.1155/2015/523914
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Article ; Online: Helicopter Control Energy Reduction Using Moving Horizontal Tail

Tugrul Oktay / Firat Sal

The Scientific World Journal, Vol

2015 Volume 2015

Abstract	Helicopter moving horizontal tail (i.e., MHT) strategy is applied in order to save helicopter flight control system (i.e., FCS) energy. For this intention complex, physics-based, control-oriented nonlinear helicopter models are used. Equations of MHT are integrated into these models and they are together linearized around straight level flight condition. A specific variance constrained control strategy, namely, output variance constrained Control (i.e., OVC) is utilized for helicopter FCS. Control energy savings due to this MHT idea with respect to a conventional helicopter are calculated. Parameters of helicopter FCS and dimensions of MHT are simultaneously optimized using a stochastic optimization method, namely, simultaneous perturbation stochastic approximation (i.e., SPSA). In order to observe improvement in behaviors of classical controls closed loop analyses are done.
Keywords	Technology ; T ; Medicine ; R ; Science ; Q
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of K-Means Clustering Algorithm for Lesion Segmentation in Dermoscopic Images

Sümeyya İLKİN / Oktay AYTAR / Tuğrul Hakan GENÇTÜRK / Suhap ŞAHİN

Gazi Üniversitesi Fen Bilimleri Dergisi, Vol 8, Iss 1, Pp 182-

2020 Volume 191

Abstract: The diagnosis of melanoma skin cancer in the early stages is of vital importance owing to the fact that their effects on the prognosis of recovery. The made of these diagnoses are mostly done with visual evaluation of the skin. Therefore, the stated ... ...

Abstract	The diagnosis of melanoma skin cancer in the early stages is of vital importance owing to the fact that their effects on the prognosis of recovery. The made of these diagnoses are mostly done with visual evaluation of the skin. Therefore, the stated diagnosis of as a result of visual evaluation of the skin is a subjective assessment that because it depends on the doctor’s expertise. In this study, the segmentation of lesion regions in skin images is performed with K-mean clustering algorithm in order to increase the accuracy of diagnosis made by doctors. In the algorithm, the system is tested by selecting K center number 2 and 4 values. A special melanoma data set has been used during the testing. The analysis of the obtained values have been realized using Peak Signal Noise Ratio (PSNR) and Correlation Coefficient (CC) metrics. The performance of this study was evaluated by comparing Canny edge detection and Mean shift algorithm previously implemented by us. In this segmentation process, the selected center number is 4 in the K-average clustering algorithm and in this situation the highest PSNR value is 17,1591dB. According to the metric results, it was observed that the segmentation performed by using the K-mean clustering algorithm which has selected center number equals to the 4 yielded more successful results.
Keywords	medical image processing ; melanoma skin cancer ; lesion segmentation ; k-means clustering algorithm ; mean shift algorithm ; canny edge detection algorithm ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Science ; Q ; Science (General) ; Q1-390
Subject code	006
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Gazi University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease.

Barman, Hasan Ali / Atici, Adem / Sahin, Irfan / Alici, Gokhan / Aktas Tekin, Esra / Baycan, Ömer Faruk / Ozturk, Fatih / Oflar, Ersan / Tugrul, Sevil / Yavuz, Mustafa Baran / Celik, Fatma Betul / Oktay, Aysu / Vahaboglu, Haluk / Adas, Mine / Turgut, Namigar / Okuyan, Ertugrul / Yildirmak, Mustafa Taner / Gungor, Baris

Coronary artery disease

2020 Volume 32, Issue 5, Page(s) 359–366

Abstract: Objective: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in ... ...

Abstract	Objective: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. Methods: For this multi-center retrospective study, data of consecutive patients who were treated for COVID-19 between 20 March and 20 April 2020 were collected. Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. In-hospital clinical outcome was compared between patients with and without cardiac injury. Results: A total of 607 hospitalized patients with COVID-19 were included in the study; the median age was 62.5 ± 14.3 years, and 334 (55%) were male. Cardiac injury was detected in 150 (24.7%) of patients included in the study. Mortality rate was higher in patients with cardiac injury (42% vs. 8%; P < 0.01). The frequency of patients who required ICU (72% vs. 19%), who developed acute kidney injury (14% vs. 1%) and acute respiratory distress syndrome (71%vs. 18%) were also higher in patients with cardiac injury. In multivariate analysis, age, coronary artery disease (CAD), elevated CRP levels, and presence of cardiac injury [odds ratio (OR) 10.58, 95% confidence interval (CI) 2.42-46.27; P < 0.001) were found to be independent predictors of mortality. In subgroup analysis, including patients free of history of CAD, presence of cardiac injury on admission also predicted mortality (OR 2.52, 95% CI 1.17-5.45; P = 0.018). Conclusion: Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/therapy ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Disease Progression ; Female ; Heart Diseases/blood ; Heart Diseases/diagnosis ; Heart Diseases/mortality ; Heart Diseases/therapy ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Patient Admission ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Troponin I/blood ; Turkey ; Up-Regulation
Chemical Substances	Biomarkers ; Troponin I
Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/MCA.0000000000000914
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Article ; Online: Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease

Barman, Hasan Ali / Atici, Adem / Sahin, Irfan / Alici, Gokhan / Aktas Tekin, Esra / Baycan, Ömer Faruk / Ozturk, Fatih / Oflar, Ersan / Tugrul, Sevil / Yavuz, Mustafa baran / Celik, Fatma Betul / Oktay, Aysu / Vahaboglu, Haluk / Adas, Mine / Turgut, Namigar / Okuyan, Ertugrul / Yıldırmak, Mustafa Taner / Gungor, Baris

Coronary Artery Disease

2020 Volume Publish Ahead of Print

Keywords	Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	1047268-x
ISSN	1473-5830 ; 0954-6928
ISSN (online)	1473-5830
ISSN	0954-6928
DOI	10.1097/mca.0000000000000914
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Article ; Online: The role of hydroxytyrosol in health and disease

Berrin Tuğrul / Latife Merve Oktay

Turkish Journal of Oncology, Vol 29, Iss 4, Pp 166-

2014 Volume 172

Abstract: Hydroxytyrosol is a phenolic compound released from the hydrolysis of oleuropein and is present in olive oil, leaf and fruit. Recently, studies on hydroxytyrosol have revealed its strong antioxidant and antiinflamatory effects. In vitro studies conducted ...

Abstract	Hydroxytyrosol is a phenolic compound released from the hydrolysis of oleuropein and is present in olive oil, leaf and fruit. Recently, studies on hydroxytyrosol have revealed its strong antioxidant and antiinflamatory effects. In vitro studies conducted in various cancer cell lines and in vivo assays carried out on animals reported strong evidences for its antiinflamatory, antiproliferative and proapoptotic influences. In addition, in cancer it is believed to have inhibitory effects during angiogenesis. Its modulatory role on bone formation and prevention of bone loss has been the attraction of some studies. If the molecular mechanisms and cellular pathways of hydroxytyrosol are elucidated, it will be possible to plan new strategies targeting various disease involved with cancer, inflammatory and cardio-vascular pathologies. In this review, various in vitro and in vivo studies investigating the antioxidant, anticancer, antiinflamatory role of hydroxytyrosol and its inhibitory effects in osteoporosis are discussed.
Keywords	Antiinflamatory; anticancer; antioxidant; antiproliferative; hydroxytyrosol; proapoptotic. ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Turkish
Publishing date	2014-12-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: HIV Seroprevalence in Mogadishu, Somalia: a Retrospective Study between 2015 and 2019.

Şahiner, Fatih / Idiris, Mohamed H / Hoşbul, Tuğrul / Adam, Abdirahim A / Osman, Marian M / Sümbül, Hilmi E / Sari, Oktay / Bahçeci, Onur

Clinical laboratory

2022 Volume 68, Issue 7

Abstract: Background: Acquired immunodeficiency syndrome (AIDS) remains a major global public health problem. This study aimed to obtain current epidemiological data on the Human immunodeficiency virus (HIV) infections in Mogadishu, Somalia.: Methods: This ... ...

Abstract	Background: Acquired immunodeficiency syndrome (AIDS) remains a major global public health problem. This study aimed to obtain current epidemiological data on the Human immunodeficiency virus (HIV) infections in Mogadishu, Somalia. Methods: This study included 92,270 anti-HIV test results reported for 82,954 different individuals between 2015 and 2019. HIV tests were performed using the Architect HIV Ag/Ab Combo assay and retested with the Elecsys HIV combi PT assay. Results: HIV seropositivity was found to be 0.32% (269/82,954) in all individuals over a period of four years. Anti-HIV seropositivity in the 0 - 14, 15 - 19, 15 - 24, 15 - 49, and > 15 age groups were as follows: 0.17% (11/6,441), 0.17% (12/7,131), 0.15% (35/24,132), 0.37% (212/56,895), and 0.34% (258/76,513), respectively. In HIV-infected patients, anti-HBs, HBsAg, anti-HCV, and anti-TP (syphilis) seropositivity was found to be 30.3% (56/185), 9.54% (23/241), 1.24% (3/242), and 3.45% (2/58), respectively. Conclusions: The findings from this study provide comprehensive data on the HIV epidemiology in Somalia. We believe that the results presented in this study will contribute to the risk analysis and planning of preventive policies of national and global health organizations.
MeSH term(s)	HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Seroprevalence ; Humans ; Retrospective Studies ; Seroepidemiologic Studies ; Somalia/epidemiology ; Syphilis
Language	English
Publishing date	2022-08-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2021.210847
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Article: Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease

Coron. artery dis

Abstract: OBJECTIVE: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in ... ...

Abstract	OBJECTIVE: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. METHODS: For this multi-center retrospective study, data of consecutive patients who were treated for COVID-19 between 20 March and 20 April 2020 were collected. Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. In-hospital clinical outcome was compared between patients with and without cardiac injury. RESULTS: A total of 607 hospitalized patients with COVID-19 were included in the study; the median age was 62.5 ± 14.3 years, and 334 (55%) were male. Cardiac injury was detected in 150 (24.7%) of patients included in the study. Mortality rate was higher in patients with cardiac injury (42% vs. 8%; P < 0.01). The frequency of patients who required ICU (72% vs. 19%), who developed acute kidney injury (14% vs. 1%) and acute respiratory distress syndrome (71%vs. 18%) were also higher in patients with cardiac injury. In multivariate analysis, age, coronary artery disease (CAD), elevated CRP levels, and presence of cardiac injury [odds ratio (OR) 10.58, 95% confidence interval (CI) 2.42-46.27; P < 0.001) were found to be independent predictors of mortality. In subgroup analysis, including patients free of history of CAD, presence of cardiac injury on admission also predicted mortality (OR 2.52, 95% CI 1.17-5.45; P = 0.018). CONCLUSION: Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #611941
Database	COVID19

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