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Article: Reverse Triggered Breath during Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist at Increasing Propofol Infusion.

Longhini, Federico / Simonte, Rachele / Vaschetto, Rosanna / Navalesi, Paolo / Cammarota, Gianmaria

2023 Volume 12, Issue 14

Abstract: Background: Reverse triggered breath (RTB) has been extensively described during assisted-controlled modes of ventilation. We aimed to assess whether RTB occurs during Pressure Support Ventilation (PSV) and Neurally Adjusted Ventilatory Assist (NAVA) at ...

Abstract	Background: Reverse triggered breath (RTB) has been extensively described during assisted-controlled modes of ventilation. We aimed to assess whether RTB occurs during Pressure Support Ventilation (PSV) and Neurally Adjusted Ventilatory Assist (NAVA) at varying depths of propofol sedation. Methods: This is a retrospective analysis of a prospective crossover randomized controlled trial conducted in an Intensive Care Unit (ICU) of a university hospital. Fourteen intubated patients for acute respiratory failure received six trials of 25 minutes randomly applying PSV and NAVA at three different propofol infusions: awake, light, and deep sedation. We assessed the occurrence of RTBs at each protocol step. The incidence level of RTBs was determined through the RTB index, which was calculated by dividing RTBs by the total number of breaths triggered and not triggered. Results: RTBs occurred during both PSV and NAVA. The RTB index was greater during PSV than during NAVA at mild (1.5 [0.0; 5.3]% vs. 0.6 [0.0; 1.1]%) and deep (5.9 [0.7; 9.0]% vs. 1.7 [0.9; 3.5]%) sedation. Conclusions: RTB occurs in patients undergoing assisted mechanical ventilation. The level of propofol sedation and the mode of ventilation may influence the incidence of RTBs.
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144857
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Article ; Online: Lung ultrasound monitoring: impact on economics and outcomes.

Cammarota, Gianmaria / Vetrugno, Luigi / Longhini, Federico

Current opinion in anaesthesiology

2022 Volume 36, Issue 2, Page(s) 234–239

Abstract: Purpose of review: This review aims to summarize the impact of lung ultrasonography (LUS) on economics and possible impact on patients' outcomes, proven its diagnostic accuracy in patients with acute respiratory failure.: Recent findings: Despite ... ...

Abstract	Purpose of review: This review aims to summarize the impact of lung ultrasonography (LUS) on economics and possible impact on patients' outcomes, proven its diagnostic accuracy in patients with acute respiratory failure. Recent findings: Despite some previous ethical concerns on LUS examination, today this technique has showed several advantages. First, it is now clear that the daily use of LUS can provide a relevant cost reduction in healthcare of patients with acute respiratory failure, while reducing the risk of transport of patients to radiological departments for chest CT scan. In addition, LUS reduces the exposition to x-rays since can replace the bedside chest X-ray examination in many cases. Indeed, LUS is characterized by a diagnostic accuracy that is even superior to portable chest X-ray when performed by well trained personnel. Finally, LUS examination is a useful tool to predict the course of patients with pneumonia, including the need for hospitalization and ICU admission, noninvasive ventilation failure and orotracheal intubation, weaning success, and mortality. Summary: LUS should be implemented not only in Intensive Care Units, but also in other setting like emergency departments. Since most data comes from the recent coronavirus disease 2019 pandemic, further investigations are required in Acute Respiratory Failure of different etiologies.
MeSH term(s)	Humans ; COVID-19 ; Lung/diagnostic imaging ; Pneumonia ; Respiratory Distress Syndrome/diagnosis ; Ultrasonography/methods ; Respiratory Insufficiency
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0000000000001231
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Zs.A 2564: Show issues

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Article: COVID-19-associated pulmonary aspergillosis in intensive care unit: A real-life experience.

Russo, Alessandro / Serraino, Riccardo / Serapide, Francesca / Bruni, Andrea / Garofalo, Eugenio / Longhini, Federico / Trecarichi, Enrico Maria / Torti, Carlo

Heliyon

2024 Volume 10, Issue 2, Page(s) e24298

Abstract: Since 2020, cases of COVID-19-associated pulmonary aspergillosis (CAPA) have been frequently described, representing an important cause of mortality, especially among patients admitted to intensive care unit (ICU). A predisposition to invasive infection ... ...

Abstract	Since 2020, cases of COVID-19-associated pulmonary aspergillosis (CAPA) have been frequently described, representing an important cause of mortality, especially among patients admitted to intensive care unit (ICU). A predisposition to invasive infection caused by
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24298
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Article ; Online: Advanced Point-of-care Bedside Monitoring for Acute Respiratory Failure.

Cammarota, Gianmaria / Simonte, Rachele / Longhini, Federico / Spadaro, Savino / Vetrugno, Luigi / De Robertis, Edoardo

Anesthesiology

2023 Volume 138, Issue 3, Page(s) 317–334

Abstract: Advanced respiratory monitoring involves several mini- or noninvasive tools, applicable at bedside, focused on assessing lung aeration and morphology, lung recruitment and overdistention, ventilation-perfusion distribution, inspiratory effort, ... ...

Abstract	Advanced respiratory monitoring involves several mini- or noninvasive tools, applicable at bedside, focused on assessing lung aeration and morphology, lung recruitment and overdistention, ventilation-perfusion distribution, inspiratory effort, respiratory drive, respiratory muscle contraction, and patient-ventilator asynchrony, in dealing with acute respiratory failure. Compared to a conventional approach, advanced respiratory monitoring has the potential to provide more insights into the pathologic modifications of lung aeration induced by the underlying disease, follow the response to therapies, and support clinicians in setting up a respiratory support strategy aimed at protecting the lung and respiratory muscles. Thus, in the clinical management of the acute respiratory failure, advanced respiratory monitoring could play a key role when a therapeutic strategy, relying on individualization of the treatments, is adopted.
MeSH term(s)	Humans ; Point-of-Care Systems ; Respiration, Artificial ; Positive-Pressure Respiration ; Respiration ; Respiratory Distress Syndrome ; Respiratory Insufficiency/therapy
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004480
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Article ; Online: Avoiding complications during prone position ventilation.

Bruni, Andrea / Garofalo, Eugenio / Longhini, Federico

Intensive & critical care nursing

2021 Volume 66, Page(s) 103064

MeSH term(s)	Humans ; Lung ; Patient Positioning ; Prone Position ; Respiration, Artificial/adverse effects ; Supine Position
Language	English
Publishing date	2021-05-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2021.103064
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Article ; Online: High flow through nasal cannula in exacerbated COPD patients: a systematic review.

Pisani, L / Astuto, M / Prediletto, I / Longhini, F

Pulmonology

2019 Volume 25, Issue 6, Page(s) 348–354

Abstract: Chronic Obstructive Pulmonary Disease (COPD) history is characterized by episodes of exacerbation of varying severity, featured by acute worsening of respiratory symptoms, commonly precipitated by respiratory tract infection. The recent ERS/ATS clinical ... ...

Abstract	Chronic Obstructive Pulmonary Disease (COPD) history is characterized by episodes of exacerbation of varying severity, featured by acute worsening of respiratory symptoms, commonly precipitated by respiratory tract infection. The recent ERS/ATS clinical practice guidelines strongly recommend the application of non invasive ventilation (NIV) for patients with acute respiratory failure (ARF) leading to acute or acute-on-chronic respiratory acidosis (pH 7.35) and not for those patients with acute exacerbation of COPD (AECOPD) and hypercapnia who are not acidotic. In recent years, High-Flow through Nasal Cannula (HFNC) has been introduced in the clinical practice. We designed the present systematic review of the literature to assess all effects of HFNC use reported in exacerbated COPD patients. In this setting, HFNC is able to keep PaCO2 unmodified, while oxygenation slightly deteriorates as opposed to NIV. Furthermore, the work of breathing is reduced with HFNC by a similar extent to NIV, while it increases by 40-50% during conventional oxygen therapy (COT). HFNC is also reported to be more comfortable than COT and NIV. Despite these results, little and limited evidence for improved clinical outcomes is currently available.
MeSH term(s)	Acidosis, Respiratory/therapy ; Blood Gas Analysis ; Disease Progression ; Humans ; Hypercapnia/therapy ; Noninvasive Ventilation/instrumentation ; Noninvasive Ventilation/methods ; Positive-Pressure Respiration/instrumentation ; Positive-Pressure Respiration/methods ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiratory Insufficiency/complications ; Respiratory Insufficiency/therapy ; Respiratory Rate ; Respiratory Therapy/instrumentation ; Respiratory Therapy/methods ; Treatment Outcome ; Work of Breathing
Language	English
Publishing date	2019-10-05
Publishing country	Spain
Document type	Journal Article ; Systematic Review
ISSN	2531-0437
ISSN (online)	2531-0437
DOI	10.1016/j.pulmoe.2019.08.001
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Article ; Online: The authors reply.

Longhini, Federico / Pisani, Lara / Nava, Stefano / Navalesi, Paolo

Critical care medicine

2020 Volume 48, Issue 1, Page(s) e76–e77

MeSH term(s)	Cross-Over Studies ; Humans ; Hypercapnia ; Noninvasive Ventilation ; Oxygen ; Respiratory Insufficiency
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000004085
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Article ; Online: Development of a customizable mouse backbone spectral flow cytometry panel to delineate immune cell populations in normal and tumor tissues.

Longhini, Ana Leda F / Fernández-Maestre, Inés / Kennedy, Margaret C / Wereski, Matthew G / Mowla, Shoron / Xiao, Wenbin / Lowe, Scott W / Levine, Ross L / Gardner, Rui

Frontiers in immunology

2024 Volume 15, Page(s) 1374943

Abstract: Introduction: In vivo: Methods: To address this issue, we designed a panel with 13 fixed markers that define the major immune populations -referred to as the backbone panel- that can be profiled in different tissues but with the option to incorporate ...

Abstract	Introduction: In vivo Methods: To address this issue, we designed a panel with 13 fixed markers that define the major immune populations -referred to as the backbone panel- that can be profiled in different tissues but with the option to incorporate up to seven additional fluorochromes, including any marker specific to the study in question. Results: This backbone panel maintains its resolution across different spectral flow cytometers and organs, both hematopoietic and non-hematopoietic, as well as tumors with complex immune microenvironments. Discussion: Having a robust backbone that can be easily customized with pre-validated drop-in fluorochromes saves time and resources and brings consistency and standardization, making it a versatile solution for immuno-oncology researchers. In addition, the approach presented here can serve as a guide to develop similar types of customizable backbone panels for different research questions requiring high-parameter flow cytometry panels.
MeSH term(s)	Animals ; Mice ; Humans ; Flow Cytometry/methods ; Fluorescent Dyes ; Neoplasms/metabolism ; Tumor Microenvironment
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1374943
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Article ; Online: Should high-flow through nasal cannula be used during bronchoscopy in critically ill patients with hypoxemic acute respiratory failure?

Longhini, Federico / Bruni, Andrea / Saraco, Giuseppe / Garofalo, Eugenio / Conti, Giorgio

Journal of Anesthesia, Analgesia and Critical Care (Online)

2021 Volume 1, Issue 1, Page(s) 4

Abstract: Flexible fiberoptic bronchoscopy (FOB) is an invasive procedure with diagnostic and/or therapeutic purposes commonly used in critically ill patients. FOB may be complicated by desaturation, onset or worsening of the respiratory failure, and hemodynamic ... ...

Abstract	Flexible fiberoptic bronchoscopy (FOB) is an invasive procedure with diagnostic and/or therapeutic purposes commonly used in critically ill patients. FOB may be complicated by desaturation, onset or worsening of the respiratory failure, and hemodynamic instability due to cardio-respiratory alterations occurring during the procedure. Increasing evidences suggest the use of high-flow through nasal cannula (HFNC) over conventional oxygen therapy (COT) in critically ill patients with acute respiratory failure (ARF). Indeed, HFNC has a rationale and possible physiologic advantages, even during FOB. However, to date, evidences in favor of HFNC over COT or continuous positive airway pressure (CPAP) or non-invasive ventilation (NIV) during FOB are still weak. Nonetheless, in critically ill patients with hypoxemic ARF, the choice of the oxygenation strategy during a FOB is challenging. Based on a review of the literature, HFNC may be preferred over COT in patients with mild to moderate hypoxemic ARF, without cardiac failure or hemodynamic instability. On the opposite, in critically ill patients with more severe hypoxemic ARF or in the presence of cardiac failure or hemodynamic instability, CPAP or NIV, applied with specifically designed interfaces, may be preferred over HFNC.
Language	English
Publishing date	2021-09-04
Publishing country	England
Document type	Journal Article ; Review
ISSN	2731-3786
ISSN (online)	2731-3786
DOI	10.1186/s44158-021-00001-y
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Article ; Online: Organisational models in primary health care to manage chronic conditions: A scoping review.

Longhini, Jessica / Canzan, Federica / Mezzalira, Elisabetta / Saiani, Luisa / Ambrosi, Elisa

Health & social care in the community

2021 Volume 30, Issue 3, Page(s) e565–e588

Abstract: Chronic diseases are increasing incessantly, and more efforts are needed in order to develop effective organisational models in primary health care, which may address the challenges posed by the consequent multimorbidity. The aim of this study was to ... ...

Abstract	Chronic diseases are increasing incessantly, and more efforts are needed in order to develop effective organisational models in primary health care, which may address the challenges posed by the consequent multimorbidity. The aim of this study was to assess and map methods, interventions and outcomes investigated over the last decade regarding the effectiveness of chronic care organisational models in primary care settings. We conducted a scoping review including systematic reviews, clinical trials, and observational studies, published from 2010 to 2020, that evaluated the effectiveness of organisational models for chronic conditions in primary care settings, including home care, community, and general practice. We included 67 international studies out of the 6,540 retrieved studies. The prevalent study design was the observational design (25 studies, 37.3%), and 62 studies (92.5%) were conducted on the adult population. Four main models emerged, called complex integrated care models. These included models grounded on the Chronic Care Model framework and similar, case or care management, and models centred on involvement of pharmacists or community health workers. Across the organisational models, self-management support and multidisciplinary teams were the most common components. Clinical outcomes have been investigated the most, while caregiver outcomes have been detected in the minority of cases. Almost one-third of the included studies reported only significant effects in the outcomes. No sufficient data were available to determine the most effective models of care. However, more complex models seem to lead to better outcomes. In conclusion, in the development of more comprehensive organisational models to manage chronic conditions in primary health care, more efforts are needed on the paediatric population, on the inclusion of caregiver outcomes in the effectiveness evaluation of organisational models and on the involvement of social community resources. As regarding the studies investigating organisational models, more detailed descriptions should be provided with regard to interventions, and the training, roles and responsibilities of health and lay figures in delivering care.
MeSH term(s)	Adult ; Child ; Chronic Disease ; Humans ; Models, Organizational ; Multimorbidity ; Pharmacists ; Primary Health Care
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.13611
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