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  1. Article ; Online: Cesarean section in the second stage of labor is associated with early-term and late preterm birth in subsequent pregnancies.

    Sapir, Aviad / Friedrich, Lior / Gat, Roni / Erez, Offer

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2023  Volume 36, Issue 1, Page(s) 2175658

    Abstract: Objectives: The objectives of this study were to determine in a population-based cohort study the association between cesarean section (CS) during the second stage of labor and the risk for preterm birth and/or cervical insufficiency in the subsequent ... ...

    Abstract Objectives: The objectives of this study were to determine in a population-based cohort study the association between cesarean section (CS) during the second stage of labor and the risk for preterm birth and/or cervical insufficiency in the subsequent pregnancy; to identify maternal and neonatal risk factors for long-term complications following CS due to prolonged second stage of labor.
    Methods: We conducted a retrospective population-based cohort study including women who had at least one consecutive delivery following a CS at our institution from 1991 to 2018, provided that the first delivery was at term. We divided the study cohort into two groups: (1) women who delivered by CS due to failure to progress during the first stage of labor (
    Results: Of the 120,147 women who met the inclusion criteria, 78,407 had a subsequent delivery during the study period. Women of group 1 were significantly older than those of group 2 (
    Conclusion: CS due to arrest of descent is an independent risk factor for subsequent preterm birth. The exact mechanisms contributing to this association are yet to be determined.
    Synopsis: Cesarean section during the second stage of labor is an independent risk factor for late preterm birth in the subsequent pregnancy when compared to cesarean section in the first stage of labor.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Cesarean Section/adverse effects ; Premature Birth/epidemiology ; Premature Birth/etiology ; Retrospective Studies ; Cohort Studies ; Labor Stage, Second
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2023.2175658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Low Covid-19 infection rate period is associated with a rebound increase in preterm birth rate.

    Meyer, Raanan / Friedrich, Lior / Levin, Gabriel

    Journal of perinatology : official journal of the California Perinatal Association

    2022  Volume 43, Issue 5, Page(s) 670–672

    MeSH term(s) Female ; Infant, Newborn ; Humans ; Pregnancy ; Premature Birth/epidemiology ; COVID-19 ; Pregnancy Complications, Infectious/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-022-01501-7
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  3. Article ; Online: Neonatal outcomes in pregnancies complicated by placenta accreta- a matched cohort study.

    Toussia-Cohen, Shlomi / Castel, Elias / Friedrich, Lior / Mor, Nizan / Ohayon, Aviran / Levin, Gabriel / Meyer, Raanan

    Archives of gynecology and obstetrics

    2024  

    Abstract: Purpose: Pregnancies complicated by placenta accreta spectrum (PAS) are associated with severe maternal morbidities. The aim of this study is to describe the neonatal outcomes in pregnancies complicated with PAS compared with pregnancies not complicated ...

    Abstract Purpose: Pregnancies complicated by placenta accreta spectrum (PAS) are associated with severe maternal morbidities. The aim of this study is to describe the neonatal outcomes in pregnancies complicated with PAS compared with pregnancies not complicated by PAS.
    Methods: A retrospective cohort study conducted at a single tertiary center between 03/2011 and 01/2022, comparing women with PAS who underwent cesarean delivery (CD) to a matched control group of women without PAS who underwent CD. We evaluated the following adverse neonatal outcomes: umbilical artery pH < 7.0, umbilical artery base excess ≤ - 12, APGAR score < 7 at 5 min, neonatal intensive care unit (NICU) admission, mechanical ventilation, hypoxic ischemic encephalopathy, seizures and neonatal death. We also evaluated a composite adverse neonatal outcome, defined as the occurrence of at least one of the adverse neonatal outcomes described above. Multivariable regression analysis was used to determine which adverse neonatal outcome were independently associated with the presence of PAS.
    Results: 265 women with PAS were included in the study group and were matched to 1382 controls. In the PAS group compared with controls, the rate of composite adverse neonatal outcomes was significantly higher (33.6% vs. 18.7%, respectively, p < 0.001). In a multivariable logistic regression analysis, Apgar score < 7 at 5 min, NICU admission and composite adverse neonatal outcome were independently associated with PAS.
    Conclusion: Neonates in PAS pregnancies had higher rates of adverse outcomes. Apgar score < 7 at 5 min, NICU admission and composite adverse neonatal outcome were independently associated with PAS.
    Language English
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07353-6
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  4. Article ; Online: The association between sinonasal anatomical variants and the laterality of orbital complications in pediatric acute rhinosinusitis.

    Daniel, Aviv / Novoa, Rosa / Pansky, Itay / Hazan, Itai / Friedrich, Lior / Kordeluk, Sofia / Tsumi, Erez / Cohen, Oded / Ziv, Oren

    International journal of pediatric otorhinolaryngology

    2024  Volume 180, Page(s) 111958

    Abstract: Introduction: As the role of sinonasal anatomical variants as predisposing factors in determining the lateralization of acute rhinosinusitis-related orbital complications (ARS-OC) in pediatrics remains a topic of debate, this study further explores the ... ...

    Abstract Introduction: As the role of sinonasal anatomical variants as predisposing factors in determining the lateralization of acute rhinosinusitis-related orbital complications (ARS-OC) in pediatrics remains a topic of debate, this study further explores the potential association between anatomical variations and ARS-OC.
    Methods: A retrospective study was conducted on children who had been admitted with ARS-OC using medical records and sinus CT scans to compare anatomical differences between the affected and contralateral sides. This study aimed to identify bony anatomical disparities that may impact OC laterality secondary to ARS. The anatomical features examined included septal deviation, concha bullosa, lamina papyracea dehiscence (LPD), and uncinate process abnormalities.
    Results: The CT scans of 57 pediatric patients (114 sides) were reviewed. Our results indicated that bony anatomical variations were associated with ARS-OC laterality (63 % vs. 37 %, P = 0.006), yielding an odds ratio of 2.91. Additionally, our study revealed a significant association between ipsilateral LPD with the increased risk of ARS-OC (39 % vs. 1.8 %, P < 0.05), with an odds ratio of 34.3 compared to the opposite side.
    Conclusions: LPD might play a role in the pathophysiology of pediatric ARS-OC, as it is associated with a significantly higher risk of affecting the ipsilateral side. Further research is necessary to determine whether LPD is a causative factor or a result of ARS.
    Language English
    Publishing date 2024-04-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2024.111958
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  5. Article ; Online: Outcomes of cesarean delivery in placenta accreta: conservative delivery vs. cesarean hysterectomy.

    Alina, Weissmann-Brenner / Elias, Castel / Eran, Kassif / Lior, Friedrich / Nizan, Mor / Gabriel, Levin / Hila, Lahav Ezra / Raanan, Meyer

    Journal of perinatal medicine

    2023  Volume 52, Issue 1, Page(s) 22–29

    Abstract: Objectives: To compare delivery outcomes of pregnancies diagnosed with placenta-accreta-syndrome (PAS) who underwent conservative treatment to patients who underwent cesarean hysterectomy.: Methods: A retrospective study of all women diagnosed with ... ...

    Abstract Objectives: To compare delivery outcomes of pregnancies diagnosed with placenta-accreta-syndrome (PAS) who underwent conservative treatment to patients who underwent cesarean hysterectomy.
    Methods: A retrospective study of all women diagnosed with PAS treated in one tertiary medical center between 03/2011 and 11/2020 was performed. Comparison was made between conservative management during cesarean delivery and cesarean hysterectomy. Conservative management included leaving uterus
    Results: A total of 249 pregnancies (0.25 % of all deliveries) were diagnosed with PAS, 208 underwent conservative cesarean delivery and 41 had cesarean hysterectomy, 31 of them were unplanned (75.6 %). The median number of previous cesarean deliveries was significantly higher in the cesarean hysterectomy group. There was no difference in the duration from the last cesarean delivery, the presence of placenta previa, pre-operative hemoglobin or platelets levels between the pregnancies with conservative management and the cesarean hysterectomy. Significantly more pregnancies with sonographic suspicion of placenta percreta and bladder invasion had cesarean hysterectomy. Cesarean hysterectomy was significantly associated with earlier delivery, with bleeding and required significantly more blood products. There was no statistically significant difference in the rate of relaparotomy following cesarean delivery or the rate of infections. Multivariable-regression-analysis revealed a significant odds ratio of 3.38 of blood loss of >3,000 mL following cesarean hysterectomy.
    Conclusions: Conservative management in delivery of PAS pregnancies is associated with less bleeding complications during surgery compared to cesarean hysterectomy.
    MeSH term(s) Pregnancy ; Humans ; Female ; Placenta Accreta/etiology ; Placenta Accreta/surgery ; Retrospective Studies ; Cesarean Section/adverse effects ; Myometrium ; Hysterectomy/adverse effects ; Placenta Previa/surgery
    Language English
    Publishing date 2023-08-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2023-0154
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  6. Article ; Online: Management of adnexal mass: A comparison of five national guidelines.

    Friedrich, Lior / Meyer, Raanan / Levin, Gabriel

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 265, Page(s) 80–89

    Abstract: Objectives: General gynecologists are often the first to face a newly diagnosed adnexal mass. Bothering mass symptoms, fertility issues, and the effect of a possible surgical intervention on fertility in term of mechanical factor and ovarian follicular ... ...

    Abstract Objectives: General gynecologists are often the first to face a newly diagnosed adnexal mass. Bothering mass symptoms, fertility issues, and the effect of a possible surgical intervention on fertility in term of mechanical factor and ovarian follicular reserve are all considerations that should be accounted for. This study summarizes and compares five different adnexal mass management guidelines, enabling clinicians to peruse consensus and controversy issues, thus choosing the optimal management method.
    Design: We retrieved, reviewed and compared the most recent national guidelines of adnexal mass management from the national societies of the United States (American College of Obstetricians and Gynecologists), England (the Royal College of Obstetricians and Gynecologists), Canada (the Society of Obstetricians and Gynaecologists of Canada), Australia (the Royal Australian College of General Practitioners), and France (French College of Gynaecologists and Obstetricians).
    Results: There is a broad consensus regarding the role of transvaginal ultrasound as part of the initial evaluation of an adnexal mass and the radiological characteristics suggesting it being malignant. The role of transabdominal ultrasound or doppler mode is controversial. The use of MRI in cases of indeterminate adnexal masses is widely accepted. Ultrasound-guided aspiration is generally not recommended. There is a broad consensus that CA-125 should not be used as an ovarian cancer disease screening tool, though its role in the initial evaluation of adnexal masses is controversial. Risk prediction models are generally accepted, particularly the 'International Ovarian Tumor Analysis simple rules' and the 'Risk of Malignancy Index'.
    Conclusion: Adnexal mass management national guidelines, though similar, had noticeable variations in the content, references cited, and recommendations made. While this variation might raise a concern as to the reproducibility of synthesizing literature, it can help practitioners present all spectra of recommendations and available data.
    MeSH term(s) Adnexal Diseases/diagnostic imaging ; Australia ; CA-125 Antigen ; Female ; Humans ; Ovarian Neoplasms/diagnostic imaging ; Reproducibility of Results ; Ultrasonography ; United States
    Chemical Substances CA-125 Antigen
    Language English
    Publishing date 2021-08-24
    Publishing country Ireland
    Document type Comparative Study ; Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.08.020
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  7. Article ; Online: Clinical implications of a cesarean scar pregnancy sonographic evaluation and reporting system.

    Meyer, Raanan / Friedrich, Lior / Plaschkes, Roni / Toussia-Cohen, Shlomi / Levin, Gabriel / Weissbach, Tal / Kassif, Eran / Mashiach, Roy

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 291, Page(s) 247–251

    Abstract: Objectives: Recently, a new standardized sonographic evaluation system for cesarean scar pregnancies (CSP) was published. We aimed to evaluate the clinical outcomes of CSP cases according to the new sonographic evaluation and reporting system.: Study ... ...

    Abstract Objectives: Recently, a new standardized sonographic evaluation system for cesarean scar pregnancies (CSP) was published. We aimed to evaluate the clinical outcomes of CSP cases according to the new sonographic evaluation and reporting system.
    Study design: A retrospective study conducted at a single tertiary center. All CSPs between 1/2011 and 4/2022 were included. Cases were evaluated by expert sonographers and classified into three categories: 1) CSP in which the largest part of the gestational sac (GS) protrudes towards the uterine cavity; 2) CSP in which the largest part of the GS is embedded in the myometrium but does not cross the serosal contour; and 3) CSP in which the GS is partially located beyond the outer contour of the cervix or uterus.Baseline characteristics, management and outcomes were compared between the three categories.
    Results: Overall, 55 patients were diagnosed with CSP during the study period; 10 (18.1 %) type 1, 31 (56.3 %) type 2, and 14 (25.4 %) type 3. Baseline characteristics were similar among groups. Compared with type 2 and 3, patients diagnosed with CSP type 1 received less methotrexate treatment [83.9 % and 78.6 % vs. 40.0 %, respectively, p = 0.020]. The rates of need for invasive procedures, urgent procedures, major bleeding, length of hospitalization, and subsequent pregnancies were similar between groups.
    Conclusions: No clinically significant differences were found between groups divided by the new standardized sonographic evaluation and reporting system for CSP in pregnancy characteristics, management, and subsequent pregnancy outcomes. Further investigation is required to enable informed management of CSP based on the new sonographic reporting system.
    MeSH term(s) Pregnancy ; Female ; Humans ; Cicatrix/diagnostic imaging ; Retrospective Studies ; Cesarean Section/adverse effects ; Pregnancy, Ectopic/diagnostic imaging ; Pregnancy, Ectopic/etiology ; Pregnancy, Ectopic/drug therapy ; Uterus ; Methotrexate/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-11-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.11.003
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  8. Article ; Online: Risk factors for bladder injury during placenta accreta spectrum surgery.

    Friedrich, Lior / Mor, Nizan / Weissmann-Brenner, Alina / Kassif, Eran / Friedrich, Shakad Noah / Weissbach, Tal / Castel, Elias / Levin, Gabriel / Meyer, Raanan

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2022  Volume 161, Issue 3, Page(s) 911–919

    Abstract: Objectives: To identify risk factors associated with bladder injury during placenta accreta spectrum (PAS) surgeries.: Methods: This retrospective cohort study was conducted at the Chaim Sheba Medical Center. The study population included pregnant ... ...

    Abstract Objectives: To identify risk factors associated with bladder injury during placenta accreta spectrum (PAS) surgeries.
    Methods: This retrospective cohort study was conducted at the Chaim Sheba Medical Center. The study population included pregnant women diagnosed with PAS undergoing uterine-preserving surgery or hysterectomy. Women with and without operative bladder injury were compared by univariate analysis followed by multivariate analysis. A sub-analysis of women without preoperative sonographic suspicion of bladder invasion was performed.
    Results: A total of 312 women were included in the study. Bladder injury incidence was 9.3% (n = 29). Uterine preservation was performed in 267/312 (85.6%) women. The number of previous cesarean deliveries and a preoperative sonogram suspicious for placenta percreta were found to be independent risk factors for intraoperative bladder injury (odds ratio [OR] 1.30, P = 0.019, and OR 5.23, P = 0.002, respectively). The number of previous cesarean deliveries and preoperative sonographic suspicion of placenta percreta were also associated with bladder injury in the sub-analysis (OR 1.30, P = 0.044 for previous cesarean deliveries, and OR 3.36, P = 0.036, for preoperative suspicion of bladder injury).
    Conclusion: The number of previous cesarean deliveries and preoperative suspicion of placenta percreta are preoperative factors that can assist in preoperative planning and intraoperative management of PAS cases.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Placenta Accreta/diagnostic imaging ; Placenta Accreta/epidemiology ; Placenta Accreta/surgery ; Cesarean Section/adverse effects ; Retrospective Studies ; Urinary Bladder/diagnostic imaging ; Hysterectomy/adverse effects ; Risk Factors ; Placenta ; Placenta Previa/surgery
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14567
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  9. Article ; Online: A marked decrease in preterm deliveries during the coronavirus disease 2019 pandemic.

    Meyer, Raanan / Bart, Yossi / Tsur, Abraham / Yinon, Yoav / Friedrich, Lior / Maixner, Nitzan / Levin, Gabriel

    American journal of obstetrics and gynecology

    2020  Volume 224, Issue 2, Page(s) 234–237

    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Female ; Humans ; Israel/epidemiology ; Multivariate Analysis ; Pandemics ; Pregnancy ; Premature Birth/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.10.017
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  10. Article ; Online: Hematologic adaptation to mask-wearing among pregnant women and obstetrical outcome during the coronavirus disease 2019 pandemic.

    Friedrich, Lior / Levin, Gabriel / Maixner, Nitzan / Bart, Yossi / Tsur, Abraham / Yinon, Yoav / Meyer, Raanan

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 154, Issue 2, Page(s) 297–303

    Abstract: Objective: To evaluate the effect of the coronavirus disease 2019 (COVID-19) mask-wearing on hematological laboratory components and obstetrical outcomes among women delivering during the COVID-19 pandemic.: Methods: Laboratory results and ... ...

    Abstract Objective: To evaluate the effect of the coronavirus disease 2019 (COVID-19) mask-wearing on hematological laboratory components and obstetrical outcomes among women delivering during the COVID-19 pandemic.
    Methods: Laboratory results and obstetrical outcomes of women with singleton gestations, admitted for delivery during the COVID-19 mask-wearing period (April-June 2020) were compared with those of women delivering during the parallel period in 2019 and with a larger cohort derived from nine pre-pandemic years (March 2011-April 2020).
    Results: Overall, 1838 women delivered during the COVID-19 pandemic. Compared with the pre-pandemic period, mean hemoglobin and fibrinogen levels were significantly higher during the mask-wearing period (12.15 ± 1.1 vs 11.96 ± 1.2, P < 0.001 and 472 ± 103.6 vs 448 ± 85.1 mg/dl, P < 0.001, respectively). Platelet levels were lower (200 ± 56.0 vs 206 ± 57.5 K/µl, P < 0.001). The rate of delivery at <34 weeks of gestation was lower during the mask-wearing period (1.1% vs 2%, odds ratio [OR] 0.57, 95% confidence intervals [CI] 0.37-0.88, P = 0.01), whereas cesarean delivery and postpartum hemorrhage rates were higher (26.7% vs 24.4%, OR 1.13, 95% CI 1.02-1.25, P = 0.022 and 4.1% vs 2.8%, OR 1.5, 95% CI 1.2-1.8, P = 0.001, respectively).
    Conclusion: A hard-to-ventilate space created by wearing a mask during the COVID-19 era may be the underlying cause of the observed higher hemoglobin level among pregnant women, possibly affecting obstetrical outcomes.
    MeSH term(s) Adult ; Blood Platelets ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cesarean Section/statistics & numerical data ; Cohort Studies ; Female ; Fibrinogen/analysis ; Hemoglobins/analysis ; Hospitalization ; Humans ; Masks ; Pandemics ; Pregnancy ; Pregnant Women/psychology ; SARS-CoV-2 ; Term Birth
    Chemical Substances Hemoglobins ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13715
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