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Article ; Online: Cancer takes many paths through G1/S.

Knudsen, Erik S / Witkiewicz, Agnieszka K / Rubin, Seth M

2023

Abstract: ... cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S phase. However, recent ... drivers and take different trajectories through the G1/S transition. We are discovering that cancer cells ...

Abstract	In the commonly accepted paradigm for control of the mammalian cell cycle, sequential cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S phase. However, recent studies using different technological approaches and examining a broad range of cancer cell types are challenging this established paradigm. An alternative model is evolving in which cell cycles utilize different drivers and take different trajectories through the G1/S transition. We are discovering that cancer cells in particular can adapt their drivers and trajectories, which has important implications for antiproliferative therapies. These studies have helped to refine an understanding of how CDK inhibition impinges on proliferation and have significance for understanding fundamental features of cell biology and cancer.
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/j.tcb.2023.10.007
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Article ; Online: Audio Interview: A Look at the U.S. Government's Covid-19 Strategy.

Rubin, Eric J / Baden, Lindsey R / Jha, Ashish / Morrissey, Stephen

The New England journal of medicine

2022 Volume 387, Issue 3, Page(s) e11

MeSH term(s)	COVID-19 ; Government ; Health Policy ; Humans ; United States
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Editorial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe2209791
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Article ; Online: Adverse childhood event subtypes and routine diabetes care utilization among U.S. adults with Type 2 diabetes.

Hoadley, Ariel / Bass, Sarah / Rubin, Daniel J

Psychological trauma : theory, research, practice and policy

2023

Abstract: ... Behavioral Risk Factor Surveillance System, a survey of a representative sample of U.S. adults. Eligible participants resided in a state ...

Abstract	Objective: Adverse childhood events (ACEs) have significant impacts on adulthood health, including greater risk of Type 2 diabetes (T2D). While there is a known connection to increased use of outpatient and emergency healthcare services, the potential role of ACEs in routine diabetes care utilization remains unclear. This study uses ACE subtypes to explain pathways to routine diabetes care utilization among adults with T2D. Method: Cross-sectional data were obtained from the 2019 Behavioral Risk Factor Surveillance System, a survey of a representative sample of U.S. adults. Eligible participants resided in a state that completed both the Adverse Childhood Experiences (ACEs) and Diabetes modules and were diagnosed with non-gestational diabetes ( Results: Factor loadings were strong, and fit indices indicated good measurement model and full structural model fits. In the full structural equation model, household dysfunction was associated with decreased likelihood of meeting frequency recommendations for A1C testing (β = -0.22, Conclusion: Specific types of ACEs may differentially relate to routine diabetes care utilization in adulthood. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001433
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Article ; Online: Emergence of probable PTSD among U.S. veterans over the military-to-civilian transition.

Copeland, Laurel A / Finley, Erin P / Rubin, Miriam L / Perkins, Daniel F / Vogt, Dawne S

Psychological trauma : theory, research, practice and policy

2022 Volume 15, Issue 4, Page(s) 697–704

Abstract: ... timing of onset.: Method: A nationwide sample representing 48,965 U.S. veterans separating ...

Abstract	Objective: Despite theorizing that posttraumatic stress disorder (PTSD) symptomatology may be exacerbated during the military-to-civilian transition, little research has delved into the trajectory of trauma-related symptomatology or the impact of diverse factors on timing of PTSD onset. To understand risk and protective factors for PTSD during the transition into civilian life, this study examined demographic, experiential, and psychosocial characteristics that may explain variation in PTSD symptoms and timing of onset. Method: A nationwide sample representing 48,965 U.S. veterans separating from military service in fall 2016 responded to six Web-based surveys over 3 years. Assessments included PTSD symptoms, stress, warfare exposures, military sexual trauma, moral injury events, resilience, and social support. Multivariable models estimated covariates of positive PTSD screen or symptoms. Results: Trauma exposure during military service was high at 59%. Probable PTSD was detected in 26% of the sample at baseline, with additional cases in each survey wave for an overall rate of 30%. Meeting criteria for probable PTSD covaried with current stress, female gender, and minority race/ethnicity; baseline psychological resilience and concurrent social support mitigated the risk. PTSD symptoms correlated positively with stress levels at current and previous time points. Social support was protective but only when contemporaneous with the PTSD symptoms. Conclusions: This study illustrates the need for ongoing social support for veterans coping with symptoms of PTSD, life stressors, and postmilitary trauma, suggesting a countervailing influence of psychological resilience and contemporaneous (but not historical) social support on symptom exacerbation. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Female ; Veterans/psychology ; Stress Disorders, Post-Traumatic/psychology ; Military Personnel/psychology ; Adaptation, Psychological ; Resilience, Psychological
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001329
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Book ; Article ; Online: Women’s empowerment in agriculture

Meinzen-Dick, Ruth S. / Rubin, Deborah / Elias, Marlène / Mulema, Annet A. / Myer, Emily

Lessons from qualitative research

2019

Abstract: There is growing recognition of the importance of women’s empowerment in its own right and ... with eight agricultural development projects in eight countries, to develop a project-level Women’s ...

Abstract	There is growing recognition of the importance of women’s empowerment in its own right and for a range of development outcomes, but less understanding of what empowerment means to rural women and men. The challenge of measuring empowerment, particularly across cultures and contexts, is also garnering attention. This paper synthesizes qualitative research conducted conjointly with quantitative surveys, working with eight agricultural development projects in eight countries, to develop a project-level Women’s Empowerment in Agriculture Index (pro-WEAI). The qualitative research sought to identify emic meanings of “empowerment,” validate the domains and indicators of the quantitative index, provide greater understanding of the context of each project and of strategies for facilitating empowerment, and test a methodology for integrating emic perspectives of empowerment with standardized etic measures that allow for comparability across contexts.
Keywords	women ; gender ; livestock ; agriculture
Language	English
Publishing date	2019-02-22T14:08:44Z
Publisher	International Food Policy Research Institute
Publishing country	fr
Document type	Book ; Article ; Online
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Article ; Online: Measurement of Direct-Photon Cross Section and Double-Helicity Asymmetry at sqrt[s]=510 GeV in p[over →]+p[over →] Collisions.

Abdulameer, N J / Acharya, U / Adare, A / Aidala, C / Ajitanand, N N / Akiba, Y / Akimoto, R / Alfred, M / Apadula, N / Aramaki, Y / Asano, H / Atomssa, E T / Awes, T C / Azmoun, B / Babintsev, V / Bai, M / Bandara, N S / Bannier, B / Barish, K N /

Bathe, S / Bazilevsky, A / Beaumier, M / Beckman, S / Belmont, R / Berdnikov, A / Berdnikov, Y / Bichon, L / Black, D / Blankenship, B / Bok, J S / Borisov, V / Boyle, K / Brooks, M L / Bryslawskyj, J / Buesching, H / Bumazhnov, V / Campbell, S / Canoa Roman, V / Chen, C-H / Chiu, M / Chi, C Y / Choi, I J / Choi, J B / Chujo, T / Citron, Z / Connors, M / Corliss, R / Corrales Morales, Y / Csanád, M / Csörgő, T / Datta, A / Daugherity, M S / David, G / Dean, C T / DeBlasio, K / Dehmelt, K / Denisov, A / Deshpande, A / Desmond, E J / Ding, L / Dion, A / Doomra, V / Do, J H / Drees, A / Drees, K A / Durham, J M / Durum, A / En'yo, H / Enokizono, A / Esha, R / Fadem, B / Fan, W / Feege, N / Fields, D E / Finger, M / Firak, D / Fitzgerald, D / Fokin, S L / Frantz, J E / Franz, A / Frawley, A D / Gallus, P / Gal, C / Garg, P / Ge, H / Giles, M / Giordano, F / Glenn, A / Goto, Y / Grau, N / Greene, S V / Grosse Perdekamp, M / Gunji, T / Guragain, H / Gu, Y / Hachiya, T / Haggerty, J S / Hahn, K I / Hamagaki, H / Hanks, J / Han, S Y / Harvey, M / Hasegawa, S / Hemmick, T K / He, X / Hill, J C / Hodges, A / Hollis, R S / Homma, K / Hong, B / Hoshino, T / Huang, J / Ikeda, Y / Imai, K / Imazu, Y / Inaba, M / Iordanova, A / Isenhower, D / Ivanishchev, D / Jacak, B V / Jeon, S J / Jezghani, M / Jiang, X / Ji, Z / Johnson, B M / Joo, E / Joo, K S / Jouan, D / Jumper, D S / Kang, J H / Kang, J S / Kawall, D / Kazantsev, A V / Key, J A / Khachatryan, V / Khanzadeev, A / Khatiwada, A / Kihara, K / Kim, C / Kim, D H / Kim, D J / Kim, E-J / Kim, H-J / Kim, M / Kim, T / Kim, Y K / Kincses, D / Kingan, A / Kistenev, E / Klatsky, J / Kleinjan, D / Kline, P / Koblesky, T / Kofarago, M / Koster, J / Kotov, D / Kovacs, L / Kurgyis, B / Kurita, K / Kurosawa, M / Kwon, Y / Lajoie, J G / Larionova, D / Lebedev, A / Lee, K B / Lee, S H / Leitch, M J / Leitgab, M / Lewis, N A / Lim, S H / Liu, M X / Li, X / Loomis, D A / Lynch, D / Lökös, S / Majoros, T / Makdisi, Y I / Makek, M / Manion, A / Manko, V I / Mannel, E / McCumber, M / McGaughey, P L / McGlinchey, D / McKinney, C / Meles, A / Mendoza, M / Meredith, B / Miake, Y / Mignerey, A C / Miller, A J / Milov, A / Mishra, D K / Mitchell, J T / Mitrankova, M / Mitrankov, Iu / Miyasaka, S / Mizuno, S / Mondal, M M / Montuenga, P / Moon, T / Morrison, D P / Moukhanova, T V / Muhammad, A / Mulilo, B / Murakami, T / Murata, J / Mwai, A / Nagamiya, S / Nagle, J L / Nagy, M I / Nakagawa, I / Nakagomi, H / Nakano, K / Nattrass, C / Nelson, S / Netrakanti, P K / Nihashi, M / Niida, T / Nouicer, R / Novitzky, N / Nukazuka, G / Nyanin, A S / O'Brien, E / Ogilvie, C A / Oh, J / Orjuela Koop, J D / Orosz, M / Osborn, J D / Oskarsson, A / Ozawa, K / Pak, R / Pantuev, V / Papavassiliou, V / Park, J S / Park, S / Patel, L / Patel, M / Pate, S F / Peng, J-C / Peng, W / Perepelitsa, D V / Perera, G D N / Peressounko, D Yu / PerezLara, C E / Perry, J / Petti, R / Pinkenburg, C / Pinson, R / Pisani, R P / Potekhin, M / Pun, A / Purschke, M L / Radzevich, P V / Rak, J / Ramasubramanian, N / Ravinovich, I / Read, K F / Reynolds, D / Riabov, V / Riabov, Y / Richford, D / Riveli, N / Roach, D / Rolnick, S D / Rosati, M / Rowan, Z / Rubin, J G / Runchey, J / Saito, N / Sakaguchi, T / Sako, H / Samsonov, V / Sarsour, M / Sato, S / Sawada, S / Schaefer, B / Schmoll, B K / Sedgwick, K / Seele, J / Seidl, R / Sen, A / Seto, R / Sett, P / Sexton, A / Sharma, D / Shein, I / Shibata, M / Shibata, T-A / Shigaki, K / Shimomura, M / Shi, Z / Shukla, P / Sickles, A / Silva, C L / Silvermyr, D / Singh, B K / Singh, C P / Singh, V / Slunečka, M / Smith, K L / Soltz, R A / Sondheim, W E / Sorensen, S P / Sourikova, I V / Stankus, P W / Stepanov, M / Stoll, S P / Sugitate, T / Sukhanov, A / Sumita, T / Sun, J / Sun, Z / Sziklai, J / Takahama, R / Takahara, A / Taketani, A / Tanida, K / Tannenbaum, M J / Tarafdar, S / Taranenko, A / Timilsina, A / Todoroki, T / Tomášek, M / Torii, H / Towell, M / Towell, R / Towell, R S / Tserruya, I / Ueda, Y / Ujvari, B / van Hecke, H W / Vargyas, M / Velkovska, J / Virius, M / Vrba, V / Vznuzdaev, E / Wang, X R / Wang, Z / Watanabe, D / Watanabe, Y / Watanabe, Y S / Wei, F / Whitaker, S / Wolin, S / Wong, C P / Woody, C L / Wysocki, M / Xia, B / Xue, L / Yalcin, S / Yamaguchi, Y L / Yanovich, A / Yoon, I / Younus, I / Yushmanov, I E / Zajc, W A / Zelenski, A / Zou, L

Physical review letters

2023 Volume 130, Issue 25, Page(s) 251901

Abstract: ... production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed ... interact via the strong force at leading order. Therefore, at sqrt[s]=510 GeV, where leading-order-effects ...

Abstract	We present measurements of the cross section and double-helicity asymmetry A_{LL} of direct-photon production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed at midrapidity (\|η\|<0.25) with the PHENIX detector at the Relativistic Heavy Ion Collider. At relativistic energies, direct photons are dominantly produced from the initial quark-gluon hard scattering and do not interact via the strong force at leading order. Therefore, at sqrt[s]=510 GeV, where leading-order-effects dominate, these measurements provide clean and direct access to the gluon helicity in the polarized proton in the gluon-momentum-fraction range 0.02<x<0.08, with direct sensitivity to the sign of the gluon contribution.<br />
MeSH term(s)	Photons ; Food ; Motion
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.251901
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Article ; Online: Cannabis Use Characteristics Associated with Self-Reported Cognitive Function in a Nationally Representative U.S. sample.

Rubin-Kahana, Dafna Sara / Butler, Kevin / Hassan, Ahmed Nabeel / Sanches, Marcos / Le Foll, Bernard

Substance use & misuse

2024 , Page(s) 1–10

Abstract: Background: With increases in cannabis use and potency, there is a need to improve our understanding of the impact of use on cognitive function. Previous research indicates long-term cannabis use may have a negative effect on executive function. Few ... ...

Abstract	Background: With increases in cannabis use and potency, there is a need to improve our understanding of the impact of use on cognitive function. Previous research indicates long-term cannabis use may have a negative effect on executive function. Few studies have examined persistence of it in protracted abstinence, and there is limited evidence of predictors of worse cognitive function in current and former users. In this study, we aim to evaluate the associations between cannabis use status (current, former, and never use) and self-report cognition. Further, we investigate if cannabis use characteristics predict self-report cognitive function. Methods: Cross-sectional cannabis use data from the National Epidemiological Survey on Alcohol and Related Conditions-III (NESARC-III), a national survey ( Results: Current ( Conclusion: While prospective studies are required to confirm, findings suggest cannabis use is linked to worse cognition. There may be some limited recovery of cognition in former users and some cannabis use characteristics predict impairment. These findings add to our understanding of the cognitive impact of cannabis use. As worse cognitive function may impact relapse, findings have implications for personalization of cannabis use disorder treatment.
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2024.2340975
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Article ; Online: Extraosseous Ewing’s Sarcoma

Alan Alexander / Kyle Hunter / Michael Rubin / Ambarish P. Bhat

Indian Journal of Radiology and Imaging, Vol 31, Iss 01, Pp 203-

Pictorial Review of Imaging Findings, Differential Diagnosis, and Pathologic Correlation

2021 Volume 209

Abstract: Extraosseous Ewing’s sarcoma (EES), first described in 1969, is a malignant mesenchymal tumor just ... like its intraosseous counterpart. Although Ewing’s sarcomas are common bone tumors in young children ...

Abstract	Extraosseous Ewing’s sarcoma (EES), first described in 1969, is a malignant mesenchymal tumor just like its intraosseous counterpart. Although Ewing’s sarcomas are common bone tumors in young children, EESs are rarer and more commonly found in older children/adults, often carrying a poorer prognosis. We discuss the multimodality imaging features of EES and the differential diagnosis of an aggressive appearing mass in proximity to skeletal structures, with pathologic correlates. This review highlights the need to recognize the variability of radiologic findings in EES such as the presence of hemorrhage, rich vascularity, and cystic or necrotic regions and its imaging similarity to other neoplasms that are closely related pathologically.
Keywords	ewing’s sarcoma ; musculoskeletal soft tissue ; oncology ; pediatric ; rhabdomyosarcoma ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Creation of an ustekinumab external control arm for Crohn’s disease using electronic health records data

PLoS ONE, Vol 18, Iss

A pilot study

2023 Volume 3

Abstract: ... cancer is limited. We piloted an approach for developing an ECA in Crohn’s disease using ... for creating an ECA in Crohn’s disease from EHR data by using a combination of informatics and manual methods ... thereby enable a future of more robust ECAs in chronic diseases like Crohn’s disease. ...

Abstract	Background Randomized trials are the gold-standard for clinical evidence generation, but they can sometimes be limited by infeasibility and unclear generalizability to real-world practice. External control arm (ECA) studies may help address this evidence gaps by constructing retrospective cohorts that closely emulate prospective ones. Experience in constructing these outside the context of rare diseases or cancer is limited. We piloted an approach for developing an ECA in Crohn’s disease using electronic health records (EHR) data. Methods We queried EHR databases and manually screened records at the University of California, San Francisco to identify patients meeting the eligibility criteria of TRIDENT, a recently completed interventional trial involving an ustekinumab reference arm. We defined timepoints to balance missing data and bias. We compared imputation models by their impacts on cohort membership and outcomes. We assessed the accuracy of algorithmic data curation against manual review. Lastly, we assessed disease activity following treatment with ustekinumab. Results Screening identified 183 patients. 30% of the cohort had missing baseline data. Nonetheless, cohort membership and outcomes were robust to the method of imputation. Algorithms for ascertaining non-symptom-based elements of disease activity using structured data were accurate against manual review. The cohort consisted of 56 patients, exceeding planned enrollment in TRIDENT. 34% of the cohort was in steroid-free remission at week 24. Conclusion We piloted an approach for creating an ECA in Crohn’s disease from EHR data by using a combination of informatics and manual methods. However, our study reveals significant missing data when standard-of-care clinical data are repurposed. More work will be needed to improve the alignment of trial design with typical patterns of clinical practice, and thereby enable a future of more robust ECAs in chronic diseases like Crohn’s disease.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic Risk Factors for Alzheimer's Disease in Racial/Ethnic Minority Populations in the U.S.: A Scoping Review.

Rubin, Lindsey / Ingram, Lucy A / Resciniti, Nicholas V / Ashford-Carroll, Brianna / Leith, Katherine Henrietta / Rose, Aubrey / Ureña, Stephanie / McCollum, Quentin / Friedman, Daniela B

Frontiers in public health

2021 Volume 9, Page(s) 784958

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Aged ; Alzheimer Disease/ethnology ; Alzheimer Disease/genetics ; Ethnic and Racial Minorities ; Ethnicity/genetics ; Genome-Wide Association Study ; Humans ; Risk Factors ; United States/epidemiology
Language	English
Publishing date	2021-12-24
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.784958
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