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Article ; Online: Pediatric hemophilia patient: Successful desensitization for drug-induced fixed urticaria with prothrombin complex concentrate.

Çelik, Hatice Irmak / Akay, Eray / Emeksiz, Zeynep Şengül / Işık, Melek / Yaralı, Hüsniye Neşe / Mısırlıoğlu, Emine Dibek

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2024 Volume 35, Issue 3, Page(s) e14105

MeSH term(s)	Humans ; Child ; Hemophilia A/drug therapy ; Blood Coagulation Factors/therapeutic use
Chemical Substances	prothrombin complex concentrates (37224-63-8) ; Blood Coagulation Factors
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.14105
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Zs.A 3096: Show issues

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Article ; Online: Does thalassemia truly cause microvascular changes without us noticing? An optical coherence tomography angiography study of the children with beta-thalassemia.

Güvenç, Umay / Ünlü, Nurten / Yaralı, Hüsniye Neşe / Özbek, Namık Yaşar

International ophthalmology

2023 Volume 43, Issue 10, Page(s) 3755–3765

Abstract: Purpose: It was aimed to evaluate the retinochoroidal microvascular alterations of pediatric beta-thalassemia patients and investigate the effect of blood transfusion on perfusion among transfusion-dependent thalassemia (TDT), by means of optical ... ...

Abstract	Purpose: It was aimed to evaluate the retinochoroidal microvascular alterations of pediatric beta-thalassemia patients and investigate the effect of blood transfusion on perfusion among transfusion-dependent thalassemia (TDT), by means of optical coherence tomography angiography (OCTA). Methods: In this multicentered, prospective, cross-sectional study, 56 TDT, 14 non-TDT (NTDT), and 63 healthy children were evaluated. The vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus, radial peripapillary capillary network, choriocapillaris, and the foveal avascular zone area (FAZ) were evaluated by OCTA. Before and after transfusion values of the TDT group were compared, and correlations were made with blood values and iron accumulation. Results: Foveal and parafoveal zones were significantly thinner among TDT patients, with larger FAZ area. Macula VD of SCP and ppVD was lowest in NTDT group. In the TDT group, a decrease in retinal nerve fiber thickness and ppVD values was detected after transfusion. A negative significant relationship was found between both hemoglobin (Hb), hematocrit (Htc), and ppVD. Conclusions: OCTA provides a better insight into retinal and choriocapillaris vascular impairment influenced by tissue hypoxia and oxidative stress in different clinical phenotypes of beta-thalassemia.
MeSH term(s)	Humans ; Child ; Fluorescein Angiography/methods ; Retinal Vessels/diagnostic imaging ; beta-Thalassemia/complications ; beta-Thalassemia/diagnosis ; Tomography, Optical Coherence/methods ; Cross-Sectional Studies ; Prospective Studies
Language	English
Publishing date	2023-06-30
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02786-z
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Zs.A 1479: Show issues

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Article ; Online: Serum interleukin-33 and soluble suppression of tumorigenicity 2 in pediatric leukemia with febrile neutropenia.

Polat, Merve Cansu / Sönmez, Çiğdem / Yarali, Neşe / Özbek, Namık Yaşar

European journal of pediatrics

2024 Volume 183, Issue 5, Page(s) 2155–2162

Abstract: The purpose of this study was to evaluate the association between interleukin-33 (IL-33) and its receptor Soluble Suppression of Tumorigenicity-2 (sST2) levels and bacterial infections during febrile neutropenia (FN) in pediatric patients with acute ... ...

Abstract	The purpose of this study was to evaluate the association between interleukin-33 (IL-33) and its receptor Soluble Suppression of Tumorigenicity-2 (sST2) levels and bacterial infections during febrile neutropenia (FN) in pediatric patients with acute lymphoblastic leukemia (ALL). In this prospective, case-control study, participants were divided into 3 groups: ALL patients with FN (Group A), ALL patients without neutropenia and fever (Group B), and healthy children without infection and chronic disease (Group C). There were 30 cases in each group. Blood samples for IL-33 and sST2 have been drawn from patients in Group A before the initiation of treatment and on days 1 and 5 of treatment, and from patients in Groups B and C at initiation. At admission, mean IL-33 level (39.02 ± 26.40 ng/L) in Group B and mean sST2 level (185.3 ± 371.49 ng/ml) in Group A were significantly higher than the other groups (p = 0.038, p < 0.001, respectively). No difference was observed in the mean IL-33 and sST2 levels in the 5-day follow-up of patients in Group A (p = 0.82, p = 0.86, respectively). IL-33 and sST2 levels were not associated with fever duration, neutropenia duration or length of hospitalization. While C-reactive protein (CRP) was significantly higher in patients with positive blood culture (p = 0.021), IL-33 (p = 0.49) and sST2 (p = 0.21) levels were not associated with culture positivity. Conclusion: IL-33 and sST2 levels were not found valuable as diagnostic and prognostic markers to predict bacterial sepsis in patients with FN. What is Known: • Neutropenic patients are at high risk of serious bacterial and viral infections, but the admission symptom is often only fever. • Febrile neutropenia has a high mortality rate if not treated effectively. What is New: • Febrile neutropenia is not only caused by bacterial infections. Therefore, new biomarkers should be identified to prevent overuse of antibiotics. • Specific biomarkers are needed to diagnose bacterial sepsis in the early phase of febrile neutropenia.
MeSH term(s)	Humans ; Interleukin-33/blood ; Female ; Male ; Interleukin-1 Receptor-Like 1 Protein/blood ; Child ; Prospective Studies ; Case-Control Studies ; Child, Preschool ; Febrile Neutropenia/blood ; Febrile Neutropenia/etiology ; Febrile Neutropenia/diagnosis ; Biomarkers/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Adolescent ; Infant ; Bacterial Infections/blood ; Bacterial Infections/diagnosis
Chemical Substances	Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; IL1RL1 protein, human ; IL33 protein, human ; Biomarkers
Language	English
Publishing date	2024-02-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05478-7
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Article: The use of intravenous immunoglobulin therapy in a tertiary pediatric hospital.

Güngör, Ali / Yarali, Nese

Saudi medical journal

2020 Volume 41, Issue 2, Page(s) 163–167

Abstract: Objectives: To determine demographic features of patients provided intravenous immunoglobulin (IVIG) excluding replacement therapy in the inpatient services and to evaluate indications for IVIG, and side effects related to therapy. Methods: Patients who ...

Abstract	Objectives: To determine demographic features of patients provided intravenous immunoglobulin (IVIG) excluding replacement therapy in the inpatient services and to evaluate indications for IVIG, and side effects related to therapy. Methods: Patients who received IVIG therapy between January 2016 and August 2018 were retrospectively identified. The demographic features, diagnosis, IVIG dose, number of days they underwent IVIG therapy, and whether or not they experienced IVIG-related side effects were recorded. Results: A total of 186 patients were included in this study, and of these, 89 (47.8%) were females. The median age of all of the patients was 48.5 months old (range 13-120 months). When the IVIG indications were examined, the hematological disease group had the highest number of patients (n=73, 39.2%). The US Food and Drug Administration (FDA) labeled use rate was 45.7%. Side effects were seen in 15 (3.81%) of the 394 IVIG infusions, 2 of which were acute kidney failure and nausea/vomiting as delayed onset side effects. The rapid onset side effects included fever (n=5), headache (n=3), rash and redness (n=2), and pain in the infusion area, hypotension, and hypertension (n=1). Conclusion: Intravenous immunoglobulin preparations are used for the treatment of many diseases due to their immunoregulatory effects. In recent years, the use of IVIGs without FDA approval has been increasing.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Child ; Child, Preschool ; Drug Utilization/statistics & numerical data ; Female ; Fever/epidemiology ; Fever/etiology ; Hematologic Diseases/therapy ; Hospitals, Pediatric/statistics & numerical data ; Humans ; Immunoglobulins, Intravenous/adverse effects ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Inpatients ; Male ; Nausea/epidemiology ; Nausea/etiology ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data ; Vomiting/epidemiology ; Vomiting/etiology
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2020-02-04
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	392302-2
ISSN	1658-3175 ; 0379-5284
ISSN (online)	1658-3175
ISSN	0379-5284
DOI	10.15537/smj.2020.2.24877
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Article ; Online: The use of intravenous immunoglobulin therapy in a tertiary pediatric hospital

Ali Güngör / Neşe Yaralı

Saudi Medical Journal, Vol 41, Iss 2, Pp 163-

2020 Volume 167

Abstract	Objectives: To determine demographic features of patients provided intravenous immunoglobulin (IVIG) excluding replacement therapy in the inpatient services and to evaluate indications for IVIG, and side effects related to therapy. Methods: Patients who received IVIG therapy between January 2016 and August 2018 were retrospectively identified. The demographic features, diagnosis, IVIG dose, number of days they underwent IVIG therapy, and whether or not they experienced IVIG-related side effects were recorded. Results: A total of 186 patients were included in this study, and of these, 89 (47.8%) were females. The median age of all of the patients was 48.5 months old (range 13-120 months). When the IVIG indications were examined, the hematological disease group had the highest number of patients (n=73, 39.2%). The US Food and Drug Administration (FDA) labeled use rate was 45.7%. Side effects were seen in 15 (3.81%) of the 394 IVIG infusions, 2 of which were acute kidney failure and nausea/vomiting as delayed onset side effects. The rapid onset side effects included fever (n=5), headache (n=3), rash and redness (n=2), and pain in the infusion area, hypotension, and hypertension (n=1). Conclusion: Intravenous immunoglobulin preparations are used for the treatment of many diseases due to their immunoregulatory effects. In recent years, the use of IVIGs without FDA approval has been increasing.
Keywords	adverse effects ; child ; intravenous immunoglobulin ; immunoregulatory ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Ministry of Defence and Aviation
Document type	Article ; Online
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Article ; Online: Dysplastic Changes of Peripheral Blood Cells in COVID-19 Infection

Yunus Murat Akçabelen, / Dilek Gürlek Gökçebay / Neşe Yaralı

Turkish Journal of Hematology, Vol 38, Iss 1, Pp 72-

2021 Volume 73

Keywords	coronavirus ; blood smear ; dysplasia ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article ; Online: Dysplastic Changes of Peripheral Blood Cells in COVID-19 Infection

Akçabelen, Yunus Murat / Gürlek Gökçebay, Dilek / Yaralı, Neşe

Turkish journal of haematology : official journal of Turkish Society of Haematology

2020 Volume 38, Issue 1, Page(s) 72–73

MeSH term(s)	Adolescent ; Blood Cells/pathology ; Blood Specimen Collection/methods ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; Female ; Humans ; Pelger-Huet Anomaly/blood ; Pelger-Huet Anomaly/etiology ; SARS-CoV-2/genetics
Keywords	covid19
Language	English
Publishing date	2020-08-19
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2185903-6
ISSN	1308-5263 ; 1300-7777
ISSN (online)	1308-5263
ISSN	1300-7777
DOI	10.4274/tjh.galenos.2020.2020.0342
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Article ; Online: COVID-19 in a child with severe aplastic anemia.

Akcabelen, Yunus Murat / Koca Yozgat, Ayca / Parlakay, Asli Nur / Yarali, Nese

Pediatric blood & cancer

2020 Volume 67, Issue 8, Page(s) e28443

MeSH term(s)	Anemia, Aplastic ; Betacoronavirus ; Biological Products ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Rheumatic Diseases ; SARS-CoV-2
Chemical Substances	Biological Products
Keywords	covid19
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.28443
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Article ; Online: Pyruvate kinase deficiency mimicking congenital dyserythropoietic anemia type I.

Yozgat, Ayça Koca / Erdem, Arzu Yazal / Kaçar, Dilek / Özbek, Namık Yaşar / Yaralı, Neşe

The Turkish journal of pediatrics

2022 Volume 64, Issue 5, Page(s) 951–955

Abstract: Background: Pyruvate kinase (PK) deficiency is the most common enzyme abnormality in the glycolytic pathway. Here, we describe two siblings with PK deficiency that mimicked congenital dyserythropoietic anemia (CDA) type I.: Case: The siblings were ... ...

Abstract	Background: Pyruvate kinase (PK) deficiency is the most common enzyme abnormality in the glycolytic pathway. Here, we describe two siblings with PK deficiency that mimicked congenital dyserythropoietic anemia (CDA) type I. Case: The siblings were referred to our hospital for evaluation of anemia when they were newborns. Their PK enzyme activities were normal. Their bone marrow aspirations and electron microscopies showed CDA-like findings. A CDA panel with next-generation sequencing showed no mutation. Though their PK enzyme levels were normal, a molecular study of the PKLR gene showed a homozygous variant c.1623G > C (p.Lys541Asn) in exon 12 of our patients. Conclusions: Although the diagnosis of pyruvate kinase deficiency is difficult, it can be confused with many other diagnoses. Bone marrow findings of these cases are similar to congenital dyserythropoietic anemia. In patients with normal pyruvate kinase enzyme levels, the diagnosis cannot be excluded and genetic analysis is required.
MeSH term(s)	Humans ; Infant, Newborn ; Pyruvate Kinase/genetics ; Anemia, Dyserythropoietic, Congenital/diagnosis ; Anemia, Dyserythropoietic, Congenital/genetics ; Pyruvate Metabolism, Inborn Errors/diagnosis ; Pyruvate Metabolism, Inborn Errors/genetics ; Anemia, Hemolytic, Congenital Nonspherocytic/diagnosis ; Anemia, Hemolytic, Congenital Nonspherocytic/genetics
Chemical Substances	Pyruvate Kinase (EC 2.7.1.40)
Language	English
Publishing date	2022-10-28
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2021.4704
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Article ; Online: 'Trying to catch up with life': The expectations and views of adolescent survivors of childhood acute lymphoblastic leukaemia about long-term follow-up care: A qualitative research.

Arpaci, Tuba / Altay, Naime / Yozgat, Ayça Koca / Yaralı, Hüsniye Neşe / Özbek, Namık Yaşar

European journal of cancer care

2022 Volume 31, Issue 6, Page(s) e13667

Abstract: Objective: The aim of this study was to explore adolescent survivors' views and expectations about long-term follow-up care.: Methods: Semi-structured, in-depth interviews were conducted with 16 adolescent survivors of childhood acute lymphoblastic ... ...

Abstract	Objective: The aim of this study was to explore adolescent survivors' views and expectations about long-term follow-up care. Methods: Semi-structured, in-depth interviews were conducted with 16 adolescent survivors of childhood acute lymphoblastic leukaemia. Survivors who had completed treatment at least 2 years ago were involved in the study. Interviews were audio-recorded and transcribed verbatim. An inductive thematic approach was used to analyse the data. Results: Four main themes and sub-themes were identified from the analysis as follows: information needs with three sub-themes 'long-term follow-up, healthy life and social life', support needs with three sub-themes 'psychosocial (peer relations etc.), school related and social-emotional (fear of relapse, body image, self-esteem, etc.)', perceived benefits with two sub-themes 'social-emotional and related to long-term follow-up' and perceived barriers 'medical-hospital related and social life'. Conclusions: Adolescent survivors mainly need support in terms of psychosocial aspects: self-esteem-body image, school, peer relations and social activities during follow-up. Identified barriers related to follow-up were school absence and not able to participate social activities. Adolescents specify health promotion approaches as benefits aspects of follow-up. The findings of this study will guide nurses in the long-term follow-up care of adolescent survivors of acute lymphoblastic leukaemia and provide an opportunity to plan individualised follow-up care.
MeSH term(s)	Adolescent ; Humans ; Follow-Up Studies ; Motivation ; Survivors/psychology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Qualitative Research
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1303114-4
ISSN	1365-2354 ; 0961-5423 ; 1360-5801
ISSN (online)	1365-2354
ISSN	0961-5423 ; 1360-5801
DOI	10.1111/ecc.13667
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