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  1. Article ; Online: To treat with curative intent or modify disease?

    Eapen, Mary

    Blood

    2023  Volume 141, Issue 1, Page(s) 4–5

    MeSH term(s) Adult ; Humans ; Conservative Treatment ; Lung Neoplasms ; Hematopoietic Stem Cell Transplantation ; Stem Cell Transplantation
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Since everyone has a donor, why are some eligible patients still not transplanted?

    Eapen, Mary

    Best practice & research. Clinical haematology

    2021  Volume 34, Issue 4, Page(s) 101321

    Abstract: Hematopoietic cell transplantation is an important treatment option for malignant and non-malignant hematologic diseases. Despite increasing the potential donor pool for hematopoietic cell transplantation there are many patients who are unable to access ... ...

    Abstract Hematopoietic cell transplantation is an important treatment option for malignant and non-malignant hematologic diseases. Despite increasing the potential donor pool for hematopoietic cell transplantation there are many patients who are unable to access this treatment. There are several biologic and non-biologic factors that may explain lower utilization of transplantation. Biologic factors associated with lower utilization include older age, multiple comorbidities, persons of African American descent and high-risk disease that may not respond optimally to hematopoietic cell transplantation. Non-biologic factors associated with lower utilization include lower educational (without a high school diploma) or social status, uninsured, Medicaid or Medicare insurance and in persons aged ≥60 years, when the distance between their residence and hospital was greater than 37 miles. The decision to proceed to hematopoietic cell transplantation is a dialogue between the patient and the treating physician. While some patients may be considered poor candidates for continued treatment including hematopoietic cell transplantation others may be offered novel pharmacologic and cellular therapies with a capacity to deliver specific immunologic antitumor responses. Pharmacologic and cellular therapies are relatively recent, and it is not known whether the biologic and non-biologic factors that limit access to transplantation will limit access to these newer treatments.
    MeSH term(s) Aged ; Hematopoietic Stem Cell Transplantation ; Humans ; Medicare ; Social Status ; Tissue Donors ; Transplantation Conditioning ; United States
    Language English
    Publishing date 2021-10-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2021.101321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to R. Meisel.

    Eapen, Mary / Brazaukas, Ruta

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 17, Page(s) 3273–3274

    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00508
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  4. Article ; Online: Corrigendum to "Endpoint selection and evaluation in hematology studies" [Best Pract Res Clin Haematol 36 (2023) 101479].

    Brazauskas, Ruta / Eapen, Mary / Wang, Tao

    Best practice & research. Clinical haematology

    2024  Volume 37, Issue 1, Page(s) 101540

    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2024.101540
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  5. Article ; Online: A resurgence of cord blood transplantation?

    Eapen, Mary

    The Lancet. Haematology

    2019  Volume 7, Issue 2, Page(s) e89–e90

    MeSH term(s) Cord Blood Stem Cell Transplantation ; Feasibility Studies ; Fetal Blood ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30234-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In-vivo T-cell depletion: burden of morbidity versus survival.

    Eapen, Mary

    The Lancet. Haematology

    2019  Volume 6, Issue 2, Page(s) e63–e64

    MeSH term(s) Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Lymphocyte Depletion/methods ; Morbidity ; Prognosis ; Quality of Life ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2019-02-02
    Publishing country England
    Document type Letter
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30002-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surviving childhood cancer: a sobering story.

    Eapen, Mary

    Blood

    2018  Volume 131, Issue 24, Page(s) 2603–2604

    MeSH term(s) Bone Marrow ; Bone Marrow Transplantation ; Child ; Humans ; Neoplasms ; Survivors ; Transplants
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-05-847517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Is a matched sibling the ideal donor for hematopoietic cell transplant?

    Eapen, Mary

    Haematologica

    2018  Volume 103, Issue 8, Page(s) 1251–1252

    MeSH term(s) Bone Marrow ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute ; Siblings ; Tissue Donors
    Language English
    Publishing date 2018-07-29
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.196980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: HCT for SCID: one size does not fit all.

    Eapen, Mary

    Blood

    2017  Volume 129, Issue 21, Page(s) 2826–2827

    MeSH term(s) Humans ; Severe Combined Immunodeficiency ; Transplantation Conditioning
    Language English
    Publishing date 2017-05-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-04-776419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endpoint selection and evaluation in hematology studies.

    Brazauskas, Ruta / Eapen, Mary / Wang, Tao

    Best practice & research. Clinical haematology

    2023  Volume 36, Issue 3, Page(s) 101479

    Abstract: Observational studies and clinical trials in hematology aim to examine treatments for blood disorders. The outcomes being studied must address the goals of the study and provide meaningful information about treatment course, disease progression, describe ...

    Abstract Observational studies and clinical trials in hematology aim to examine treatments for blood disorders. The outcomes being studied must address the goals of the study and provide meaningful information about treatment course, disease progression, describe patients' survival experience and quality of life. Endpoints are the specific measures of these outcomes, and much consideration should be given to their selection. In this review, we describe the outcomes and endpoints frequently used in studying hematologic diseases and provide general guidelines for their statistical analysis. The main focus is on clinical outcomes which are commonly used in establishing treatment safety and efficacy. We also briefly discuss the role surrogate and composite endpoints play in hematology studies. The importance of patient reported outcomes to comprehensive assessment of the treatment effectiveness is highlighted. Provided practical considerations for choosing primary and secondary endpoints may be helpful in designing hematology clinical trials.
    MeSH term(s) Humans ; Quality of Life ; Disease Progression ; Hematology
    Language English
    Publishing date 2023-05-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2023.101479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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