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Article: Electrochemical Benzylic C(sp³)–H Acyloxylation

Atkins, Alexander P. / Rowett, Albert C. / Heard, David M. / Tate, Joseph A. / Lennox, Alastair J. J.

Organic letters. 2022 July 13, v. 24, no. 28

2022

Abstract: The development of sustainable C(sp³)–H functionalization methods is of great interest ...

Abstract	The development of sustainable C(sp³)–H functionalization methods is of great interest to the pharmaceutical and agrochemical industries. Anodic oxidation is an efficient means of producing benzylic cations that can undergo subsequent in situ nucleophilic attack to afford functionalized benzylic products. Herein, we demonstrate the suitability of carboxylic acids as nucleophiles to yield benzylic esters. This method employs a series of secondary benzylic substrates and functionalized carboxylic acids and is demonstrated on a gram scale in flow.
Keywords	Lewis bases ; agrochemicals ; electrochemistry ; oxidation
Language	English
Dates of publication	2022-0713
Size	p. 5105-5108.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.2c01930
Database	NAL-Catalogue (AGRICOLA)

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Article: MDM2 RNA binding is blocked by novel monoclonal antibody h-MDM2-F4-14.

Anderson, John J / Challen, Christine / Atkins, Helen / Suaeyun, R / Crosier, Stephen / Lunec, John

International journal of oncology

2007 Volume 31, Issue 3, Page(s) 545–555

Abstract: ... binding activity by newly produced MDM2 monoclonal antibodies anti-h-mdm2 F4-14 and F2-2. A variety ... C and D. In contrast, antibody F2-2 reacts only with full-length MDM2 protein. The ability of h-mdm2 ...

Abstract	Amplification of MDM2 has been described in a variety of human cancers. Prognostic studies have revealed that abnormal MDM2 expression correlates with poor prognosis. Many of the consequences of mdm2/p53 interactions have been investigated, and mdm2-p53 dependent events characterized. In contrast, understanding of mdm2-p53 independent activities is comparatively in it's infancy amongst these the ability of mdm2 to bind RNA. However, although the significance of this activity has been the subject of some speculation, the precise role and impact of this function upon cell replication or apoptosis has yet to be fully defined. These studies have been obstructed by a lack of specific reagents able to interfere with this reaction. As a prelude to further exploring the significance of mdm2 RNA binding we report the inhibition of mdm2 RNA binding activity by newly produced MDM2 monoclonal antibodies anti-h-mdm2 F4-14 and F2-2. A variety of MDM2 specific antibodies have been produced and applied in research without complete knowledge of their reactivity profiles, but in the face of the growing number of mdm2 RNA isoforms, the results of such studies can be difficult to interpret. Each of the RNA binding inhibitory antibodies produced in this study was found to be reactive with full length MDM2 protein expressed in tumor cell lysates, transfected NIH3T3 cell lysates and via eukaryotic cell free rabbit reticulocyte in vitro translation. Antibody F4-14, the most potently inhibitory antibody, reacts strongly with the full length MDM2 together with protein isoforms A, B, C and D. In contrast, antibody F2-2 reacts only with full-length MDM2 protein. The ability of h-mdm2-F4-14 and to a lesser extent F2-2 to inhibit RNA binding presents the possibility of modulating human mdm2s ability to bind RNA, compromise this function and present opportunities to investigate in more detail the biological significance of this activity.
MeSH term(s)	Animals ; Antibodies, Monoclonal/chemistry ; Antigens, Neoplasm/chemistry ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Humans ; Immunotherapy/methods ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Protein Biosynthesis ; Protein Isoforms ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; Proto-Oncogene Proteins c-mdm2/chemistry ; Rabbits ; Reticulocytes/metabolism
Chemical Substances	Antibodies, Monoclonal ; Antigens, Neoplasm ; Protein Isoforms ; h-MDM2-F4-14 monoclonal antibody ; MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2007-09
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154403-x
ISSN	1019-6439
ISSN	1019-6439
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3690: Show issues

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Article ; Online: Infrared multiple photon dissociation spectra of proton- and sodium ion-bound glycine dimers in the N-H and O-H stretching region.

Atkins, Chad G / Rajabi, Khadijeh / Gillis, Elizabeth A L / Fridgen, Travis D

The journal of physical chemistry. A

2008 Volume 112, Issue 41, Page(s) 10220–10225

Abstract: ... multiple photon dissociation (IRMPD) spectroscopy in the N-H and O-H stretching region and electronic ... anharmonic N-H and O-H stretching modes. As well, the shared proton stretch is observed at 2440 cm (-1 ... to the O-H stretch and the asymmetric and symmetric NH 2 stretching modes. The positions of these bands are ...

Abstract	The proton- and the sodium ion-bound glycine homodimers are studied by a combination of infrared multiple photon dissociation (IRMPD) spectroscopy in the N-H and O-H stretching region and electronic structure calculations. For the proton-bound glycine dimer, in the region above 3100 cm (-1), the present spectrum agrees well with one recorded previously. The present work also reveals a weak, broad absorption spanning the region from 2650 to 3300 cm (-1). This feature is assigned to the strongly hydrogen-bonded and anharmonic N-H and O-H stretching modes. As well, the shared proton stretch is observed at 2440 cm (-1). The IRMPD spectra for the proton-bound glycine dimer confirms that the lowest energy structure is an ion-dipole complex between N-protonated glycine and the carboxyl group of the second glycine. This spectrum also helps to eliminate the existence of any of the higher-energy structures considered. The IRMPD spectrum for the sodium ion-bound dimer is a much simpler spectrum consisting of three bands assigned to the O-H stretch and the asymmetric and symmetric NH 2 stretching modes. The positions of these bands are very similar to those observed for the proton-bound glycine dimer. Numerous structures were considered and the experimental spectrum agrees with the B3LYP/6-31+G(d,p) predicted spectrum for the lowest energy structure, two bidentate glycine molecules bound to Na (+). Though some of the structures cannot be completely ruled out by comparing the experimental and theoretical spectra, they are energetically disfavored by at least 20 kJ mol (-1).
MeSH term(s)	Computer Simulation ; Dimerization ; Glycine/chemistry ; Hydrogen Bonding ; Ions/chemistry ; Models, Chemical ; Osmolar Concentration ; Photons ; Sodium/chemistry ; Spectrophotometry, Infrared/methods
Chemical Substances	Ions ; Sodium (9NEZ333N27) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2008-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp805514b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structures of bare and hydrated [Pb(aminoacid-H)]+ complexes using infrared multiple photon dissociation spectroscopy.

Burt, Michael B / Decker, Sarah G A / Atkins, Chad G / Rowsell, Mark / Peremans, André / Fridgen, Travis D

The journal of physical chemistry. B

2011 Volume 115, Issue 39, Page(s) 11506–11518

Abstract: ... with a basic side chain (Lys) were compared. These experiments demonstrated that all [Pb(Aa-H)](+) complexes ... Pb(2+). IRMPD spectroscopy was also performed on the monohydrated analogues of the [Pb(Aa-H ... complexes. The [Pb(Aa-H)H(2)O](+) complexes, where Aa = Ala, Val, Leu, and Ile, exhibited two N-H stretches ...

Abstract	Infrared multiple-photon dissociation (IRMPD) spectroscopy was used to determine the gas-phase structures of deprotonated Pb(2+)/amino acid (Aa) complexes with and without a solvent molecule present. Five amino acid complexes with side chains containing only carbon and hydrogen (Ala, Val, Leu, Ile, Pro) and one with a basic side chain (Lys) were compared. These experiments demonstrated that all [Pb(Aa-H)](+) complexes have Pb(2+) covalently bound between the amine nitrogen and carbonyl oxygen. The nonhydrated complexes containing Ala, Val, Leu, Ile, and Pro are amine-deprotonated, whereas the one containing Lys is deprotonated at its carboxylic acid. The difference is attributed to the polar and basic side chain of lysine, which helps stabilize Pb(2+). IRMPD spectroscopy was also performed on the monohydrated analogues of the [Pb(Aa-H)](+) complexes. The [Pb(Aa-H)H(2)O](+) complexes, where Aa = Ala, Val, Leu, and Ile, exhibited two N-H stretches as well as a carboxylic acid O-H and a PbO-H stretch. Hence, their structures are monohydrated versions of the amine-deprotonated [Pb(Aa-H)](+) complexes where a proton transfer has occurred from the lead-bound water to the deprotonated amine. The IRMPD spectrum and calculations suggest that [Pb(Pro-H)H(2)O](+) has a hydrated carboxylate salt structure. The structure of [Pb(Lys-H)H(2)O](+) was also carboxyl-deprotonated, but Pb(2+) is bound to the carbonyl oxygen and the amine nitrogen, with one of the protons belonging to the water transferred to the basic side chain. This results in an intramolecular hydrogen bond that does not absorb in the region of the spectrum probed in these experiments. The IRMPD spectra and structural characterizations were confirmed and aided by infrared spectra calculated at the B3LYP/6-31+G(d,p) level of theory and 298 K enthalpies and Gibbs energies using the MP2(full)/6-311++G(2d,2p) method on the B3LYP geometries.
MeSH term(s)	Amino Acids/chemistry ; Coordination Complexes/chemistry ; Hydrogen Bonding ; Lead/chemistry ; Photons ; Spectrophotometry, Infrared ; Thermodynamics ; Water/chemistry
Chemical Substances	Amino Acids ; Coordination Complexes ; Water (059QF0KO0R) ; Lead (2P299V784P)
Language	English
Publishing date	2011-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp2068655
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Update on the DREAMseq trial in melanoma.

Atkins, Michael B

Clinical advances in hematology & oncology : H&O

2023 Volume 21, Issue 6, Page(s) 304–306

MeSH term(s)	Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Skin Neoplasms
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Interview
ZDB-ID	2271951-9
ISSN	1543-0790
ISSN	1543-0790
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Estimation of 24-h aldosterone secretion in the dog using the urine aldosterone:creatinine ratio.

Gardner, Sarah Y / Atkins, Clarke E / Rausch, William P / DeFrancesco, Teresa C / Chandler, Donald Walt / Keene, Bruce W

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

2007 Volume 9, Issue 1, Page(s) 1–7

Abstract: ... represents a more consistent "pooled" index of aldosterone secretion, but obtaining 24-h urine samples is ... creatinine ratio, measured from spot urine samples, would correlate well with 24-h urinary aldosterone ... excretion, and would provide a simple index of aldosterone excretion that would eliminate the need for 24-h ...

Abstract	Objectives: One potential method of evaluating renin-angiotensin-aldosterone system (RAAS) activation involves the quantification of urinary aldosterone excretion. While blood concentrations of aldosterone are easily obtained, results may be misleading because of minute-to-minute variation in aldosterone secretion and subsequent blood concentrations. Urinary aldosterone concentration measurement represents a more consistent "pooled" index of aldosterone secretion, but obtaining 24-h urine samples is time-consuming, difficult, and fraught with potential error. We postulated that the urinary aldosterone:creatinine ratio, measured from spot urine samples, would correlate well with 24-h urinary aldosterone excretion, and would provide a simple index of aldosterone excretion that would eliminate the need for 24-h urine collection. Animals, materials and methods: After validating an assay for aldosterone in canine urine, 24-h urinary aldosterone excretion was determined by radioimmunoassay from 8 normal, male beagle dogs under control conditions, after RAAS stimulation with amlodipine administration, and after RAAS attenuation with the addition of enalapril to amlodipine administration. Spot urine samples, each obtained at the same time of day, were used to determine the aldosterone:creatinine ratio during control conditions, RAAS stimulation, and RAAS attenuation. Results: The aldosterone:creatinine ratio from spot-checked urine samples correlated well with 24-h urinary aldosterone excretion (r=0.77, P<0.0001). Conclusions: A spot urinary aldosterone:creatinine ratio might be substituted for 24-h urinary aldosterone determination.
MeSH term(s)	Aldosterone/secretion ; Aldosterone/urine ; Animals ; Creatinine/urine ; Dog Diseases/diagnosis ; Dog Diseases/urine ; Dogs/metabolism ; Dogs/urine ; Female ; Male ; Radioimmunoassay/methods ; Radioimmunoassay/veterinary ; Renin-Angiotensin System/physiology
Chemical Substances	Aldosterone (4964P6T9RB) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2007-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	2198278-8
ISSN	1875-0834 ; 1760-2734
ISSN (online)	1875-0834
ISSN	1760-2734
DOI	10.1016/j.jvc.2006.11.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structure of [Pb(Gly-H)]+ and the monosolvated water and methanol solvated species by infrared multiple-photon dissociation spectroscopy, energy-resolved collision-induced dissociation, and electronic structure calculations.

Atkins, Chad G / Banu, Laura / Rowsell, Mark / Blagojevic, Voislav / Bohme, Diethard K / Fridgen, Travis D

The journal of physical chemistry. B

2009 Volume 113, Issue 43, Page(s) 14457–14464

Abstract: ... dissociation of lead(II) complexed with the conjugate acid of the amino acid glycine ([Pb(Gly-H ... In such a structure lead(II) can act as an effective conduit for proton/hydrogen shifts, making H(2)O loss competitive ... with that of CO in the [Pb(Gly-H)](+) complex and leading to solvent deprotonation and formation of [PbOR(Gly ...

Abstract	Infrared multiple-photon dissociation (IRMPD) spectroscopy, collision-induced dissociation mass spectrometry, and theoretical calculations are combined to provide new insights into the structure and dissociation of lead(II) complexed with the conjugate acid of the amino acid glycine ([Pb(Gly-H)](+)) in the presence and absence of solvent. Unexpectedly, these experiments show the main site of lead(II) coordination to be the deprotonated amino group of glycine, with additional coordination to the carbonyl group. In such a structure lead(II) can act as an effective conduit for proton/hydrogen shifts, making H(2)O loss competitive with that of CO in the [Pb(Gly-H)](+) complex and leading to solvent deprotonation and formation of [PbOR(Gly)](+) (R = H, CH(3)) ions when solvent is present in the complex. The structural assignments based on IRMPD spectroscopy are complemented with isotopic labeling experiments (H(2)(18)O) and experiments done on the ethyl ester of glycine.
Language	English
Publishing date	2009-10-29
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp905654v
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stem Cell Transplantation to Treat Multiple Sclerosis.

Atkins, Harold

JAMA

2019 Volume 321, Issue 2, Page(s) 153–155

MeSH term(s)	Hematopoietic Stem Cell Transplantation ; Humans ; Multiple Sclerosis ; Stem Cell Transplantation
Language	English
Publishing date	2019-01-15
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2018.20777
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Article ; Online: Design of a wearable shoulder exoskeleton robot with dual-purpose gravity compensation and a compliant misalignment compensation mechanism.

Atkins, John / Chang, Dongjune / Lee, Hyunglae

Wearable technologies

2024 Volume 5, Page(s) e4

Abstract: This paper presents the design and validation of a wearable shoulder exoskeleton robot intended to serve as a platform for assistive controllers that can mitigate the risk of musculoskeletal disorders seen in workers. The design features a four-bar ... ...

Abstract	This paper presents the design and validation of a wearable shoulder exoskeleton robot intended to serve as a platform for assistive controllers that can mitigate the risk of musculoskeletal disorders seen in workers. The design features a four-bar mechanism that moves the exoskeleton's center of mass from the upper shoulders to the user's torso, dual-purpose gravity compensation mechanism located inside the four-bar's linkages that supports the full gravitational loading from the exoskeleton with partial user's arm weight compensation, and a novel 6 degree-of-freedom (DoF) compliant misalignment compensation mechanism located between the end effector and the user's arm to allow shoulder translation while maintaining control of the arm's direction. Simulations show the four-bar design lowers the center of mass by cm and the kinematic chain can follow the motion of common upper arm trajectories. Experimental tests show the gravity compensation mechanism compensates gravitational loading within Nm over the range of shoulder motion and the misalignment compensation mechanism has the desired 6 DoF stiffness characteristics and range of motion to adjust for shoulder center translation. Finally, a workspace admittance controller was implemented and evaluated showing the system is capable of accurately reproducing simulated impedance behavior with transparent low-impedance human operation.
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ISSN	2631-7176
ISSN (online)	2631-7176
DOI	10.1017/wtc.2024.1
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Article: Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients.

O'Brien, E / McInnes, G T / Stanton, A / Thom, S / Caulfield, M / Atkins, N / Nichol, F M

Journal of human hypertension

2001 Volume 15 Suppl 1, Page(s) S47–51

MeSH term(s)	Blood Pressure/drug effects ; Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory/methods ; Circadian Rhythm ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Multicenter Studies as Topic ; Regression Analysis
Language	English
Publishing date	2001-05-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/sj.jhh.1001076
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