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  1. Book: Stemm cell transplantation in children: current results and controversies

    Trigg, Michael E.

    meeting 8, Scottsdale, Arizona, 20 - 22 January 2005

    (Pediatric transplantation : Supplement ; 7)

    2005  

    Author's details guest ed. Michael E. Trigg
    Series title Pediatric transplantation : Supplement ; 7
    Pediatric transplantation
    Pediatric transplantation ; Supplement
    Collection Pediatric transplantation
    Pediatric transplantation ; Supplement
    Language English
    Size 91 S. : graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT014607452
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  2. Book: Stemm cell transplantation in children: current results and controversies - meeting 7

    Trigg, Michael E.

    [Stem Cell Transplant Meeting] ; Hilton Head Island, South Carolina, 6 - 8 March 2003

    (Pediatric transplantation : Supplement ; 5)

    2004  

    Institution Stem Cell Transplant Meeting
    Author's details guest ed. Michael E. Trigg
    Series title Pediatric transplantation : Supplement ; 5
    Pediatric transplantation
    Pediatric transplantation ; Supplement
    Collection Pediatric transplantation
    Pediatric transplantation ; Supplement
    Language English
    Size 88 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT014081529
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  3. Book ; Conference proceedings: Marrow transplantation in children: current results and controversies

    Trigg, Michael E.

    meeting #6, St. Augustine, FL, USA, 8 - 10 November 2001

    (Pediatric transplantation : Supplement ; 3)

    2003  

    Event/congress Pediatric Stem Cell Transplant Meeting (2001, SaintAugustineFla.)
    Author's details guest ed. Michael E. Trigg
    Series title Pediatric transplantation : Supplement ; 3
    Pediatric transplantation
    Pediatric transplantation ; Supplement
    Collection Pediatric transplantation
    Pediatric transplantation ; Supplement
    Language English
    Size 108 S. : graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT013959127
    ISBN 1-4051-1659-5 ; 978-1-4051-1659-6
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  4. Book ; Conference proceedings: Proceedings of the Conference on Marrow Transplantation in Children

    Trigg, Michael E.

    Palm Beach, June 1998

    (Pediatric transplantation : Supplement ; 1)

    1999  

    Event/congress Conference on Marrow Transplantation in Children (1998, PalmBeachFla.)
    Author's details guest ed. Michael E. Trigg
    Series title Pediatric transplantation : Supplement ; 1
    Pediatric transplantation
    Pediatric transplantation ; Supplement
    Collection Pediatric transplantation
    Pediatric transplantation ; Supplement
    Language English
    Size 130 S.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT011158485
    ISBN 87-16-16371-0 ; 978-87-16-16371-4
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  5. Book: Marrow transplantation in children

    Trigg, Michael E.

    current results and controversies ; the Third Pediatric Bone Marrow Transplant Meeting, held in Ft. Lauderdale on January 23 - 25, 1997

    (Cancer research therapy & control ; 9,1/2 = Special issue)

    1999  

    Institution Pediatric Bone Marrow Transplant Meeting
    Author's details [guest ed.:] Michael E. Trigg
    Series title Cancer research therapy & control ; 9,1/2 = Special issue
    Cancer research, therapy and control
    Collection Cancer research, therapy and control
    Language English
    Size S. 1 - 191 : graph. Darst.
    Publisher Harwood
    Publishing place St. Helier u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013522708
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  6. Book: Marrow transplantation in children

    Trigg, Michael E.

    current results and controversies, meeting #2 ; June 1 - 3, 1995, Hilton Head Island, South Carolina, USA

    (Bone marrow transplantation ; 18, Suppl. 3)

    1996  

    Author's details org.: Michael E. Trigg
    Series title Bone marrow transplantation ; 18, Suppl. 3
    Collection
    Keywords Bone Marrow Transplantation / in infancy & childhood / congresses ; Neoplasms / in infancy & childhood / congresses ; Neoplasms / therapy / congresses ; Kind ; Knochenmarktransplantation
    Subject Knochenmark ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size S77 S. : graph. Darst.
    Publisher Stockton
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007422271
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  7. Article ; Online: Hematopoietic stem cells.

    Trigg, Michael E

    Pediatrics

    2004  Volume 113, Issue 4 Suppl, Page(s) 1051–1057

    Abstract: The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental toxins and infectious agents. Occasionally, severe aplastic anemia occurs secondary to exposure to some of these toxins or ... ...

    Abstract The hematopoietic system of the young child acquires, through time, the ability to cope with exposure to a number of environmental toxins and infectious agents. Occasionally, severe aplastic anemia occurs secondary to exposure to some of these toxins or infectious agents. The occurrence of severe aplastic anemia provides an opportunity to study the maturation of the hematopoietic system because often the immune system is partially intact. Hematopoietic stem cell transplants permit the study of the complete reconstitution of the hematopoietic and immunologic system. Stem cell transplants are often used to treat severe aplastic anemia or, alternatively, may be part of the treatment for an underlying malignant disease or a genetic disease. Sources of stem cells and the age of the recipient and donor have an impact on the success of the stem cell transplant. A stem cell transplantation provides a window of opportunity to study and observe the normal maturation of the immune system and the sensitivity. Very clearly, children recover from severe aplastic anemia and stem cell transplantations more readily with fewer problems and complications than adults. The environmental risks that a child who received a stem cell transplantation faces are related primarily to the deficiencies of the hematopoietic system and immune system during the recovery phase. Therefore, diminished resistance to infectious agents, primarily viruses and other opportunistic organisms, are the primary risk that children who are recovering from these transplantations face. There are few data on the susceptibility of these children to the toxic effects of other environmental toxicants during the recovery period, which may take years before complete recovery.
    MeSH term(s) Anemia, Aplastic/etiology ; Anemia, Aplastic/immunology ; Anemia, Aplastic/therapy ; Antineoplastic Agents/adverse effects ; Busulfan/administration & dosage ; Child ; Fetal Blood/cytology ; Fetal Blood/transplantation ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/immunology ; Humans ; Lymphocytes/physiology ; Neutropenia/etiology ; Transplantation Conditioning/adverse effects ; Transplantation Immunology/physiology
    Chemical Substances Antineoplastic Agents ; Busulfan (G1LN9045DK)
    Language English
    Publishing date 2004-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Post-transplant immune recovery and the implication for infection risk.

    Trigg, Michael E

    International journal of hematology

    2003  Volume 76 Suppl 1, Page(s) 199–205

    MeSH term(s) Humans ; Immune System/cytology ; Immune System/growth & development ; Opportunistic Infections/etiology ; Opportunistic Infections/immunology ; Opportunistic Infections/therapy ; Risk ; Stem Cell Transplantation/adverse effects ; Transplantation Immunology
    Language English
    Publishing date 2003-04-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0925-5710 ; 0917-1258
    ISSN (online) 1865-3774
    ISSN 0925-5710 ; 0917-1258
    DOI 10.1007/bf03165245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chemotherapy-induced nausea and vomiting: antiemetic trials that impacted clinical practice.

    Trigg, Michael E / Higa, Gerald M

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2010  Volume 16, Issue 4, Page(s) 233–244

    Abstract: Objective: to review the scientific evidence related to serotonin and substance P and the clinical impact targeting these two neurotransmitters have had managing chemotherapy-induced nausea and vomiting (CINV).: Data source: a PubMed search (January ... ...

    Abstract Objective: to review the scientific evidence related to serotonin and substance P and the clinical impact targeting these two neurotransmitters have had managing chemotherapy-induced nausea and vomiting (CINV).
    Data source: a PubMed search (January 1968 to December 2008), restricted to English-language publications, was conducted using the key words antiemetics, cancer chemotherapy, cisplatin, serotonin, substance P, NK(1), and 5-HT(3). Abstracts emanating from the meetings of the American Society of Clinical Oncology and Multinational Association of Supportive Care in Cancer during the period May 2000 to June 2008 were also reviewed.
    Data synthesis: two important outcomes emanated from well-conducted antiemetic clinical trials (Table 1): first, evidence that serotonin and substance P are major mediators of acute and delayed symptoms and second, improved, though not complete, control of CINV.
    Conclusion: serotonin-type 3 and neurokinin-1 receptor antagonists are the most effective agents currently available. In most cases, these agents are used in conjunction with glucocorticoids. The use of these three types of agents is incorporated into current clinical practice guidelines. Further understanding of the biological and biochemical basis of nausea and vomiting may enhance management of this potentially debilitating adverse effect.
    MeSH term(s) Animals ; Antiemetics/therapeutic use ; Antineoplastic Agents/adverse effects ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Humans ; Nausea/chemically induced ; Nausea/drug therapy ; Neurokinin-1 Receptor Antagonists ; Practice Guidelines as Topic ; Serotonin/metabolism ; Serotonin 5-HT3 Receptor Antagonists/therapeutic use ; Serotonin Antagonists/therapeutic use ; Substance P/antagonists & inhibitors ; Substance P/metabolism ; Vomiting/chemically induced ; Vomiting/drug therapy
    Chemical Substances Antiemetics ; Antineoplastic Agents ; Glucocorticoids ; Neurokinin-1 Receptor Antagonists ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists ; Serotonin (333DO1RDJY) ; Substance P (33507-63-0)
    Language English
    Publishing date 2010-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155209354655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Milestones in the development of pediatric hematopoietic stem cell transplantation--50 years of progress.

    Trigg, Michael E

    Pediatric transplantation

    2002  Volume 6, Issue 6, Page(s) 465–474

    Abstract: In the 1950s, the first infusions of hematopoietic stem cells were given as a form of treatment for childhood leukemia. This heralded the beginning of a field that has expanded to include the treatment of immune deficiencies, a variety of leukemias and ... ...

    Abstract In the 1950s, the first infusions of hematopoietic stem cells were given as a form of treatment for childhood leukemia. This heralded the beginning of a field that has expanded to include the treatment of immune deficiencies, a variety of leukemias and solid tumors, and then genetic diseases. A number of milestones are highlighted, particularly in regard to the use of alternative sources of hematopoietic stem cells such as unrelated donors, peripheral blood stem cells and umbilical cord stem cells. In addition, newer techniques of using non-myeloablative preparative regimens helped to reduce the toxicity and long-term consequences of hematopoietic stem cell transplant. Many diseases now benefit from the replacement of the marrow stem cells and the provision of a new immune system and improved immune surveillance.
    MeSH term(s) Bone Marrow Transplantation/history ; Child ; Hematopoietic Stem Cell Transplantation/history ; History, 20th Century ; Humans ; Leukemia, Myeloid, Acute/history ; Leukemia, Myeloid, Acute/therapy ; Neuroblastoma/history ; Neuroblastoma/therapy ; Peripheral Blood Stem Cell Transplantation/history ; Tissue Donors/history
    Language English
    Publishing date 2002-11-26
    Publishing country Denmark
    Document type Historical Article ; Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1034/j.1399-3046.2002.00022.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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