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Article ; Online: Influence of the antiretroviral therapy on the growth pattern of children and adolescents living with HIV/AIDS.

Almeida, Flávia Jacqueline / Kochi, Cristiane / Sáfadi, Marco Aurélio Palazzi

2018 Volume 95 Suppl 1, Page(s) 95–101

Abstract: Objective: Weight and height growth impairment is one of the most frequent manifestations in HIV-infected children and may be the first sign of disease, being considered a marker of disease progression and an independent risk factor for death. The aim ... ...

Abstract	Objective: Weight and height growth impairment is one of the most frequent manifestations in HIV-infected children and may be the first sign of disease, being considered a marker of disease progression and an independent risk factor for death. The aim of this review is to evaluate the influence of antiretroviral therapy on the growth pattern of children and adolescents living with HIV/AIDS. Source of data: A non-systematic review was carried out in the PubMed database, with the terms "HIV", "Weight and height growth", "ART" and "children". The most relevant publications were selected. Data synthesis: Antiretroviral therapy has significantly reduced morbidity and mortality in HIV-infected children and is clearly associated with recovery of weight and height-for-age Z-scores, especially when started early, in the asymptomatic child still without weight-height impairment. Therapeutic strategies involving the GH/IGF-1 axis, especially for children with growth impairment, are still being studied. Conclusions: HIV-infected children show early weight-height impairment; antiretroviral therapy improves the anthropometric profile of these children.
MeSH term(s)	Adolescent ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Body Height/drug effects ; Child ; Child Development/drug effects ; Child Development/physiology ; Child, Preschool ; Disease Progression ; Female ; Growth Disorders/chemically induced ; Growth Disorders/physiopathology ; Growth and Development/drug effects ; Growth and Development/physiology ; HIV Infections/drug therapy ; HIV Infections/physiopathology ; Humans ; Infant ; Infant, Newborn ; Male
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2018-12-27
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.1016/j.jped.2018.12.007
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Article: Oral treatment with a chemically characterized parsley (

Frattani, Flávia Serra / Assafim, Mariane / Casanova, Livia Marques / de Souza, Jacqueline Elis / Chaves, Douglas Siqueira de Almeida / Costa, Sônia Soares / Zingali, Russolina Benedeta

Journal of traditional and complementary medicine

2020 Volume 11, Issue 3, Page(s) 287–291

Abstract: Petroselinum ... ...

Abstract	Petroselinum crispum
Language	English
Publishing date	2020-04-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2709698-1
ISSN	2225-4110
ISSN	2225-4110
DOI	10.1016/j.jtcme.2020.04.003
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Article ; Online: Hematuria Associated With SARS-CoV-2 Infection in a Child.

Almeida, Flávia Jacqueline / Olmos, Rodrigo Diaz / Oliveira, Danielle Bruna Leal / Monteiro, Cairo Oliveira / Thomazelli, Luciano Matsumiya / Durigon, Edison Luiz / Sáfadi, Marco Aurélio Palazzi

The Pediatric infectious disease journal

2020 Volume 39, Issue 7, Page(s) e161

MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Coronavirus Infections/blood ; Coronavirus Infections/urine ; Female ; Hematuria/blood ; Hematuria/urine ; Hematuria/virology ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/urine ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002737
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Article ; Online: Determinants of preterm birth: proposal for a hierarchical theoretical model.

Rocha, Aline Dos Santos / Falcão, Ila Rocha / Teixeira, Camila Silveira Silva / Alves, Flávia Jôse Oliveira / Ferreira, Andrêa Jacqueline Fortes / Silva, Natanael de Jesus / Almeida, Marcia Furquim de / Ribeiro-Silva, Rita de Cássia

Ciencia & saude coletiva

2022 Volume 27, Issue 8, Page(s) 3139–3152

Abstract: Preterm birth (PB) is a syndrome resulting from a complex relationship between multiple factors which do not have fully understood relationships and causality. This article discusses a hierarchical theoretical model of PB determinants, considering ... ...

Title translation	Determinantes do nascimento prematuro: proposta de um modelo teórico hierarquizado.
Abstract	Preterm birth (PB) is a syndrome resulting from a complex relationship between multiple factors which do not have fully understood relationships and causality. This article discusses a hierarchical theoretical model of PB determinants, considering maternal characteristics such as sociodemographic, psychosocial, nutritional, behavioral and biological aspects, traditionally associated with increased risk of PB. The variables were distributed in six dimensions within three hierarchical levels (distal, intermediate and proximal). In this model, the socioeconomic determinants of the mother, family, household and neighborhood play indirect effects on PB through variables at the intermediate level, which in turn affect biological risk factors at the proximal level that have a direct effect on PB. The study presents a hierarchical theoretical model of the factors involved in the PB determination chain and their interrelationships. Understanding these interrelationships is an important step in trying to break the causal chain that makes some women vulnerable to preterm birth.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Models, Theoretical ; Mothers ; Premature Birth/epidemiology ; Risk Factors ; Socioeconomic Factors
Language	English
Publishing date	2022-05-07
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232022278.03232022
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Article ; Online: Vaccination in Pediatric Patients with Sickle-Cell Disease: Uptake Report and Mini-Review.

Jarovsky, Daniel / Bastos, Phillipe Romanzini / de Matos, Samantha Faria / Almeida, Flávia Jacqueline / Sáfadi, Marco Aurélio Palazzi / Hegg, Izabella Campos Oliveira / Luporini, Silvia Maria / Berezin, Eitan Naaman

Journal of tropical pediatrics

2022 Volume 68, Issue 3

Abstract: Background: Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is ... ...

Abstract	Background: Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is unknown. Material and methods: Children under 18 years with SCD presenting to routine medical consultations had their vaccination status evaluated according to the national recommendations. Data obtained were classified as 'Adequate', 'Delayed' or 'Missing' vaccination and compared among age groups. Results: From 117 children screened, 100 had their vaccination card available. Vaccination coverage of routine vaccines was above 95% for all primary series and both age groups, with varied rates of delays and low missing doses. Among SCD extended vaccination, the most frequently delayed and missed vaccines were those specifically recommended to individuals with SCD as per national guidelines-and particularly those against encapsulated bacteria. Significant and varied rates of missing doses occurred in primary series and booster doses for PPSV23, Hib, menC, hepatitis A and varicella. The average influenza vaccination rate was 69.5%, with higher rates among younger children. Conclusions: Children with SCD have alarming under-vaccination rates. Basic prevention strategies in Brazil should be reassessed in this specific population.
MeSH term(s)	Adolescent ; Anemia, Sickle Cell/complications ; Brazil/epidemiology ; Child ; Communicable Diseases ; Humans ; Infant ; Vaccination ; Vaccination Coverage
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	800065-7
ISSN	1465-3664 ; 0449-3281 ; 0142-6338
ISSN (online)	1465-3664
ISSN	0449-3281 ; 0142-6338
DOI	10.1093/tropej/fmac034
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Article ; Online: Perceptions of nurses regarding the management of snakebite envenomations: Limits and possibilities.

Rocha, Gisele Dos Santos / Souza Rodrigues, Maria Francisca / Rocha, Yasmim Vieira / Beckman de Lima, Huxlan / Ramos, Flávia Regina / Teixeira, Elizabeth / Monteiro, Wuelton / Sachett, Jacqueline de Almeida Gonçalves

Toxicon : official journal of the International Society on Toxinology

2022 Volume 223, Page(s) 106995

Abstract: Snakebites can be caused by harmless or venomous snakes and, according to their severity and frequency, can be considered events of medical importance. In health facilities in remote areas, nurses work in the first line of care of patients that are ... ...

Abstract	Snakebites can be caused by harmless or venomous snakes and, according to their severity and frequency, can be considered events of medical importance. In health facilities in remote areas, nurses work in the first line of care of patients that are victims of these envenomations. The aim was to discover the perception of nurses regarding the management of snakebites, its limitations and possibilities, with a view to professional empowerment in the context of primary health care. This is exploratory and descriptive research, with a qualitative approach, developed at FMT-HVD in Manaus, Amazonas state, Brazil, in the year 2021. The participants were nurses who work in basic health units in the municipalities of Careiro da Várzea, Ipixuna and Boa Vista do Ramos in the state of Amazonas. For data collection, the focus group strategy was adopted. Thematic content analysis was employed, which was carried out in the stages of pre-analysis; exploration or coding of the material; treatment of the results, inference and interpretation. After processing the data obtained, four topics emerged from the coding: Topic 1 - limitations in the primary care. Topic 2 - the need for infrastructure and personnel. Topic 3 - the need for continuing education. Topic 4 - the perception of training regarding the management of snakebite envenomations. The results showed a lack of antivenom in the healthcare units where nurses work. Another aspect highlighted by the nurses is the absence of a doctor in situ to perform the primary care or out of hours care in the units. The nurses' perceptions regarding the management of snakebite envenomations revealed the existence of failures in relation to the subject, such as the lack of antivenom, poor infrastructure in the units and the lack of a doctor, which must be solved, since the nurses are the most active professionals in primary health care, in addition to the high incidence of snakebite envenomations in the Brazilian Amazon.
MeSH term(s)	Animals ; Humans ; Snake Bites/epidemiology ; Antivenins/therapeutic use ; Snakes ; Incidence ; Nurses
Chemical Substances	Antivenins
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2022.106995
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Article ; Online: Characteristics and clinical outcomes of COVID-19 in children: a hospital-based surveillance study in Latin America's hardest-hit city.

Jarovsky, Daniel / de Freitas Fongaro, Giuliana / Zampol, Renata Mazzotti / de Oliveira, Thales Araújo / Farias, Camila Giuliana Almeida / da Silva, Daniella Gregória Bomfim Prado / Cavalcante, Denis Tadeu Gomes / Nery, Sabrina Bortolin / de Moraes, José Cassio / de Oliveira, Francisco Ivanildo / Almeida, Flávia Jacqueline / Sáfadi, Marco Aurélio Palazzi

IJID regions

2022 Volume 7, Page(s) 52–62

Abstract: Background: In 2020, Brazil became the epicentre of the coronavirus disease (COVID-19) pandemic in Latin America, resulting in an unparalleled health catastrophe. Nevertheless, comprehensive clinical reports in Brazilian children are not available.: ... ...

Abstract	Background: In 2020, Brazil became the epicentre of the coronavirus disease (COVID-19) pandemic in Latin America, resulting in an unparalleled health catastrophe. Nevertheless, comprehensive clinical reports in Brazilian children are not available. Methods: This retrospective, hospital-based, active surveillance study was performed to identify paediatric patients with COVID-19 who presented at a private academic medical centre in a large urban area between March 2020 and March 2021. Clinical and demographic information was analysed for those requiring hospitalization, those with severe illness and those with clinical syndromes. Results: In total, 964 symptomatic cases were evaluated; of these, 17.7% required hospitalization, and 27.5% of hospitalized cases were classified as severe/critical. Acute bronchiolitis and pneumonia were the most common causes of hospitalization among the severe cases. Twenty-seven hospitalized children fulfilled the diagnostic criteria for multi-system inflammatory syndrome (median age 29 months; 85.2% cases were non-severe). A significant co-existing condition was present in 29% of hospitalized children. The risk of hospitalization was higher in children with at least one comorbidity, children aged <2 years and obese children. Increased risk of severe disease was described among those with leukopenia, leukocytosis or any significant comorbidity. No deaths occurred among the study population. Conclusion: Although most children with COVID-19 experienced mild disease, and no deaths occurred among the study population, a significant proportion of cases required hospitalization and developed severe illness. Obesity, young age, underlying comorbidity, leukopenia and leukocytosis were risk factors for hospitalization or severe disease.
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2022.12.003
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Article ; Online: Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats

Flávia Serra Frattani / Mariane Assafim / Livia Marques Casanova / Jacqueline Elis de Souza / Douglas Siqueira de Almeida Chaves / Sônia Soares Costa / Russolina Benedeta Zingali

Journal of Traditional and Complementary Medicine, Vol 11, Iss 3, Pp 287-

2021 Volume 291

Abstract: Petroselinum crispum var. neapolitanum Danert (Apiaceae) (PC), popularly known as parsley, is an herb native to the Mediterranean region widely cultivated around the world for culinary and ethnomedicinal purposes. The herb is traditionally used in ... ...

Abstract	Petroselinum crispum var. neapolitanum Danert (Apiaceae) (PC), popularly known as parsley, is an herb native to the Mediterranean region widely cultivated around the world for culinary and ethnomedicinal purposes. The herb is traditionally used in various parts of the world to treat arterial hypertension, hemorrhoid, nose bleeding, hyperlipidemia, and pain, among other indications. The aim of this study was to evaluate the antithrombotic activity of an aqueous extract PC in rats. Aerial parts of a flat-leaf variety of parsley were extracted by decoction. In vivo thrombosis in rat models as well as ex vivo assays were used in the evaluation of PC antithrombotic effects. Intravenous administration of PC (25 mg/kg.b.w), 5 min before thrombosis induction, reduced the venous thrombus formation by 98.2%, while oral administration (125 mg/kg.b.w) impaired it by 76.2%. In the arterial thrombosis model, the oral administration of PC at 15 or 25 mg/kg.b.w, 60 min before thrombosis induction, increased the carotid artery occlusion time by 150% (37.0 ± 6.44 min) and 240% (more than 60 min), respectively. A HPLC-DAD-MS/MS profile of PC extract used in this study was provided. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives. Our results indicate that PC is a potential candidate for the development of a phytotherapeutic drug in the treatment of thromboembolic diseases and provide a detailed chemical profile useful for controlling PC extract production in view of phytotherapy.
Keywords	Petroselinum crispum var. neapolitanum Danert ; Parsley ; Deep venous thrombosis ; Arterial thrombosis ; Chemical profile ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: L-glutathione 1% promotes neuroprotection of nitrergic neurons and reduces the oxidative stress in the jejunum of rats with Walker-256-bearing tumor.

de Oliveira, Ana Paula / Perles, Juliana Vanessa Colombo Martins / de Souza, Sara Raquel Garcia / Sestak, Sabrina Silva / da Motta Lima, Fabiana Galvão / Almeida, Gustavo Henrique Doná Rodrigues / Cicero, Lídia Rodrigues / Clebis, Naianne Kelly / Guarnier, Flávia Alessandra / Blegniski, Fernanda Pascoal / Vasconcelos, Roseane Carvalho / Araújo, Aurigena Antunes / Comar, Jurandir Fernando / Moreira, Lucas Stafuza / Sehaber-Sierakowski, Camila Cavicchioli / Zanoni, Kassio Papi Silva / Zanoni, Jacqueline Nelisis

Neurogastroenterology and motility

2023 Volume 35, Issue 12, Page(s) e14688

Abstract: Aims: Our main goals were to investigate the effects of L-glutathione (1%) treatment in Walker-256 tumor-bearing rats by analyzing immunoreactive neurons (IR), responsive to the nNOS enzyme and 3-Nitrotyrosine, in their jejunum myenteric plexus. ... ...

Abstract	Aims: Our main goals were to investigate the effects of L-glutathione (1%) treatment in Walker-256 tumor-bearing rats by analyzing immunoreactive neurons (IR), responsive to the nNOS enzyme and 3-Nitrotyrosine, in their jejunum myenteric plexus. Moreover, the oxidative state and inflammatory process in these animals were investigated. Methods: Four experimental groups were utilized: control (C), control treated with L-glutathione (CGT), Walker-256 tumor-bearing rats (TW), and Walker-256 tumor-bearing rats treated with L-glutathione (TWGT). After 14 days of tumor inoculation, the jejunum was collected for immunohistochemical techniques and assessment of oxidative status. Plasma was collected to evaluate oxidative status and measure cytokines. Results: The TW group exhibited a decrease of reduced glutathione in their jejunum, which was prevented in the L-glutathione treated TWGT group. TW animals presented pronounced oxidative stress by increasing levels of lipoperoxidation in their jejunum and malondialdehyde in their plasma; however, the L-glutathione treatment in TWGT group was not able to avoid it. The total antioxidant capacity was altered in groups TW and TWGT, yet the last one had a better index in their plasma. The IL-10, and TNF-α levels increased in TWGT animals. The nNOS-IR neuron density decreased in the jejunum myenteric plexus of the TW group, which was avoided in the TWGT group. The nNOS +3-Nitrotyrosine neurons quantification did not show significative alterations. Conclusion: The treatment with L-glutathione (1%) imposed an important defense to some parameters of oxidative stress induced by TW-256, leading to neuroprotection to the loss in the nNOS-IR neuron density.
MeSH term(s)	Rats ; Animals ; Jejunum ; Nitrergic Neurons ; Rats, Wistar ; Neuroprotection ; Oxidative Stress ; Glutathione/metabolism ; Myenteric Plexus/pathology ; Neoplasms/metabolism ; Neoplasms/pathology
Chemical Substances	Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14688
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Article: Hematuria Associated With SARS-CoV-2 Infection in a Child

Almeida, Flávia Jacqueline / Olmos, Rodrigo Diaz / Oliveira, Danielle Bruna Leal / Monteiro, Cairo Oliveira / Thomazelli, Luciano Matsumiya / Durigon, Edison Luiz / Sáfadi, Marco Aurélio Palazzi

Pediatr Infect Dis J

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #197292
Database	COVID19

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