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  1. Article ; Online: The effect of social media interventions on physical activity and dietary behaviours in young people and adults: a systematic review.

    Goodyear, Victoria A / Wood, Grace / Skinner, Bethany / Thompson, Janice L

    The international journal of behavioral nutrition and physical activity

    2021  Volume 18, Issue 1, Page(s) 72

    Abstract: Background: The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical activity and ...

    Abstract Background: The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical activity and diet-related behaviours, and assess differences in outcomes across different population groups.
    Methods: A systematic search of the literature was conducted across 5 databases (Medline, Embase, EBSCO Education, Wiley and Scopus) using key words related to social media, physical activity, diet, and age. The inclusion criteria were: participants age 13+ years in the general population; an intervention that used commercial social media platform(s); outcomes related to changes to diet/eating or physical activity behaviours; and quantitative, qualitative and mixed methods studies. Quality appraisal tools that aligned with the study designs were used. A mixed methods approach was used to analyse and synthesise all evidence.
    Results: Eighteen studies were included: randomised control trials (n = 4), non-controlled trials (n = 3), mixed methods studies (n = 3), non-randomised controlled trials (n = 5) and cross-sectional studies (n = 3). The target population of most studies was young female adults (aged 18-35) attending college/university. The interventions reported on positive changes to physical activity and diet-related behaviours through increases in physical activity levels and modifications to food intake, body composition and/or body weight. The use of Facebook, Facebook groups and the accessibility of information and interaction were the main characteristics of social media interventions. Studies also reported on Instagram, Reddit, WeChat and Twitter and the use of photo sharing and editing, groups and sub-groups and gamification.
    Conclusions: Social media interventions can positively change physical activity and diet-related behaviours, via increases in physical activity levels, healthy modifications to food intake, and beneficial changes to body composition or body weight. New evidence is provided on the contemporary uses of social media (e.g. gamification, multi-model application, image sharing/editing, group chats) that can be used by policy makers, professionals, organisations and/or researchers to inform the design of future social media interventions. This study had some limitations that mainly relate to variation in study design, over-reliance of self-reported measures and sample characteristics, that prevented comparative analysis. Registration number: PROPSERO; CRD42020210806 .
    MeSH term(s) Adolescent ; Adult ; Diet/statistics & numerical data ; Exercise ; Female ; Humans ; Male ; Social Media ; Young Adult
    Language English
    Publishing date 2021-06-05
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2134691-4
    ISSN 1479-5868 ; 1479-5868
    ISSN (online) 1479-5868
    ISSN 1479-5868
    DOI 10.1186/s12966-021-01138-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Peripheral blood mononuclear cell transcriptome profile in a clinical trial with subcutaneous, grass pollen allergoid immunotherapy.

    Starchenka, Sviatlana / Oluwayi, Kemi / Heath, Matthew / Armfield, Oliver / Shamji, Mohamed / Layhadi, Janice / Lis, Katarzyna / Cadavez, Lisa / Rusyn, Olesya / Skinner, Murray / De Kam, Pieter-Jan

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2024  Volume 54, Issue 2, Page(s) 130–142

    Abstract: Introduction: Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in allergic airway diseases. Underlying immunological mechanisms and candidate biomarkers, which may be translated into predictive/surrogate measures of clinical ...

    Abstract Introduction: Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in allergic airway diseases. Underlying immunological mechanisms and candidate biomarkers, which may be translated into predictive/surrogate measures of clinical efficacy, remain an active area of research. The aim of this study was to evaluate Pollinex Quattro (PQ) Grass AIT induced immunomodulatory mechanisms, based on transcriptome profiling of peripheral blood mononuclear cells.
    Methods: 119 subjects with grass pollen induced seasonal allergic rhinitis (SAR) were randomized in a 2:2:1:1 ratio to receive a cumulative dose of PQ Grass as a conventional or extended pre-seasonal regimen, placebo, or placebo with MicroCrystalline Tyrosine. Gene expression analysis was an exploratory endpoint evaluated in a subgroup of 30 subjects randomly selected from the four treatment arms. Samples were collected at three time points: screening (baseline), before the start of the grass pollen season and at the end of the season. This study was funded by the manufacturer of PQ.
    Results: Transcriptome analysis demonstrated that the most significant changes in gene expression, for both treatment regimens, were at the end of the grass pollen season, with the main Th1 candidate molecules (IL-12A, IFNγ) upregulated and Th2 signature cytokines downregulated (IL-4, IL-13, IL-9) (p < .05). Canonical pathways analysis demonstrated Th1, Th2, Th17 and IL-17 as the most significantly enriched pathways based on absolute value of activation z-score (IzI score ≥ 2, p < .05). Upstream regulator analysis showed pronounced inhibition of pro-inflammatory allergic molecules IgE, IL-17A, IL-17F, IL-25 (IL-17E) (IzI score ≥ 2, FDR < 0.05) and activation of pro-tolerogenic molecules IL-12A, IL-27, IL-35 (EBI3) at the end of the grass pollen season.
    Conclusion: Peripheral blood mononuclear cells transcriptome profile showed an inhibition of Th2, Th17 pro-inflammatory allergic responses and immune deviation towards Th1 responses. PQ Grass extended regimen exhibited a superior mechanistic efficacy profile in comparison with PQ conventional regimen.
    MeSH term(s) Humans ; Allergoids ; Allergens ; Transcriptome ; Leukocytes, Mononuclear ; Pollen ; Poaceae/genetics ; Desensitization, Immunologic
    Chemical Substances Allergoids ; Allergens
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of social media interventions on physical activity and dietary behaviours in young people and adults

    Victoria A. Goodyear / Grace Wood / Bethany Skinner / Janice L. Thompson

    International Journal of Behavioral Nutrition and Physical Activity, Vol 18, Iss 1, Pp 1-

    a systematic review

    2021  Volume 18

    Abstract: Abstract Background The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical ... ...

    Abstract Abstract Background The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical activity and diet-related behaviours, and assess differences in outcomes across different population groups. Methods A systematic search of the literature was conducted across 5 databases (Medline, Embase, EBSCO Education, Wiley and Scopus) using key words related to social media, physical activity, diet, and age. The inclusion criteria were: participants age 13+ years in the general population; an intervention that used commercial social media platform(s); outcomes related to changes to diet/eating or physical activity behaviours; and quantitative, qualitative and mixed methods studies. Quality appraisal tools that aligned with the study designs were used. A mixed methods approach was used to analyse and synthesise all evidence. Results Eighteen studies were included: randomised control trials (n = 4), non-controlled trials (n = 3), mixed methods studies (n = 3), non-randomised controlled trials (n = 5) and cross-sectional studies (n = 3). The target population of most studies was young female adults (aged 18–35) attending college/university. The interventions reported on positive changes to physical activity and diet-related behaviours through increases in physical activity levels and modifications to food intake, body composition and/or body weight. The use of Facebook, Facebook groups and the accessibility of information and interaction were the main characteristics of social media interventions. Studies also reported on Instagram, Reddit, WeChat and Twitter and the use of photo sharing and editing, groups and sub-groups and gamification. Conclusions Social media interventions can positively change physical activity and diet-related behaviours, via increases in physical activity levels, healthy modifications to food intake, and beneficial changes to body ...
    Keywords Physical activity ; Diet ; Social media ; Facebook ; Instagram ; Reddit ; Nutritional diseases. Deficiency diseases ; RC620-627 ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hemophagocytic Lymphohistiocytosis.

    Skinner, Janice / Yankey, Benedicta / Shelton, Brenda K

    AACN advanced critical care

    2019  Volume 30, Issue 2, Page(s) 151–164

    Abstract: Hemophagocytic lymphohistiocytosis is a life-threatening condition associated with hyperinflammation and multiple organ dysfunction. It has many causes, symptoms, and outcomes. Early recognition is critical for treatment. Fever, cytopenias, coagulopathy, ...

    Abstract Hemophagocytic lymphohistiocytosis is a life-threatening condition associated with hyperinflammation and multiple organ dysfunction. It has many causes, symptoms, and outcomes. Early recognition is critical for treatment. Fever, cytopenias, coagulopathy, and hepatosplenomegaly are hallmark findings. Identifying the trigger event is crucial but challenging because of the varied presentations and infrequent provider experience. Diagnostic features include anemia, thrombocytopenia, neutropenia, elevated ferritin, hypertriglyceridemia, hypofibrinogenemia, hemophagocytosis (in bone marrow, spleen, or lymph nodes), low or absent natural killer cells, and elevated soluble interleukin 2 receptor assay. Primary treatment goals are eliminating the underlying trigger and suppressing hyperinflammation with steroids, immunoglobulins, or immunomodulators. Specific treatment includes corticosteroids, etoposide, and antithymocyte globulin followed by hematopoietic stem cell transplantation in patients with refractory or relapsing disease. Prompt immunochemical therapy is essential but often complicated by a high risk of treatment-related morbidity and disease recurrence. Despite these challenges, improvements in diagnostic technology and treatment have enhanced survival.
    MeSH term(s) Critical Care Nursing ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/nursing ; Lymphohistiocytosis, Hemophagocytic/physiopathology ; Nursing Diagnosis
    Language English
    Publishing date 2019-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2019463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Appraisal of Clinical Care Practices for Child Obesity Treatment. Part I: Interventions.

    Skinner, Asheley C / Staiano, Amanda E / Armstrong, Sarah C / Barkin, Shari L / Hassink, Sandra G / Moore, Jennifer E / Savage, Jennifer S / Vilme, Helene / Weedn, Ashley E / Liebhart, Janice / Lindros, Jeanne / Reilly, Eileen M

    Pediatrics

    2023  Volume 151, Issue 2

    Abstract: The objective of this technical report is to provide clinicians with evidence-based, actionable information upon which to make assessment and treatment decisions for children and adolescents with obesity. In addition, this report will provide an evidence ...

    Abstract The objective of this technical report is to provide clinicians with evidence-based, actionable information upon which to make assessment and treatment decisions for children and adolescents with obesity. In addition, this report will provide an evidence base to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) "What are clinically based, effective treatments for obesity?" and (KQ2) "What is the risk of comorbidities among children with obesity?" See Appendix 1 for the conceptual framework and a priori key questions.
    MeSH term(s) Child ; Adolescent ; Humans ; Pediatric Obesity/epidemiology ; Pediatric Obesity/therapy ; Overweight ; Comorbidity
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-060642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Appraisal of Clinical Care Practices for Child Obesity Treatment. Part II: Comorbidities.

    Skinner, Asheley C / Staiano, Amanda E / Armstrong, Sarah C / Barkin, Shari L / Hassink, Sandra G / Moore, Jennifer E / Savage, Jennifer S / Vilme, Helene / Weedn, Ashley E / Liebhart, Janice / Lindros, Jeanne / Reilly, Eileen M

    Pediatrics

    2023  Volume 151, Issue 2

    Abstract: The objective of this technical report is to provide clinicians with actionable evidence-based information upon which to make treatment decisions. In addition, this report will provide an evidence base on which to inform clinical practice guidelines for ... ...

    Abstract The objective of this technical report is to provide clinicians with actionable evidence-based information upon which to make treatment decisions. In addition, this report will provide an evidence base on which to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents. To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) "What are effective clinically based treatments for obesity?" and (KQ2) "What is the risk of comorbidities among children with obesity?" See Appendix 1 for the conceptual framework and a priori Key Questions.
    MeSH term(s) Child ; Adolescent ; Humans ; Pediatric Obesity/epidemiology ; Pediatric Obesity/therapy ; Overweight ; Comorbidity
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-060643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Improved accuracy in multicomponent surface complexation models using surface-sensitive analytical techniques: Adsorption of arsenic onto a TiO

    Bullen, Jay C / Kenney, Janice P L / Fearn, Sarah / Kafizas, Andreas / Skinner, Stephen / Weiss, Dominik J

    Journal of colloid and interface science

    2020  Volume 580, Page(s) 834–849

    Abstract: Novel composite materials are increasingly developed for water treatment applications with the aim of achieving multifunctional behaviour, e.g. combining adsorption with light-driven remediation. The application of surface complexation models (SCM) is ... ...

    Abstract Novel composite materials are increasingly developed for water treatment applications with the aim of achieving multifunctional behaviour, e.g. combining adsorption with light-driven remediation. The application of surface complexation models (SCM) is important to understand how adsorption changes as a function of pH, ionic strength and the presence of competitor ions. Component additive (CA) models describe composite sorbents using a combination of single-phase reference materials. However, predictive adsorption modelling using the CA-SCM approach remains unreliable, due to challenges in the quantitative determination of surface composition. In this study, we test the hypothesis that characterisation of the outermost surface using low energy ion scattering (LEIS) improves CA-SCM accuracy. We consider the TiO
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2020.06.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effect of social media interventions on physical activity and dietary behaviours in young people and adults: a systematic review

    Goodyear, Victoria A. / Wood, Grace / Skinner, Bethany / Thompson, Janice L.

    Int J Behav Nutr Phys Act. 2021 Dec., v. 18, no. 1 p.72-72

    2021  

    Abstract: BACKGROUND: The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical activity and ... ...

    Abstract BACKGROUND: The objectives of this systematic review were to update the evidence base on social media interventions for physical activity and diet since 2014, analyse the characteristics of interventions that resulted in changes to physical activity and diet-related behaviours, and assess differences in outcomes across different population groups. METHODS: A systematic search of the literature was conducted across 5 databases (Medline, Embase, EBSCO Education, Wiley and Scopus) using key words related to social media, physical activity, diet, and age. The inclusion criteria were: participants age 13+ years in the general population; an intervention that used commercial social media platform(s); outcomes related to changes to diet/eating or physical activity behaviours; and quantitative, qualitative and mixed methods studies. Quality appraisal tools that aligned with the study designs were used. A mixed methods approach was used to analyse and synthesise all evidence. RESULTS: Eighteen studies were included: randomised control trials (n = 4), non-controlled trials (n = 3), mixed methods studies (n = 3), non-randomised controlled trials (n = 5) and cross-sectional studies (n = 3). The target population of most studies was young female adults (aged 18–35) attending college/university. The interventions reported on positive changes to physical activity and diet-related behaviours through increases in physical activity levels and modifications to food intake, body composition and/or body weight. The use of Facebook, Facebook groups and the accessibility of information and interaction were the main characteristics of social media interventions. Studies also reported on Instagram, Reddit, WeChat and Twitter and the use of photo sharing and editing, groups and sub-groups and gamification. CONCLUSIONS: Social media interventions can positively change physical activity and diet-related behaviours, via increases in physical activity levels, healthy modifications to food intake, and beneficial changes to body composition or body weight. New evidence is provided on the contemporary uses of social media (e.g. gamification, multi-model application, image sharing/editing, group chats) that can be used by policy makers, professionals, organisations and/or researchers to inform the design of future social media interventions. This study had some limitations that mainly relate to variation in study design, over-reliance of self-reported measures and sample characteristics, that prevented comparative analysis. Registration number: PROPSERO; CRD42020210806 .
    Keywords body composition ; body weight ; education ; females ; food intake ; issues and policy ; people ; physical activity ; systematic review
    Language English
    Dates of publication 2021-12
    Size p. 72.
    Publishing place BioMed Central
    Document type Article ; Online
    Note Review
    ZDB-ID 2134691-4
    ISSN 1479-5868
    ISSN 1479-5868
    DOI 10.1186/s12966-021-01138-3
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation.

    Wang, Janice C / Bindokas, Vytautas P / Skinner, Matthew / Emrick, Todd / Marks, Jeremy D

    Neurochemistry international

    2017  Volume 109, Page(s) 126–140

    Abstract: Global brain ischemia can lead to widespread neuronal death and poor neurologic outcomes in patients. Despite detailed understanding of the cellular and molecular mechanisms mediating neuronal death following focal and global brain hypoxia-ischemia, ... ...

    Abstract Global brain ischemia can lead to widespread neuronal death and poor neurologic outcomes in patients. Despite detailed understanding of the cellular and molecular mechanisms mediating neuronal death following focal and global brain hypoxia-ischemia, treatments to reduce ischemia-induced brain injury remain elusive. One pathway central to neuronal death following global brain ischemia is mitochondrial dysfunction, one consequence of which is the cascade of intracellular events leading to mitochondrial outer membrane permeabilization. A novel approach to rescuing injured neurons from death involves targeting cellular membranes using a class of synthetic molecules called Pluronics. Pluronics are triblock copolymers of hydrophilic poly[ethylene oxide] (PEO) and hydrophobic poly[propylene oxide] (PPO). Evidence is accumulating to suggest that hydrophilic Pluronics rescue injured neurons from death following substrate deprivation by preventing mitochondrial dysfunction. Here, we will review current understanding of the nature of interaction of Pluronic molecules with biological membranes and the efficacy of F-68, an 80% hydrophilic Pluronic, in rescuing neurons from injury. We will review data indicating that F-68 reduces mitochondrial dysfunction and mitochondria-dependent death pathways in a model of neuronal injury in vitro, and present new evidence that F-68 acts directly on mitochondria to inhibit mitochondrial outer membrane permeabilization. Finally, we will present results of a pilot, proof-of-principle study suggesting that F-68 is effective in reducing hippocampal injury induced by transient global ischemia in vivo. By targeting mitochondrial dysfunction, F-68 and other Pluronic molecules constitute an exciting new approach to rescuing neurons from acute injury.
    MeSH term(s) Animals ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Gerbillinae ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Membranes/drug effects ; Mitochondrial Membranes/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Pilot Projects ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/metabolism ; Polyethylene Glycols/pharmacology ; Propylene Glycols/chemistry ; Propylene Glycols/metabolism ; Propylene Glycols/pharmacology ; Rats ; Rats, Sprague-Dawley ; Substrate Specificity/drug effects ; Substrate Specificity/physiology
    Chemical Substances PEO-PPO-PEO ; Propylene Glycols ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2017-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2017.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Feasibility of

    Haggerty, Kevin P / Barkan, Susan E / Skinner, Martie / Ben Packard, W / Cole, Janice J

    Journal of the Society for Social Work and Research

    2016  Volume 7, Issue 4, Page(s) 639–659

    Abstract: Objective: To test the feasibility, usability, and proximal outcomes of : Method: Families (n = 60) fostering teens between 11 and 15 years of age were recruited into the study and randomly assigned into the self-administered program with telephone ... ...

    Abstract Objective: To test the feasibility, usability, and proximal outcomes of
    Method: Families (n = 60) fostering teens between 11 and 15 years of age were recruited into the study and randomly assigned into the self-administered program with telephone support from a family consultant (n = 32) or a waitlist control condition (n = 28).
    Results: Overall satisfaction with the program was high, with 100% of parents reporting they would recommend the program to other caregivers and reporting being "very satisfied" or "satisfied with the program. Program completion was good, with 62% of families completing all 91 specified tasks. Analyses of proximal outcomes revealed increased communication about sex and substance use (posttest1 OR = 1.97, and 2.03, respectively). Teens in the intervention vs. the waitlist condition reported lower family conflict (OR=.48), and more family rules related to monitoring (OR = 4.02) and media use (OR = 3.24). Caregivers in the waitlist group reported significant increases in the teen's positive involvements (partial eta sq = 17% increase) after receiving the intervention.
    Conclusions: Overall, program participation appeared to lead to stronger family management, better communication between teens and caregivers around monitoring and media use, teen participation in setting family rules, and decreased teen attitudes favorable to antisocial behavior. This small pilot study shows promising results for this adapted program.
    Language English
    Publishing date 2016-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2598656-9
    ISSN 1948-822X ; 1948-822X ; 2334-2315
    ISSN (online) 1948-822X
    ISSN 1948-822X ; 2334-2315
    DOI 10.1086/686986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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