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Book ; Online ; E-Book: Hybrid PET/MR neuroimaging

Franceschi, Ana M. / Franceschi, Dinko

a comprehensive approach

2022

Author's details	Ana M. Franceschi, Dinko Franceschi editors
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (xix, 875 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021192221
ISBN	978-3-030-82367-2 ; 9783030823665 ; 3-030-82367-9 ; 3030823660
DOI	10.1007/978-3-030-82367-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski et al.

Franceschi, C / Bahnini, A / Cappelli, M / Cuaranta, R L / Dadon, M / Delfrate, R / Ermini, S / Gianesini, S / Mendoza, E / Passariello, F / Puskas, A

American journal of surgery

2017 Volume 216, Issue 5, Page(s) 1035

MeSH term(s)	Humans ; Prospective Studies ; Varicose Veins ; Vascular Surgical Procedures
Language	English
Publishing date	2017-11-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2017.10.038
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Article ; Online: Corrigendum to INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma.

van den Bent, Martin / Eoli, Marica / Sepulveda, Juan Manuel / Smits, Marion / Walenkamp, Annemiek / Frenel, Jean-Sebastian / Franceschi, Enrico / Clement, Paul M / Chinot, Olivier / de Vos, Filip / Whenham, Nicolas / Sanghera, Paul / Weller, Michael / Dubbink, H J / French, Pim / Looman, Jim / Dey, Jyotirmoy / Krause, Scott / Ansell, Pete /

Nuyens, Sarah / Spruyt, Maarten / Brilhante, Joana / Coens, Corneel / Gorlia, Thierry / Golfinopoulos, Vassilis

Neuro-oncology

2020 Volume 23, Issue 8, Page(s) 1415

Language	English
Publishing date	2020-07-01
Publishing country	England
Document type	Published Erratum
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noaa115
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Article ; Online: INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma.

Van Den Bent, Martin / Eoli, Marica / Sepulveda, Juan Manuel / Smits, Marion / Walenkamp, Annemiek / Frenel, Jean-Sebastian / Franceschi, Enrico / Clement, Paul M / Chinot, Olivier / De Vos, Filip / Whenham, Nicolas / Sanghera, Paul / Weller, Michael / Dubbink, H J / French, Pim / Looman, Jim / Dey, Jyotirmoy / Krause, Scott / Ansell, Pete /

Nuyens, Sarah / Spruyt, Maarten / Brilhante, Joana / Coens, Corneel / Gorlia, Thierry / Golfinopoulos, Vassilis

Neuro-oncology

2019 Volume 22, Issue 5, Page(s) 684–693

Abstract: Background: Depatuxizumab mafodotin (Depatux-M) is a tumor-specific antibody-drug conjugate ... the toxin monomethylauristatin-F. We investigated Depatux-M in combination with temozolomide or ... irradiation with temozolomide. Patients were randomized to either Depatux-M 1.25 mg/kg every 2 weeks ...

Abstract	Background: Depatuxizumab mafodotin (Depatux-M) is a tumor-specific antibody-drug conjugate consisting of an antibody (ABT-806) directed against activated epidermal growth factor receptor (EGFR) and the toxin monomethylauristatin-F. We investigated Depatux-M in combination with temozolomide or as a single agent in a randomized controlled phase II trial in recurrent EGFR amplified glioblastoma. Methods: Eligible were patients with centrally confirmed EGFR amplified glioblastoma at first recurrence after chemo-irradiation with temozolomide. Patients were randomized to either Depatux-M 1.25 mg/kg every 2 weeks intravenously, or this treatment combined with temozolomide 150-200 mg/m2 day 1-5 every 4 weeks, or either lomustine or temozolomide. The primary endpoint of the study was overall survival. Results: Two hundred sixty patients were randomized. In the primary efficacy analysis with 199 events (median follow-up 15.0 mo), the hazard ratio (HR) for the combination arm compared with the control arm was 0.71 (95% CI = 0.50, 1.02; P = 0.062). The efficacy of Depatux-M monotherapy was comparable to that of the control arm (HR = 1.04, 95% CI = 0.73, 1.48; P = 0.83). The most frequent toxicity in Depatux-M treated patients was a reversible corneal epitheliopathy, occurring as grades 3-4 adverse events in 25-30% of patients. In the long-term follow-up analysis with median follow-up of 28.7 months, the HR for the comparison of the combination arm versus the control arm was 0.66 (95% CI = 0.48, 0.93). Conclusion: This trial suggests a possible role for the use of Depatux-M in combination with temozolomide in EGFR amplified recurrent glioblastoma, especially in patients relapsing well after the end of first-line adjuvant temozolomide treatment. (NCT02343406).
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/drug therapy ; ErbB Receptors/genetics ; Glioblastoma/drug therapy ; Humans ; Lomustine/therapeutic use ; Temozolomide/therapeutic use
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Alkylating ; Lomustine (7BRF0Z81KG) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; depatuxizumab mafodotin (F3R7A4P04N) ; Temozolomide (YF1K15M17Y)
Keywords	covid19
Language	English
Publishing date	2019-11-20
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noz222
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Article: INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma

Nuyens, Sarah / Spruyt, Maarten / Brilhante, Joana / Coens, Corneel / Gorlia, Thierry / Golfinopoulos, Vassilis

Neuro oncol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32609812
Database	COVID19

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Article ; Online: EGFR mutations are associated with response to depatux-m in combination with temozolomide and result in a receptor that is hypersensitive to ligand.

Neuro-oncology advances

2019 Volume 2, Issue 1, Page(s) vdz051

Abstract: ... glioblastomas showed a trend towards improved overall survival when patients were treated with depatux-m plus ... improved outcome in the depatux-m + TMZ combination arm. Such SNVs are common to the extracellular domain ... the therapeutic efficacy of depatux-m as increased ligand-induced activation will result in increased exposure ...

Abstract	Background: The randomized phase II INTELLANCE-2/EORTC_1410 trial on EGFR-amplified recurrent glioblastomas showed a trend towards improved overall survival when patients were treated with depatux-m plus temozolomide compared with the control arm of alkylating chemotherapy only. We here performed translational research on material derived from this clinical trial to identify patients that benefit from this treatment. Methods: Targeted DNA-sequencing and whole transcriptome analysis was performed on clinical trial samples. High-throughput, high-content imaging analysis was done to understand the molecular mechanism underlying the survival benefit. Results: We first define the tumor genomic landscape in this well-annotated patient population. We find that tumors harboring EGFR single-nucleotide variations (SNVs) have improved outcome in the depatux-m + TMZ combination arm. Such SNVs are common to the extracellular domain of the receptor and functionally result in a receptor that is hypersensitive to low-affinity EGFR ligands. These hypersensitizing SNVs and the ligand-independent EGFRvIII variant are inversely correlated, indicating two distinct modes of evolution to increase EGFR signaling in glioblastomas. Ligand hypersensitivity can explain the therapeutic efficacy of depatux-m as increased ligand-induced activation will result in increased exposure of the epitope to the antibody-drug conjugate. We also identified tumors harboring mutations sensitive to "classical" EGFR tyrosine-kinase inhibitors, providing a potential alternative treatment strategy. Conclusions: These data can help guide treatment for recurrent glioblastoma patients and increase our understanding into the molecular mechanisms underlying EGFR signaling in these tumors.
Language	English
Publishing date	2019-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdz051
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Article ; Online: Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo.

Laperchia, Claudia / Allegra Mascaro, Anna L / Sacconi, Leonardo / Andrioli, Anna / Mattè, Alessandro / De Franceschi, Lucia / Grassi-Zucconi, Gigliola / Bentivoglio, Marina / Buffelli, Mario / Pavone, Francesco S

PloS one

2013 Volume 8, Issue 2, Page(s) e56144

Abstract: ... for in vivo brain studies with two-photon fluorescence (TPF) microscopy. Mice of the thy1GFP-M line have been ... in lymph nodes and blood of thy1GFP-M mice, supporting their identity as DCs. Thus, TPF microscopy has here ... indicate that the thy1GFP-M mouse line provides a novel animal model for the study of subsets ...

Abstract	Transgenic mice expressing fluorescent proteins in specific cell populations are widely used for in vivo brain studies with two-photon fluorescence (TPF) microscopy. Mice of the thy1GFP-M line have been engineered for selective expression of green fluorescent protein (GFP) in neuronal populations. Here, we report that TPF microscopy reveals, at the brain surface of these mice, also motile non-neuronal GFP+ cells. We have analyzed the behavior of these cells in vivo and characterized in brain sections their immunophenotype.With TPF imaging, motile GFP+ cells were found in the meninges, subarachnoid space and upper cortical layers. The striking feature of these cells was their ability to move across the brain parenchyma, exhibiting evident shape changes during their scanning-like motion. In brain sections, GFP+ cells were immunonegative to antigens recognizing motile cells such as migratory neuroblasts, neuronal and glial precursors, mast cells, and fibroblasts. GFP+ non-neuronal cells exhibited instead the characteristic features and immunophenotype (CD11c and major histocompatibility complex molecule class II immunopositivity) of dendritic cells (DCs), and were immunonegative to the microglial marker Iba-1. GFP+ cells were also identified in lymph nodes and blood of thy1GFP-M mice, supporting their identity as DCs. Thus, TPF microscopy has here allowed the visualization for the first time of the motile behavior of brain DCs in situ. The results indicate that the thy1GFP-M mouse line provides a novel animal model for the study of subsets of these professional antigen-presenting cells in the brain. Information on brain DCs is still very limited and imaging in thy1GFP-M mice has a great potential for analyses of DC-neuron interaction in normal and pathological conditions.
MeSH term(s)	Animals ; Brain/cytology ; Cell Movement ; Choroid Plexus/cytology ; DNA-Binding Proteins ; Dendritic Cells/cytology ; Dendritic Cells/metabolism ; Green Fluorescent Proteins/genetics ; Lymph Nodes/cytology ; Meninges/cytology ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence, Multiphoton ; Models, Animal ; Nerve Tissue Proteins/metabolism ; Nuclear Proteins/metabolism ; Regulatory Sequences, Nucleic Acid
Chemical Substances	DNA-Binding Proteins ; Nerve Tissue Proteins ; NeuN protein, mouse ; Nuclear Proteins ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2013-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0056144
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Article ; Online: Validation of a Modified-Multidimensional Prognostic Index (m-MPI) including the Mini Nutritional Assessment Short-Form (MNA-SF) for the prediction of one-year mortality in hospitalized elderly patients.

Sancarlo, D / D'Onofrio, G / Franceschi, M / Scarcelli, C / Niro, V / Addante, F / Copetti, M / Ferrucci, L / Fontana, L / Pilotto, A

The journal of nutrition, health & aging

2011 Volume 15, Issue 3, Page(s) 169–173

Abstract: ... the mortality of the MPI with a modified version of the MPI (m-MPI) that included the Mini ... MPI1=2.8% versus m-MPI1=2.8%,p=0.946; MPI2=8.9% versus m-MPI2=9%,p=0.904; MPI3=21.9% versus m-MPI3=21.9 ... p=0.978) and 1-year of follow-up (MPI1=10.8% versus m-MPI1=10.5%,p=0.686; MPI2=27.3% versus m-MPI2 ...

Abstract	Background: The mortality prediction represents a key factor in the managing of elderly hospitalized patients. Since in older subjects mortality results from a combination of biological, functional, nutritional, psychological and environmental factors, a Multidimensional Prognostic Index (MPI) that predict short- and long-term mortality based on a standardized comprehensive geriatric assessment (CGA) has recently been developed and validated. Objective: This study compares the accuracy in predicting the mortality of the MPI with a modified version of the MPI (m-MPI) that included the Mini Nutritional Assessment-Short Form (MNA-SF) instead of the standard MNA. Design: This prospective study with a one-year follow-up included 4088 hospitalized patients aged 65 years and older. A standardized CGA that included information on functional (Activities of Daily Living, ADL and Instrumental-ADL), cognitive (Short Portable Mental Status Questionnaire), risk of pressure sore (Exton-Smith Scale), comorbidities (CIRS Index), medications, living status and nutritional status (MNA and MNA-SF) was used to calculate the MPI using a previously validated algorithm. Results: Higher MPI values were significantly associated with higher mortality rates with a close agreement between the estimated and the observed mortality both after 1-month (MPI1=2.8% versus m-MPI1=2.8%,p=0.946; MPI2=8.9% versus m-MPI2=9%,p=0.904; MPI3=21.9% versus m-MPI3=21.9,p=0.978) and 1-year of follow-up (MPI1=10.8% versus m-MPI1=10.5%,p=0.686; MPI2=27.3% versus m-MPI2=28%, p=0.495; MPI3=52.8% versus m-MPI3=52.7%,p=0.945). The estimated areas under the receiver operating characteristics (ROC) curves suggested a clinically negligible difference between the two indices. Conclusion: The m-MPI is as sensitive as the MPI in stratifying hospitalized elderly patients into groups at varying risk of short- and long-term mortality, but with fewer items.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Female ; Geriatric Assessment ; Health Status Indicators ; Hospital Mortality ; Humans ; Male ; Mental Health ; Nutrition Assessment ; Prognosis ; Prospective Studies ; ROC Curve ; Surveys and Questionnaires/standards
Language	English
Publishing date	2011-02-22
Publishing country	France
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-010-0293-5
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Article ; Online: Two-photon microscopy imaging of thy1GFP-M transgenic mice

Claudia Laperchia / Anna L Allegra Mascaro / Leonardo Sacconi / Anna Andrioli / Alessandro Mattè / Lucia De Franceschi / Gigliola Grassi-Zucconi / Marina Bentivoglio / Mario Buffelli / Francesco S Pavone

PLoS ONE, Vol 8, Iss 2, p e

a novel animal model to investigate brain dendritic cell subsets in vivo.

2013 Volume 56144

Abstract	Transgenic mice expressing fluorescent proteins in specific cell populations are widely used for in vivo brain studies with two-photon fluorescence (TPF) microscopy. Mice of the thy1GFP-M line have been engineered for selective expression of green fluorescent protein (GFP) in neuronal populations. Here, we report that TPF microscopy reveals, at the brain surface of these mice, also motile non-neuronal GFP+ cells. We have analyzed the behavior of these cells in vivo and characterized in brain sections their immunophenotype.With TPF imaging, motile GFP+ cells were found in the meninges, subarachnoid space and upper cortical layers. The striking feature of these cells was their ability to move across the brain parenchyma, exhibiting evident shape changes during their scanning-like motion. In brain sections, GFP+ cells were immunonegative to antigens recognizing motile cells such as migratory neuroblasts, neuronal and glial precursors, mast cells, and fibroblasts. GFP+ non-neuronal cells exhibited instead the characteristic features and immunophenotype (CD11c and major histocompatibility complex molecule class II immunopositivity) of dendritic cells (DCs), and were immunonegative to the microglial marker Iba-1. GFP+ cells were also identified in lymph nodes and blood of thy1GFP-M mice, supporting their identity as DCs. Thus, TPF microscopy has here allowed the visualization for the first time of the motile behavior of brain DCs in situ. The results indicate that the thy1GFP-M mouse line provides a novel animal model for the study of subsets of these professional antigen-presenting cells in the brain. Information on brain DCs is still very limited and imaging in thy1GFP-M mice has a great potential for analyses of DC-neuron interaction in normal and pathological conditions.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vorasidenib in IDH mutant WHO grade 2 gliomas: time to stop sitting on the fence?

Dipasquale, Angelo / Franceschi, Enrico / Lombardi, Giuseppe / Simonelli, Matteo

Neuro-oncology advances

2024 Volume 6, Issue 1, Page(s) vdae003

Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Editorial
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdae003
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