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  1. Article ; Online: Late-onset cutaneous manifestations in a patient with severe COVID-19 infection.

    Mizutani, Yuki / Nagai, Miki / Tsuzuku, Akifumi

    The Journal of dermatology

    2020  Volume 47, Issue 10, Page(s) e347–e348

    MeSH term(s) Aged ; COVID-19/complications ; Erythema/virology ; Humans ; Male ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15520
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  2. Article ; Online: Relative bradycardia in patients with moderate-to-severe COVID-19: a retrospective cohort study.

    Yoshizane, Takashi / Ishihara, Atsushi / Mori, Teruki / Tsuzuku, Akifumi / Suzuki, Jun / Noda, Toshiyuki

    SN comprehensive clinical medicine

    2022  Volume 4, Issue 1, Page(s) 65

    Abstract: Coronavirus-related disease (COVID-19) can result in relative bradycardia; however, there are no reports on relative bradycardia in patients with moderate-to-severe COVID-19 who require oxygen. We retrospectively investigated 45 patients with moderate-to- ...

    Abstract Coronavirus-related disease (COVID-19) can result in relative bradycardia; however, there are no reports on relative bradycardia in patients with moderate-to-severe COVID-19 who require oxygen. We retrospectively investigated 45 patients with moderate-to-severe COVID-19 and examined the relationship between heart rate and body temperature at the time of initiating oxygen or mechanical ventilation. For three consecutive days after initiating oxygen therapy, body temperature (day's highest temperature), heart rate, and other vital signs were measured simultaneously. We checked for relative bradycardia and analyzed the differences between patients with moderate COVID-19 (oxygen requirement ≤ 5 L/min) and those with severe COVID-19 (oxygen requirement ≥ 5 L/min). Of the 45 patients, 28 and 17 had moderate and severe COVID-19, respectively. The heart rate increased with increasing body temperature, and almost all patients satisfied the criteria of relative bradycardia. In Spearman's rank correlation analysis, body temperature was significantly correlated with heart rate (
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-022-01146-9
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  3. Article: Successful removal of a broncholith using a cryo-probe under rigid bronchoscopy: A case report.

    Ando, Moe / Saka, Hideo / Matsuo, Yasuhiro / Lee, Shin / Morishita, Tetsuji / Fujita, Kei / Tsuzuku, Akifumi

    Respirology case reports

    2022  Volume 10, Issue 9, Page(s) e01024

    Abstract: Broncholithiasis is a rare condition in which lymph nodes, cartilage or inhaled material in the bronchi become calcified. Removal of the broncholith is indicated when it causes symptoms such as hemoptysis and obstructive pneumonia. Although there are ... ...

    Abstract Broncholithiasis is a rare condition in which lymph nodes, cartilage or inhaled material in the bronchi become calcified. Removal of the broncholith is indicated when it causes symptoms such as hemoptysis and obstructive pneumonia. Although there are various methods for removing broncholiths, no international recommendations exist. We report a case of safe removal of broncholiths using a cryo-probe under rigid bronchoscopy. A 72-year-old man presented with blood-tinged sputum for 5 months. Chest computed tomography (CT) revealed collapse of the middle lung lobe. Flexible bronchoscopy demonstrated broncholiths at the orifice of the middle lobe. We successfully removed the broncholiths with a cryo-probe under rigid bronchoscopy without any complications. Our experience suggests that removal of broncholiths can be safely and successfully performed using a cryo-probe under rigid bronchoscopy.
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1024
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  4. Article: Evaluating the one-time chair stand test for predicting the coronavirus disease severity in patients during hospital admission: a cohort study in Japan.

    Ishihara, Atsushi / Yoshizane, Takashi / Mori, Teruki / Sasaki, Yui / Hosokawa, Takahiro / Suzuki, Jun / Tsuzuku, Akifumi / Asano, Fumihiro / Noda, Toshiyuki

    International journal of emergency medicine

    2023  Volume 16, Issue 1, Page(s) 23

    Abstract: Background: This study aimed to understand whether the one-time chair stand test (CS-1) is useful for predicting the severity of coronavirus disease (COVID-19) in 101 patients admitted to the hospital with acute respiratory failure.: Methods: This ... ...

    Abstract Background: This study aimed to understand whether the one-time chair stand test (CS-1) is useful for predicting the severity of coronavirus disease (COVID-19) in 101 patients admitted to the hospital with acute respiratory failure.
    Methods: This single-centered, prospective observational cohort study enrolled 101 critically ill adult patients hospitalized with COVID-19 who underwent the CS-1 as a dynamic evaluation tool in clinical practice between late April 2020 and October 2021. Data on demographic characteristics, symptoms, laboratory values, computed tomography findings, and clinical course after admission were collected. Furthermore, the data was compared, and the association between the intubation and non-intubation groups was determined. We also calculated the cutoff point, area under the curve (AUC), and 95% confidence interval (CI) of the change in oxygen saturation (ΔSpO
    Results: Thirty-three out of 101 patients (33%) were intubated during hospitalization. There was no significant difference in the resting SpO
    Conclusion: For COVID-19 patients with acute respiratory failure, the CS-1 performed on admission was useful for predicting the severity of COVID-19. Furthermore, the CS-1 can be utilized as a remote and simple evaluation parameter. Thus, it could have potential clinical applications in the future.
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411462-5
    ISSN 1865-1380 ; 1865-1372
    ISSN (online) 1865-1380
    ISSN 1865-1372
    DOI 10.1186/s12245-023-00497-x
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  6. Article ; Online: Late‐onset cutaneous manifestations in a patient with severe COVID‐19 infection

    Mizutani, Yuki / Nagai, Miki / Tsuzuku, Akifumi

    The Journal of Dermatology

    2020  Volume 47, Issue 10

    Keywords Dermatology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15520
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation.

    Tsuzuku, Akifumi / Asano, Fumihiro / Katayama, Masaki / Mori, Kosuke / Sasaki, Yui / Kuzunishi, Yutaro / Taguchi, Mayuka / Muto, Yuya / Baba, Yasutomo / Tsuchida, Akimasa / Kato, Tomoya / Murakami, Anri / Masuda, Atsunori / Yoshizane, Takashi / Suzuki, Jun

    Internal medicine (Tokyo, Japan)

    2023  Volume 62, Issue 23, Page(s) 3519–3523

    Abstract: The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an ... ...

    Abstract The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
    MeSH term(s) Humans ; COVID-19/complications ; Autopsy ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/pathology
    Language English
    Publishing date 2023-09-29
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2006-23
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  8. Article ; Online: Use of an Ultrathin vs Thin Bronchoscope for Peripheral Pulmonary Lesions: A Randomized Trial.

    Oki, Masahide / Saka, Hideo / Asano, Fumihiro / Kitagawa, Chiyoe / Kogure, Yoshihito / Tsuzuku, Akifumi / Ando, Masahiko

    Chest

    2019  Volume 156, Issue 5, Page(s) 954–964

    Abstract: Background: When evaluating peripheral pulmonary lesions, a 3.0-mm ultrathin bronchoscope (UTB) with a 1.7-mm working channel is advantageous regarding good access to the peripheral airway, whereas a 4.0-mm thin bronchoscope provides a larger 2.0-mm ... ...

    Abstract Background: When evaluating peripheral pulmonary lesions, a 3.0-mm ultrathin bronchoscope (UTB) with a 1.7-mm working channel is advantageous regarding good access to the peripheral airway, whereas a 4.0-mm thin bronchoscope provides a larger 2.0-mm working channel, which allows the use of various instruments including a guide sheath (GS), larger forceps, and an aspiration needle. This study compared multimodal bronchoscopy using a UTB and a thin bronchoscope with multiple sampling methods for the diagnosis of peripheral pulmonary lesions.
    Methods: Patients with peripheral pulmonary lesions ≤ 30 mm in diameter were recruited and randomized to undergo endobronchial ultrasonography, virtual bronchoscopy, and fluoroscopy-guided bronchoscopy using a 3.0-mm UTB (UTB group) or a 4.0-mm thin bronchoscope (thin bronchoscope group). In the thin bronchoscope group, the use of small forceps with a GS or standard forceps without the GS was permitted. In addition, needle aspiration was performed for lesions into which an ultrasound probe could not be inserted.
    Results: A total of 360 patients were enrolled, and 356 were included in the analyses (median largest lesional diameter, 19 mm). The overall diagnostic yield was significantly higher in the UTB group than in the thin bronchoscope group (70.1% vs 58.7%, respectively; P = .027). The procedure duration was significantly shorter in the UTB group (median, 24.8 vs 26.8 min, respectively; P = .008). The complication rates were 2.8% and 4.5%, respectively (P = .574).
    Conclusions: Multimodal bronchoscopy using a UTB afforded a higher diagnostic yield than that using a thin bronchoscope in the diagnosis of small peripheral pulmonary lesions.
    Trial registry: UMIN Clinical Trials Registry; No.: UMIN000010133; URL: https://www.umin.ac.jp/ctr/.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bronchoscopes ; Bronchoscopy/methods ; Endosonography ; Equipment Design ; Female ; Humans ; Image-Guided Biopsy/methods ; Lung/diagnostic imaging ; Lung Neoplasms/diagnosis ; Male ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Solitary Pulmonary Nodule/diagnosis
    Language English
    Publishing date 2019-07-26
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.06.038
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  9. Article ; Online: Pleomorphic Carcinoma with Exophthalmos and a Subsequent Diagnosis of Paraneoplastic Syndrome.

    Kuzunishi, Yutaro / Tsuzuku, Akifumi / Asano, Fumihiro / Sasaki, Yui / Matsuno, Rina / Taguchi, Mayuka / Muto, Yuya / Tsuchida, Masaaki / Baba, Yasutomo / Kato, Tomoya / Murakami, Anri / Masuda, Atsunori / Daido, Hisashi / Matsumoto, Shinsuke

    Internal medicine (Tokyo, Japan)

    2020  Volume 60, Issue 4, Page(s) 605–609

    Abstract: The patient was a 75-year-old man who developed polyopia and exophthalmos. Chest computed tomography (CT) revealed a mass in the left upper lobe. A CT-guided biopsy suggested lung adenocarcinoma. He was treated by neoadjuvant chemotherapy followed by ... ...

    Abstract The patient was a 75-year-old man who developed polyopia and exophthalmos. Chest computed tomography (CT) revealed a mass in the left upper lobe. A CT-guided biopsy suggested lung adenocarcinoma. He was treated by neoadjuvant chemotherapy followed by left upper lobectomy. He was diagnosed with stage IIB pleomorphic carcinoma postoperatively. Preoperative head magnetic resonance imaging revealed exophthalmos and bilateral swelling of the extraocular muscles. The thyroid function of the patient was within the normal range, and he tested negative for autoantibodies. As his symptoms and swelling of the extraocular muscles improved postoperatively, he was diagnosed with paraneoplastic syndrome.
    MeSH term(s) Aged ; Carcinoma ; Diplopia ; Exophthalmos/diagnosis ; Exophthalmos/etiology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Male ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-30
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.5286-20
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  10. Article ; Online: A Patient with Lung Adenocarcinoma Accompanied by Whole Right Lung Torsion Induced by the Accumulation of a Large Amount of Pleural Effusion.

    Taguchi, Mayuka / Tsuzuku, Akifumi / Matsumoto, Shinsuke / Sasaki, Yui / Matsuno, Rina / Kuzunishi, Yutaro / Muto, Yuya / Tsuchida, Masaaki / Baba, Yasutomo / Kato, Tomoya / Murakami, Anri / Masuda, Atsunori / Asano, Fumihiro

    Internal medicine (Tokyo, Japan)

    2020  Volume 60, Issue 4, Page(s) 595–599

    Abstract: A 68-year-old man visited a physician with a chief complaint of difficulty breathing. Right pleural effusion was noted, and he was referred to our department for a close examination and treatment. Thoracoscopy was performed under local anesthesia, and ... ...

    Abstract A 68-year-old man visited a physician with a chief complaint of difficulty breathing. Right pleural effusion was noted, and he was referred to our department for a close examination and treatment. Thoracoscopy was performed under local anesthesia, and pleural dissemination of lung adenocarcinoma was noted, so a chest drain was placed. Since poor right lung inflation persisted and whole right lung torsion was observed on computed tomography, thoracoscopy-assisted thoracotomic reduction of lung torsion was performed. In this patient, the right middle lobe and anterior chest wall were adhered, suggesting that whole right lung torsion occurred when atelectasis was formed due to pleural effusion.
    MeSH term(s) Adenocarcinoma of Lung/complications ; Adenocarcinoma of Lung/diagnostic imaging ; Aged ; Humans ; Lung ; Lung Neoplasms/complications ; Lung Neoplasms/diagnostic imaging ; Male ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Torsion Abnormality/complications ; Torsion Abnormality/diagnostic imaging ; Torsion Abnormality/surgery
    Language English
    Publishing date 2020-09-30
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.5277-20
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