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  1. Article ; Online: New facet of CARs: HBV-specific CARs as inhibitors of virus morphogenesis and release.

    Hildt, Eberhard / Hu, Jianming

    Gut

    2024  Volume 73, Issue 4, Page(s) 566–567

    MeSH term(s) Humans ; Hepatitis B virus ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Morphogenesis
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331462
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Correction to: Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-β1 signaling : Effect of punicalagin on mechanical trauma induced SUI.

    Tang, Jianming / Liu, Cheng / Min, Jie / Hu, Ming / Li, Yang / Hong, Li

    International urogynecology journal

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-024-05790-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3070: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Accuracy and reliability of mandibular digital model superimposition based on the morphological characteristics of vessels in extraction adult patients.

    Hu, Yaozheng / Zheng, Mengyu / Chen, Jin / Guo, Chenlin / Chen, Jianming

    BMC oral health

    2024  Volume 24, Issue 1, Page(s) 125

    Abstract: Background: This study aimed to validate the availability of superimposing full-color mandibular digital models (DMs) by the morphological characteristics of vessels in extraction adult patients.: Methods: Twenty-eight adult patients were included, ... ...

    Abstract Background: This study aimed to validate the availability of superimposing full-color mandibular digital models (DMs) by the morphological characteristics of vessels in extraction adult patients.
    Methods: Twenty-eight adult patients were included, and their DMs were superimposed with pre- and posttreatment cone beam computed tomography (CBCT) and the morphological characteristics of lingual vessels. The measurements of each tooth were compared under the same coordinate system.
    Results: The ICC results displayed exceptional agreement in intra- and interrater assessments, with scores exceeding 0.891 in the crown for intrarater agreement and scores surpassing 0.888 in the crown for interrater agreement. Furthermore, no statistically significant differences were found in the 2 superimposition methods (P > 0.05).
    Conclusion: The morphological characteristics of vessels under the mucogingival junction in the lingual side of mandible of are stable enough for the superimposition of mandibular DMs in the adult patients undergo orthodontic treatment with premolars extraction.
    MeSH term(s) Adult ; Humans ; Reproducibility of Results ; Cone-Beam Computed Tomography ; Dental Care ; Mandible/diagnostic imaging ; Patients
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03836-9
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  4. Article ; Online: Copper ion affects oxidant decay and combined aspartic acid transformation during chlorination in water pipes: Differentiated action on the yield of trihalomethanes and haloacetonitriles.

    Hu, Jun / Chen, Qiaonv / Liu, Fei / Qiang, Zhimin / Yu, Jianming

    Water research

    2024  Volume 251, Page(s) 121153

    Abstract: The chlorination of extracellular polymeric substances (EPS) secreted by biofilm often induces the formation of high-toxic disinfection byproducts (DBPs) in drinking water distribution systems. The protein components in EPS are the main precursors of ... ...

    Abstract The chlorination of extracellular polymeric substances (EPS) secreted by biofilm often induces the formation of high-toxic disinfection byproducts (DBPs) in drinking water distribution systems. The protein components in EPS are the main precursors of DBPs, which mostly exist in the form of combined amino acids. The paper aimed to study the action of a pipe corrosion product (Cu
    MeSH term(s) Disinfectants/chemistry ; Copper ; Aspartic Acid ; Halogenation ; Trihalomethanes ; Oxidants ; Water Pipe Smoking ; Water Purification ; Water Pollutants, Chemical/analysis ; Disinfection ; Chlorine/chemistry
    Chemical Substances Disinfectants ; Copper (789U1901C5) ; Aspartic Acid (30KYC7MIAI) ; Trihalomethanes ; Oxidants ; Water Pollutants, Chemical ; Chlorine (4R7X1O2820)
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 78/260: Show issues
    Z 3381: Show issues

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  5. Article ; Online: Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results.

    Hong, Xupeng / Hu, Jianming

    Journal of hepatology

    2021  Volume 75, Issue 4, Page(s) 997–998

    MeSH term(s) Hepatitis B Core Antigens ; Hepatitis B e Antigens
    Chemical Substances Hepatitis B Core Antigens ; Hepatitis B e Antigens
    Language English
    Publishing date 2021-05-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.04.041
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Simvastatin alleviates epithelial-mesenchymal transition and oxidative stress of high glucose-induced lens epithelial cells

    Fu, Jianming / Hu, Xiaojie

    Experimental and therapeutic medicine

    2022  Volume 23, Issue 6, Page(s) 420

    Abstract: Diabetic cataracts (DC) is one of the main causes of blindness among patients with diabetes mellitus. The aim of the present study was to examine the effect of simvastatin on lens epithelial cells in DC and the underlying mechanism. The viability of ... ...

    Abstract Diabetic cataracts (DC) is one of the main causes of blindness among patients with diabetes mellitus. The aim of the present study was to examine the effect of simvastatin on lens epithelial cells in DC and the underlying mechanism. The viability of SRA01/04 cells treated with different concentrations of simvastatin was detected using a Cell Counting Kit-8 assay before and after high glucose (HG) treatment. The expression levels of E-cadherin, N-cadherin, Vimentin and α-smooth muscle actin (α-SMA), proteins associated with epithelial-mesenchymal transition (EMT), in addition to RhoA, Rho-associated kinases (ROCK)1 and ROCK2, proteins related to RhoA/ROCK signaling, were also measured in SRA01/04 cells treated with HG and simvastatin, with or without U46619, using western blot analysis. DCFH-DA dyes, superoxide dismutase (SOD) and glutathione (GSH)/glutathione disulfide (GSSG) kits were used to measure the levels of oxidative stress parameters in SRA01/04 cells treated with HG and simvastatin with or without U46619. The cell viability of SRA01/04 cells treated with simvastatin was found to be significantly elevated after HG treatment. The protein expression levels of E-cadherin were increased but those of N-cadherin, Vimentin and α-SMA decreased after HG and simvastatin treatment, and this was reversed by U46619. The levels of SOD and GSH-GSSG were found to be increased whereas reactive oxygen species levels were decreased, effects that were reversed by U46619. Additionally, the protein expression levels of RhoA, ROCK1 and ROCK2 were markedly decreased. These findings provided evidence that simvastatin increased HG-induced SRA01/04 cell viability and exerted inhibitory effects on EMT and oxidative stress that occurs during DC.
    Language English
    Publishing date 2022-04-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11347
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  7. Article ; Online: Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation.

    Hong, Xupeng / Hu, Jianming

    Journal of virology

    2022  Volume 96, Issue 15, Page(s) e0071822

    Abstract: Hepatitis B virus (HBV) core protein (HBc), the building block of the viral capsid, plays a critical role throughout the HBV life cycle. There are two highly conserved lysine residues, namely, K7 and K96, on HBc, which have been proposed to function at ... ...

    Abstract Hepatitis B virus (HBV) core protein (HBc), the building block of the viral capsid, plays a critical role throughout the HBV life cycle. There are two highly conserved lysine residues, namely, K7 and K96, on HBc, which have been proposed to function at various stages of viral replication, potentially through lysine-specific posttranslational modifications (PTMs). Here, we substituted K7 and K96 with alanine or arginine, which would also block potential PTMs on these two lysine residues, and tested the effects of these substitutions on HBV replication and infection. We found that the two lysine residues were dispensable for all intracellular steps of HBV replication. In particular, all mutants were competent to form the covalently closed circular DNA (cccDNA) via the intracellular amplification pathway, indicating that K7 and K96, or any PTMs of these residues, were not essential for nucleocapsid uncoating, a prerequisite for cccDNA formation. Furthermore, we found that K7A and K7R mutations did not affect
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Conserved Sequence/genetics ; DNA, Circular/biosynthesis ; DNA, Circular/genetics ; DNA, Circular/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Hepatitis B/virology ; Hepatitis B Core Antigens/chemistry ; Hepatitis B Core Antigens/genetics ; Hepatitis B Core Antigens/metabolism ; Hepatitis B virus/chemistry ; Hepatitis B virus/genetics ; Hepatitis B virus/growth & development ; Hepatitis B virus/metabolism ; Humans ; Lysine/genetics ; Lysine/metabolism ; Mutation ; Nucleocapsid/metabolism ; Polyadenylation/genetics ; RNA, Viral/biosynthesis ; RNA, Viral/genetics ; Viral Core Proteins/chemistry ; Viral Core Proteins/genetics ; Viral Core Proteins/metabolism ; Virion/growth & development ; Virus Replication/genetics
    Chemical Substances DNA, Circular ; DNA, Viral ; Hepatitis B Core Antigens ; RNA, Viral ; Viral Core Proteins ; p22 core protein, hepatitis B virus ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00718-22
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Organic dye-loaded reduced titanium dioxide as a broadband saturable absorber for ultrafast fiber lasers.

    Lu, Xiaochan / Li, Shuang / Yan, Miao / Chen, Jianming / Deng, Tingting / Nie, Guohui / Wang, Zhenhong / Liang, Hu / Zhang, Bin

    RSC advances

    2024  Volume 14, Issue 17, Page(s) 11728–11733

    Abstract: As a rising star among metal oxide nanomaterials, titanium dioxide ( ... ...

    Abstract As a rising star among metal oxide nanomaterials, titanium dioxide (TiO
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08925h
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  9. Article ; Online: Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke.

    Chen, Zhihua / Hu, Wei / Wang, Jiahong / Rao, Donggen / Zhu, Jianming

    Cellular and molecular biology (Noisy-le-Grand, France)

    2024  Volume 70, Issue 3, Page(s) 142–147

    Abstract: The diagnostic biomarkers associated with ischemic stroke (IS) that may have clinical utility remain elucidated. Thus, the potential functional lncRNAs in IS were explored. The Gene Expression Omnibus database provided the transcriptome profile of IS for ...

    Abstract The diagnostic biomarkers associated with ischemic stroke (IS) that may have clinical utility remain elucidated. Thus, the potential functional lncRNAs in IS were explored. The Gene Expression Omnibus database provided the transcriptome profile of IS for download. WGCNA analysis and integrated bioinformatics were used to find genes that were differentially expressed (DEGs). The Starbase database created the lncRNA-based ceRNA network. In order to investigate the molecular mechanism and involved pathways of DEGs in IS, functional enrichment analysis was carried out. Using qRT-PCR, lncRNAs identified as putative IS biomarkers were confirmed to be expressed in a permanent middle cerebral artery occlusion (MCAO) model. Using the annexin V/PI apoptosis test, the amount of apoptosis in oxygen-glucose deprivation (OGD) cells was measured. A total of 1600 common differentially expressed - protein-coding RNA (DE-pcRNAs) and 26 DE-lncRNAs were identified. The results of enrichment analysis indicate that the cytokine may be regulated by common DE-pcRNAs and are vital in the progress of IS. A lncRNAs-mediated ceRNA network including lncRNAs AU020206, Brip1os, F630028O10Rik and 9530082P21Rik was constructed. The expression of these lncRNAs was significantly increased in MCAO model. Knockdown of lncRNA AU020206 inhibited microglia apoptosis in OGD cell model. We constructed a lncRNAs-mediated ceRNA network and found that lncRNA AU020206 inhibited microglia apoptosis in OGD cell model. These findings provided further evidence for the diagnosis and a novel avenue for targeted therapy of IS.
    MeSH term(s) RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Apoptosis/genetics ; Apoptosis/drug effects ; Ischemic Stroke/genetics ; Ischemic Stroke/pathology ; Ischemic Stroke/metabolism ; Animals ; Microglia/metabolism ; Microglia/drug effects ; Microglia/pathology ; Gene Knockdown Techniques ; Male ; Gene Regulatory Networks ; Infarction, Middle Cerebral Artery/genetics ; Infarction, Middle Cerebral Artery/pathology ; Glucose/metabolism ; Glucose/deficiency ; Computational Biology/methods ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Transcriptome/genetics ; Disease Models, Animal
    Chemical Substances RNA, Long Noncoding ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-03-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2024.70.3.21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Azomycin Orchestrate Colistin-Resistant

    Hu, Panjie / Chen, Huanchang / Zhao, Deyi / Ma, Zhexiao / Zeng, Weiliang / Han, Yijia / Zhou, Tieli / Cao, Jianming / Shen, Mo

    ACS infectious diseases

    2024  Volume 10, Issue 2, Page(s) 662–675

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Mice ; Colistin/pharmacology ; Enterobacter cloacae ; Anti-Bacterial Agents/pharmacology ; Nitroimidazoles
    Chemical Substances Colistin (Z67X93HJG1) ; azomycin (K8E96XL55D) ; Anti-Bacterial Agents ; Nitroimidazoles
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00526
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