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Article ; Online: The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study.

Zhang, Lihan / Liu, Shuochuan / Yue, Guangxing / Niu, Hong / Hu, Mengjin / Zheng, Yuling / Tang, Jingwen

2024

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2023-0708
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Article ; Online: High-Level

Yue, Mingyu / Liu, Mengsu / Gao, Song / Ren, Xuefeng / Zhou, Shenghu / Rao, Yijian / Zhou, Jingwen

Journal of agricultural and food chemistry

2024 Volume 72, Issue 8, Page(s) 4292–4300

Abstract: ... ...

Abstract	(2
MeSH term(s)	Yarrowia/genetics ; Yarrowia/metabolism ; NADP/metabolism ; Metabolic Engineering ; Metabolic Networks and Pathways ; Flavanones
Chemical Substances	eriodictyol (Q520486B8Y) ; NADP (53-59-8) ; Flavanones
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08861
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Article ; Online: Metabolic Pathway Coupled with Fermentation Process Optimization for High-Level Production of Retinol in

Ren, Xuefeng / Liu, Mengsu / Yue, Mingyu / Zeng, Weizhu / Zhou, Shenghu / Zhou, Jingwen / Xu, Sha

Journal of agricultural and food chemistry

2024 Volume 72, Issue 15, Page(s) 8664–8673

Abstract: Retinol is a lipid-soluble form of vitamin A that is crucial for human visual and immune functions. The production of retinol through microbial fermentation has been the focus of recent exploration. However, the obtained titer remains limited and the ... ...

Abstract	Retinol is a lipid-soluble form of vitamin A that is crucial for human visual and immune functions. The production of retinol through microbial fermentation has been the focus of recent exploration. However, the obtained titer remains limited and the product is often a mixture of retinal, retinol, and retinoic acid, necessitating purification. To achieve efficient biosynthesis of retinol in
MeSH term(s)	Humans ; Vitamin A/metabolism ; Fermentation ; Yarrowia/genetics ; Yarrowia/metabolism ; Bioreactors ; beta Carotene/metabolism ; Metabolic Networks and Pathways ; Metabolic Engineering
Chemical Substances	Vitamin A (11103-57-4) ; beta Carotene (01YAE03M7J)
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c00377
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Article ; Online: Kallikrein-Related Peptidase 4 Promotes Proliferation, Migration, Invasion, and Pro-Angiogenesis of Endometrial Stromal Cells via Regulation of Brain-Derived Neurotrophic Factor Production in Endometriosis.

Shi, Jingwen / Qi, Yue / Sun, Yuanchen / Huang, Ying

The American journal of pathology

2023 Volume 194, Issue 1, Page(s) 121–134

Abstract: Endometriosis is a common benign gynecologic condition. Endometriosis lesions are associated with endometrial cell proliferation, migration, invasion, and neovascularization, while the specific molecular mechanisms are still elusive. Transcriptome ... ...

Abstract	Endometriosis is a common benign gynecologic condition. Endometriosis lesions are associated with endometrial cell proliferation, migration, invasion, and neovascularization, while the specific molecular mechanisms are still elusive. Transcriptome sequencing has been used for the identification of diagnostic markers in endometriosis. Here, transcriptome profiling revealed that kallikrein-related peptidase 4 (KLK4) expression was up-regulated in ectopic endometrium (EC) tissues of patients with endometriosis. KLK4 mediates the degradation of extracellular matrix proteins, and its proteolytic activity activates many tumorigenic and metastatic pathways via tumor invasion and migration. Nevertheless, whether KLK4 serves as an important regulatory factor in endometriosis remains unclear. This study confirmed that KLK4 was highly expressed in ectopic endometrial stromal cells (EC-ESCs). KLK4 overexpression promoted proliferation and suppressed apoptosis of EC-ESCs, induced cell migration and invasion, and enhanced angiogenesis in vivo. Mechanistically, KLK4 overexpression mediated the protein cleavage of pro-brain-derived neurotrophic factor in EC-ESCs. Finally, brain-derived neurotrophic factor was a vital downstream substrate of KLK4 maintained the proliferation, metastasis, and pro-angiogenesis abilities and inhibited apoptosis of ESCs through a rescue study. Together, these findings demonstrate the promotive role of KLK4 in endometriosis development. In addition, the study provides a new insight that KLK4 might be a potential therapeutic target and prognostic marker for patients with endometriosis.
MeSH term(s)	Female ; Humans ; Angiogenesis ; Brain-Derived Neurotrophic Factor ; Cell Movement ; Cell Proliferation ; Endometriosis/pathology ; Endometrium/pathology ; Kallikreins/genetics ; Kallikreins/metabolism ; Stromal Cells/metabolism
Chemical Substances	Brain-Derived Neurotrophic Factor ; Kallikreins (EC 3.4.21.-) ; kallikrein 4 (EC 3.4.21.-)
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2023.10.006
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Article ; Online: Phosphoproteomics Revealed Differentially Expressed Sites and Function of the Bovine Milk Fat Globule Membrane in Colostrum and Mature Milk.

Bai, Xue / Shang, Jingwen / Wu, Chunshuang / Yu, Hong / Chen, Xinping / Yue, Xiqing / Yang, Mei

Journal of agricultural and food chemistry

2024 Volume 72, Issue 11, Page(s) 6040–6052

Abstract: One type of large and intricate post-translational modification of milk proteins that has significant biological implications is phosphorylation. The characterization of phosphoproteins found in the bovine milk fat globule membrane (MFGM) is still mostly ...

Abstract	One type of large and intricate post-translational modification of milk proteins that has significant biological implications is phosphorylation. The characterization of phosphoproteins found in the bovine milk fat globule membrane (MFGM) is still mostly unknown. Here, label-free phosphoproteomics was used to identify 94 phosphorylation sites from 54 MFGM phosphoproteins in bovine colostrum (BC) and 136 phosphorylation sites from 91 MFGM phosphoproteins in bovine mature milk (BM). αs1-Casein and β-casein were the most phosphorylated proteins in bovine colostrum. In bovine mature milk, perilipin-2 was the protein with the greatest number of phosphorylation sites. The results show that bovine colostrum MFGM phosphoproteins were mainly involved in immune function, whereas bovine mature MFGM phosphoproteins were mainly involved in metabolic function. Plasminogen and osteopontin were the most strongly interacting proteins in colostrum, whereas perilipin-2 was the most strongly interacting protein in bovine mature milk. This work demonstrates the unique alterations in the phosphorylation manner of the bovine MFGM protein during lactation and further expands our knowledge of the site characteristics of bovine MFGM phosphoproteins. This result confirms the value of MFGM as a reference ingredient for infant formula during different stages.
MeSH term(s)	Female ; Pregnancy ; Infant ; Humans ; Animals ; Colostrum/metabolism ; Perilipin-2/metabolism ; Milk/metabolism ; Glycolipids/metabolism ; Lipid Droplets/metabolism ; Milk Proteins/metabolism ; Caseins/metabolism ; Glycoproteins
Chemical Substances	milk fat globule ; Perilipin-2 ; Glycolipids ; Milk Proteins ; Caseins ; Glycoproteins
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08957
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Article ; Online: YaliCMulti and YaliHMulti: Stable, efficient multi-copy integration tools for engineering Yarrowia lipolytica.

Liu, Mengsu / Wu, Junjun / Yue, Mingyu / Ning, Yang / Guan, Xin / Gao, Song / Zhou, Jingwen

Metabolic engineering

2024 Volume 82, Page(s) 29–40

Abstract: Yarrowia lipolytica is widely used in biotechnology to produce recombinant proteins, food ingredients and diverse natural products. However, unstable expression of plasmids, difficult and time-consuming integration of single and low-copy-number plasmids ... ...

Abstract	Yarrowia lipolytica is widely used in biotechnology to produce recombinant proteins, food ingredients and diverse natural products. However, unstable expression of plasmids, difficult and time-consuming integration of single and low-copy-number plasmids hampers the construction of efficient production pathways and application to industrial production. Here, by exploiting sequence diversity in the long terminal repeats (LTRs) of retrotransposons and ribosomal DNA (rDNA) sequences, a set of vectors and methods that can recycle multiple and high-copy-number plasmids was developed that can achieve stable integration of long-pathway genes in Y. lipolytica. By combining these sequences, amino acids and antibiotic tags with the Cre-LoxP system, a series of multi-copy site integration recyclable vectors were constructed and assessed using the green fluorescent protein (HrGFP) reporter system. Furthermore, by combining the consensus sequence with the vector backbone of a rapidly degrading selective marker and a weak promoter, multiple integrated high-copy-number vectors were obtained and high levels of stable HrGFP expression were achieved. To validate the universality of the tools, simple integration of essential biosynthesis modules was explored, and 7.3 g/L of L-ergothioneine and 8.3 g/L of (2S)-naringenin were achieved in a 5 L fermenter, the highest titres reported to date for Y. lipolytica. These novel multi-copy genome integration strategies provide convenient and effective tools for further metabolic engineering of Y. lipolytica.
MeSH term(s)	Yarrowia/genetics ; Yarrowia/metabolism ; Plasmids/genetics ; Metabolic Engineering ; Biotechnology ; Recombinant Proteins/genetics
Chemical Substances	Recombinant Proteins
Language	English
Publishing date	2024-01-14
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2024.01.003
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Article ; Online: Establishment and validation of an immune infiltration predictive model for ovarian cancer

Zhenxia Song / Jingwen Zhang / Yue Sun / Zhongmin Jiang / Xiaoning Liu

BMC Medical Genomics, Vol 16, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background The most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked at how the TP53 mutation associates the immunophenotype of ovarian cancer and the prognosis of ... ...

Abstract	Abstract Background The most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked at how the TP53 mutation associates the immunophenotype of ovarian cancer and the prognosis of the disease. Methods We investigated the state of TP53 mutations and expression profiles in culturally diverse groups and datasets and developed an immune infiltration predictive model relying on immune-associated genes differently expressed between TP53 WT and TP53 MUT ovarian cancer cases. We aimed to construct an immune infiltration predictive model (IPM) to enhance the prognosis of ovarian cancer and investigate the impact of the IPM on the immunological microenvironment. Results TP53 mutagenesis affected the expression of seventy-seven immune response-associated genes. An IPM was implemented and evaluated on ovarian cancer patients to distinguish individuals with low- and high-IPM subgroups of poor survival. For diagnostic and therapeutic use, a nomogram is thus created. According to pathway enrichment analysis, the pathways of the human immune response and immune function abnormalities were the most associated functions and pathways with the IPM genes. Furthermore, patients in the high-risk group showed low proportions of macrophages M1, activated NK cells, CD8+ T cells, and higher CTLA-4, PD-1, PD-L1, and TIM-3 than patients in the low-risk group. Conclusions The IPM model may identify high-risk patients and integrate other clinical parameters to predict their overall survival, suggesting it is a potential methodology for optimizing ovarian cancer prognosis.
Keywords	TP53 mutation ; Ovarian cancer ; IPM ; Immune infiltration ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety analysis of immunotherapy in non-small cell lung cancer patients with MET alterations.

Wang, Yanhua / Wei, Jingwen / Xu, Manyi / Xiang, Jing / Shao, Keda / Hao, Yue / Song, Zhengbo

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2024

Abstract: Background: Mesenchymal epithelial transition factor (MET) is a rare oncologic driver gene, and information on immunotherapy for non-small cell lung cancer (NSCLC) patients with this driver gene is limited. Here we evaluate the efficacy and safety of ... ...

Abstract	Background: Mesenchymal epithelial transition factor (MET) is a rare oncologic driver gene, and information on immunotherapy for non-small cell lung cancer (NSCLC) patients with this driver gene is limited. Here we evaluate the efficacy and safety of immune checkpoint inhibitors (ICI) under different therapeutic regimen for NSCLC patients with MET alterations. Methods: From June 2019 to December 2023, we assessed the efficacy and toxicity of ICIs in 42 NSCLC patients with MET alterations. Survival curves were plotted using the Kaplan-Meier method and the Cox proportional hazards model applied for univariate and multivariate analyses. We assessed the size of target lesion according to RECIST v1.1, and objective response rate (ORR) was defined as the sum of complete response (CR) and partial response (PR), disease control rate (DCR) as the sum of CR, PR, and disease stable. Results: A total of 42 NSCLC patients with MET alterations were included in this retrospective study, 10 was MET 14 skipping mutation and 32 was MET amplification. The ORR for ICI treatment was 30.95% and the DCR was 71.43%. Median progression-free survival (mPFS) and median overall survival (OS) were 4.40 and 13.97 months, respectively. There exists statistical differences between the mPFS of ICI monotherapy and combine ICI therapy (2.8 vs 7.8 months, p = 0.022). The incidence of drug-related adverse reactions was 47.62%, mainly bone marrow suppression (14.28%), immune-related pneumonia (7.14%), and liver function impairment (7.14%), and six patients (14.28%) experiencing grade 3 or above adverse events. Conclusion: NSCLC patients with MET alterations can benefit from immunotherapy, especially the patients treated by combined ICI therapy. However, special attention should be paid to the occurrence of grade 3/4 adverse reactions while using the combined ICI therapy.
Language	English
Publishing date	2024-04-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-024-03455-y
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Article ; Online: Enhanced production of l-sorbose by systematic engineering of dehydrogenases in

Liu, Li / Chen, Yue / Yu, Shiqin / Chen, Jian / Zhou, Jingwen

Synthetic and systems biotechnology

2022 Volume 7, Issue 2, Page(s) 730–737

Abstract: l-Sorbose is an essential intermediate for the industrial production of vitamin C (l-ascorbic acid) ...

Abstract	l-Sorbose is an essential intermediate for the industrial production of vitamin C (l-ascorbic acid)
Language	English
Publishing date	2022-03-16
Publishing country	China
Document type	Journal Article
ISSN	2405-805X
ISSN (online)	2405-805X
DOI	10.1016/j.synbio.2022.02.008
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Article ; Online: Establishment and validation of an immune infiltration predictive model for ovarian cancer.

Song, Zhenxia / Zhang, Jingwen / Sun, Yue / Jiang, Zhongmin / Liu, Xiaoning

BMC medical genomics

2023 Volume 16, Issue 1, Page(s) 227

Abstract: Background: The most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked at how the TP53 mutation associates the immunophenotype of ovarian cancer and the prognosis of the ... ...

Abstract	Background: The most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked at how the TP53 mutation associates the immunophenotype of ovarian cancer and the prognosis of the disease. Methods: We investigated the state of TP53 mutations and expression profiles in culturally diverse groups and datasets and developed an immune infiltration predictive model relying on immune-associated genes differently expressed between TP53 WT and TP53 MUT ovarian cancer cases. We aimed to construct an immune infiltration predictive model (IPM) to enhance the prognosis of ovarian cancer and investigate the impact of the IPM on the immunological microenvironment. Results: TP53 mutagenesis affected the expression of seventy-seven immune response-associated genes. An IPM was implemented and evaluated on ovarian cancer patients to distinguish individuals with low- and high-IPM subgroups of poor survival. For diagnostic and therapeutic use, a nomogram is thus created. According to pathway enrichment analysis, the pathways of the human immune response and immune function abnormalities were the most associated functions and pathways with the IPM genes. Furthermore, patients in the high-risk group showed low proportions of macrophages M1, activated NK cells, CD8 Conclusions: The IPM model may identify high-risk patients and integrate other clinical parameters to predict their overall survival, suggesting it is a potential methodology for optimizing ovarian cancer prognosis.
MeSH term(s)	Humans ; Female ; CD8-Positive T-Lymphocytes ; Ovarian Neoplasms/genetics ; Mutation ; Killer Cells, Natural ; Macrophages ; Tumor Microenvironment
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411865-5
ISSN	1755-8794 ; 1755-8794
ISSN (online)	1755-8794
ISSN	1755-8794
DOI	10.1186/s12920-023-01657-x
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