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  1. Article ; Online: A New Era in Critical Care Trials: Linking ICU Practice to Long-Term Outcomes.

    Hippensteel, Joseph A / Aggarwal, Neil R / Mikkelsen, Mark E

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 7, Page(s) 782–784

    MeSH term(s) Adult ; Humans ; Respiration, Artificial ; Critical Care ; Intensive Care Units ; Cognition ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202402-0349ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proteoglycans and glycosaminoglycans in central nervous system injury.

    Siddiqui, Noah / Oshima, Kaori / Hippensteel, Joseph A

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 1, Page(s) C46–C55

    Abstract: The brain and spinal cord constitute the central nervous system (CNS), which when injured, can be exceedingly devastating. The mechanistic roles of proteoglycans (PGs) and their glycosaminoglycan (GAG) side chains in such injuries have been extensively ... ...

    Abstract The brain and spinal cord constitute the central nervous system (CNS), which when injured, can be exceedingly devastating. The mechanistic roles of proteoglycans (PGs) and their glycosaminoglycan (GAG) side chains in such injuries have been extensively studied. CNS injury immediately alters endothelial and extracellular matrix (ECM) PGs and GAGs. Subsequently, these alterations contribute to acute injury, postinjury fibrosis, and postinjury repair. These effects are central to the pathophysiology of CNS injury. This review focuses on the importance of PGs and GAGs in multiple forms of injury including traumatic brain injury, spinal cord injury, and stroke. We highlight the causes and consequences of degradation of the PG and GAG-enriched endothelial glycocalyx in early injury and discuss the pleiotropic roles of PGs in neuroinflammation. We subsequently evaluate the dualistic effects of PGs on recovery: both PG/GAG-mediated inhibition and facilitation of repair. We then report promising therapeutic strategies that may prove effective for repair of CNS injury including PG receptor inhibition, delivery of endogenous, pro-repair PGs and GAGs, and direct degradation of pathological GAGs. Finally, we discuss the importance of two PG- and GAG-containing ECM structures (synapses and perineuronal nets) in CNS injury and recovery.
    MeSH term(s) Central Nervous System/metabolism ; Extracellular Matrix/metabolism ; Glycosaminoglycans/analysis ; Glycosaminoglycans/metabolism ; Proteoglycans/chemistry
    Chemical Substances Glycosaminoglycans ; Proteoglycans
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00053.2022
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  3. Article ; Online: Prevalence of venous thromboembolism in critically ill patients with COVID-19.

    Hippensteel, Joseph A / Burnham, Ellen L / Jolley, Sarah E

    British journal of haematology

    2020  Volume 190, Issue 3, Page(s) e134–e137

    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Venous Thromboembolism/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16908
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  4. Article ; Online: Endothelial glycocalyx degradation during sepsis: Causes and consequences.

    Sullivan, Ryan C / Rockstrom, Matthew D / Schmidt, Eric P / Hippensteel, Joseph A

    Matrix biology plus

    2021  Volume 12, Page(s) 100094

    Abstract: The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate, ... ...

    Abstract The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, and hyaluronic acid. In health and disease, the endothelial glycocalyx is a central regulator of vascular permeability, inflammation, coagulation, and circulatory tonicity. During sepsis, a life-threatening syndrome seen commonly in hospitalized patients, the endothelial glycocalyx is degraded, significantly contributing to its many clinical manifestations. In this review we discuss the intrinsically linked mechanisms responsible for septic endothelial glycocalyx destruction: glycosaminoglycan degradation and proteoglycan cleavage. We then examine the consequences of local endothelial glycocalyx loss to several organ systems and the systemic consequences of shed glycocalyx constituents. Last, we explore clinically relevant non-modifiable and modifiable factors that exacerbate or protect against endothelial glycocalyx shedding during sepsis.
    Language English
    Publishing date 2021-11-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-0285
    ISSN (online) 2590-0285
    DOI 10.1016/j.mbplus.2021.100094
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  5. Article ; Online: Predictors of adverse outcomes in aged patients critically ill with COVID-19: a retrospective study.

    Rockstrom, Matthew / Balaban, Eric / Fakhri, Shoaib / Peterson, Ryan A / Jin, Ying / Jolley, Sarah E / Erlandson, Kristine M / Hippensteel, Joseph A

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2023  Volume 71, Issue 4, Page(s) 315–320

    Abstract: Older patients represent an inordinate proportion of intensive care unit (ICU) admissions and ICU mortality associated with coronavirus disease 2019 (COVID-19). In this retrospective cohort study, we examine 198 patients, aged 18 years or older, admitted ...

    Abstract Older patients represent an inordinate proportion of intensive care unit (ICU) admissions and ICU mortality associated with coronavirus disease 2019 (COVID-19). In this retrospective cohort study, we examine 198 patients, aged 18 years or older, admitted to the ICU from March to June 2020. We aim to understand the relationships between age, number of comorbidities, and independent living prior to admission on outcomes of mortality, length of stay, renal failure, respiratory failure, and shock. In this cohort, we find that overall mortality was associated with respiratory failure severity (for every decrease of P:F by 50, odds ratio (OR) 2.98 (1.65-6.08)), acute renal failure (OR 4.61 (1.2-19.7)), and age 65 or greater (OR: 3.7 (1.86-7.36)). Surprisingly, increasing age was associated with less severe respiratory failure (R = 0.22, p < 0.01). When adjusting for pre-existing chronic kidney disease, age was not associated with development of acute kidney injury (OR: 1.01 (0.99-1.03)). While chronologic age is associated with mortality, it is not associated independently with severe end organ damage. This is consistent with growing evidence suggesting that a complex interplay between multimorbidity, immunosenescence, and physiologic age is primarily responsible for the vulnerability to COVID-19.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; Critical Illness ; Respiratory Insufficiency/complications ; Hospital Mortality ; Acute Kidney Injury
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1177/10815589221150644
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  6. Article ; Online: Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte.

    Hippensteel, Joseph A / Schmidt, Eric P

    American journal of respiratory and critical care medicine

    2017  Volume 197, Issue 4, Page(s) 416–418

    MeSH term(s) Critical Illness ; DNA, Mitochondrial ; Erythrocytes ; Humans ; Lung Injury ; Toll-Like Receptor 9
    Chemical Substances DNA, Mitochondrial ; TLR9 protein, human ; Toll-Like Receptor 9
    Language English
    Publishing date 2017-10-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201710-2094ED
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  7. Article ; Online: Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis.

    Hippensteel, Joseph A / Shapiro, Nathan I / Schmidt, Eric P

    American journal of respiratory and critical care medicine

    2018  Volume 198, Issue 8, Page(s) 981–983

    MeSH term(s) Animals ; Endotoxemia ; Fluid Therapy ; Resuscitation ; Sepsis ; Sheep ; Shock
    Language English
    Publishing date 2018-07-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201806-1071ED
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  9. Article ; Online: Prevalence of venous thromboembolism in critically ill patients with COVID‐19

    Hippensteel, Joseph A. / Burnham, Ellen L. / Jolley, Sarah E.

    British Journal of Haematology

    2020  Volume 190, Issue 3

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16908
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  10. Article ; Online: Intravital Microscopy in the Mouse Lung.

    Yang, Yimu / Hippensteel, Joseph A / Schmidt, Eric P

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1809, Page(s) 331–339

    Abstract: While reductionist in vitro approaches have allowed for careful interrogation of cellular pathways that underlie innate immune responses, they often fail to capture the complex multicellular interactions characteristic of acute inflammation. Intravital ... ...

    Abstract While reductionist in vitro approaches have allowed for careful interrogation of cellular pathways that underlie innate immune responses, they often fail to capture the complex multicellular interactions characteristic of acute inflammation. Intravital microscopy, by directly observing alveolar cell-cell interactions, provides unique insight into the complex intercellular mechanisms responsible for alveolar inflammation. This review discusses multiple potential approaches to intravital pulmonary imaging, with specific attention to in vivo microscopy of the freely moving mouse lung.
    MeSH term(s) Animals ; Intravital Microscopy/methods ; Lung/cytology ; Mice
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8570-8_21
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