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  1. Article ; Online: Letter to the Editor: "Midodrine to liberate ICU patients from intravenous vasopressors: Another negative fixed-dose trial".

    Riker, Richard R / Gagnon, David J

    Journal of critical care

    2022  Volume 69, Page(s) 153995

    MeSH term(s) Administration, Intravenous ; Clinical Trials as Topic ; Humans ; Intensive Care Units ; Midodrine ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Midodrine (6YE7PBM15H)
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.153995
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    Zs.A 2152: Show issues Location:
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  2. Article ; Online: Delirium-Beyond the CAM-ICU.

    Riker, Richard R / Fraser, Gilles L

    Critical care medicine

    2020  Volume 48, Issue 1, Page(s) 134–136

    MeSH term(s) Cerebral Hemorrhage ; Cohort Studies ; Delirium ; Humans ; Intensive Care Units ; Prospective Studies
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004056
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    Zs.A 1261: Show issues Location:
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  3. Article ; Online: Midodrine administration during critical illness: fixed-dose or titrate to response?

    Riker, Richard R / Gagnon, David J

    Intensive care medicine

    2020  Volume 47, Issue 2, Page(s) 249–251

    MeSH term(s) Critical Illness ; Humans ; Hypotension/drug therapy ; Intensive Care Units ; Midodrine ; Vasoconstrictor Agents/adverse effects
    Chemical Substances Vasoconstrictor Agents ; Midodrine (6YE7PBM15H)
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06321-x
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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Medications for opioid use disorder prescribed at hospital discharge associated with decreased opioid agonist dispensing in patients with opioid use disorder requiring critical care: A retrospective study.

    Quaye, Aurora / Wampole, Chelsea / Riker, Richard R / Seder, David B / Sauer, William J / Richard, Janelle / Craig, Wendy / Gagnon, David J

    Journal of substance use and addiction treatment

    2023  Volume 155, Page(s) 209176

    Abstract: Introduction: Buprenorphine is highly effective for the treatment of opioid use disorder (OUD), and, in recent years, the rates of patients maintained on buprenorphine requiring critical care have been steadily increasing. Currently, no unified guidance ...

    Abstract Introduction: Buprenorphine is highly effective for the treatment of opioid use disorder (OUD), and, in recent years, the rates of patients maintained on buprenorphine requiring critical care have been steadily increasing. Currently, no unified guidance exists for buprenorphine management during critical illness. Likewise, we do not know if patients maintained on buprenorphine for OUD are prescribed medications for OUD (MOUD) following hospital discharge or if buprenorphine management influences mu opioid agonist dispensing.
    Methods: In our cohort of adults over the age of 18 with OUD, receiving buprenorphine formulations in the 3 months preceding their ICU admission, we sought to investigate the relationship between receipt of MOUD and non-MOUD opioid prescribing up to 12 months following hospital discharge. This was a single-center, retrospective cohort study approved by the MaineHealth institutional review board. The study analyzed differences in prescription rates between discharge and subsequent time points using chi square or Fisher's exact test, as appropriate. We performed analyses using SPSS Statistical Software version 28 (IBM SPSS Inc., Armonk, NY) with significance set at p < 0.05.
    Results: We identified a statistically significant increase in MOUD prescribing 3 months posthospital discharge in patients who received MOUD at time of discharge (87.9 % vs 40 % p = 0.002.) The study found a significant increase in nonbuprenorphine opioid prescribing in patients who did not receive an MOUD prescription at time of discharge (24.2 % vs 70 % p = 0.007). This trend persisted at the 6-month and 12-month time points; however, it did not reach statistical significance. Additionally, the study identified a significant reduction in the incidence of non-MOUD opioid dispensing in patients prescribed MOUD at each time point measured (p = 0.007, p < 0.001. p < 0.001 and p = 0.008 at discharge, 3, 6, and 12 months, respectively).
    Conclusions: These findings support continuing buprenorphine dispensing following hospital discharge.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Analgesics, Opioid/therapeutic use ; Patient Discharge ; Retrospective Studies ; Practice Patterns, Physicians' ; Opioid-Related Disorders/drug therapy ; Buprenorphine/therapeutic use ; Critical Care ; Hospitals
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2949-8759
    ISSN (online) 2949-8759
    DOI 10.1016/j.josat.2023.209176
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  5. Article ; Online: Buprenorphine Continuation During Critical Illness Associated With Decreased Inpatient Opioid Use in Individuals Maintained on Buprenorphine for Opioid Use Disorder in a Retrospective Study.

    Quaye, Aurora / Wampole, Chelsea / Riker, Richard R / Seder, David B / Sauer, William J / Richard, Janelle M / Craig, Wendy Y / Gagnon, David J

    Journal of clinical pharmacology

    2023  Volume 63, Issue 9, Page(s) 1067–1073

    Abstract: The number of patients maintained on buprenorphine is steadily increasing. To date, no study has reported buprenorphine management practices for these patients during critical illness, nor its relationship with supplemental full-agonist opioid ... ...

    Abstract The number of patients maintained on buprenorphine is steadily increasing. To date, no study has reported buprenorphine management practices for these patients during critical illness, nor its relationship with supplemental full-agonist opioid administration during their hospital stay. In this single-center retrospective study, we have explored the incidence of buprenorphine continuation during critical illness among patients receiving buprenorphine for the treatment of opioid use disorder. Additionally, we investigated the relationship between nonbuprenorphine opioid exposure and buprenorphine administration during the intensive care unit (ICU) and post-ICU phases of care. Our study included adults maintained on buprenorphine for opioid use disorder admitted to the ICU between December 1, 2014, and May 31, 2019. Nonbuprenorphine, full agonist opioid doses were converted to fentanyl equivalents (FEs). Fifty-one (44%) patients received buprenorphine during the ICU phase of care, with an average dose of 8 (8-12) mg/day. During the post-ICU phase of care, 68 (62%) received buprenorphine, with an average dose of 10 (7-14) mg/day. Lack of mechanical ventilation and acetaminophen use were also associated with buprenorphine use. Full agonist opioid use was more frequent on days when buprenorphine was not given (odds ratio [OR], 6.2 [95% CI, 2.3-16.4]; P < .001). Additionally, the average cumulative dose of opioids given on nonbuprenorphine administration days was significantly higher both in the ICU (OR, 1803 [95% CI, 1271-2553] vs OR, 327 [95% CI, 152-708] FEs/day; P < 0.001) and after ICU discharge (OR, 1476 [95% CI, 962-2265] vs OR, 238 [95% CI, 150-377] FEs/day; P < .001). Given these findings, buprenorphine continuation during critical illness should be considered, as it is associated with significantly decreased full agonist opioid use.
    MeSH term(s) Adult ; Humans ; Buprenorphine/adverse effects ; Analgesics, Opioid/adverse effects ; Retrospective Studies ; Inpatients ; Critical Illness ; Opioid-Related Disorders/drug therapy
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2286
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  6. Article ; Online: In the Middle of Difficulty Lies Opportunity.-Albert Einstein.

    Riker, Richard R / Fraser, Gilles L

    Critical care medicine

    2018  Volume 46, Issue 11, Page(s) 1881–1882

    MeSH term(s) Delirium ; Humans
    Language English
    Publishing date 2018-07-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003399
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    Zs.A 1261: Show issues Location:
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  7. Article ; Online: Understanding post-cardiac arrest myoclonus.

    Seder, David B / Riker, Richard R

    Resuscitation

    2018  Volume 131, Page(s) A3–A4

    MeSH term(s) Heart Arrest ; Humans ; Myoclonus
    Language English
    Publishing date 2018-08-04
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2018.08.001
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    Zs.A 1048: Show issues Location:
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  8. Article ; Online: Response to Dr. Panda and Colleagues.

    Leclerc, Angela M / Riker, Richard R / Brown, Caitlin S / Gagnon, David J

    Neurocritical care

    2021  Volume 35, Issue 1, Page(s) 279–280

    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01258-5
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    Zs.A 6538: Show issues Location:
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  9. Article ; Online: Vasopressin-Induced Hyponatremia in Patients With Aneurysmal Subarachnoid Hemorrhage: A Case Series and Literature Review.

    Subba, Hilamber / Riker, Richard R / Dunn, Susan / Gagnon, David J

    Journal of pharmacy practice

    2021  Volume 36, Issue 3, Page(s) 689–694

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Female ; Male ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Hyponatremia/chemically induced ; Hyponatremia/diagnosis ; Vasopressins ; Sodium ; Treatment Outcome
    Chemical Substances Vasopressins (11000-17-2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900211053497
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  10. Article ; Online: Caution Warranted Regarding Transfusion for Subarachnoid Hemorrhage.

    Riker, Richard R / Seder, David B

    Critical care medicine

    2017  Volume 45, Issue 9, Page(s) e986–e987

    MeSH term(s) Blood Transfusion ; Erythrocyte Transfusion ; Humans ; Oxygen ; Platelet Transfusion ; Subarachnoid Hemorrhage
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-08-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002508
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