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  1. Article ; Online: Tixagevimab-Cilgavimab Treatment and Cardiovascular Events: Immortal Time Bias.

    Montastruc, François / de Canecaude, Claire

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 76, Issue 11, Page(s) 2044–2045

    MeSH term(s) Humans ; Antibodies, Monoclonal ; Cardiovascular Diseases/epidemiology
    Chemical Substances tixagevimab ; cilgavimab (1KUR4BN70F) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad089
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  2. Article ; Online: Tramadol and the risk of bleeding complications in patients on oral anticoagulants: a pharmacovigilance study.

    Montastruc, Jean-Louis / Montastruc, François / Bura-Rivière, Alessandra

    European journal of clinical pharmacology

    2023  Volume 79, Issue 5, Page(s) 701–702

    MeSH term(s) Humans ; Tramadol/adverse effects ; Pharmacovigilance ; Anticoagulants/adverse effects ; Adverse Drug Reaction Reporting Systems ; Administration, Oral
    Chemical Substances Tramadol (39J1LGJ30J) ; Anticoagulants
    Language English
    Publishing date 2023-03-28
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-023-03480-w
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  3. Article: Financement de la psychiatrie en France, la question des médicaments onéreux : exemple de l’Esketamine dans l’épisode dépressif caractérisé résistant.

    Taillefer de Laportalière, Tanguy / Jullien, Adeline / Eyvrard, Frédéric / Yrondi, Antoine / Montastruc, François / Cestac, Philippe / Dintilhac, Audrey / Juillard-Condat, Blandine

    L'Encephale

    2023  

    Abstract: In France, the funding of mental health institutions relies on an annual budget allocation ...

    Title translation Funding of psychiatry in France, the problem of expensive drugs. Example of Esketamine in the case of resistant depressive episodes.
    Abstract In France, the funding of mental health institutions relies on an annual budget allocation. Esketamine, a non-competitive NMDA glutamate receptor antagonist, has been approved for adults with treatment-resistant major depressive disorder since 2019. However, due to its high cost (€200 per 28 mg device, excluding tax), the aim of this work was to evaluate whether the income received by an institution for the management of a patient treated with Esketamine could cover the purchase of devices, based on real clinical data. Within our institution, seven patients underwent treatment with Esketamine during the study period resulting in a total usage of 714 devices, amounting to a purchase cost of €142,800. Over the course of the follow-up period, the institution received €149,054 in revenue for the treatment of these patients. Our analysis reveals that the expense associated with Esketamine constitutes 95.8 % of the income generated from caring for these patients. This not only raises questions about the pricing of this drug but also highlights the lack of a funding system for costly psychiatric drugs. This concern extends to somatic treatments associated with psychiatric care.
    Language French
    Publishing date 2023-11-30
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2023.09.007
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  4. Article ; Online: Lamotrigine and risk of arrhythmias: A global pharmacovigilance analysis.

    Orts, Lisa / Flumian, Clara / Montastruc, François

    Journal of the neurological sciences

    2023  Volume 448, Page(s) 120644

    MeSH term(s) Humans ; Lamotrigine/adverse effects ; Pharmacovigilance ; Anticonvulsants/adverse effects ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/drug therapy ; Triazines
    Chemical Substances Lamotrigine (U3H27498KS) ; Anticonvulsants ; Triazines
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2023.120644
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  5. Article ; Online: Drug-induced psychiatric disorders: A pharmacovigilance update.

    Montastruc, François / Taillefer de Laportaliere, Tanguy

    Therapie

    2023  Volume 79, Issue 2, Page(s) 173–179

    Abstract: The psychiatric risks associated with drugs are sometimes one of the few restrictions on the use of certain drug classes, such as corticosteroids in patients with a history of severe psychotic episodes associated with this drug class. In this non- ... ...

    Abstract The psychiatric risks associated with drugs are sometimes one of the few restrictions on the use of certain drug classes, such as corticosteroids in patients with a history of severe psychotic episodes associated with this drug class. In this non-exhaustive review, we propose to deal with the most recent issues concerning psychiatric disorders induced by drugs and encountered in doctors' clinical practice. Firstly, we look at depressive disorders and suicide risks, secondly at psychotic and manic disorders and thirdly at anxiety and sleep disorders. While lot of drugs are associated with psychiatric disorders, the confounding by indication represents an important methodological gap since information on the psychiatric profile of patients is not always available. This is particularly the case for serotonin reuptake inhibitors and esketamine used as antidepressants. Recent pharmacovigilance concerns of psychiatric disorders emerged with montelukast, orexin receptor antagonists or cystic fibrosis transmembrane regulator (CFTR) modulators.
    MeSH term(s) Humans ; Pharmacovigilance ; Mental Disorders/chemically induced ; Mental Disorders/drug therapy ; Mental Disorders/epidemiology ; Antidepressive Agents/adverse effects ; Selective Serotonin Reuptake Inhibitors
    Chemical Substances Antidepressive Agents ; Selective Serotonin Reuptake Inhibitors
    Language English
    Publishing date 2023-10-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2023.09.007
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  6. Article ; Online: Blood pressure measurements after mRNA-SARS-CoV-2 tozinameran vaccination: a retrospective analysis in a university hospital in France.

    Bouhanick, Beatrice / Brusq, Clara / Bongard, Vanina / Tessier, Samuel / Montastruc, Jean-Louis / Senard, Jean-Michel / Montastruc, François / Herin, Fabrice

    Journal of human hypertension

    2022  Volume 36, Issue 6, Page(s) 580–581

    MeSH term(s) Blood Pressure ; COVID-19/prevention & control ; Hospitals ; Humans ; RNA, Messenger ; Retrospective Studies ; SARS-CoV-2 ; Vaccination
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-021-00634-0
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  7. Article ; Online: Parasitic Infections and Biological Therapies Targeting Type 2 Inflammation: A VigiBase Study.

    Lifar, Philippine / Montastruc, François / Reber, Laurent L / Magnaval, Jean-François / Guilleminault, Laurent

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 9, Page(s) 1253–1255

    MeSH term(s) Humans ; Asthma ; Parasitic Diseases ; Biological Therapy ; Inflammation
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1898LE
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  8. Article ; Online: Un prix éditorial pour un article publié dans THERAPIES en 2020 : « La pharmacogénétique au service du soin en France : une discipline qui évolue ! ».

    Montastruc, Jean-Louis

    Therapie

    2021  Volume 77, Issue 1, Page(s) 1–2

    Title translation An editorial award for an article published in THERAPIES in 2020: "Pharmacogenetics for health care in France: An evolving discipline!"
    Language French
    Publishing date 2021-11-25
    Publishing country France
    Document type Editorial
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2021.11.008
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  9. Article ; Online: Withdrawal syndrome after antipsychotics discontinuation: an analysis of the WHO database of spontaneous reports (Vigibase) between 2000 and 2022.

    Storck, Wilhelm / de Laportalière, Tanguy Taillefer / Yrondi, Antoine / Javelot, Hervé / Berna, Fabrice / Montastruc, François

    Psychopharmacology

    2024  

    Abstract: Rationale: Withdrawal syndrome (WDS) has been described after discontinuation of antipsychotics. WDS could be the consequence of an over-activation of the dopaminergic pathway. Antipsychotics with a higher affinity for dopamine D2 receptors could be ... ...

    Abstract Rationale: Withdrawal syndrome (WDS) has been described after discontinuation of antipsychotics. WDS could be the consequence of an over-activation of the dopaminergic pathway. Antipsychotics with a higher affinity for dopamine D2 receptors could be associated with a higher risk of WDS. This study aims to address this statement and evaluate the risk difference for withdrawal syndrome between antipsychotics based on pharmacovigilance data.
    Methods: We collected individual reports registered in Vigibase® between 01/01/2000 and 31/12/2022 of patients treated with antipsychotics and who had presented WDS. A disproportionality analysis was performed to evaluate the risk of reporting WDS with each antipsychotic compared to all other antipsychotics. We performed a correlation analysis to assess the correlation between the risk of reporting WDS for each antipsychotic in relation with their pKi for D2 and 5HT2A receptors.
    Results: The most frequent psychiatric withdrawal symptoms after antipsychotic discontinuation were insomnia, anxiety and depression. Tremor, headache and dizziness were among the most frequently reported neurologic withdrawal symptoms. Tiotixene had the highest risk of reporting WDS (ROR 7.08; 95%CI 3.49 - 14.35) followed by pimozide (ROR 4.35; 95%CI 1.93 - 9.77), quetiapine (ROR 4.24; 95%CI 3.87 - 4.64), thioridazine (ROR 4.17; 95%CI 2.50-6.98) and ziprasidone (ROR 2.98; 95%CI 2.41-3.67). We found a poor correlation between D2/5HT2A binding affinity and the risk of reporting withdrawal syndrome (R
    Conclusion: Our results suggest that there might be a risk difference for WDS between antipsychotics. Tiotixene, pimozide and quetiapine were associated with a higher risk of reporting a WDS whereas this risk was lower with chlorpromazine, clozapine and fluphenazine. We could not address the issue of withdrawal psychosis, withdrawal dyskinesia, rebound psychosis or supersensitivity psychosis due to the lack of specific WHO medDRA coded terms to identify potential cases.
    Language English
    Publishing date 2024-02-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-024-06554-4
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  10. Article ; Online: Risk of abnormal uterine bleeding associated with high-affinity compared with low-affinity serotonin and norepinephrine reuptake inhibitors.

    Engler, Julie / Filliter, Christopher / Montastruc, François / Abenhaim, Haim / Rej, Soham / Renoux, Christel

    Journal of affective disorders

    2024  Volume 350, Page(s) 813–821

    Abstract: Background: Concerns have been raised about the potential association between selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitors (SNRIs) and the risk of abnormal uterine bleeding (AUB), which may be influenced ... ...

    Abstract Background: Concerns have been raised about the potential association between selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitors (SNRIs) and the risk of abnormal uterine bleeding (AUB), which may be influenced by the affinity of SSRIs/SNRIs for serotonin transporter. Thus, we assessed whether SSRIs/SNRIs with high-affinity for serotonin transporter are associated with AUB compared to SSRIs/SNRIs with low-affinity in non-pregnant women.
    Methods: Using the UK Clinical Practice Research Datalink, we identified a cohort of women aged 15-24 years, newly prescribed a high- or low-affinity SSRI/SNRI between 1990 and 2019. Confounding was addressed using standardized morbidity ratio weighting. We used weighted Cox proportional hazards models to estimate the hazard ratio (HR) and 95 % confidence interval (CI) of AUB associated with high-affinity compared with low-affinity SSRIs/SNRIs. We assessed the risk of anemia as a secondary outcome.
    Results: The cohort included 156,307 users of high-affinity SSRIs/SNRIs and 102,631 users of low-affinity SSRIs/SNRIs. High-affinity SSRIs/SNRIs were not associated with an increased risk of AUB compared with low-affinity SSRIs/SNRIs (incidence rates: 46.3 versus 42.4 per 1000 person-years, respectively; HR 1.01, 95 % CI 0.93-1.09). Duration of use, age, and comorbidities did not modify the risk. However, high-affinity SSRIs/SNRIs were associated with an increased risk of anemia (HR 1.29, 95 % CI 1.04-1.61) compared with low-affinity SSRIs/SNRIs.
    Limitations: Residual confounding may still be present.
    Conclusions: The risk of AUB did not differ between high- and low-affinity SSRIs/SNRIs. However, the potential risk of anemia suggests the need for monitoring and further investigation of the risk of AUB with these medications.
    MeSH term(s) Humans ; Female ; Selective Serotonin Reuptake Inhibitors/adverse effects ; Serotonin and Noradrenaline Reuptake Inhibitors/adverse effects ; Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Uterine Hemorrhage ; Anemia ; Norepinephrine
    Chemical Substances Selective Serotonin Reuptake Inhibitors ; Serotonin and Noradrenaline Reuptake Inhibitors ; Serotonin (333DO1RDJY) ; Serotonin Plasma Membrane Transport Proteins ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.163
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