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Article: [Achievements of moxibustion therapy in Wushier Bingfang (prescriptions for fifty-two diseases) of Mawangdui silk manuscript].

Zhang, Lei / Cai, Rong-Lin / Hu, Ling

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2013 Volume 33, Issue 3, Page(s) 279–280

Abstract: Wushier Bingfang (Prescriptions for Fifty-two Diseases), the unearthed Mawangdui silk manuscript ...

Abstract	Wushier Bingfang (Prescriptions for Fifty-two Diseases), the unearthed Mawangdui silk manuscript from the Han Dynasty (206 B. C.-220 A. D. ) is studied in this article. It is held that the book preserved the earliest prescription of moxibustion. It recorded intensive indications of moxibustion, abundant materials as well as manipulations of moxibustioin. The value and achievements of the book is further revealed.
MeSH term(s)	Acupuncture Therapy/history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Moxibustion/history
Language	Chinese
Publishing date	2013-03
Publishing country	China
Document type	English Abstract ; Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lysosomes Initiating and DNAzyme-Assisted Intracellular Signal Amplification Strategy for Quantification of Alpha-Fetoprotein in a Single Cell.

Chen, Shengyu / Zhao, Jingjin / Xu, Chunhuan / Shi, Bingfang / Xu, Jiayao / Hu, Shengqiang / Zhao, Shulin

Analytical chemistry

2023 Volume 96, Issue 1, Page(s) 85–91

Abstract: Cellular trace proteins are critical for maintaining normal cell functions, with their quantitative analysis in individual cells aiding our understanding of the role of cell proteins in biological processes. This study proposes a strategy for the ... ...

Abstract	Cellular trace proteins are critical for maintaining normal cell functions, with their quantitative analysis in individual cells aiding our understanding of the role of cell proteins in biological processes. This study proposes a strategy for the quantitative analysis of alpha-fetoprotein in single cells, utilizing a lysosome microenvironment initiation and a DNAzyme-assisted intracellular signal amplification technique based on electrophoretic separation. A nanoprobe targeting lysosomes was prepared, facilitating the intracellular signal amplification of alpha-fetoprotein. Following intracellular signal amplification, the levels of alpha-fetoprotein (AFP) in 20 HepG2 hepatoma cells and 20 normal HL-7702 hepatocytes were individually evaluated using microchip electrophoresis with laser-induced fluorescence detection (MCE-LIF). Results demonstrated overexpression of alpha-fetoprotein in hepatocellular carcinoma cells. This strategy represents a novel technique for single-cell protein analysis and holds significant potential as a powerful tool for such analyses.
MeSH term(s)	Humans ; alpha-Fetoproteins/analysis ; DNA, Catalytic ; Electrophoresis, Microchip/methods ; Nucleic Acid Amplification Techniques/methods ; Lysosomes/chemistry ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms ; Tumor Microenvironment
Chemical Substances	alpha-Fetoproteins ; DNA, Catalytic
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03152
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Zs.A 4033: Show issues

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Article ; Online: Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities.

Liu, Yali / Du, Jianqing / Wang, Yanfen / Cui, Xiaoyong / Dong, Jichang / Gu, Pan / Hao, Yanbin / Xue, Kai / Duan, Hongbo / Xia, Anquan / Hu, Yi / Dong, Zhi / Wu, Bingfang / Kropp, Jürgen P / Fu, Bojie

Innovation (Cambridge (Mass.))

2024 Volume 5, Issue 2, Page(s) 100573

Abstract: Differences in progress across sustainable development goals (SDGs) are widespread globally; meanwhile, the rising call for prioritizing specific SDGs may exacerbate such gaps. Nevertheless, how these progress differences would influence global ... ...

Abstract	Differences in progress across sustainable development goals (SDGs) are widespread globally; meanwhile, the rising call for prioritizing specific SDGs may exacerbate such gaps. Nevertheless, how these progress differences would influence global sustainable development has been long neglected. Here, we present the first quantitative assessment of SDGs' progress differences globally by adopting the SDGs progress evenness index. Our results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because (1) it is strongly associated with many public health risks (e.g., air pollution), social inequalities (e.g., gender inequality, modern slavery, wealth gap), and a reduction in life expectancy; (2) it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems, increasing the challenges related to biodiversity conservation; (3) most countries with low average SDGs performance show lower progress evenness, which further hinders their fulfillment of SDGs; and (4) many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness, which is partly ascribed to the antagonism between climate actions and other goals. These findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors, caution must be exercised to avoid new problems from intensifying uneven progress across goals. Moreover, our study reveals that the urgent needs regarding SDGs of different regions seem complementary, emphasizing that regional collaborations (e.g., demand-oriented carbon trading between SDGs poorly performed and well-performed countries) may promote sustainable development achievements at the global scale.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ISSN	2666-6758
ISSN (online)	2666-6758
DOI	10.1016/j.xinn.2024.100573
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Article ; Online: Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling.

Shan, Enfang / Huo, Ying / Wang, Haobin / Zhang, Ziheng / Hu, Jingwan / Wang, Guyu / Liu, Wei / Yan, Bingfang / Hiroaki, Honda / Yang, Jian

Neoplasia (New York, N.Y.)

2022 Volume 27, Page(s) 100783

Abstract: Colorectal cancer (CRC) is the second deadly and the third most common malignancy worldwide. It has been projected that annual new cases of CRC will increase by 63% in 2040, constituting an even greater health challenge for decades to come. This study ... ...

Abstract	Colorectal cancer (CRC) is the second deadly and the third most common malignancy worldwide. It has been projected that annual new cases of CRC will increase by 63% in 2040, constituting an even greater health challenge for decades to come. This study has linked DEC1 (differentiated embryonic chondrocyte expressed gene 1) to the pathogenesis of CRC. Based on the analysis of patient samples and database data, DEC1 is expressed much higher in CRC than the adjacent normal tissues. CRC patients with higher DEC1 expression have a shorter survival time. The carcinogenesis protocol with azoxymethane/dextran sulfate induces a higher number of tumors with larger sizes in DEC1
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinogenesis ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Mice ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Chemical Substances	BHLHE40 protein, human ; Basic Helix-Loop-Helix Transcription Factors ; Homeodomain Proteins ; Interleukin-6 ; STAT3 Transcription Factor ; STAT3 protein, human
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2022.100783
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Zs.A 5203: Show issues

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Article ; Online: An Interannual Transfer Learning Approach for Crop Classification in the Hetao Irrigation District, China

Yueran Hu / Hongwei Zeng / Fuyou Tian / Miao Zhang / Bingfang Wu / Sven Gilliams / Sen Li / Yuanchao Li / Yuming Lu / Honghai Yang

Remote Sensing, Vol 14, Iss 1208, p

2022 Volume 1208

Abstract: Crop type classification is critical for crop production estimation and optimal water allocation. Crop type data are challenging to generate if crop reference data are lacking, especially for target years with reference data missed in collection. Is it ... ...

Abstract	Crop type classification is critical for crop production estimation and optimal water allocation. Crop type data are challenging to generate if crop reference data are lacking, especially for target years with reference data missed in collection. Is it possible to transfer a trained crop type classification model to retrace the historical spatial distribution of crop types? Taking the Hetao Irrigation District (HID) in China as the study area, this study first designed a 10 m crop type classification framework based on the Google Earth Engine (GEE) for crop type mapping in the current season. Then, its interannual transferability to accurately retrace historical crop distributions was tested. The framework used Sentinel-1/2 data as the satellite data source, combined percentile, and monthly composite approaches to generate classification metrics and employed a random forest classifier with 300 trees for crop classification. Based on the proposed framework, this study first developed a 10 m crop type map of the HID for 2020 with an overall accuracy (OA) of 0.89 and then obtained a 10 m crop type map of the HID for 2019 with an OA of 0.92 by transferring the trained model for 2020 without crop reference samples. The results indicated that the designed framework could effectively identify HID crop types and have good transferability to obtain historical crop type data with acceptable accuracy. Our results found that SWIR1, Green, and Red Edge2 were the top three reflectance bands for crop classification. The land surface water index (LSWI), normalized difference water index (NDWI), and enhanced vegetation index (EVI) were the top three vegetation indices for crop classification. April to August was the most suitable time window for crop type classification in the HID. Sentinel-1 information played a positive role in the interannual transfer of the trained model, increasing the OA from 90.73% with Sentinel 2 alone to 91.58% with Sentinel-1 and Sentinel-2 together.
Keywords	crop type classification ; random forest classifier ; interannual transfer ; GPS ; video and GIS (GVG) ; Google Earth Engine ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: [Determination of 15 carbonyl compounds in soil using improved solid phase extraction-high performance liquid chromatography].

Xue, Kun-Peng / Yu, Ling-Yu / Ren, Xing-Fa / Tu, Bing-Fang / Chen, Chao / Xu, Ting / He, Huan / Hu, Shuai

Se pu = Chinese journal of chromatography

2023 Volume 41, Issue 3, Page(s) 265–273

Abstract: An improved solid phase extraction (SPE)-high performance liquid chromatography method was established to determine 15 carbonyl compounds, namely, formaldehyde (FOR), acetaldehyde (ACETA), acrolein (ACR), acetone (ACETO), propionaldehyde (PRO), ... ...

Abstract	An improved solid phase extraction (SPE)-high performance liquid chromatography method was established to determine 15 carbonyl compounds, namely, formaldehyde (FOR), acetaldehyde (ACETA), acrolein (ACR), acetone (ACETO), propionaldehyde (PRO), crotonaldehyde (CRO), butyraldehyde (BUT), benzaldehyde (BEN), isovaleraldehyde (ISO),
Language	Chinese
Publishing date	2023-03-01
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1872-2059
ISSN (online)	1872-2059
DOI	10.3724/SP.J.1123.2022.05021
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Article: Toward Combatting COVID-19: A Risk Assessment System.

Wang, Qianlong / Guo, Yifan / Ji, Tianxi / Wang, Xufei / Hu, Bingfang / Li, Pan

IEEE internet of things journal

2021 Volume 8, Issue 21, Page(s) 15953–15964

Abstract: The coronavirus disease 2019 (COVID-19) has rapidly become a significant public health emergency all over the world since it was first identified in Wuhan, China, in December 2019. Until today, massive disease-related data have been collected, both ... ...

Abstract	The coronavirus disease 2019 (COVID-19) has rapidly become a significant public health emergency all over the world since it was first identified in Wuhan, China, in December 2019. Until today, massive disease-related data have been collected, both manually and through the Internet of Medical Things (IoMT), which can be potentially used to analyze the spread of the disease. On the other hand, with the help of IoMT, the analysis results of the current status of COVID-19 can be delivered to people in real time to enable situational awareness, which may help mitigate the disease spread in communities. However, current accessible data on COVID-19 are mostly at a macrolevel, such as for each state, county, or metropolitan area. For fine-grained areas, such as for each city, community, or geographical coordinate, COVID-19 data are usually not available, which prevents us from obtaining information on the disease spread in closer neighborhoods around us. To address this problem, in this article, we propose a two-level risk assessment system. In particular, we define a "risk index." Then, we develop a risk assessment model, called MK-DNN, by taking advantage of the multikernel density estimation (MKDE) and deep neural network (DNN). We train MK-DNN at the macrolevel (for each metro area), which subsequently enables us to obtain the risk indices at the microlevel (for each geographic coordinate). Moreover, a heuristic validation method is further designed to help validate the obtained microlevel risk indices. Simulations conducted on real-world data demonstrate the accuracy and validity of our proposed risk assessment system.
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article
ISSN	2327-4662
ISSN	2327-4662
DOI	10.1109/JIOT.2021.3070042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Interannual Transfer Learning Approach for Crop Classification in the Hetao Irrigation District, China

Hu, Yueran / Zeng, Hongwei / Tian, Fuyou / Zhang, Miao / Wu, Bingfang / Gilliams, Sven / Li, Sen / Li, Yuanchao / Lu, Yuming / Yang, Honghai

Remote Sensing. 2022 Mar. 01, v. 14, no. 5

2022

Abstract	Crop type classification is critical for crop production estimation and optimal water allocation. Crop type data are challenging to generate if crop reference data are lacking, especially for target years with reference data missed in collection. Is it possible to transfer a trained crop type classification model to retrace the historical spatial distribution of crop types? Taking the Hetao Irrigation District (HID) in China as the study area, this study first designed a 10 m crop type classification framework based on the Google Earth Engine (GEE) for crop type mapping in the current season. Then, its interannual transferability to accurately retrace historical crop distributions was tested. The framework used Sentinel-1/2 data as the satellite data source, combined percentile, and monthly composite approaches to generate classification metrics and employed a random forest classifier with 300 trees for crop classification. Based on the proposed framework, this study first developed a 10 m crop type map of the HID for 2020 with an overall accuracy (OA) of 0.89 and then obtained a 10 m crop type map of the HID for 2019 with an OA of 0.92 by transferring the trained model for 2020 without crop reference samples. The results indicated that the designed framework could effectively identify HID crop types and have good transferability to obtain historical crop type data with acceptable accuracy. Our results found that SWIR1, Green, and Red Edge2 were the top three reflectance bands for crop classification. The land surface water index (LSWI), normalized difference water index (NDWI), and enhanced vegetation index (EVI) were the top three vegetation indices for crop classification. April to August was the most suitable time window for crop type classification in the HID. Sentinel-1 information played a positive role in the interannual transfer of the trained model, increasing the OA from 90.73% with Sentinel 2 alone to 91.58% with Sentinel-1 and Sentinel-2 together.
Keywords	Internet ; crop production ; irrigation ; models ; reflectance ; remote sensing ; surface water ; vegetation ; vegetation index ; water allocation ; China
Language	English
Dates of publication	2022-0301
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs14051208
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration.

Liu, Xuezhao / Xin, Dazhuan Eric / Zhong, Xiaowen / Zhao, Chuntao / Li, Zhidan / Zhang, Liguo / Dourson, Adam J / Lee, Lindsay / Mishra, Shreya / Bayat, Arman E / Nicholson, Eva / Seibel, William L / Yan, Bingfang / Mason, Joel / Turner, Bradley J / Gonsalvez, David G / Ong, William / Chew, Sing Yian / Ghosh, Balaram /

Yoon, Sung Ok / Xin, Mei / He, Zhigang / Tchieu, Jason / Wegner, Michael / Nave, Klaus-Armin / Franklin, Robin J M / Dutta, Ranjan / Trapp, Bruce D / Hu, Ming / Smith, Matthew A / Jankowski, Michael P / Barton, Samantha K / He, Xuelian / Lu, Q Richard

Cell

2024

Abstract: Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found that oligodendrocytes in ... ...

Abstract	Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found that oligodendrocytes in the lesions are epigenetically silenced. Developing a transgenic reporter labeling differentiated oligodendrocytes for phenotypic screening, we identified a small-molecule epigenetic-silencing-inhibitor (ESI1) that enhances myelin production and ensheathment. ESI1 promotes remyelination in animal models of demyelination and enables de novo myelinogenesis on regenerated CNS axons. ESI1 treatment lengthened myelin sheaths in human iPSC-derived organoids and augmented (re)myelination in aged mice while reversing age-related cognitive decline. Multi-omics revealed that ESI1 induces an active chromatin landscape that activates myelinogenic pathways and reprograms metabolism. Notably, ESI1 triggered nuclear condensate formation of master lipid-metabolic regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. Our study highlights the potential of targeting epigenetic silencing to enable CNS myelin regeneration in demyelinating diseases and aging.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.04.005
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article: Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer.

Song, Yurong / Kerr, Travis D / Sanders, Chelsea / Dai, Lisheng / Baxter, Shaneen S / Somerville, Brandon / Baugher, Ryan N / Mellott, Stephanie D / Young, Todd B / Lawhorn, Heidi E / Plona, Teri M / Xu, Bingfang / Wei, Lei / Hu, Qiang / Liu, Song / Hutson, Alan / Karim, Baktiar / Burkett, Sandra / Difilippantonio, Simone /

Pinto, Ligia / Gebert, Johannes / Kloor, Matthias / Lipkin, Steven M / Sei, Shizuko / Shoemaker, Robert H

Frontiers in oncology

2023 Volume 13, Page(s) 1223915

Abstract: Background: Genome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., : Methods: To better understand the biology of MMRd cancers, elucidate the resistance mechanisms to immune modulation, and develop ... ...

Abstract	Background: Genome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., Methods: To better understand the biology of MMRd cancers, elucidate the resistance mechanisms to immune modulation, and develop vaccines and therapeutic testing platforms for this high-risk population, we generated organoids and an orthotopic mouse model from intestine tumors developed in a Msh2-deficient mouse model, and followed with a detailed characterization. Results: The organoids were shown to be of epithelial origin with stem cell features, to have a high frameshift mutation frequency with MSI-H and chromosome instability, and intra- and inter-tumor heterogeneity. An orthotopic model using intra-cecal implantation of tumor fragments derived from organoids showed progressive tumor growth, resulting in the development of adenocarcinomas mixed with mucinous features and distant metastasis in liver and lymph node. Conclusions: The established organoids with characteristics of MSI-H cancers can be used to study MMRd cancer biology. The orthotopic model, with its distant metastasis and expressing frameshift peptides, is suitable for evaluating the efficacy of neoantigen-based vaccines or anticancer drugs in combination with other therapies.
Language	English
Publishing date	2023-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1223915
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