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Article ; Online: Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective.

Blagden, Sarah P / Yu, Ly-Mee / Ellis, Stephanie / Hughes, Helen / Shaaban, Abeer / Fennelly-Barnwell, Jonathan / Lythgoe, Mark P / Cooper, Alison M / Maignen, Francois M / Buckland, Sean W / Kearns, Pamela R / Brown, Louise C

British journal of cancer

2022 Volume 128, Issue 3, Page(s) 474–477

Abstract: In our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design (CID) trials to evaluate cancer drugs. Within weeks of its publication, the UK was hit by the first wave of the SARS-CoV-2 pandemic. Large CID trials ... ...

Abstract	In our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design (CID) trials to evaluate cancer drugs. Within weeks of its publication, the UK was hit by the first wave of the SARS-CoV-2 pandemic. Large CID trials were prioritised to compare the efficacy of new and repurposed COVID-19 treatments and inform regulatory decisions. The unusual circumstances of the pandemic meant studies such as RECOVERY were opened almost immediately and recruited record numbers of participants. However, trial teams were required to make concessions and adaptations to these studies to ensure recruitment was rapid and broad. As these are relevant to cancer trials that enrol patients with similar risk factors, we have added three new recommendations to our original ten: employing pragmatism such as using focused information sheets and collection of only the most relevant data; minimising negative environmental impacts with paperless systems; and using direct-to-patient communication methods to improve uptake. These recommendations can be applied to all oncology CID trials to improve their inclusivity, uptake and efficiency. Above all, the success of CID studies during the COVID-19 pandemic underscores their efficacy as tools for rapid treatment evaluation.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Consensus ; Medical Oncology
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-022-02051-7
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Uh III Zs.142: Show issues

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Article: Hepatic Kupffer cells: the portal that permits infection of hepatocytes by malarial sporozoites?

Barnwell, J W

Hepatology (Baltimore, Md.)

2001 Volume 33, Issue 5, Page(s) 1331–1333

MeSH term(s)	Animals ; Humans ; Kupffer Cells/parasitology ; Kupffer Cells/physiology ; Liver/parasitology ; Malaria/parasitology ; Malaria/physiopathology ; Plasmodium/physiology
Language	English
Publishing date	2001-05
Publishing country	United States
Document type	Comment ; Editorial ; Review
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1053/jhep.2001.24740
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Zs.A 1660: Show issues

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Article ; Online: An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors.

Gatton, Michelle L / Ciketic, Sadmir / Barnwell, John W / Cheng, Qin / Chiodini, Peter L / Incardona, Sandra / Bell, David / Cunningham, Jane / González, Iveth J

PloS one

2018 Volume 13, Issue 5, Page(s) e0197395

Abstract: Background: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely ... ...

Abstract	Background: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. Methods: Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain). Only RDTs with a FP rate against clean negative samples less than 10% were included. Paired t-tests were used to compare product-specific FP rates on clean negative samples and samples containing non-Plasmodium infectious agents and immunological factors. Results: Forty (18%) RDTs showed no FP results against any tested infectious agent or immunological factor. In the remaining RDTs significant and clinically relevant increases in FP rates were observed for samples containing HAMA and RF (P<0.001). There were significant correlations between product-matched FP rates for RF and HAMA on all RDT test bands (P<0.001), and FP rates for each infectious agent and immunological factor were also correlated between test bands of combination RDTs (P≤0.002). Conclusions: False positive results against non-Plasmodium infectious agents and immunological factors does not appear to be a universal property of malaria RDTs. However, since many malaria RDTs have elevated FP rates against HAMA and RF positive samples practitioners may need to consider the possibility of false positive results for malaria in patients with conditions that stimulate HAMA or RF.
MeSH term(s)	Antigens, Protozoan/blood ; Chagas Disease/diagnosis ; Chagas Disease/parasitology ; Dengue/diagnosis ; Dengue/parasitology ; Diagnostic Tests, Routine/methods ; False Positive Reactions ; Humans ; Immune System ; Leishmaniasis/diagnosis ; Leishmaniasis/parasitology ; Malaria/diagnosis ; Plasmodium vivax ; Reproducibility of Results ; Schistosomiasis/diagnosis ; Schistosomiasis/parasitology ; Sensitivity and Specificity
Chemical Substances	Antigens, Protozoan
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0197395
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Article: Malaria. A new escape and evasion tactic.

Barnwell, J W

Nature

1999 Volume 398, Issue 6728, Page(s) 562–563

MeSH term(s)	Adaptation, Physiological ; Animals ; Antigenic Variation ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Biological Evolution ; Genes, Protozoan ; Mice ; Multigene Family ; Phenotype ; Plasmodium/genetics ; Plasmodium/immunology ; Plasmodium/physiology ; Plasmodium yoelii/genetics ; Plasmodium yoelii/immunology ; Plasmodium yoelii/physiology ; Rodentia
Chemical Substances	Antigens, Protozoan
Language	English
Publishing date	1999-04-15
Publishing country	England
Document type	Comment ; News
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/19198
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi.

Fonseca, Luis L / Joyner, Chester J / Saney, Celia L / Moreno, Alberto / Barnwell, John W / Galinski, Mary R / Voit, Eberhard O

Malaria journal

2018 Volume 17, Issue 1, Page(s) 410

Abstract: Background: Malaria is a major mosquito transmitted, blood-borne parasitic disease that afflicts humans. The disease causes anaemia and other clinical complications, which can lead to death. Plasmodium vivax is known for its reticulocyte host cell ... ...

Abstract	Background: Malaria is a major mosquito transmitted, blood-borne parasitic disease that afflicts humans. The disease causes anaemia and other clinical complications, which can lead to death. Plasmodium vivax is known for its reticulocyte host cell specificity, but many gaps in disease details remain. Much less is known about the closely related species, Plasmodium cynomolgi, although it is naturally acquired and causes zoonotic malaria. Here, a computational model is developed based on longitudinal analyses of P. cynomolgi infections in nonhuman primates to investigate the erythrocyte dynamics that is pertinent to understanding both P. cynomolgi and P. vivax malaria in humans. Methods: A cohort of five P. cynomolgi infected Rhesus macaques (Macaca mulatta) is studied, with individuals exhibiting a plethora of clinical outcomes, including varying levels of anaemia. A discrete recursive model with age structure is developed to replicate the dynamics of P. cynomolgi blood-stage infections. The model allows for parasitic reticulocyte preference and assumes an age preference among the mature RBCs. RBC senescence is modelled using a hazard function, according to which RBCs have a mean lifespan of 98 ± 21 days. Results: Based on in vivo data from three cohorts of macaques, the computational model is used to characterize the reticulocyte lifespan in circulation as 24 ± 5 h (n = 15) and the rate of RBC production as 2727 ± 209 cells/h/µL (n = 15). Analysis of the host responses reveals a pre-patency increase in the number of reticulocytes. It also allows the quantification of RBC removal through the bystander effect. Conclusions: The evident pre-patency increase in reticulocytes is due to a shift towards the release of younger reticulocytes, which could result from a parasite-induced factor meant to increase reticulocyte availability and satisfy the parasite's tropism, which has an average value of 32:1 in this cohort. The number of RBCs lost due to the bystander effect relative to infection-induced RBC losses is 62% for P. cynomolgi infections, which is substantially lower than the value of 95% previously determined for another simian species, Plasmodium coatneyi.
MeSH term(s)	Animals ; Erythrocytes/parasitology ; Macaca mulatta ; Malaria/parasitology ; Malaria/physiopathology ; Male ; Models, Biological ; Monkey Diseases/parasitology ; Monkey Diseases/physiopathology ; Plasmodium cynomolgi/physiology ; Reticulocytes/parasitology
Language	English
Publishing date	2018-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2091229-8
ISSN	1475-2875 ; 1475-2875
ISSN (online)	1475-2875
ISSN	1475-2875
DOI	10.1186/s12936-018-2560-6
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Article ; Online: Biomonitoring of exposure to Great Lakes contaminants among licensed anglers and Burmese refugees in Western New York: Toxic metals and persistent organic pollutants, 2010-2015.

Hsu, Wan-Hsiang / Zheng, Yue / Savadatti, Sanghamitra S / Liu, Ming / Lewis-Michl, Elizabeth L / Aldous, Kenneth M / Parsons, Patrick J / Kannan, Kurunthachalam / Rej, Robert / Wang, Wei / Palmer, Christopher D / Wattigney, Wendy A / Irvin-Barnwell, Elizabeth / Hwang, Syni-An

International journal of hygiene and environmental health

2022 Volume 240, Page(s) 113918

Abstract: Between 2010 and 2015, the New York State Department of Health (NYSDOH) conducted a biomonitoring program to gather exposure data on Great Lakes contaminants among licensed anglers and Burmese refugees living in western New York who ate locally caught ... ...

Abstract	Between 2010 and 2015, the New York State Department of Health (NYSDOH) conducted a biomonitoring program to gather exposure data on Great Lakes contaminants among licensed anglers and Burmese refugees living in western New York who ate locally caught fish. Four hundred and nine adult licensed anglers and 206 adult Burmese refugees participated in this program. Participants provided blood and urine samples and completed a detailed questionnaire. Herein, we present blood metal levels (cadmium, lead, and total mercury) and serum persistent organic pollutant concentrations [polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dichlorodiphenyldichloroethylene (DDE), and trans-nonachlor]. Multiple linear regression was applied to investigate the associations between analyte concentrations and indicators of fish consumption (locally caught fish meals, store-bought fish meals, and consuming fish/shellfish in the past week). Licensed anglers consumed a median of 16 locally caught fish meals and 22 store-bought fish meals while Burmese refugees consumed a median of 106 locally caught fish meals and 104 store-bought fish/shellfish meals in the past year. Compared to the general U.S. adult population, licensed anglers had higher blood lead and mercury levels; and Burmese refuges had higher blood cadmium, lead, and mercury, and higher serum DDE levels. Eating more locally caught fish was associated with higher blood lead, blood mercury, and serum ∑PCBs concentrations among licensed anglers. Licensed anglers and Burmese refugees who reported fish/shellfish consumption in the past week had elevated blood mercury levels compared with those who reported no consumption. Among licensed anglers, eating more store-bought fish meals was also associated with higher blood mercury levels. As part of the program, NYSDOH staff provided fish advisory outreach and education to all participants on ways to reduce their exposures, make healthier choices of fish to eat, and waters to fish from. Overall, our findings on exposure levels and fish consumption provide information to support the development and implementation of exposure reduction public health actions.
MeSH term(s)	Animals ; Biological Monitoring ; Fishes ; Food Contamination ; Humans ; Lakes ; New York ; Persistent Organic Pollutants ; Polychlorinated Biphenyls ; Refugees ; Water Pollutants, Chemical
Chemical Substances	Water Pollutants, Chemical ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2022-01-08
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2009176-X
ISSN	1618-131X ; 1438-4639
ISSN (online)	1618-131X
ISSN	1438-4639
DOI	10.1016/j.ijheh.2022.113918
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Zs.A 5334: Show issues

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Article ; Online: Maternal serum progesterone concentration and early conceptus development of bovine embryos produced in vivo or in vitro.

Barnwell, C V / Farin, P W / Whisnant, C S / Alexander, J E / Farin, C E

Domestic animal endocrinology

2015 Volume 52, Page(s) 75–81

Abstract: The hormone progesterone is essential for proper embryonic development. The objective of this study was to examine the relationship between recipient serum concentrations of progesterone, at the time of embryo transfer and at conceptus recovery, on ... ...

Abstract	The hormone progesterone is essential for proper embryonic development. The objective of this study was to examine the relationship between recipient serum concentrations of progesterone, at the time of embryo transfer and at conceptus recovery, on conceptus development from in vivo- or in vitro-produced embryos. Embryos were produced in vivo by superovulation of Holstein cows (IVO; n = 17) or in vitro with either serum-containing (IVPS; n = 27) or serum-restricted medium (IVPSR; n = 34). Single grade I blastocysts from each embryo production system were transferred into heifers on day 7 of development. Conceptuses were recovered on day 17 of gestation and classified as complete, degenerated, or no conceptus. Compared with the IVO group, in vitro-produced embryos had more (P = 0.055) degenerated conceptuses (IVO, 0%; IVPS, 18.5%; and IVPSR, 20.6%). There were no differences in progesterone concentrations at the time of transfer when recipients received either male or female embryos (P > 0.05). Progesterone concentrations in recipients receiving in vivo-produced embryos were higher (P < 0.05; 3.74 ± 0.4 ng/mL; least-squares mean ± standard error of the mean) on day 7 compared with those receiving in vitro-produced embryos (IVPS, 2.4 ± 0.2; IVPSR, 2.58 ± 0.3 ng/mL). However, there was no difference in progesterone concentration on day 7 between treatment groups for heifers from which short conceptuses (≤194 mm) were recovered on day 17. In contrast, when longer (>194 mm) conceptuses were recovered on day 17, heifers receiving in vitro-produced embryos had lower (P = 0.05) serum concentrations of progesterone on day 7 compared with those receiving in vivo-produced embryos (IVPS, 2.2 ± 0.5; IVPSR, 2.3 ± 0.5; IVO, 3.9 ± 0.5 ng/mL). In conclusion, differences in autonomy may exist between in vitro- and in vivo-produced embryos during the period of conceptus elongation with in vitro-produced embryos relying more on intrinsic factors to influence elongation.
MeSH term(s)	Animals ; Blastocyst/physiology ; Cattle/embryology ; Embryo Transfer/veterinary ; Embryonic Development/physiology ; Female ; Fertilization in Vitro/veterinary ; Gestational Age ; Male ; Pregnancy ; Progesterone/blood ; Superovulation
Chemical Substances	Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2015.03.004
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Zs.A 4204: Show issues

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Article ; Online: Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys.

Burns, James M / Miura, Kazutoyo / Sullivan, JoAnn / Long, Carole A / Barnwell, John W

Malaria journal

2016 Volume 15, Page(s) 159

Abstract: Background: The production of properly folded, recombinant sub-unit Plasmodium falciparum malaria vaccine candidates in sufficient quantities is often a challenge. Success in vaccine immunogenicity studies in small animal models does not always predict ... ...

Abstract	Background: The production of properly folded, recombinant sub-unit Plasmodium falciparum malaria vaccine candidates in sufficient quantities is often a challenge. Success in vaccine immunogenicity studies in small animal models does not always predict immunogenicity in non-human primates and/or human subjects. The aim of this study was to assess the immunogenicity of a chimeric blood-stage malaria vaccine in Aotus monkeys. This vaccine candidate includes the neutralizing B cell epitopes of P. falciparum merozoite surface protein 1 (rPfMSP119) genetically linked to a highly immunogenic, well-conserved P. falciparum merozoite surface protein 8 (rPfMSP8 (ΔAsn/Asp)) partner. Methods: Aotus nancymaae monkeys were immunized with purified rPfMSP1/8 or rPfMSP8 (ΔAsn/Asp) formulated with Montanide ISA 720 as adjuvant, or with adjuvant alone. Antibody responses to MSP119 and MSP8 domains were measured by ELISA following primary, secondary and tertiary immunizations. The functionality of vaccine-induced antibodies was assessed in a standard P. falciparum blood-stage in vitro growth inhibition assay. Non-parametric tests with corrections for multiple comparisons when appropriate were used to determine the significance of differences in antigen-specific IgG titres and in parasite growth inhibition. Results: The chimeric rPfMSP1/8 vaccine was shown to be well tolerated and highly immunogenic with boost-able antibody responses elicited to both PfMSP8 and PfMSP119 domains. Elicited antibodies were highly cross-reactive between FVO and 3D7 alleles of PfMSP119 and potently inhibited the in vitro growth of P. falciparum blood-stage parasites. Conclusions: Similar to previous results with inbred and outbred mice and with rabbits, the PfMSP1/8 vaccine was shown to be highly effective in eliciting P. falciparum growth inhibitory antibodies upon immunization of non-human primates. The data support the further assessment of PfMSP1/8 as a component of a multivalent vaccine for use in human subjects. As important, the data indicate that rPfMSP8 (ΔAsn/Asp) can be used as a malaria specific carrier protein to: (1) drive production of antibody responses to neutralizing B cell epitopes of heterologous vaccine candidates and (2) facilitate production of properly folded, recombinant P. falciparum subunit vaccines in high yield.
MeSH term(s)	Adjuvants, Immunologic/administration & dosage ; Animals ; Antibodies, Protozoan/blood ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Aotidae ; Cross Reactions ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Fabaceae ; Humans ; Malaria Vaccines/administration & dosage ; Malaria Vaccines/genetics ; Malaria Vaccines/immunology ; Malaria, Falciparum/immunology ; Malaria, Falciparum/prevention & control ; Mannitol/administration & dosage ; Mannitol/analogs & derivatives ; Merozoite Surface Protein 1/genetics ; Merozoite Surface Protein 1/immunology ; Merozoites/immunology ; Oleic Acids/administration & dosage ; Plasmodium falciparum/genetics ; Plasmodium falciparum/growth & development ; Plasmodium falciparum/immunology ; Protozoan Proteins/genetics ; Protozoan Proteins/immunology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Treatment Outcome ; Vaccines, Subunit/administration & dosage ; Vaccines, Subunit/genetics ; Vaccines, Subunit/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology
Chemical Substances	Adjuvants, Immunologic ; Antibodies, Protozoan ; Antigens, Protozoan ; Malaria Vaccines ; Merozoite Surface Protein 1 ; Oleic Acids ; Protozoan Proteins ; Recombinant Fusion Proteins ; Vaccines, Subunit ; Vaccines, Synthetic ; merozoite surface protein 8, Plasmodium ; mannide monooleate (25339-93-9) ; Mannitol (3OWL53L36A)
Language	English
Publishing date	2016-03-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-016-1226-5
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Article ; Online: Transcriptome profiling of

Gunalan, Karthigayan / Sá, Juliana M / Moraes Barros, Roberto R / Anzick, Sarah L / Caleon, Ramoncito L / Mershon, J Patrick / Kanakabandi, Kishore / Paneru, Monica / Virtaneva, Kimmo / Martens, Craig / Barnwell, John W / Ribeiro, Jose M / Miller, Louis H

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 14, Page(s) 7053–7061

Abstract: Unlike the case in Asia and Latin America, ...

Abstract	Unlike the case in Asia and Latin America,
MeSH term(s)	Animals ; Antigens, Protozoan/genetics ; Antigens, Protozoan/metabolism ; Duffy Blood-Group System/genetics ; Duffy Blood-Group System/metabolism ; Erythrocytes/metabolism ; Erythrocytes/parasitology ; Gene Expression Profiling ; Malaria, Vivax/genetics ; Malaria, Vivax/metabolism ; Plasmodium vivax/genetics ; Plasmodium vivax/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Saimiri
Chemical Substances	Antigens, Protozoan ; Duffy Blood-Group System ; Duffy antigen binding protein, Plasmodium ; Protozoan Proteins ; Receptors, Cell Surface
Language	English
Publishing date	2019-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1818485116
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Zs.A 1148: Show issues

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Article ; Online: Five-year results of randomized bioactive versus bare metal coils in the treatment of intracranial aneurysms: the Matrix and Platinum Science (MAPS) Trial.

McDougall, Cameron G / Johnston, S Claiborne / Hetts, Steven W / Gholkar, Anil / Barnwell, Stanley L / Vazquez Suarez, Juan Carlos / Massó Romero, Javier / Chaloupka, John C / Bonafe, Alain / Wakhloo, Ajay K / Tampieri, Donatella / Dowd, Christopher F / Fox, Allan J / Turk, Aquilla S

Journal of neurointerventional surgery

2020 Volume 13, Issue 10, Page(s) 930–934

Abstract: Background: No randomized trial of intracranial aneurysm coiling has compared long-term efficacy of polymer-modified coils to bare metal coils (BMCs). We report 5-year results comparing Matrix: Methods: A total of 626 patients were randomized to BMCs ...

Abstract	Background: No randomized trial of intracranial aneurysm coiling has compared long-term efficacy of polymer-modified coils to bare metal coils (BMCs). We report 5-year results comparing Matrix Methods: A total of 626 patients were randomized to BMCs or Matrix Results: Of 580 patients eligible for 5-year follow-up, 431 (74.3%) completed follow-up or reached TAR. Matrix Conclusions: After 5 years Matrix
MeSH term(s)	Aneurysm, Ruptured/therapy ; Embolization, Therapeutic/adverse effects ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Treatment Outcome
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2020-016906
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