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  1. Article: Pregabalin alters reproductive performance in male mice and causes congenital anomalies in offspring.

    Mestre, Viviane de Fátima / Martins, Caio Cezar Nantes / Brito, Lorrany Victor de / Zeffa, Aline Campos / Sestário, Camila Salvador / Salles, Maria José Sparça

    Reproduction, fertility, and development

    2023  Volume 35, Issue 18, Page(s) 750–759

    Abstract: Context: Pregabalin is an anticonvulsant drug with analgesic activity for the treatment of neuropathic pain.: Aims: To valuate the toxicity of pregabalin in reproductive parameters, spermatogenesis, and teratogenicity in the offspring of mice.: ... ...

    Abstract Context: Pregabalin is an anticonvulsant drug with analgesic activity for the treatment of neuropathic pain.
    Aims: To valuate the toxicity of pregabalin in reproductive parameters, spermatogenesis, and teratogenicity in the offspring of mice.
    Methods: Twenty male mice were randomly distributed into two groups: PGB group and group C (n =10 per group). The animals in the PGB group received, via gavage, 200mg/kg of pregabalin diluted in distilled water daily, for a period of 45days. Group C received distilled water under the same experimental design.
    Key results: In the paternal parameters of the PGB group, there was a significant increase in the size of the testicles, morphological alterations in the spermatozoa, a decrease in the Johnsen score, an increase in the Leydig cells, and a decrease in the serum level of testosterone. In the intrauterine development parameters of females mated with males from the PGB group, a significant decrease in placental weight, weight and length of fetuses, and fetal viability rate was observed. There was a significant increase in the number of resorptions and post-implantation losses. The significant anomalies observed in the offspring were alteration in the size of the kidneys, absent metacarpals and phalanges, alteration in the sternum, and supernumerary thoracic vertebrae.
    Conclusion: Results suggest that pregabalin had toxic effects on the reproductive function of male mice and teratogenic potential.
    Implications: The findings of this study may provide new hypotheses, taking into account the risk-benefit ratio for male reproduction and offspring health.
    MeSH term(s) Male ; Mice ; Female ; Animals ; Pregnancy ; Pregabalin/pharmacology ; Placenta ; Analgesics/adverse effects ; Reproduction ; Teratogenesis ; Water
    Chemical Substances Pregabalin (55JG375S6M) ; Analgesics ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-11-27
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1019913-5
    ISSN 1448-5990 ; 1031-3613
    ISSN (online) 1448-5990
    ISSN 1031-3613
    DOI 10.1071/RD22287
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  2. Article: Healing of tumor-induced osteomalacia as assessed by high-resolution peripheral quantitative computed tomography is not similar across the skeleton in the first years following complete tumor excision.

    Salles Rosa Neto, Nilton / Pereira, Rosa Maria Rodrigues / Yuki, Emily Figueiredo Neves / Souza, Fernando Henrique Carlos de / Takayama, Liliam / Carneiro, Maria Inez da Silveira / Lima, Luiz Guilherme Cernaglia Aureliano de / Ishy, Augusto / Elias, Alexandre José Reis

    Bone reports

    2024  Volume 21, Page(s) 101758

    Abstract: Tumor-induced osteomalacia is caused by excessive fibroblast growth factor 23 production mainly from phosphaturic mesenchymal tumors. Surgical excision or tumor ablation are the preferred treatment. Information on bone microarchitecture parameters ... ...

    Abstract Tumor-induced osteomalacia is caused by excessive fibroblast growth factor 23 production mainly from phosphaturic mesenchymal tumors. Surgical excision or tumor ablation are the preferred treatment. Information on bone microarchitecture parameters assessed by high-resolution peripheral quantitative computed tomography is limited. We report a woman with hypophosphatemic osteomalacia with generalized pain, weakness and recurrent fractures, and a large thoracic vertebral mass extending to the posterior mediastinum. Detailed radiologic and histopathologic evaluation revealed a phosphaturic mesenchymal tumor. Two surgeries were necessary for complete removal of the mass. Clinical symptoms improved after attaining normophosphatemia. Four-year post-surgical HR-pQCT parameters, compared to baseline, showed in the left distal radius, stable trabecular and cortical volumetric bone mineral density although below reference range. There was stability of trabecular number and thickness. Both stiffness and failure load decreased. A shift in cortical parameters was noted in year 2. In the left distal tibia, trabecular volumetric bone mineral density decreased whereas cortical volumetric bone mineral density markedly increased, as did cortical area. There was stability in the trabecular number and thickness. Both stiffness and failure load improved. Findings from HR-pQCT measurements in this patient disclosed that the healing of osteomalacia is not similar across the peripheral skeletal sites in the first years following tumor removal. Results contrasted low but stable volumetric bone mineral density in the distal radius with increase in the distal tibia at the expense of cortical bone. Our report helps further delineate the pattern of bone healing after treatment of this rare bone disorder.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2821774-3
    ISSN 2352-1872
    ISSN 2352-1872
    DOI 10.1016/j.bonr.2024.101758
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  3. Article ; Online: P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis.

    de Salles, Érika Machado / Raeder, Paulo Lisboa / Angeli, Claudia Blanes / Santiago, Verônica Feijoli / de Souza, Cristiane Naffah / Ramalho, Theresa / Câmara, Niels Olsen Saraiva / Palmisano, Giuseppe / Álvarez, José Maria / D'Império Lima, Maria Regina

    Frontiers in immunology

    2023  Volume 14, Page(s) 1140426

    Abstract: Introduction: This study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP).: Methods: In vivo: Results: ...

    Abstract Introduction: This study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP).
    Methods: In vivo
    Results: We show that P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. Cell-intrinsic P2RX7 signaling sustains the glycolytic pathway and causes bioenergetic mitochondrial stress in activated CD4+ T cells. We also show
    Conclusion: These data demonstrate that P2RX7-mediated metabolic reprograming for aerobic glycolysis is a key event for Th1 differentiation and suggest that ATP synthase inhibition is a downstream effect of P2RX7 signaling that potentiates the Th1 response.
    MeSH term(s) Animals ; Mice ; Mice, Inbred C57BL ; Receptors, Purinergic P2X7/metabolism ; Th1 Cells/cytology ; Th1 Cells/metabolism ; Cell Differentiation ; Glycolysis ; Plasmodium chabaudi ; Malaria/immunology ; Adenosine Triphosphate ; Adenosine Triphosphatases ; Mitochondria/metabolism ; T-Box Domain Proteins/metabolism ; Oxidative Phosphorylation ; Signal Transduction ; Cells, Cultured
    Chemical Substances P2rx7 protein, mouse ; Receptors, Purinergic P2X7 ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine Triphosphatases (EC 3.6.1.-) ; T-box transcription factor TBX21 ; T-Box Domain Proteins
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1140426
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  4. Article ; Online: Intrauterine exposure to omeprazole increases the risk of teeth morphological anomalies in the offspring of a murine model.

    Frítola, Márjori / Sestario, Camila Salvador / Martins, Caio Cezar Nantes / Ezequiel, Bruna Santos / Morimoto, Juliano / Salles, Maria José Sparça

    Odontology

    2022  Volume 111, Issue 2, Page(s) 401–408

    Abstract: Conditions experienced in early life have long-lasting effects on offspring health. Despite this, little is known about how maternal exposure to drugs during pregnancy affects offspring teeth morphogenesis. In humans, omeprazole is a common drug used to ... ...

    Abstract Conditions experienced in early life have long-lasting effects on offspring health. Despite this, little is known about how maternal exposure to drugs during pregnancy affects offspring teeth morphogenesis. In humans, omeprazole is a common drug used to mitigate Gastroesophageal Reflux Disease. Importantly, omeprazole is a non-specific proton-pump inhibitor, which may inhibit the proton pumps expressed in the developing tooth germ. To date, however, the effects of intrauterine life exposure to omeprazole on offspring tooth development remain unknown. In this study, we addressed this gap in a murine model. Pregnant female Swiss mice were exposed to daily doses of 40 mg/kg of omeprazole from the 5
    MeSH term(s) Humans ; Pregnancy ; Female ; Animals ; Mice ; Omeprazole/adverse effects ; Disease Models, Animal ; Proton Pump Inhibitors/adverse effects ; Gastroesophageal Reflux ; Odontogenesis
    Chemical Substances Omeprazole (KG60484QX9) ; Proton Pump Inhibitors
    Language English
    Publishing date 2022-10-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2092085-4
    ISSN 1618-1255 ; 1618-1247
    ISSN (online) 1618-1255
    ISSN 1618-1247
    DOI 10.1007/s10266-022-00749-x
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  5. Article ; Online: Prediabetes, type 2 diabetes mellitus and risk of Parkinson's disease: A population-based cohort study.

    Sánchez-Gómez, Almudena / Díaz, Yesika / Duarte-Salles, Talita / Compta, Yaroslau / Martí, Maria José

    Parkinsonism & related disorders

    2021  Volume 89, Page(s) 22–27

    Abstract: Background: Association of type 2 diabetes mellitus (T2D) with subsequent Parkinson's disease (PD) has supported the link between glucose metabolism and PD. We assessed the risk of PD not only in T2D but also in prediabetes.: Methods: We conducted a ... ...

    Abstract Background: Association of type 2 diabetes mellitus (T2D) with subsequent Parkinson's disease (PD) has supported the link between glucose metabolism and PD. We assessed the risk of PD not only in T2D but also in prediabetes.
    Methods: We conducted a retrospective cohort study of the population attended in primary care centres of the Catalan Health Institute in Catalonia between 2006 and 2018. The data were obtained from the Information System for Research in Primary Care (SIDIAP). We created a cohort of T2D and prediabetes patients (HbA1c ≥ 5.7-6.4% without antidiabetic drugs or previous T2D diagnosis) and compared to a reference cohort. The outcome was PD diagnosis and we excluded PD before or during the first year of follow-up. We used multivariate Cox regression models to calculate hazard ratios (HR) and 95% confidence intervals (95%CI). We excluded subjects with atypical and secondary parkinsonisms.
    Results: The exposed cohorts comprised of 281.153 patients with T2D and 266.379 with prediabetes and a reference cohort of 2.556.928 subjects. T2D and prediabetes were associated with higher risk of PD (HRadjusted 1.19, 95%CI 1.13-1.25, and 1.07, 1.00-1.14; respectively). In analyses stratified by sex, prediabetes was only associated with PD risk in women (1.12, 1.03-1.22 vs. 1.01, 0.99-1.10 in men). When analysis was stratified by age, T2D and prediabetes were associated with a greater PD risk both in women (2.36, 1.96-2.84 and 2.10, 1.70-2.59 respectively) and men (1.74, 1.52-2.00 and 1.90, 1.57-2.30 respectively) below 65 years-old.
    Conclusions: We report for the first time that prediabetes increases the odds of subsequent PD and replicate the association with established T2D. Both associations predominate in women and young individuals.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Comorbidity ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Parkinson Disease/epidemiology ; Prediabetic State/epidemiology ; Retrospective Studies ; Risk ; Sex Factors ; Spain/epidemiology ; Young Adult
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2021.06.002
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  6. Article: Congenital anomalies and spontaneous abortion in mice resulting from the use of escitalopram.

    Sestario, Camila Salvador / de Fátima Mestre, Viviane / Nantes Martins, Caio Cezar / Campos Zeffa, Aline / Frítola, Márjori / Sparça Salles, Maria José

    Reproduction, fertility, and development

    2022  Volume 34, Issue 17, Page(s) 1099–1106

    Abstract: Context: Escitalopram (ESC) use during pregnancy has not been associated with teratogenic effects in fetuses.: Aims: To investigate whether ESC administered during pregnancy in mice induces maternal toxicity and teratogenicity in offspring.: ... ...

    Abstract Context: Escitalopram (ESC) use during pregnancy has not been associated with teratogenic effects in fetuses.
    Aims: To investigate whether ESC administered during pregnancy in mice induces maternal toxicity and teratogenicity in offspring.
    Methods: Treated mice groups G1 and control G0 (n =15 per group). Administration of ESC (G1) and saline solution (G0) during pregnancy and euthanasia on the 18thday. Pregnant female mice were treated with ESC (20mg/kg, via gavage) or saline solution (control group) from the 5th to the 17thday of gestation, when implantation was consolidated. During intraembryonic development until the day before delivery, the drug had an influence on the development of alterations from its maintenance in the uterine environment and its development to the disturbance causing skeletal or visceral malformations.
    Key results: The intrauterine development parameters that were altered by ESC treatment were: number of resorptions (G0: [0.93±0.24]); G1: [3.33±0.51]), post-implantation loss (G0: [3.95±1.34], G1: [13.75±3.62]) and reduced fetal viability: [97.30±1.00]; G1: [81.09±6.22]). Regarding fetal formation, the treated group had visceral malformations with a significant frequency: cleft palate (G0: [1.0%], G1: [11.86%]) and reduced kidneys (G0: [0%]; G1: [10.17%]). Regarding skeletal malformations, a higher frequency was observed in the following parameters: incomplete supraoccipital ossification (G0: [0%], G1: [15.25]), absence of ribs (G0: [0%], G1 (G0: [0%], G1 [15.25%]) and absence of one or more of the foot phalanges (G0: [1.0%]; 64%]).
    Conclusion: Results indicate that ESC is an embryotoxic and teratogenic drug.
    Implications: Until further studies are performed, greater caution is necessary in prescribing the drug to pregnant women.
    MeSH term(s) Humans ; Mice ; Pregnancy ; Female ; Animals ; Abnormalities, Drug-Induced/etiology ; Abortion, Spontaneous/chemically induced ; Escitalopram ; Saline Solution ; Teratogens
    Chemical Substances Escitalopram (4O4S742ANY) ; Saline Solution ; Teratogens
    Language English
    Publishing date 2022-10-11
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1019913-5
    ISSN 1448-5990 ; 1031-3613
    ISSN (online) 1448-5990
    ISSN 1031-3613
    DOI 10.1071/RD22033
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  7. Article ; Online: Breaking bad news in ophthalmology: a literature review.

    Vasconcellos, Cecília Francini Cabral de / Pellissari, Marina Cruz / Zin, Olivia Araujo / Salles, Mariana Valim / Sallum, Juliana Maria Ferraz / Vasconcellos, José Paulo Cabral de

    Arquivos brasileiros de oftalmologia

    2022  Volume 87, Issue 1, Page(s) 104

    Abstract: Medical specialties have recognized that breaking bad news assists clinical practice by mitigating the impact of difficult conversations. This scenario also encourages various studies on breaking bad news in ophthalmology since certain ocular diagnoses ... ...

    Abstract Medical specialties have recognized that breaking bad news assists clinical practice by mitigating the impact of difficult conversations. This scenario also encourages various studies on breaking bad news in ophthalmology since certain ocular diagnoses can be considered bad news. Thus, the objective is to review the scientific literature on breaking bad news in ophthalmology. The literature databases like MEDLINE/PUBMED, EMBASE, LILACS, SCOPUS, COCHRANE, and SCIELO, were screened for related research publications. Two independent reviewers read all the articles and short-listed the most relevant ones. Seven articles, in the formats of original article, review, editorial, oral communication, and correspondence, were reviewed. Conclusively it reveals that ophthalmologists are concerned with communicating bad news effectively but lack related studies. Nevertheless, there is a growing realization that training in breaking bad news can increase physicians' confidence during communication, thus, benefiting the therapeutic relationship with the patient and his family. Therefore, it would be valuable to include breaking bad news training in the curriculum of residencies.
    MeSH term(s) Humans ; Physician-Patient Relations ; Ophthalmology/education ; Internship and Residency ; Communication ; Ophthalmologists
    Language English
    Publishing date 2022-09-23
    Publishing country Brazil
    Document type Review ; Journal Article
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.2022-0104
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  8. Article: Clinical, radiographic, and genetic observations in 2 families with cleidocranial dysplasia.

    Mestre, Viviane Fátima / Spoladori, Isabella Carolina / Osiak, Lucas Brust / Paiva, Wagner José Martins / Ferreira de Lima, Renata Lúcia / Silveira, Bianca Carvalho / Salles, Maria José Sparça

    General dentistry

    2022  Volume 70, Issue 4, Page(s) 59–66

    Abstract: The clinical, radiographic, and molecular alterations in 7 individuals belonging to 2 families with clinical characteristics of cleidocranial dysplasia (CCD) were investigated. The patients underwent karyotype and genetic sequencing examinations. ... ...

    Abstract The clinical, radiographic, and molecular alterations in 7 individuals belonging to 2 families with clinical characteristics of cleidocranial dysplasia (CCD) were investigated. The patients underwent karyotype and genetic sequencing examinations. Cytogenetic analysis did not demonstrate any alterations. The next-generation sequencing technique employed for the molecular analysis revealed sequence variations in the RUNX2 gene: c.568C>T (p.Arg190Trp) in exon 4 in family A and c.1205del (p.Pro402Argfs*82) in exon 9 in family B. Incomplete closure of anterior fontanels, hypoplastic clavicles, and dental changes were observed in all 7 patients. Uncommon clinical findings, such as partial hearing loss and bilateral clavicular agenesis, were noted in some patients. According to the literature consulted, this is the first time that the total absence of the pubic bone in a study subject is being reported. The variable expression among individuals of the same family and between families A and B suggests the absence of a genotype-phenotype relationship. Early diagnosis allows the dentist to minimize the effects of changes associated with CCD by monitoring and providing appropriate treatment, and the identification of genetic sequence variations enables appropriate family genetic counseling.
    MeSH term(s) Cleidocranial Dysplasia/diagnostic imaging ; Cleidocranial Dysplasia/genetics ; Core Binding Factor Alpha 1 Subunit/genetics ; Humans
    Chemical Substances Core Binding Factor Alpha 1 Subunit
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603650-8
    ISSN 0363-6771
    ISSN 0363-6771
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  9. Article ; Online: MANEJO DE PLANTAS DE COBERTURA DE SOLO EM PRODUÇÃO HORTÍCOLA FAMILIAR EM NOVA FRIBURGO, RJ

    Ricardo Edson Salles / Renato Linhares de Assis / José Guilherme Marinho Guerra / Janaina Ribeiro Costa Rouws / Adriana Maria de Aquino

    Nativa, Vol 10, Iss

    2022  Volume 1

    Abstract: O uso de plantas de cobertura de solo nas rotações de cultivo de hortaliças nos ambientes de montanha de Nova Friburgo - RJ tem sido adaptado empiricamente às condições locais pelos agricultores. Nesse sentido, objetivou-se estabelecer conhecimentos ... ...

    Abstract O uso de plantas de cobertura de solo nas rotações de cultivo de hortaliças nos ambientes de montanha de Nova Friburgo - RJ tem sido adaptado empiricamente às condições locais pelos agricultores. Nesse sentido, objetivou-se estabelecer conhecimentos acerca da relação de diferentes épocas de plantio e de corte das plantas, com o aporte de fitomassa e de nitrogênio (N) e carbono (C) de aveia preta (Avena strigosa Schreb.) e tremoço branco (Lupinus albus L.). Para tanto, foi conduzido um experimento de março de 2015 a fevereiro de 2016, em uma unidade de produção orgânica em Nova Friburgo, estado do Rio de Janeiro. O delineamento adotado foi em blocos ao acaso, com três repetições, em esquema de parcelas sub-subdivididas. Nas parcelas foram avaliadas três épocas de plantio: março, julho e outubro; nas subparcelas as duas plantas de cobertura (aveia preta e tremoço branco), e nas sub-subparcelas as quatro épocas de coleta das plantas de cobertura: aos 30, 60, 90 e 120 dias após o plantio. Concluiu-se que as duas espécies de plantas de cobertura testadas apresentaram bom potencial para inserção nos sistemas de rotação de cultivo de hortaliças de Nova Friburgo, com desenvolvimento regular do tremoço branco nas diferentes épocas de plantio e restrições para plantio da aveia preta em períodos mais quentes e chuvosos. Palavras-chave: manejo orgânico; adubação verde; plantio direto; aveia preta; tremoço branco. Management of soil cover plants in family horticultural production in Nova Friburgo, RJ ABSTRACT: Farmers in the mountainous environment of Nova Friburgo state of Rio de Janeiro have been adapting soil cover plants empirically to the crop rotations. In this regard, with the purpose to establish the knowledge about the relationship between different planting and cutting seasons, with the contribution of phytomass and nitrogen (N) and carbon (C) of black oats (Avena strigosa Schreb.) and white lupine (Lupinus albus L.), was an experiment carried out from March 2015 to February 2016 at an organic production unit in ...
    Keywords manejo orgânico ; adubação verde ; plantio direto ; aveia preta ; tremoço branco ; Agriculture ; S ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Universidade Federal de Mato Grosso (UFMT)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

    Rondaan, Christien / Maso, Alessandra / Birlutiu, Rares-Mircea / Fernandez Sampedro, Marta / Soriano, Alex / Diaz de Brito, Vicens / Gómez Junyent, Joan / Del Toro, Maria Dolores / Hofstaetter, Jochen Gerhard / Salles, Mauro José / Esteban, Jaime / Wouthuyzen-Bakker, Marjan

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  

    Abstract: Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a ... ...

    Abstract Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.
    Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.
    Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).
    Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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