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  1. Article ; Online: Hepatic Stellate Cells and Retinoids: Toward A Much More Defined Relationship.

    Blaner, William S

    Hepatology (Baltimore, Md.)

    2019  Volume 69, Issue 2, Page(s) 484–486

    MeSH term(s) Carcinoma, Hepatocellular ; Hepatic Stellate Cells ; Humans ; Liver Cirrhosis ; Liver Neoplasms ; Myosins ; Receptors, Retinoic Acid ; Retinoids
    Chemical Substances Receptors, Retinoic Acid ; Retinoids ; retinoic acid receptor beta ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2019-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.30293
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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.

    Blaner, William S

    Pharmacology & therapeutics

    2019  Volume 197, Page(s) 153–178

    Abstract: Much evidence has accumulated in the literature over the last fifteen years that indicates vitamin A has a role in metabolic disease prevention and causation. This literature proposes that vitamin A can affect obesity development and the development of ... ...

    Abstract Much evidence has accumulated in the literature over the last fifteen years that indicates vitamin A has a role in metabolic disease prevention and causation. This literature proposes that vitamin A can affect obesity development and the development of obesity-related diseases including insulin resistance, type 2 diabetes, hepatic steatosis and steatohepatitis, and cardiovascular disease. Retinoic acid, the transcriptionally active form of vitamin A, accounts for many of the reported associations. However, a number of proteins involved in vitamin A metabolism, including retinol-binding protein 4 (RBP4) and aldehyde dehydrogenase 1A1 (ALDH1A1, alternatively known as retinaldehyde dehydrogenase 1 or RALDH1), have also been identified as being associated with metabolic disease. Some of the reported effects of these vitamin A-related proteins are proposed to be independent of their roles in assuring normal retinoic acid homeostasis. This review will consider both human observational data as well as published data from molecular studies undertaken in rodent models and in cells in culture. The primary focus of the review will be on the effects that vitamin A per se and proteins involved in vitamin A metabolism have on adipocytes, adipose tissue biology, and adipose-related disease, as well as on early stage liver disease, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
    MeSH term(s) Animals ; Homeostasis ; Humans ; Metabolic Diseases/metabolism ; Obesity/metabolism ; Signal Transduction ; Vitamin A/metabolism ; Vitamins/metabolism
    Chemical Substances Vitamins ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2019-01-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2019.01.006
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    Zs.A 1183: Show issues Location:
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  3. Article ; Online: Retinoid Actions: A New Horizon.

    Blaner, William S

    Endocrinology

    2017  Volume 158, Issue 9, Page(s) 2719–2721

    MeSH term(s) Humans ; Receptors, Retinoic Acid ; Retinoids
    Chemical Substances Receptors, Retinoic Acid ; Retinoids
    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2017-00622
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  4. Article ; Online: Acyl-CoA wax alcohol acyltransferase 2: its regulation and actions in support of color vision.

    Blaner, William S

    Journal of lipid research

    2017  Volume 58, Issue 4, Page(s) 633–635

    MeSH term(s) Acyltransferases ; Color Vision ; Diacylglycerol O-Acyltransferase ; Substrate Specificity
    Chemical Substances Acyltransferases (EC 2.3.-) ; Diacylglycerol O-Acyltransferase (EC 2.3.1.20)
    Language English
    Publishing date 2017-02-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.C075838
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    Zs.A 175: Show issues Location:
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  5. Article ; Online: Dietary Vitamin A Affects the Function of Incretin-Producing Enteroendocrine Cells in Male Mice Fed a High-Fat Diet.

    Calderon, Rossana M / Golczak, Marcin / Paik, Jisun / Blaner, William S

    The Journal of nutrition

    2023  Volume 153, Issue 10, Page(s) 2901–2914

    Abstract: Background: Retinol-binding protein 2 (RBP2) is an intracellular carrier for vitamin A in the absorptive enterocytes. Mice lacking RBP2 (Rbp2: Objectives: Given RBP2's role in intracellular retinoid trafficking, we aimed to evaluate whether dietary ... ...

    Abstract Background: Retinol-binding protein 2 (RBP2) is an intracellular carrier for vitamin A in the absorptive enterocytes. Mice lacking RBP2 (Rbp2
    Objectives: Given RBP2's role in intracellular retinoid trafficking, we aimed to evaluate whether dietary vitamin A affects incretin-secreting cell function and gene expression.
    Methods: Male Rbp2
    Results: Rbp2
    Conclusions: Our data support a role for RBP2 and dietary vitamin A in incretin secretion and gene expression in mice fed a HFD.
    MeSH term(s) Mice ; Male ; Animals ; Incretins/metabolism ; Diet, High-Fat/adverse effects ; Vitamin A/metabolism ; Gastric Inhibitory Polypeptide ; Glucagon-Like Peptide 1 ; Enteroendocrine Cells ; Blood Glucose/metabolism ; Insulin
    Chemical Substances Incretins ; Vitamin A (11103-57-4) ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide 1 (89750-14-1) ; Blood Glucose ; Insulin
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2023.08.030
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    Uc I Zs.205: Show issues Location:
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  6. Article ; Online: Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?

    Blaner, William S / Shmarakov, Igor O / Traber, Maret G

    Annual review of nutrition

    2021  Volume 41, Page(s) 105–131

    Abstract: Vitamin A, acting through its metabolite, all- ...

    Abstract Vitamin A, acting through its metabolite, all-
    MeSH term(s) Antioxidants/metabolism ; Antioxidants/therapeutic use ; Humans ; Tretinoin ; Vitamin A ; Vitamin E/metabolism ; Vitamins/therapeutic use
    Chemical Substances Antioxidants ; Vitamins ; Vitamin A (11103-57-4) ; Vitamin E (1406-18-4) ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-082018-124228
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    Zs.A 1786: Show issues Location:
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  7. Article ; Online: Control by the brain of vitamin A homeostasis.

    Imoesi, Peter I / Olarte-Sánchez, Cristian M / Croce, Lorenzo / Blaner, William S / Morgan, Peter J / Heisler, Lora / McCaffery, Peter

    iScience

    2023  Volume 26, Issue 8, Page(s) 107373

    Abstract: Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, ... ...

    Abstract Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107373
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  8. Article ; Online: Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms.

    Plau, Jacqueline / Morgan, Christopher E / Fedorov, Yuriy / Banerjee, Surajit / Adams, Drew J / Blaner, William S / Yu, Edward W / Golczak, Marcin

    ACS chemical biology

    2023  Volume 18, Issue 10, Page(s) 2309–2323

    Abstract: The dysregulation of retinoid metabolism has been linked to prevalent ocular diseases including age-related macular degeneration and Stargardt disease. Modulating retinoid metabolism through pharmacological approaches holds promise for the treatment of ... ...

    Abstract The dysregulation of retinoid metabolism has been linked to prevalent ocular diseases including age-related macular degeneration and Stargardt disease. Modulating retinoid metabolism through pharmacological approaches holds promise for the treatment of these eye diseases. Cellular retinol-binding protein 1 (CRBP1) is the primary transporter of all-
    MeSH term(s) Animals ; Mice ; Retinol-Binding Proteins, Cellular/metabolism ; Ligands ; Vitamin A/metabolism ; Eye ; Carrier Proteins
    Chemical Substances Retinol-Binding Proteins, Cellular ; Ligands ; Vitamin A (11103-57-4) ; Carrier Proteins
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00402
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  9. Article ; Online: Vitamin E: the enigmatic one!

    Blaner, William S

    Journal of lipid research

    2013  Volume 54, Issue 9, Page(s) 2293–2294

    MeSH term(s) Humans ; Vitamin E/chemistry ; Vitamin E/metabolism ; Vitamin E Deficiency/prevention & control
    Chemical Substances Vitamin E (1406-18-4)
    Language English
    Publishing date 2013-07-11
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.E042267
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  10. Article ; Online: The fat-soluble vitamins 100 years later: where are we now?

    Blaner, William S

    Journal of lipid research

    2013  Volume 54, Issue 7, Page(s) 1716–1718

    MeSH term(s) Animals ; Fats/chemistry ; Fats/metabolism ; Humans ; Solubility ; Vitamin A/chemistry ; Vitamin A/metabolism
    Chemical Substances Fats ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2013-05-07
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.E039891
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