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  1. Article ; Online: Memories of Stress: The Imprinted Cancer Risk After HCV Cure.

    Lupberger, Joachim / Baumert, Thomas F

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 2, Page(s) 323–324

    MeSH term(s) Humans ; Neoplasms ; Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges.

    Lupberger, Joachim / Baumert, Thomas F

    Journal of clinical medicine

    2021  Volume 11, Issue 1

    Abstract: Chronic viral hepatitis is a key risk factor for liver fibrosis and hepatocellular carcinoma (HCC) [ ... ]. ...

    Abstract Chronic viral hepatitis is a key risk factor for liver fibrosis and hepatocellular carcinoma (HCC) [...].
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11010208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Virus-Induced Risk of Hepatocellular Carcinoma

    Joachim Lupberger / Thomas F. Baumert

    Journal of Clinical Medicine, Vol 11, Iss 208, p

    Recent Progress and Future Challenges

    2022  Volume 208

    Abstract: Chronic viral hepatitis is a key risk factor for liver fibrosis and hepatocellular carcinoma (HCC) [.] ...

    Abstract Chronic viral hepatitis is a key risk factor for liver fibrosis and hepatocellular carcinoma (HCC) [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Inflammation-related prognostic markers in resected hepatocellular carcinoma.

    Giannone, Fabio / Slovic, Nevena / Pessaux, Patrick / Schuster, Catherine / Baumert, Thomas F / Lupberger, Joachim

    Frontiers in oncology

    2023  Volume 13, Page(s) 1267870

    Abstract: Hepatocellular carcinoma is usually detected late and therapeutic options are unsatisfactory. Despite marked progress in patient care, HCC remains among the deadliest cancers world-wide. While surgical resection remains a key option for early-stage HCC, ... ...

    Abstract Hepatocellular carcinoma is usually detected late and therapeutic options are unsatisfactory. Despite marked progress in patient care, HCC remains among the deadliest cancers world-wide. While surgical resection remains a key option for early-stage HCC, the 5-year survival rates after surgical resection are limited. One reason for limited outcomes is the lack of reliable prognostic biomarkers to predict HCC recurrence. HCC prognosis has been shown to correlate with different systemic and pathological markers which are associated with patient survival and HCC recurrence. Liver inflammatory processes offer a large variety of systemic and pathological markers which may be exploited to improve the reliability of prognosis and decision making of liver surgeons and hepatologists. The following review aims to dissect the potential tools, targets and prognostic meaning of inflammatory markers in patients with resectable HCC. We analyze changes in circulant cellular populations and assess inflammatory biomarkers as a surrogate of impaired outcomes and provide an overview on predictive gene expression signatures including inflammatory transcriptional patterns, which are representative of poor survival in these patients.
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1267870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interferon revisited: Peering behind the lines of antiviral defense.

    Virzì, Alessia / Roca Suarez, Armando Andres / Lupberger, Joachim

    Journal of hepatology

    2020  Volume 73, Issue 3, Page(s) 496–498

    MeSH term(s) Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C/drug therapy ; Humans ; Interferons/pharmacology ; Organelles ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-07-11
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.05.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences.

    Boulahtouf, Zakaria / Virzì, Alessia / Baumert, Thomas F / Verrier, Eloi R / Lupberger, Joachim

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the ... ...

    Abstract Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the conventional study of protein-host interactions, the rapid technological development of -omics and bioinformatics has allowed highlighting the important role of signaling networks in viral pathogenesis. In this review, we provide an integrated look on the three major viruses associated with chronic viral hepatitis in patients, summarizing similarities and differences in virus-induced cellular signaling relevant to the viral life cycles and liver disease progression.
    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Chlamydia Infections ; Hepatitis B/complications ; Hepatitis B virus ; Hepatitis Delta Virus ; Hepatitis, Chronic/complications ; Hepatitis, Viral, Human/complications ; Humans ; Liver Neoplasms/pathology
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nucleic Acid-Induced Signaling in Chronic Viral Liver Disease.

    Roca Suarez, Armando Andres / Testoni, Barbara / Baumert, Thomas F / Lupberger, Joachim

    Frontiers in immunology

    2021  Volume 11, Page(s) 624034

    Abstract: A hallmark for the development and progression of chronic liver diseases is the persistent dysregulation of signaling pathways related to inflammatory responses, which eventually promotes the development of hepatic fibrosis, cirrhosis and hepatocellular ... ...

    Abstract A hallmark for the development and progression of chronic liver diseases is the persistent dysregulation of signaling pathways related to inflammatory responses, which eventually promotes the development of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The two major etiological agents associated with these complications in immunocompetent patients are hepatitis B virus (HBV) and hepatitis C virus (HCV), accounting for almost 1.4 million liver disease-associated deaths worldwide. Although both differ significantly from the point of their genomes and viral life cycles, they exert not only individual but also common strategies to divert innate antiviral defenses. Multiple virus-modulated pathways implicated in stress and inflammation illustrate how chronic viral hepatitis persistently tweaks host signaling processes with important consequences for liver pathogenesis. The following review aims to summarize the molecular events implicated in the sensing of viral nucleic acids, the mechanisms employed by HBV and HCV to counter these measures and how the dysregulation of these cellular pathways drives the development of chronic liver disease and the progression toward HCC.
    MeSH term(s) Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; DNA, Viral/immunology ; Hepacivirus/immunology ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/mortality ; Hepatitis B, Chronic/pathology ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/mortality ; Hepatitis C, Chronic/pathology ; Humans ; Liver Neoplasms/immunology ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; RNA, Viral/immunology ; Signal Transduction/immunology
    Chemical Substances DNA, Viral ; RNA, Viral
    Language English
    Publishing date 2021-02-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.624034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis.

    Virzì, Alessia / Roca Suarez, Armando Andres / Baumert, Thomas F / Lupberger, Joachim

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 1

    Abstract: Hepatitis C virus (HCV) is a major cause of liver disease including metabolic disease, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HCV induces and promotes liver disease progression by perturbing a range of survival, proliferative, and ... ...

    Abstract Hepatitis C virus (HCV) is a major cause of liver disease including metabolic disease, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HCV induces and promotes liver disease progression by perturbing a range of survival, proliferative, and metabolic pathways within the proinflammatory cellular microenvironment. The recent breakthrough in antiviral therapy using direct-acting antivirals (DAAs) can cure >90% of HCV patients. However, viral cure cannot fully eliminate the HCC risk, especially in patients with advanced liver disease or comorbidities. HCV induces an epigenetic viral footprint that promotes a pro-oncogenic hepatic signature, which persists after DAA cure. In this review, we summarize the main signaling pathways deregulated by HCV infection, with potential impact on liver pathogenesis. HCV-induced persistent signaling patterns may serve as biomarkers for the stratification of HCV-cured patients at high risk of developing HCC. Moreover, these signaling pathways are potential targets for novel chemopreventive strategies.
    MeSH term(s) Antiviral Agents/therapeutic use ; Biomarkers/analysis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Hepacivirus/drug effects ; Hepacivirus/pathogenicity ; Hepatitis C/drug therapy ; Hepatitis C/genetics ; Hepatitis C/virology ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Oncogenes ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Antiviral Agents ; Biomarkers
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a037366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Profibrotic Signaling and HCC Risk during Chronic Viral Hepatitis: Biomarker Development.

    Virzì, Alessia / Gonzalez-Motos, Victor / Tripon, Simona / Baumert, Thomas F / Lupberger, Joachim

    Journal of clinical medicine

    2021  Volume 10, Issue 5

    Abstract: Despite breakthroughs in antiviral therapies, chronic viral hepatitis B and C are still the major causes of liver fibrosis and hepatocellular carcinoma (HCC). Importantly, even in patients with controlled infection or viral cure, the cancer risk cannot ... ...

    Abstract Despite breakthroughs in antiviral therapies, chronic viral hepatitis B and C are still the major causes of liver fibrosis and hepatocellular carcinoma (HCC). Importantly, even in patients with controlled infection or viral cure, the cancer risk cannot be fully eliminated, highlighting a persisting oncogenic pressure imposed by epigenetic imprinting and advanced liver disease. Reliable and minimally invasive biomarkers for early fibrosis and for residual HCC risk in HCV-cured patients are urgently needed. Chronic infection with HBV and/or HCV dysregulates oncogenic and profibrogenic signaling within the host, also displayed in the secretion of soluble factors to the blood. The study of virus-dysregulated signaling pathways may, therefore, contribute to the identification of reliable minimally invasive biomarkers for the detection of patients at early-stage liver disease potentially complementing existing noninvasive methods in clinics. With a focus on virus-induced signaling events, this review provides an overview of candidate blood biomarkers for liver disease and HCC risk associated with chronic viral hepatitis and epigenetic viral footprints.
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10050977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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